DK0560138T3 - Liposomal active substance preparations and methods for their preparation - Google Patents

Liposomal active substance preparations and methods for their preparation

Info

Publication number
DK0560138T3
DK0560138T3 DK93102968.0T DK93102968T DK0560138T3 DK 0560138 T3 DK0560138 T3 DK 0560138T3 DK 93102968 T DK93102968 T DK 93102968T DK 0560138 T3 DK0560138 T3 DK 0560138T3
Authority
DK
Denmark
Prior art keywords
preparation
methods
active substance
substance preparations
liposomal
Prior art date
Application number
DK93102968.0T
Other languages
Danish (da)
Inventor
Peter Dr Kurka
Peter Dr Serno
Roland Dr Rupp
Bernd Dipl-Ing Klinksiek
Karl-Hans Dr Dee
Horst-Dieter Dr Friedel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0560138T3 publication Critical patent/DK0560138T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a liposomal dihydropyridine formulation which can be administered parenterally and is based on liposomes with a phospholipid membrane, where the drug/phospholipid ratio is between 1:20 and 1:100, and the average liposome diameter is between 40 and 200 nm, and which has a pH between 4.5 and 6.5 after reconstitution, and to a process for its manufacture.
DK93102968.0T 1992-03-10 1993-02-25 Liposomal active substance preparations and methods for their preparation DK0560138T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207481A DE4207481A1 (en) 1992-03-10 1992-03-10 LIPOSOMAL ACTIVE SUBSTANCE FORMULATIONS AND METHOD FOR THE PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
DK0560138T3 true DK0560138T3 (en) 1996-08-05

Family

ID=6453618

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93102968.0T DK0560138T3 (en) 1992-03-10 1993-02-25 Liposomal active substance preparations and methods for their preparation

Country Status (8)

Country Link
EP (1) EP0560138B1 (en)
JP (1) JPH0616540A (en)
AT (1) ATE136212T1 (en)
CA (1) CA2091113A1 (en)
DE (2) DE4207481A1 (en)
DK (1) DK0560138T3 (en)
ES (1) ES2086802T3 (en)
GR (1) GR3019592T3 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU726572B2 (en) * 1994-02-16 2000-11-09 Aventis Pharma S.A. Cosmetics or pharmaceutical compositions consisting of liposomes
FR2716110B1 (en) * 1994-02-16 1996-04-05 Roussel Uclaf Cosmetic or pharmaceutical compositions comprising liposomes.
DE4432378A1 (en) * 1994-09-12 1996-03-14 Bayer Ag Injectable liposomal drug preparations
WO1996009037A1 (en) * 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
JPH0924269A (en) * 1995-07-10 1997-01-28 M Technic Kk Manufacture of micro-capsule using phosphorous lipid
DE19542499A1 (en) * 1995-11-15 1997-05-22 Bayer Ag Method and device for producing a parenteral drug preparation
DE19623950A1 (en) * 1996-06-15 1997-12-18 Boehringer Ingelheim Kg Pharmaceutical preparation in the form of liposomes
DE19757224A1 (en) 1997-12-22 1999-07-01 Bayer Ag Method and device for in-situ formulation of a drug solution for parenteral administration
WO2000069412A1 (en) * 1999-05-14 2000-11-23 Esperion Luv Development, Inc. Method of treating angina and/or anginal equivalents, and pharmaceutical compositions and kit related thereto
JP2006245154A (en) 2005-03-02 2006-09-14 Rohm Co Ltd Semiconductor integrated circuit device
JP2007082365A (en) 2005-09-16 2007-03-29 Rohm Co Ltd Temperature protection circuit, power supply device, and electronic apparatus
EP2076244B1 (en) * 2006-10-10 2016-12-07 Jina Pharmaceuticals Inc. Aqueous systems for the preparation of lipid-based pharmaceutical compounds; compositions, methods, and uses thereof
US8728504B2 (en) 2010-02-05 2014-05-20 Basf Se Process for solubilizing hydrophobic active ingredients in aqueous medium
CN102741327B (en) 2010-02-05 2014-11-05 巴斯夫欧洲公司 Method for solubilizing hydrophobic active ingredients in an aqueous solution
EP2682106A1 (en) 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Method of solubilizing biologically active compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3339861A1 (en) * 1983-11-04 1985-05-15 Bayer Ag, 5090 Leverkusen Medicinal formulation containing dihydropyridines
DE3515335C2 (en) * 1985-04-27 1995-01-26 Bayer Ag Pharmaceutical preparation containing dihydropyridines and process for their preparation
EP0461333B1 (en) * 1990-06-11 1995-03-29 Idi Farmaceutici S.P.A. Phospholipidic liposomes containing active principles and a process for the production thereof

Also Published As

Publication number Publication date
CA2091113A1 (en) 1993-09-11
DE4207481A1 (en) 1993-09-16
EP0560138A1 (en) 1993-09-15
ATE136212T1 (en) 1996-04-15
EP0560138B1 (en) 1996-04-03
GR3019592T3 (en) 1996-07-31
ES2086802T3 (en) 1996-07-01
DE59302084D1 (en) 1996-05-09
JPH0616540A (en) 1994-01-25

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