DE9405878U1 - Rhenchodepressive substance - Google Patents
Rhenchodepressive substanceInfo
- Publication number
- DE9405878U1 DE9405878U1 DE9405878U DE9405878U DE9405878U1 DE 9405878 U1 DE9405878 U1 DE 9405878U1 DE 9405878 U DE9405878 U DE 9405878U DE 9405878 U DE9405878 U DE 9405878U DE 9405878 U1 DE9405878 U1 DE 9405878U1
- Authority
- DE
- Germany
- Prior art keywords
- substance
- rhenchodepressive
- collagen
- cross
- same effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims 6
- 108010035532 Collagen Proteins 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 206010041235 Snoring Diseases 0.000 claims description 2
- 230000000975 bioactive effect Effects 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 206010038669 Respiratory arrest Diseases 0.000 description 1
- 108010077465 Tropocollagen Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 108060002894 fibrillar collagen Proteins 0.000 description 1
- 102000013373 fibrillar collagen Human genes 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000010352 nasal breathing Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 125000003508 trans-4-hydroxy-L-proline group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Die Rhenchopathie oder in der Umgangssprache das Schnarchen ist eine Form der Belästigung des sozialen Umfeldes, das oft zu familiären Spannungen führt.Rhenchopathy, or colloquially known as snoring, is a form of social nuisance that often leads to family tensions.
Sie oder es tritt überwiegend in Schlafrückenlage auf und ist durch Schwingungen oder Flattern des weichen Gaumensegels, auch Velum genannt, bedingt. Das Zurückfallen der Zunge, die Behinderung der Nasenatmung und andere Faktoren sind zusätzlich zu benennen. Eine besondere pathologische Form stellt die Rhenchopathie in Kombination mit der sog. Schlafapnoe dar, bei der es zum kuzfristigen Atemstillstand kommt.It occurs predominantly when sleeping on your back and is caused by vibrations or fluttering of the soft palate, also known as the velum. The tongue falling back, obstruction of nasal breathing and other factors must also be mentioned. A special pathological form is rhenchopathy in combination with so-called sleep apnea, which causes short-term respiratory arrest.
Als Gegenmaßnahmen werden v. a. eine Verhinderung der Rückenlage und in Extremfällen eine straffend Gaumensegelplastik empfohlen.The recommended countermeasures include preventing the patient from lying on their back and, in extreme cases, tightening velumplasty.
Nun ist seit einigen Jahren in der plastischen Chirurgie als Alternative zum Skalpell bei Narbenkorrekturen die gezielte Injektion von Rindercollagen bekannt, das allerdings einen hohen Grad an früher Resorption aufweist.For several years now, the targeted injection of bovine collagen has been known in plastic surgery as an alternative to the scalpel in scar correction, although this has a high degree of early resorption.
Fibrilläres Collagen besteht aus sich wiederholenden Polypeptid-Untereinheiten, genannt Tropocollagen. Diese sind zu parallelen Bündeln angeordnet und weisen eine charakteristische 64-nm lange Querstreifung zumindest bei den meisten CoUagenen auf.Fibrillar collagen consists of repeating polypeptide subunits called tropocollagen. These are arranged in parallel bundles and exhibit a characteristic 64-nm-long cross-striation, at least in most collagens.
Es besteht die Möglichkeit, über den Chemismus Collagen mit seinem ungewöhnlich hohen Anteil von Prolin- und Hydroxyprolinresten zusätzlich kovalent quer zu vernetzen.It is possible to additionally covalently cross-link collagen with its unusually high proportion of proline and hydroxyproline residues via its chemistry.
Im Falle der kosmetischen Applikation ist damit die Möglichkeit geschaffen, das Collagen nicht nur subcutan zu injizieren und die Resorption zu verzögern.In the case of cosmetic application, this creates the possibility of not only injecting the collagen subcutaneously and delaying its resorption.
Aus diesem Grundgedanken heraus entstand der erfinderische Gedanke, quervernetztes Collagen, bevorzugt mit biologischen und/oder bioaktiven Füllstoffen ins Velum zu applizieren, um auf diesem Wege eine angestrebte Velumstraffung ohne phonetische Beeinträchtigungen zu schaffen.From this basic idea arose the inventive idea of applying cross-linked collagen, preferably with biological and/or bioactive fillers, into the velum in order to achieve the desired velum tightening without phonetic impairments.
Wirktsoff und Anwendung sind in Verbindung mit der Beschreibung den Ansprüchen zu entnehmen.The active ingredient and application can be found in the claims in conjunction with the description.
Claims (2)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE9405878U DE9405878U1 (en) | 1994-04-08 | 1994-04-08 | Rhenchodepressive substance |
| DE19500548A DE19500548A1 (en) | 1994-04-08 | 1995-01-11 | Compsn. for treating snoring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE9405878U DE9405878U1 (en) | 1994-04-08 | 1994-04-08 | Rhenchodepressive substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE9405878U1 true DE9405878U1 (en) | 1995-10-12 |
Family
ID=6907091
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE9405878U Expired - Lifetime DE9405878U1 (en) | 1994-04-08 | 1994-04-08 | Rhenchodepressive substance |
| DE19500548A Withdrawn DE19500548A1 (en) | 1994-04-08 | 1995-01-11 | Compsn. for treating snoring |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19500548A Withdrawn DE19500548A1 (en) | 1994-04-08 | 1995-01-11 | Compsn. for treating snoring |
Country Status (1)
| Country | Link |
|---|---|
| DE (2) | DE9405878U1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008097890A2 (en) * | 2007-02-02 | 2008-08-14 | Thomas Jefferson University | Method and use of a bioreplaceable tissue material implant for treating snoring |
-
1994
- 1994-04-08 DE DE9405878U patent/DE9405878U1/en not_active Expired - Lifetime
-
1995
- 1995-01-11 DE DE19500548A patent/DE19500548A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE19500548A1 (en) | 1996-03-07 |
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