DK0529022T3 - New Leukotriene B4? Derivatives, Methods for their Preparation and Use - Google Patents

New Leukotriene B4? Derivatives, Methods for their Preparation and Use

Info

Publication number
DK0529022T3
DK0529022T3 DK92905138.1T DK92905138T DK0529022T3 DK 0529022 T3 DK0529022 T3 DK 0529022T3 DK 92905138 T DK92905138 T DK 92905138T DK 0529022 T3 DK0529022 T3 DK 0529022T3
Authority
DK
Denmark
Prior art keywords
stands
alkyl
bromine
chlorine
possibly substituted
Prior art date
Application number
DK92905138.1T
Other languages
Danish (da)
Inventor
Josef Heindl
Wolfgang Froehlich
Roland Ekerdt
Claudia Giesen
Werner Skuballa
Bernd Buchmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0529022T3 publication Critical patent/DK0529022T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/12—Alcohols containing rings other than six-membered aromatic rings containing five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses new leukotriene B4 derivatives of formula (I), wherein R?1 stands for CH2?OH, CH3?, CF3?, COOR?5, CONR?6R?7, or R?1 together with R?2 stands for a carbonyl group, R?2 and R?3 are the same or different and stand for H or an organic acid residue containing 1 to 15 carbon atoms, R?4 stands for H, C1?-C10? alkyl, possibly substituted one or more times by chlorine or bromine, C3?-C10? cycloalkyl, a C6?-C10? aryl residue possibly substituted one or more times by chlorine, bromine or phenyl, C1?-C4? alkyl, C1?-C4? alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy, or a 5- or 6-membered aromatic heterocyclic ring with at least one heteroatom, R?5 stands for hydrogen, C1?-C10? alkyl, C3?-C10? cycloalkyl, a C6?-C10? aryl residue possibly substituted one to three times by chlorine, bromine or phenyl, C1?-C4? alkyl, C1?-C4? alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy, CH2?-CO-(C6?-C10?) aryl or a 5- or 6-membered ring with at least one heteroatom, A stands for a trans,trans-CH=CH-CH=CH, a -CH2?CH2?-CH=CH- or a tetramethylene group, B stands for a C1?-C10? straight-chain or branched-chain alkylene group, possibly substituted by fluorine, or the group of formula (a), D stands for a direct bond, oxygen, sulphur, -C=C-, -CH=CR8? or, together with B, for a direct bond, R6? and R7? are the same or different and stand for H or C1?-C4? alkyl or R7? stands for H and R6? stands for C1?-C10? alkanoyl or C1?-C10? alkanesulphonyl, R8? stands for H, C1?-C5? alkyl, chlorine or bromine, n is equal to 3 to 5 and, when R5? stands for hydrogen, their salts with physiologically tolerable bases and their cyclodextrin clathrates.
DK92905138.1T 1991-03-12 1992-02-24 New Leukotriene B4? Derivatives, Methods for their Preparation and Use DK0529022T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4108351A DE4108351A1 (en) 1991-03-12 1991-03-12 NEW LEUKOTRIA-B (DOWN ARROW) 4 (DOWN ARROW) DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
DK0529022T3 true DK0529022T3 (en) 1996-02-05

Family

ID=6427320

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92905138.1T DK0529022T3 (en) 1991-03-12 1992-02-24 New Leukotriene B4? Derivatives, Methods for their Preparation and Use

Country Status (14)

Country Link
EP (1) EP0529022B1 (en)
JP (1) JPH06500566A (en)
AT (1) ATE128460T1 (en)
AU (1) AU1267892A (en)
CA (1) CA2082818A1 (en)
DE (2) DE4108351A1 (en)
DK (1) DK0529022T3 (en)
ES (1) ES2079857T3 (en)
GR (1) GR3018361T3 (en)
HU (1) HUT63596A (en)
IE (1) IE920792A1 (en)
NO (1) NO924347D0 (en)
PT (1) PT100227B (en)
WO (1) WO1992016504A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70477A (en) * 1991-11-29 1995-10-30 Schering Ag Leukotriene-b4 derivatives, process for preparing the same and medicaments contg. them cont. the same
US5783602A (en) * 1994-01-27 1998-07-21 Schering Aktiengesellschaft Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
DE19722848A1 (en) * 1997-05-23 1998-11-26 Schering Ag Leukotriene B¶4¶ derivatives, especially Oximo LTB¶4¶ antagonists
DE19722846A1 (en) * 1997-05-23 1998-12-24 Schering Ag Leukotriene B¶4¶ derivatives, especially 7-methylcyclohexyl LTB¶4¶ antagonists
US7327275B2 (en) 2004-02-02 2008-02-05 Gecko Alliance Group Inc. Bathing system controller having abnormal operational condition identification capabilities

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103445A3 (en) * 1982-09-03 1984-10-17 Teijin Limited Process for production of prostaglandins E or F, and novel 7-(thiocarbo-acyloxy) prostaglandins E or F
DE3917597A1 (en) * 1989-05-26 1990-11-29 Schering Ag NEW LEUKOTRIA-B (DOWN ARROW) 4 (DOWN ARROW) DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
DE59203817D1 (en) 1995-11-02
ATE128460T1 (en) 1995-10-15
IE920792A1 (en) 1992-09-23
EP0529022A1 (en) 1993-03-03
NO924347L (en) 1992-11-11
NO924347D0 (en) 1992-11-11
PT100227B (en) 1999-09-30
EP0529022B1 (en) 1995-09-27
HUT63596A (en) 1993-09-28
JPH06500566A (en) 1994-01-20
DE4108351A1 (en) 1992-09-17
ES2079857T3 (en) 1996-01-16
AU1267892A (en) 1992-10-21
GR3018361T3 (en) 1996-03-31
HU9203544D0 (en) 1993-01-28
WO1992016504A1 (en) 1992-10-01
PT100227A (en) 1993-07-30
CA2082818A1 (en) 1992-09-13

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