DE9218581U1 - Measuring head for determining the mechanical properties of soft biological tissue - Google Patents

Measuring head for determining the mechanical properties of soft biological tissue

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Publication number
DE9218581U1
DE9218581U1 DE9218581U DE9218581U DE9218581U1 DE 9218581 U1 DE9218581 U1 DE 9218581U1 DE 9218581 U DE9218581 U DE 9218581U DE 9218581 U DE9218581 U DE 9218581U DE 9218581 U1 DE9218581 U1 DE 9218581U1
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Prior art keywords
measuring head
tissue
sensors
twisting
head according
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Expired - Lifetime
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DE9218581U
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German (de)
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Priority to DE9218581U priority Critical patent/DE9218581U1/en
Priority claimed from DE19924229549 external-priority patent/DE4229549A1/en
Publication of DE9218581U1 publication Critical patent/DE9218581U1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0055—Detecting, measuring or recording by applying mechanical forces or stimuli by applying suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/22—Investigating strength properties of solid materials by application of mechanical stress by applying steady torsional forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0058—Kind of property studied
    • G01N2203/0089—Biorheological properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/02—Details not specific for a particular testing method
    • G01N2203/026—Specifications of the specimen
    • G01N2203/0262—Shape of the specimen
    • G01N2203/0278—Thin specimens
    • G01N2203/0282—Two dimensional, e.g. tapes, webs, sheets, strips, disks or membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/02—Details not specific for a particular testing method
    • G01N2203/04—Chucks, fixtures, jaws, holders or anvils
    • G01N2203/0417—Chucks, fixtures, jaws, holders or anvils using vacuum

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)

Description

Dr.Thomas U. Becker ·&Bgr;@&thgr;&Igr;<&THgr;&Ggr;··&'· Vl &iacgr;&iacgr;&Igr;&Igr;&bgr;&Ggr; · Dn Kar|-Ernst Müller Dr.Thomas U. Becker ·&Bgr;@&thgr;&Igr;<&THgr;&Ggr;··&'· Vl &iacgr;&Igr;&Igr;&bgr;&Ggr; · Dn Kar| - Ernst Müller

Diplomingenieur ·· · · *) ^* · JJ. DiplomingenieurGraduate engineer ·· · · *) ^* · JJ. Graduate engineer

European Patent Attorney * ·**· «PaterSanwälte· ······· European Patent AttorneyEuropean Patent Attorney * ·**· «PaterSanwälte· ······· European Patent Attorney

Anmelder:Applicant:

Prof. Dr. Christoph Härtung
Dipl.-Ing. Oliver Kohr
Im Klampfeid 12Prof. Dr. Christoph Härtung
Dipl.-Ing. Oliver Kohr
In Klampfeid 12

30966 Hemmingen ION 13112-G kül230966 Hemmingen ION 13112-G kül2

Meßkopf zur Bestimmung der mechanischen Eigenschaften weicher biologischer GewebeMeasuring head for determining the mechanical properties of soft biological tissues

BeschreibungDescription

Die Erfindung betrifft einen Meßkopf zur Bestimmung der mechanischen Eigenschaften weicher biologischer Gewebe und Quantifizierung des Stofftransportes und des Transportes von auf das Gewebe applizierten Substanzen durch dieses Gewebe mittels dynamischer Verdrillung.The invention relates to a measuring head for determining the mechanical properties of soft biological tissues and quantifying the transport of substances and the transport of substances applied to the tissue through this tissue by means of dynamic twisting.

Ein solcher Meßkopf dient der Bestimmung der mechanischen Eigenschaften weicher biologischer Gewebe sowie deren relativer Änderung und der Quantifizierung des Stofftransportes und Transportes applizierter Substanzen durch das weiche Gewebe nach Ort und Zeit.Such a measuring head is used to determine the mechanical properties of soft biological tissues as well as their relative change and to quantify the transport of substances and the transport of applied substances through the soft tissue according to location and time.

