DK0492494T3 - Process for the preparation of procaine - Google Patents
Process for the preparation of procaineInfo
- Publication number
- DK0492494T3 DK0492494T3 DK91121929.3T DK91121929T DK0492494T3 DK 0492494 T3 DK0492494 T3 DK 0492494T3 DK 91121929 T DK91121929 T DK 91121929T DK 0492494 T3 DK0492494 T3 DK 0492494T3
- Authority
- DK
- Denmark
- Prior art keywords
- procaine
- preparation
- alcohol
- diethylaminoethanol
- esterified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
The process is characterised in that p-nitrobenzoic acid is esterified in butanol in a manner known per se, the nitro ester is catalytically hydrogenated without intermediate isolation and the resulting hydrogenation solution, after removal by distillation of the majority of the alcohol used, is reacted with diethylaminoethanol in the presence of alkali metal alkoxides at 80 to 150 DEG C, preferably 80 to 130 DEG C, and in the course of this the alcohol liberated is continuously removed in vacuo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4041179A DE4041179A1 (en) | 1990-12-21 | 1990-12-21 | PROCESS FOR PRODUCING PROCAIN |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0492494T3 true DK0492494T3 (en) | 1996-12-02 |
Family
ID=6421030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91121929.3T DK0492494T3 (en) | 1990-12-21 | 1991-12-20 | Process for the preparation of procaine |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0492494B1 (en) |
JP (1) | JPH04295452A (en) |
CN (1) | CN1028360C (en) |
AT (1) | ATE140915T1 (en) |
CZ (1) | CZ282438B6 (en) |
DE (3) | DE4041179A1 (en) |
DK (1) | DK0492494T3 (en) |
ES (1) | ES2091855T3 (en) |
GR (1) | GR3020704T3 (en) |
HU (1) | HU208303B (en) |
MX (1) | MX9102747A (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1396913A (en) * | 1917-10-11 | 1921-11-15 | Levinstein Ltd | Production of aminoalkylesters and of alkylaminoalkylesters of para aminobenzoic acid |
US1676470A (en) * | 1921-09-27 | 1928-07-10 | Abbott Lab | Production of esters of aromatic acids |
AT213874B (en) * | 1958-08-22 | 1961-03-10 | Leuna Werke Veb | Process for the preparation of p-aminobenzoic acid alkamine esters |
US3660411A (en) * | 1970-06-15 | 1972-05-02 | Universal Oil Prod Co | Esterification process |
-
1990
- 1990-12-21 DE DE4041179A patent/DE4041179A1/en not_active Withdrawn
- 1990-12-21 DE DE4042433A patent/DE4042433A1/en not_active Withdrawn
-
1991
- 1991-12-19 CZ CS913922A patent/CZ282438B6/en unknown
- 1991-12-20 DK DK91121929.3T patent/DK0492494T3/en active
- 1991-12-20 HU HU914076A patent/HU208303B/en not_active IP Right Cessation
- 1991-12-20 MX MX9102747A patent/MX9102747A/en not_active IP Right Cessation
- 1991-12-20 ES ES91121929T patent/ES2091855T3/en not_active Expired - Lifetime
- 1991-12-20 DE DE59108052T patent/DE59108052D1/en not_active Expired - Fee Related
- 1991-12-20 CN CN91111746.6A patent/CN1028360C/en not_active Expired - Fee Related
- 1991-12-20 EP EP91121929A patent/EP0492494B1/en not_active Expired - Lifetime
- 1991-12-20 JP JP3337432A patent/JPH04295452A/en active Pending
- 1991-12-20 AT AT91121929T patent/ATE140915T1/en not_active IP Right Cessation
-
1996
- 1996-08-01 GR GR960402049T patent/GR3020704T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE4042433A1 (en) | 1992-09-03 |
ATE140915T1 (en) | 1996-08-15 |
GR3020704T3 (en) | 1996-11-30 |
HU914076D0 (en) | 1992-03-30 |
EP0492494A1 (en) | 1992-07-01 |
HU208303B (en) | 1993-09-28 |
MX9102747A (en) | 1992-06-01 |
DE4041179A1 (en) | 1992-07-02 |
JPH04295452A (en) | 1992-10-20 |
CS392291A3 (en) | 1992-07-15 |
CN1062722A (en) | 1992-07-15 |
DE59108052D1 (en) | 1996-09-05 |
HUT59657A (en) | 1992-06-29 |
ES2091855T3 (en) | 1996-11-16 |
CN1028360C (en) | 1995-05-10 |
EP0492494B1 (en) | 1996-07-31 |
CZ282438B6 (en) | 1997-07-16 |
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