DEP0045279DA - Process for obtaining antidiabetic drugs that are also effective per os - Google Patents
Process for obtaining antidiabetic drugs that are also effective per osInfo
- Publication number
- DEP0045279DA DEP0045279DA DEP0045279DA DE P0045279D A DEP0045279D A DE P0045279DA DE P0045279D A DEP0045279D A DE P0045279DA
- Authority
- DE
- Germany
- Prior art keywords
- concentrate
- obtaining
- antidiabetic drugs
- effective per
- cultures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 6
- 229940127003 anti-diabetic drug Drugs 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 4
- 102000004877 Insulin Human genes 0.000 claims description 2
- 108090001061 Insulin Proteins 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 229940125396 insulin Drugs 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002594 sorbent Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 239000008223 sterile water Substances 0.000 claims 1
- 238000005292 vacuum distillation Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 description 3
- 241000228212 Aspergillus Species 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241000735284 Irena Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
Description
Verftthr« »m Qamimmng auoh per ο* wlA»mm AnfridiabetloaVerftthr « » m Qamimmng auoh per ο * wlA »mm Anfridiabetloa
Ate,3 Iasaila Mat bekanntlich den Kachteii, te Mafea~fia»k»Äl on* wirksam zn. werden» so dat äs nur ia 1om vo» Kinspritsungen applitiert werden Irena» Äs luit deshalb schon seit längerer 2eit versucht, andere - sieh per Oft ν Ixksaao· * Mit .el f ««lon« den Blat- «b4 Harasuokerspiegel en senken ve»· a§g©B9 st gewinnen. Insbesondere sind m& Getreidearten resp. deren Xeiolingea und «g Kulturen von Uefen and iiilohsaurebaJEille» Stoffe isoliert «erden, fite die eine eoleh« "IrksesJkeit behauptet wurde, »aeh des heutigen SttsA der fher&pie haben eich jedoch derartige Pziiparate - «ei es wegen «angelnde* TUrksaiokeit oder aus anderen Qründen · nicht durohsetnen könne», ee 4eJ et nach wit vor &» Mitteln, weiche das Insulin in d«r erstrebten Veise su er» garnen bazw. «tt ersetaen vernSgen, fehlt.Ate, 3 Iasaila Mat, as is well known, the Kachteii, te Mafea ~ fia »k» Äl on * effective zn. are "so äs dat only ia 1 om be applitiert vo" Kinspritsungen Irena »Äs luit therefore quite some 2eit tried other - see per Often ν Ixksaao · * 's b4 Harasuokerspiegel With .el f" "lon" to reduce Blat- ve »· a§g © B 9 st win. In particular, m & types of grain, respectively. whose xeiolingea and "g cultures of Uefen and IIilohsaurebaJEille" isolate "substances, fite an eoleh""insanity has been asserted," in today's place of fher & pie, however, I have such devices - whether it is because of "angled" turksaiokeity or from others Reasons · could not go through », ee 4eJ et after wit before &» means, which the insulin in the desired veise su er »yarns or« tt ersetaen understand, is missing.
Γ.6 wurde nun gefunden, da£ Kulturen von ßehiamelpilsen »aeh geeigneter Aafarbeitang sowohl per os al« ftueh parenteral wirksame Aatidlabetiea liefern, und »i erstreckt sieh diese Srkeaatais auf fa»t alle Penicillins- und Aspergillusaxtea. /ür die erfindangsgenäae Isolierung solcher «irketoffe eignen sieh 41» für die Oevinnung der Aatibiotlea aus Pilskultaren bekannt gewordenen Verfahren. Äwfcyts also sowohl Iw Oberflächen- al· auoh la Suoaer» Verfahren arbeiten, wie auch die Kulturen auf mannigfache art und Iiis« und BtittelB der verschiedensten HahrlSsungen hergestellt sein können. Dach den Verfahren der vorliegenden Erfindung werden die iäycelien der Iulturen in üblicher vi eise extrahiert, 4i« erhal tenea Sxtrakte eowie die Ährlißitagi» dialysiert end die Dialvsate - gegebenenfalls unter Einschaltung weiterer &a aioh bekannter Keinigungsaethoden - in schonender Seise kansentriert, worauf stan die erhalten«» Stoffe einer Behandlung sit Kohlenwasserstoffen unterwirft, ^lne bevorzugte AusfUhrungsfora für die Aufarbeitung der Iultüren ist (natürlich ohne daß dadurch eine Beschränkung hinsiohtlieh der Art und Vteise der «inxelnen Verfahrensstufe» ausgesprochen sein soll) s.B. folgende:It has now been found that cultures of diamonds are suitable for both perosal and parenteral lactation supply, and I see this Srkeaatais extends to almost all penicillin and Aspergillus axtea. For the inventive isolation of such active substances see 41 »suitable for the extraction of the Aatibiotlea from Pilskultaren methods which have become known. Äwfcyts so both Iw surface al · auoh la Suoaer » Procedures work, just as cultures can be produced in a variety of ways and means of the most varied of solutions. Roof the In the process of the present invention, the cycelia of the cultures are extracted in the usual way, 4i "obtain tenea extracts as well as the earliest ingredients" dialyzed end the dialvsate - possibly with the involvement of other & a aioh known refinement methods - in a gentle seise kansentriert, whereupon the received "" substances were subjected to treatment with hydrocarbons, a preferred embodiment for the processing of the doors is (of course without any restriction as to the type and form of the "internal procedural stage" being stated) see B. the following:
Faoh Abtrennung der KahrlSsuag, erhalten aus der Iultur eines hoehgesüohteton Staat»«« von Aspergillus alger, bringt zsa» das Oberflächen- oder submerse Mycelium in steriles destilliertes Tiasser und Uli einige Stunden diffundiere», worauf die Siffasate sowie die Hslhrl 8 sung swecks Abtrennnng unerwünschter Begleitstoffe dialysiert worden. Sias* »iinr« Keinigung 4« • einselnea oder vereinigte* - Oialysate besteht darin, dad nan sie »InwFaoh separation of the KahrlSsuag, obtained from the culture of a Hoehgesüohteton State »« «of Aspergillus alger, bring zsa» the surface or submerged mycelium in sterile distilled Tiasser and Uli a few hours diffuse », whereupon the Siffasate as well as the solution swecks separation of undesired accompanying substances were dialyzed. Sias * "iinr" no decision 4 " • single or combined * - Oialysate consists in that because they »Inw
Claims (1)
Family
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