Weiche biologische Gewebe sind unter anderem die Haut, Gefäßwände etc.Soft biological tissues include the skin, vascular walls, etc.

BsenhüttenstraBe2 ■ D-40^*2'Ra*ng9n &bull;.^leier7(e)äi*d2*/a3(Jä8-t.8429O1 ■ Telefax(0)2102/83069BsenhüttenstraBe2 ■ D-40^*2'Ra*ng9n &bull;.^leier7(e)äi*d2*/a3(Jä8-t.8429O1 ■ Telefax(0)2102/83069

Bei bekannten Verfahren dieser Art wird der Meßkopf mit einem doppelseitigen Klebeband an das Gewebe angekoppelt.In known methods of this type, the measuring head is coupled to the tissue with a double-sided adhesive tape.

Demgegenüber betrifft die Erfindung einen Meßkopf zur Bestimmung der mechanischen Eigenschaften weicher biologischer Gewebe und zur Quantifizierung des Stofftransportes und des Transportes von auf das Gewebe applizierten Substanzen durch dieses Gewebe mittels dynamischer Verdrillung, mit einem, an das Gewebe ankoppelbaren Verdrillstempel, dessen Verdrillwinkel über Winkelsensoren und dessen Verdrillmoment über einen Drehmomentensensor erfaßbar ist, sowie einer Vorspanneinrichtung zur definierten Ansaugung und Vorspannung des Gewebes, wobei die Vorspanneinrichtung Weg- und Drucksensoren zum definierten Ansaugen des Gewebes nach Weg- oder Druckvorgaben umfaßt.In contrast, the invention relates to a measuring head for determining the mechanical properties of soft biological tissue and for quantifying the transport of substances and the transport of substances applied to the tissue through this tissue by means of dynamic twisting, with a twisting stamp that can be coupled to the tissue, the twisting angle of which can be detected via angle sensors and the twisting moment of which can be detected via a torque sensor, as well as a pre-tensioning device for the defined suction and pre-tensioning of the tissue, wherein the pre-tensioning device comprises displacement and pressure sensors for the defined suction of the tissue according to displacement or pressure specifications.

Im Unterschied zu dem vorgenannten Verfahren wird der erfindungsgemäße Meßkopf also mittels Unterdruck an das Gewebe angekoppelt.In contrast to the aforementioned method, the measuring head according to the invention is coupled to the tissue by means of negative pressure.

Die Ankopplungseinheit des Meßkopfes besteht aus zwei Teilen:The coupling unit of the measuring head consists of two parts:

a) der Vorspanneinrichtunga) the pre-tensioning device

b) dem Verdrillstempel.b) the twisting die.

Die Ankopplung erfolgt in zwei Schritten. Zuerst wird das Gewebe definiert in der Vorspannvorrichtung vorgespannt. Danach wird das Gewebe an den Verdrillstempel gekoppelt. Die Vorspannvorrichtung besitzt Weg- und Drucksensoren, um ein definiertes Ansaugen des Gewebes nach Weg- oder Druckvorgaben zu gewährleisten. Nach einer Ausführungsform befinden sich drei Wegsensoren am Umfang der Vorspanneinrichtung zur Überprüfung der Gleichmäßigkeit der Vorspannung.The coupling takes place in two steps. First, the fabric is pre-tensioned in a defined manner in the pre-tensioning device. Then the fabric is coupled to the twisting die. The pre-tensioning device has displacement and pressure sensors to ensure a defined suction of the fabric according to displacement or pressure specifications. According to one embodiment, three displacement sensors are located on the circumference of the pre-tensioning device to check the uniformity of the pre-tension.

Danach prägt der Verdrillstempel ein dynamisches Verdrillmoment oder einen dynamischen Verdrillwinkel auf das Gewebe. Eine weitere Ausführungsform der Erfindung sieht vor, daß die Antriebseinheit des Meßkopfes zum Beispiel aus einem Gleichstrommotor, einem Schrittmotor oder einem Schwingerreger besteht.The twisting stamp then imprints a dynamic twisting moment or a dynamic twisting angle on the fabric. A further embodiment of the invention provides that the drive unit of the measuring head consists of, for example, a DC motor, a stepper motor or a vibration exciter.

