DK0434095T3 - Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer - Google Patents
Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorerInfo
- Publication number
- DK0434095T3 DK0434095T3 DK90125245.2T DK90125245T DK0434095T3 DK 0434095 T3 DK0434095 T3 DK 0434095T3 DK 90125245 T DK90125245 T DK 90125245T DK 0434095 T3 DK0434095 T3 DK 0434095T3
- Authority
- DK
- Denmark
- Prior art keywords
- ortho
- substituted aryl
- compounds
- alkoxyalkyl
- hydroxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45600489A | 1989-12-21 | 1989-12-21 | |
| US60914590A | 1990-11-06 | 1990-11-06 | |
| US07/623,596 US5162569A (en) | 1989-12-21 | 1990-12-12 | Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0434095T3 true DK0434095T3 (da) | 1994-03-07 |
Family
ID=27412651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90125245.2T DK0434095T3 (da) | 1989-12-21 | 1990-12-21 | Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5162569A (da) |
| EP (1) | EP0434095B1 (da) |
| JP (1) | JPH04210667A (da) |
| AT (1) | ATE101125T1 (da) |
| CA (1) | CA2032827A1 (da) |
| DE (1) | DE69006471T2 (da) |
| DK (1) | DK0434095T3 (da) |
| ES (1) | ES2062286T3 (da) |
| IE (1) | IE66056B1 (da) |
| PT (1) | PT96297A (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486539A (en) * | 1989-12-21 | 1996-01-23 | G. D. Searle & Co. | Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
| US5247119A (en) * | 1990-12-12 | 1993-09-21 | G. D. Searle & Co. | Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
| WO1996010090A1 (en) * | 1994-09-29 | 1996-04-04 | Merck & Co., Inc. | A high capacity screen for immunoregulants |
| AU2008266798B2 (en) | 2007-06-20 | 2014-07-17 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154810B (de) * | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
| JPS5118940B2 (da) * | 1971-12-25 | 1976-06-14 | ||
| DE2946545A1 (de) * | 1979-11-17 | 1981-05-27 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen |
| US4593042A (en) * | 1985-10-18 | 1986-06-03 | G. D. Searle & Co. | Bicyclo-substituted phenylacetonitrile derivatives |
| DE3603032A1 (de) * | 1986-01-31 | 1987-08-06 | Basf Ag | Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel |
| CS258534B1 (en) * | 1986-07-18 | 1988-08-16 | Ludvik Blaha | Derivatives of valeronitrile and method of their preparation |
| DE3642331A1 (de) * | 1986-12-11 | 1988-06-23 | Basf Ag | Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel |
-
1990
- 1990-12-12 US US07/623,596 patent/US5162569A/en not_active Expired - Lifetime
- 1990-12-20 PT PT96297A patent/PT96297A/pt not_active Application Discontinuation
- 1990-12-20 CA CA002032827A patent/CA2032827A1/en not_active Abandoned
- 1990-12-20 IE IE462690A patent/IE66056B1/en not_active IP Right Cessation
- 1990-12-21 DK DK90125245.2T patent/DK0434095T3/da active
- 1990-12-21 DE DE69006471T patent/DE69006471T2/de not_active Expired - Fee Related
- 1990-12-21 ES ES90125245T patent/ES2062286T3/es not_active Expired - Lifetime
- 1990-12-21 JP JP2419049A patent/JPH04210667A/ja active Pending
- 1990-12-21 EP EP90125245A patent/EP0434095B1/en not_active Expired - Lifetime
- 1990-12-21 AT AT90125245T patent/ATE101125T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69006471T2 (de) | 1994-06-16 |
| IE904626A1 (en) | 1991-07-17 |
| EP0434095A1 (en) | 1991-06-26 |
| EP0434095B1 (en) | 1994-02-02 |
| DE69006471D1 (de) | 1994-03-17 |
| JPH04210667A (ja) | 1992-07-31 |
| PT96297A (pt) | 1991-09-30 |
| IE66056B1 (en) | 1995-12-13 |
| US5162569A (en) | 1992-11-10 |
| ATE101125T1 (de) | 1994-02-15 |
| CA2032827A1 (en) | 1991-06-22 |
| ES2062286T3 (es) | 1994-12-16 |
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