DK0537007T3 - Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener - Google Patents

Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener

Info

Publication number
DK0537007T3
DK0537007T3 DK92309184.7T DK92309184T DK0537007T3 DK 0537007 T3 DK0537007 T3 DK 0537007T3 DK 92309184 T DK92309184 T DK 92309184T DK 0537007 T3 DK0537007 T3 DK 0537007T3
Authority
DK
Denmark
Prior art keywords
drug
prepare
cells induced
protein transferase
transferase inhibitors
Prior art date
Application number
DK92309184.7T
Other languages
Danish (da)
English (en)
Inventor
Scott A Biller
Mariano Barbacid
David R Magnin
Eric M Gordon
Chester A Meyers
Veerasway Manne
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25102836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0537007(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of DK0537007T3 publication Critical patent/DK0537007T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK92309184.7T 1991-10-11 1992-10-08 Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener DK0537007T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77495791A 1991-10-11 1991-10-11

Publications (1)

Publication Number Publication Date
DK0537007T3 true DK0537007T3 (da) 1995-09-25

Family

ID=25102836

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92309184.7T DK0537007T3 (da) 1991-10-11 1992-10-08 Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener

Country Status (9)

Country Link
US (1) US6087349A (el)
EP (1) EP0537007B1 (el)
JP (1) JPH05221866A (el)
AT (1) ATE126059T1 (el)
CA (1) CA2080172A1 (el)
DE (1) DE69204007T2 (el)
DK (1) DK0537007T3 (el)
ES (1) ES2075630T3 (el)
GR (1) GR3017904T3 (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312814A (en) * 1992-12-09 1994-05-17 Bristol-Myers Squibb Co. α-phosphonocarboxylate squalene synthetase inhibitors
HUT77406A (hu) * 1994-03-15 1998-04-28 Eisai Co., Ltd., 1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények
US5436263A (en) * 1994-03-22 1995-07-25 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5420334A (en) * 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5510371A (en) * 1994-06-06 1996-04-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
CA2251716A1 (en) * 1996-04-15 1997-10-23 W. Gillies Mckenna Sensitization of cells to radiation and chemotherapy
WO1998007692A1 (en) 1996-08-17 1998-02-26 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
FR2780974B1 (fr) * 1998-07-08 2001-09-28 Sod Conseils Rech Applic Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
EP1644388A2 (en) 2003-06-27 2006-04-12 ODANI, Akira Bisphosphonate complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
US5196409A (en) * 1989-08-20 1993-03-23 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism
US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5185248A (en) * 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation

Also Published As

Publication number Publication date
EP0537007A1 (en) 1993-04-14
EP0537007B1 (en) 1995-08-09
DE69204007T2 (de) 1996-03-21
JPH05221866A (ja) 1993-08-31
GR3017904T3 (en) 1996-01-31
DE69204007D1 (de) 1995-09-14
US6087349A (en) 2000-07-11
CA2080172A1 (en) 1993-04-12
ES2075630T3 (es) 1995-10-01
ATE126059T1 (de) 1995-08-15

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