Der Verdrillwinkel wird - wie ausgeführt - mittels Winkelsensoren erfaßt, die zum Beispiel Hallsensoren oder optische Sensoren sein können. Das Verdrillmoment wird durch einen Drehmomenten- oder Kraftsensor erfaßt.As stated, the twist angle is measured using angle sensors, which can be Hall sensors or optical sensors, for example. The twisting moment is measured using a torque or force sensor.

Eingangs- und Ausgangssignale werden in einem Amplituden- und Phasengang ausgewertet, über die die mechanischen Eigenschaften des Gewebes bestimmt sowie der Stofftransport nach Ort und Zeit quantifiziert werden können. Der Amplitudengang informiert im wesentlichen über die elasto-mechanischen Eigenschaften, der Phasengang informiert im wesentlichen über die viskosen Eigenschaften.Input and output signals are evaluated in an amplitude and phase response, which can be used to determine the mechanical properties of the tissue and to quantify the transport of material according to location and time. The amplitude response essentially provides information about the elastomechanical properties, the phase response essentially provides information about the viscous properties.

Veränderungen im Amplituden- und Phasengang ermöglichen den Stofftransport und den Transport applizierter Stoffe durch das Gewebe nach Ort und Zeit zu quantifizieren. Massenveränderungen durch Applikation von Stoffmengen auf das Gewebe sowie sich danach einstellende Veränderungen in den elastischen Strukturen des Gewebes, zum Beispiel durch Kosmetika, Arzneimittel etc. bilden sich im wesentlichen im Amplitudengang ab. Veränderungen der viskosen Gewebestrukturen infolge von Stoffeinlagerungen in das Gewebe äußern sich im wesentlichen im Phasengang.Changes in the amplitude and phase response make it possible to quantify the transport of substances and the transport of applied substances through the tissue according to location and time. Mass changes due to the application of quantities of substances to the tissue as well as subsequent changes in the elastic structures of the tissue, for example due to cosmetics, medicines, etc., are essentially reflected in the amplitude response. Changes in the viscous tissue structures as a result of substances being deposited in the tissue are essentially reflected in the phase response.

Eine weitere Ausführungsform der Erfindung sieht vor, daß durch kontinuierliche Messung und Aufzeichnung eines BODE-Diagramms Migrationsprozesse applizierter Stoffe durch das Gewebe als Funktion des Ortes und der Zeit ermittelt werden können, wozu der Meßkopf mit einer entsprechenden Einrichtung zur kontinuierlichen Messung und Aufzeichnung eines BODE-Diagramms ausgebildet ist.A further embodiment of the invention provides that by continuously measuring and recording a BODE diagram, migration processes of applied substances through the tissue can be determined as a function of location and time, for which purpose the measuring head is designed with a corresponding device for continuously measuring and recording a BODE diagram.

Die einzige Figur zeigt die wesentlichen Komponenten des erfindungsgemäßen Meßkopfes und das damit auszuübende Verfahren. Die nachstehende Bezugszeichenliste ordnet die einzelnen Bezugszeichen einzelnen Bauteilen zu:The single figure shows the essential components of the measuring head according to the invention and the method to be carried out with it. The following list of reference symbols assigns the individual reference symbols to individual components:

