DK0511187T3 - Process for Preparation of 1H-Benzimidazoles - Google Patents

Process for Preparation of 1H-Benzimidazoles

Info

Publication number
DK0511187T3
DK0511187T3 DK92870051.7T DK92870051T DK0511187T3 DK 0511187 T3 DK0511187 T3 DK 0511187T3 DK 92870051 T DK92870051 T DK 92870051T DK 0511187 T3 DK0511187 T3 DK 0511187T3
Authority
DK
Denmark
Prior art keywords
benzimidazoles
benzimidazol
carboxyphenyl
preparation
reacted
Prior art date
Application number
DK92870051.7T
Other languages
Danish (da)
Inventor
Gysel August Van
Andre Maquestiau
Eynde Jean-Jacques Vanden
Annie Mayence
Jean-Claude Vanovervelt
Original Assignee
Proviron Fine Chemicals N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proviron Fine Chemicals N V filed Critical Proviron Fine Chemicals N V
Application granted granted Critical
Publication of DK0511187T3 publication Critical patent/DK0511187T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Process for the preparation of 1H-benzimidazoles substituted in position 2, preferably those corresponding to the general formula <IMAGE> in which R1 represents a linear or branched alkyl containing 1 to 13 carbon atoms, a phenyl, halophenyl, 4-nitrophenyl, 4-methylphenyl, 4-cyanophenyl, 4-carboxyphenyl, benzyl, thienyl, furanyl, pyridyl, or 1,3- or 1,4-phenylene, R2 represents a hydrogen or chlorine atom, nitro or carboxyl, 2-(4-chlorophenyl)-1H-benzimidazol-5-yl, or 2-(4-carboxyphenyl)- 1H-benzimidazol-5-yl, and n is equal to 1 or 2. According to the invention, an aldehyde, a thionyl halide and a nitrogen-containing aromatic heterocyclic compound are reacted together, the product formed is then reacted with an optionally substituted 1,2-benzenediamine and the 1H-benzimidazole thus obtained is separated from the reaction mixture. Using this process, 1H-benzimidazoles are obtained in a single stage, under moderate conditions, with very high yields.
DK92870051.7T 1991-04-18 1992-03-30 Process for Preparation of 1H-Benzimidazoles DK0511187T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108279A GB9108279D0 (en) 1991-04-18 1991-04-18 A method of preparing 1h-benzimidazoles

Publications (1)

Publication Number Publication Date
DK0511187T3 true DK0511187T3 (en) 1997-04-07

Family

ID=10693485

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92870051.7T DK0511187T3 (en) 1991-04-18 1992-03-30 Process for Preparation of 1H-Benzimidazoles

Country Status (7)

Country Link
EP (1) EP0511187B1 (en)
AT (1) ATE145398T1 (en)
DE (1) DE69215266T2 (en)
DK (1) DK0511187T3 (en)
ES (1) ES2096740T3 (en)
GB (1) GB9108279D0 (en)
GR (1) GR3022603T3 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
BR0206161A (en) * 2001-10-19 2005-02-01 Ortho Mcneil Pharm Inc 2-phenyl benzimidazoles and imidazo- [4,5] -pyridines as cds1 / chk2 inhibitors and adjuvants for chemotherapy or radiation therapy in cancer treatment
GB0821913D0 (en) * 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
EP2251010A1 (en) 2009-05-08 2010-11-17 Sygnis Bioscience GmbH & Co. KG Use of thiabendazole and derivatives thereof for the therapy of neurological conditions
AR077405A1 (en) 2009-07-10 2011-08-24 Sanofi Aventis DERIVATIVES OF INDOL INHIBITORS OF HSP90, COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF CANCER
CN101735152A (en) * 2009-12-18 2010-06-16 长沙理工大学 2,2'-(1,4-phenylene)bi(benzimidazole-5-carboxylic acid) and preparation method thereof
DK2575968T3 (en) 2010-06-01 2016-05-30 Summit Therapeutics Plc COMPOUNDS FOR THE TREATMENT OF Clostridium difficile-associated disease
KR20150039551A (en) * 2013-10-02 2015-04-10 제이에스알 가부시끼가이샤 Curable composition, cured film and process for forming the same, and compound
CN110272390A (en) * 2019-07-15 2019-09-24 北京大学 Polyphosphate kinase targeted inhibition agent P8

Also Published As

Publication number Publication date
DE69215266T2 (en) 1997-05-28
ES2096740T3 (en) 1997-03-16
EP0511187A1 (en) 1992-10-28
ATE145398T1 (en) 1996-12-15
GB9108279D0 (en) 1991-06-05
DE69215266D1 (en) 1997-01-02
GR3022603T3 (en) 1997-05-31
EP0511187B1 (en) 1996-11-20

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