DK0525076T3 - Rekombinante galdesaltaktiverede lipaser - Google Patents
Rekombinante galdesaltaktiverede lipaserInfo
- Publication number
- DK0525076T3 DK0525076T3 DK91908492T DK91908492T DK0525076T3 DK 0525076 T3 DK0525076 T3 DK 0525076T3 DK 91908492 T DK91908492 T DK 91908492T DK 91908492 T DK91908492 T DK 91908492T DK 0525076 T3 DK0525076 T3 DK 0525076T3
- Authority
- DK
- Denmark
- Prior art keywords
- bal
- cdna
- pro
- base
- sequence
- Prior art date
Links
- 102100035687 Bile salt-activated lipase Human genes 0.000 title abstract 6
- 101710130200 Bile salt-activated lipase Proteins 0.000 title abstract 6
- 239000002299 complementary DNA Substances 0.000 abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 102100033639 Acetylcholinesterase Human genes 0.000 abstract 1
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract 1
- 102000003914 Cholinesterases Human genes 0.000 abstract 1
- 108090000322 Cholinesterases Proteins 0.000 abstract 1
- 108020005350 Initiator Codon Proteins 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 108091036407 Polyadenylation Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 101000715641 Rattus norvegicus Bile salt-activated lipase Proteins 0.000 abstract 1
- 108020005038 Terminator Codon Proteins 0.000 abstract 1
- 108091036066 Three prime untranslated region Proteins 0.000 abstract 1
- 229940022698 acetylcholinesterase Drugs 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 229940048961 cholinesterase Drugs 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004251 human milk Anatomy 0.000 abstract 1
- 235000020256 human milk Nutrition 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
- A23C9/1216—Other enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Saccharide Compounds (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50463590A | 1990-04-04 | 1990-04-04 | |
| US07/537,426 US5200183A (en) | 1987-11-19 | 1990-06-12 | Recombinant bile salt activated lipases |
| PCT/US1991/002328 WO1991015234A1 (fr) | 1990-04-04 | 1991-04-04 | Lipases recombinantes activees par le sel biliaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0525076T3 true DK0525076T3 (da) | 1999-08-30 |
Family
ID=27054892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98200772T DK0861897T3 (da) | 1990-04-04 | 1991-04-04 | Rekombinante galdesaltaktiverede lipaser |
| DK91908492T DK0525076T3 (da) | 1990-04-04 | 1991-04-04 | Rekombinante galdesaltaktiverede lipaser |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98200772T DK0861897T3 (da) | 1990-04-04 | 1991-04-04 | Rekombinante galdesaltaktiverede lipaser |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5200183A (fr) |
| EP (2) | EP0861897B1 (fr) |
| JP (3) | JP3665329B2 (fr) |
| AT (2) | ATE242813T1 (fr) |
| DE (2) | DE69130735T2 (fr) |
| DK (2) | DK0861897T3 (fr) |
| ES (2) | ES2201401T3 (fr) |
| GR (1) | GR3029711T3 (fr) |
| HK (2) | HK1011929A1 (fr) |
| WO (1) | WO1991015234A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173408A (en) * | 1989-11-13 | 1992-12-22 | Lange Louis George Iii | Mammalian pancreatic cholesterol esterase |
| HRP930935A2 (en) * | 1992-06-11 | 1994-12-31 | Astra Ab | New dna sequences |
| SE9300686D0 (sv) | 1993-03-01 | 1993-03-01 | Astra Ab | Novel polypeptides |
| IS4130A (is) * | 1993-03-01 | 1994-09-02 | Ab Astra | Ný fjölpeptíð |
| US5696087A (en) * | 1994-12-01 | 1997-12-09 | Oklahoma Medical Research Foundation | Method and compositions for reducing cholesterol absorption |
| US5681819A (en) * | 1994-12-01 | 1997-10-28 | Oklahoma Medical Research Foundation | Method and compositions for reducing cholesterol absorption |
| US5821226A (en) * | 1994-12-01 | 1998-10-13 | Oklahoma Medical Research Foundation | BAL C-tail drug delivery molecules |