1 Meßkopf1 measuring head

2 Vorspanneinrichtung2 Pre-tensioning device

3 Wegsensoren3 displacement sensors

4 Drucksensoren4 pressure sensors

5 Verdrillstempel5 twisting dies

6 Antriebseinheit6 Drive unit

7 Winkelsensor7 Angle sensor

8 Drehmomentensensor8 Torque sensor

9 Auswerteeinheit.9 Evaluation unit.

Das Gewebe wird zuerst in der Vorspanneinrichtung 2 nach Weg- und Druckvorgaben definiert vorgespannt und anschließend an den Verdrillstempel 5 nach Druckvorgaben gekoppelt. Das Gewebe wird durch Unterdruck an den Meßkopf gekoppelt. Es erfolgt eine dynamische Verdrillung des Gewebes. Das dynamische Verdrillmoment beziehungsweise der Verdrillwinkel werden auf das Gewebe geprägt und der resultierende Verdrillwinkel oder das resultierende Verdrillmoment werden erfaßt. Der Amplituden- und Phasengang zurThe fabric is first pre-tensioned in the pre-tensioning device 2 according to the path and pressure specifications and then coupled to the twisting die 5 according to the pressure specifications. The fabric is coupled to the measuring head by negative pressure. The fabric is then dynamically twisted. The dynamic twisting moment or the twisting angle are stamped onto the fabric and the resulting twisting angle or the resulting twisting moment are recorded. The amplitude and phase response to the

5 _5 _

Quantifizierung des Stofftransportes und des Transportes applizierter Substanzen werden nach Ort und Zeit herangezogen. Stoffeinlagerungen in das Gewebe sowie sich danach einstellende Veränderungen der elastischen und viskosen Gewebestrukturen werden durch den Amplituden- und Phasengang quantifiziert.Quantification of the transport of substances and the transport of applied substances are used according to location and time. Substance deposits in the tissue as well as subsequent changes in the elastic and viscous tissue structures are quantified by the amplitude and phase response.

Claims (6)

Dr.ThomasU.Becker RPCköT &f MÜllSC Dr. Karl-Ernst MüllerDr.ThomasU.Becker RPCköT &f MÜllSC Dr. Karl-Ernst Müller Diplomingenieur ,, . .* &igr;) « · · * DiplomingenieurGraduate engineer ,, . .* &igr;) « · · * Graduate engineer European Patent Attorney I J * * . ßaifentänweifte « *..!?.!· European Patent AttorneyEuropean Patent Attorney I J * * . ßaifentänweifte « *..!?.!· European Patent Attorney Anmelder:Applicant: Prof. Dr. Christoph Härtung
Dipl.-Ing. Oliver Kohr
Im Klampfeid 12Prof. Dr. Christoph Härtung
Dipl.-Ing. Oliver Kohr
In Klampfeid 12 30966 Hemmingen ION 13122-G kül230966 Hemmingen ION 13122-G kül2 Meßkopf zur Bestimmung der mechanischen Eigenschaften weicher biologischer GewebeMeasuring head for determining the mechanical properties of soft biological tissues SchutzansprücheProtection claims 1. Meßkopf zur Bestimmung der mechanischen Eigenschaften weicher biologischer Gewebe und Quantifizierung des Stofftransportes und des Transportes von auf das Gewebe applizierten Substanzen durch dieses Gewebe mittels dynamischer Verdrillung, gekennzeichnet durch folgende Merkmale:1. Measuring head for determining the mechanical properties of soft biological tissues and quantifying the transport of substances and the transport of substances applied to the tissue through this tissue by means of dynamic twisting, characterized by the following features: einen, an das Gewebe ankoppelbaren Verdrillstempel (5), dessen Verdrillwinkel über Winkelsensoren (7) und dessen Verdrillmoment über einen Drehmomentensensor (8) erfaßbar ist,a twisting die (5) which can be coupled to the fabric and whose twisting angle can be detected via angle sensors (7) and whose twisting torque can be detected via a torque sensor (8), eine Vorspanneinrichtung (2) zur definierten Ansaugung und Vorspannung des Gewebes, wobei die Vorspanneinrichtung (2) Weg- und Drucksensoren (3, 4) zum definierten Ansaugen des Gewebes nach Weg- oder Druckvorgaben umfaßt.a pre-tensioning device (2) for the defined suction and pre-tensioning of the tissue, wherein the pre-tensioning device (2) comprises displacement and pressure sensors (3, 4) for the defined suction of the tissue according to displacement or pressure specifications. Eisenhüttenstraße 2 ■ D-408§2 Rftingej · ^efon"^2»&2f88Ö|8+ei2901 · Telefax (0)2102/83069Eisenhüttenstrasse 2 ■ D-408§2 Rftingej · ^efon"^2»&2f88Ö|8+ei2901 · Telefax (0)2102/83069 2. Meßkopf nach Anspruch 1, dadurch gekennzeichnet, daß über die Vorspanneinrichtung (2) ein Unterdruck gegenüber dem Gewebe aufbringbar ist.2. Measuring head according to claim 1, characterized in that a negative pressure can be applied to the tissue via the pretensioning device (2). 3. Meßkopf nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß am Umfang der Vorspanneinrichtung (2) drei Wegsensoren (3) angeordnet sind.3. Measuring head according to claim 1 or 2, characterized in that three displacement sensors (3) are arranged on the circumference of the pretensioning device (2). 4. Meßkopf nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Winkelsensoren (7) Hallsensoren oder optische Sensoren sind.4. Measuring head according to one of claims 1 to 3, characterized in that the angle sensors (7) are Hall sensors or optical sensors. 5. Meßkopf nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß der Meßkopf als Antriebseinheit einen Gleichstrommotor, einen Schrittmotor oder einen Schwingerreger aufweist.5. Measuring head according to one of claims 1 to 4, characterized in that the measuring head has a direct current motor, a stepper motor or a vibration exciter as a drive unit. 6. Meßkopf nach einem der Ansprüche 1 bis 5, gekennzeichnet durch eine Einrichtung zur kontinuierlichen Messung und Aufzeichnung eines BODE-Diagramms.6. Measuring head according to one of claims 1 to 5, characterized by a device for continuous measurement and recording of a BODE diagram.
DE9218581U 1992-09-04 1992-09-04 Measuring head for determining the mechanical properties of soft biological tissue Expired - Lifetime DE9218581U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE9218581U DE9218581U1 (en) 1992-09-04 1992-09-04 Measuring head for determining the mechanical properties of soft biological tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19924229549 DE4229549A1 (en) 1992-09-04 1992-09-04 Determination method for mechanical properties of biological tissue - using in situ measuring head applying dynamic twisting
DE9218581U DE9218581U1 (en) 1992-09-04 1992-09-04 Measuring head for determining the mechanical properties of soft biological tissue

Publications (1)

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DE9218581U1 true DE9218581U1 (en) 1994-09-01

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DE9218581U Expired - Lifetime DE9218581U1 (en) 1992-09-04 1992-09-04 Measuring head for determining the mechanical properties of soft biological tissue

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905493C2 (en) * 1999-02-10 2002-03-14 Mipm Mammendorfer Inst Fuer Ph Measuring device for the reproducible determination of the quality of human tissue
FR2858206A1 (en) * 2003-07-28 2005-02-04 Fabre Pierre Dermo Cosmetique Skin extensometer for measurement of skin properties comprises jaws, for applying mechanical traction and compression force parallel to skin surface, anchored to skin surface by vacuum
WO2011064517A1 (en) * 2009-11-30 2011-06-03 Universite De Rennes 1 Continuous or instrumented indentation device

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905493C2 (en) * 1999-02-10 2002-03-14 Mipm Mammendorfer Inst Fuer Ph Measuring device for the reproducible determination of the quality of human tissue
FR2858206A1 (en) * 2003-07-28 2005-02-04 Fabre Pierre Dermo Cosmetique Skin extensometer for measurement of skin properties comprises jaws, for applying mechanical traction and compression force parallel to skin surface, anchored to skin surface by vacuum
WO2011064517A1 (en) * 2009-11-30 2011-06-03 Universite De Rennes 1 Continuous or instrumented indentation device
FR2953291A1 (en) * 2009-11-30 2011-06-03 Univ Rennes PORTABLE INSTRUMENTAL INDENTATION DEVICE
US9228928B2 (en) 2009-11-30 2016-01-05 Universite De Rennes 1 Continuous or instrumented indentation device

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