| US6342218B1 (en) | 1997-02-14 | 2002-01-29 | Oklahoma Medical Research Foundation | Method for treatment of SLE |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| US6299868B1 (en) | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US6264937B1 (en) | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US7048917B1 (en) | 1998-01-09 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| US7049345B2 (en) * | 2001-06-29 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| CA2812852A1 (fr) | 2010-10-21 | 2012-04-26 | Swedish Orphan Biovitrum Ab (Publ) | Procede pour augmenter l'absorption d'acides gras insatures par des nourrissons humains |
| JP5850940B2 (ja) * | 2010-10-21 | 2016-02-03 | スウェディッシュ オーファン バイオビトラム パブリーク アクチエボラグ | ヒト乳児の発育速度を増大させる方法 |
| RU2013156071A (ru) * | 2011-05-18 | 2015-06-27 | Сведиш Орфан Биовитрум Аб (Пабл) | СПОСОБ ОЧИСТКИ БЕЛКОВ ПРИ НИЗКОМ pH |
| BR112014006798A2 (pt) * | 2011-09-26 | 2017-06-13 | Swedish Orphan Biovitrum Ab (Publ) | formulações melhoradas de lípase estimulada por sal billiar humana recombinantes |
| CA3066521A1 (fr) * | 2017-06-19 | 2018-12-27 | Swedish Orphan Biovitrum Ab (Publ) | Proteine de fusion presentant un polypeptide d'extension de demi-vie |
| WO2019201855A1 (fr) * | 2018-04-16 | 2019-10-24 | Swedish Orphan Biovitrum Ab (Publ) | Protéine de fusion lysosomale |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4944944A (en) * | 1987-11-19 | 1990-07-31 | Oklahoma Medical Research Foundation | Dietary compositions and methods using bile salt-activated lipase |
-
1990
- 1990-06-12 US US07/537,426 patent/US5200183A/en not_active Expired - Lifetime
-
1991
- 1991-04-04 ES ES98200772T patent/ES2201401T3/es not_active Expired - Lifetime
- 1991-04-04 DK DK98200772T patent/DK0861897T3/da active
- 1991-04-04 ES ES91908492T patent/ES2129026T3/es not_active Expired - Lifetime
- 1991-04-04 EP EP98200772A patent/EP0861897B1/fr not_active Expired - Lifetime
- 1991-04-04 WO PCT/US1991/002328 patent/WO1991015234A1/fr active IP Right Grant
- 1991-04-04 AT AT98200772T patent/ATE242813T1/de not_active IP Right Cessation
- 1991-04-04 DE DE69130735T patent/DE69130735T2/de not_active Expired - Lifetime
- 1991-04-04 DE DE69133279T patent/DE69133279T2/de not_active Expired - Lifetime
- 1991-04-04 DK DK91908492T patent/DK0525076T3/da active
- 1991-04-04 JP JP50765191A patent/JP3665329B2/ja not_active Expired - Lifetime
- 1991-04-04 EP EP91908492A patent/EP0525076B1/fr not_active Expired - Lifetime
- 1991-04-04 AT AT91908492T patent/ATE175356T1/de not_active IP Right Cessation
-
1996
- 1996-10-09 JP JP8268964A patent/JPH09132597A/ja active Pending
-
1998
- 1998-12-10 HK HK98113143A patent/HK1011929A1/xx not_active IP Right Cessation
- 1998-12-10 HK HK00100411A patent/HK1021547A1/xx not_active IP Right Cessation
-
1999
- 1999-03-16 GR GR990400798T patent/GR3029711T3/el unknown
-
2000
- 2000-09-08 JP JP2000274215A patent/JP2001112468A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2201401T3 (es) | 2004-03-16 |
| EP0861897B1 (fr) | 2003-06-11 |
| ATE242813T1 (de) | 2003-06-15 |
| HK1011929A1 (en) | 1999-07-23 |
| EP0525076A4 (en) | 1993-05-12 |
| ATE175356T1 (de) | 1999-01-15 |
| JP2001112468A (ja) | 2001-04-24 |
| JP3665329B2 (ja) | 2005-06-29 |
| JPH05508763A (ja) | 1993-12-09 |
| JPH09132597A (ja) | 1997-05-20 |
| EP0861897A2 (fr) | 1998-09-02 |
| EP0525076A1 (fr) | 1993-02-03 |
| WO1991015234A1 (fr) | 1991-10-17 |
| DK0861897T3 (da) | 2003-09-29 |
| HK1021547A1 (en) | 2000-06-16 |
| DE69130735T2 (de) | 1999-06-17 |
| DE69130735D1 (de) | 1999-02-18 |
| DE69133279T2 (de) | 2004-05-06 |
| EP0525076B1 (fr) | 1999-01-07 |
| DE69133279D1 (de) | 2003-07-17 |
| EP0861897A3 (fr) | 1999-05-12 |
| ES2129026T3 (es) | 1999-06-01 |
| GR3029711T3 (en) | 1999-06-30 |
| US5200183A (en) | 1993-04-06 |
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