DE881568C - Process for the preparation of metal pectin compounds for therapeutic use - Google Patents

Description

Process for the preparation of metal pectin compounds for therapeutic use The invention relates to a method for producing new Metal pectin compounds.

So far, mixed metal pectin compounds are in the American Patents 2,418,865 and 2,418,866 to F. B r y a n t. It deals These are insoluble sodium calcium pectinates, compared to the soluble ones Pectins for oral administration are beneficial.

The compounds which are obtained according to the present invention are not pectinates, but. rather, metal pectin aluminates, which are differ significantly in their chemical behavior from the already known pectinates.

All pectinates mentioned in the American patents mentioned have the following basic structure: while the compounds according to the invention should have the following basic structure: The metal pectin aluminates according to the invention are obtained in that a pectin, e.g. B.

Citrus pectin, beet pectin and the like with an alkali and an aluminum compound is reacted, the alkali preferably being NaOH or KOH and the aluminum compound advantageously use aluminum chloride, aluminum sulfate, aluminum hydroxide will. Furthermore, you can in aqueous solution or in the presence of an organic Solvent, such as. B. ethyl alcohol, isopropyl alcohol, acetone, etc., work.

Furthermore, the reaction should be in weakly acidic, neutral or weakly take place in an alkaline medium.

Some advantageous embodiments are described in the following: , a) Pectini (e.g. citrus pectin, apple pectin, beet pectin) is mixed with aqueous alkali, z. B. NaOH, KOH, saponified in excess and then the calculated amount or a Excess of an aluminum salt, e.g. B. solid aluminum chloride or aluminum chloride dissolved in water, Aluminum sulfate, added.

You will choose the amount of alkali expediently such that the pH of the Final mix is about 7 to 8. b) You can proceed in the same way as under a) was described, where, instead of in aqueous solution, the pectin non-substantially hydrating solvent, e.g. B.

Ethyl alcohol, isopropyl alcohol, or acetone will work. Depending on the reaction time and the chemical composition of the starting material is obtained in this way likewise to one which is at least partially demethylated with respect to the starting material Product. c) You can direct the course of the implementation so that first one Aluminate is obtained as an intermediate product and this is then reacted with the pectin is brought, both in aqueous solution and in one of the pectin not substantially hydrating solvent can be worked. d) Finally you can also use pectin with a water-soluble aluminum salt, e.g. B. aluminum sulfate or chloride, grind and add this mixture to the calculated amount. Caustic soda Stir, using water, an alcohol-water mixture or as the solvent Can use alcohol.

The following examples explain how the pectin aluminates of this invention can be obtained.

Example I Turn 1000 g of apple pectin with a solution of 500 g of sodium hydroxide treated in 4000 g of water for about 1 hour at room temperature.

Then 750 g of crystallized aluminum chloride are added to the reaction mixture stirred in and the product formed filtered off or centrifuged off, thoroughly washed with water, dried and ground. In this way you get a gray, very fine powder, which should be largely to completely demethylated. Care must be taken that the final reaction mixture is neither extremely acidic nor reacts alkaline, otherwise products with a low aluminum, minium, content are created, which are no longer aluminates.

The reaction can also in a not significantly hydrating the pectin Solvents, e.g. B. aqueous ethyl alcohol, acetone or isopropyl alcohol, made will. This is obtained depending on the duration of the reaction and the starting material used at least partially to completely demethylated preparations.

Instead of 500 g of NaOH, 700 g of potassium hydroxide can be used with the same success use, obtaining the corresponding potassium salt.

Example 2 10 parts of apple pectin are mixed with a solution of 3 parts Sodium hydroxide, 5.8 parts of aluminum hydroxide, 30 parts of water and 70 parts of alcohol treated for 10 minutes and the resulting product filtered off, washed well, then dried and pulverized. In this way, partially methylated ones are obtained Preparations.

If you use pectic acid instead of apple pectin in this example completely demethylated preparations are obtained.

Instead of 3 parts of NaOH, 4.2 parts of potassium hydroxide can also be used use, obtaining the corresponding potassium salt.

Example 1 3 100 parts of pectin are crystallized with 25 parts Aluminum chloride rubbed in a mortar and this mixture with 15 parts of sodium hydroxide (about as n / 1 lye) stirred. It is filtered off and washed with water or alcohol or a water-alcohol mixture free of chlorine ions, dries and pulverized Instead of 15 parts of NaOH, 21 parts of potassium hydroxide can be used corresponding potassium salt is obtained.

The commercially available pectins, according to the invention as starting materials are used vary in their chemical composition, which is why the composition the products obtainable when working according to these examples also depending on Choice of the starting material and the reaction time or. Reaction conditions varied.

The products according to the invention are insoluble in water and therefore significantly more suitable for oral use than those previously known, slimy and sticky soluble pectins, pectinates and pectates. By exposure of hydrochloric acid, e.g. B. in the stomach, pectin from the products according to the invention is under Development of its known valuable therapeutic properties in freedom set. The new products have considerable adsorptive power and strong buffer effect.

The sodium resp. Potassium pectin aluminates can be used as such as an adsorbent.

Given the excellent buffer effect of the new erfindungsgeäß They are also suitable as an additive to other products, which are mainly to be taken orally. Medication. So you can the products according to the invention and, if desired, also Mixtures of the compounds according to the invention, for example the following medicaments add: a) Preparations that are sometimes poorly tolerated when administered orally are e.g. B. iron, mercury, phosphorus, arsenic, antimony and bismuth preparations, Phenolic, benzoic, salicylic and barbituric acid derivatives, pyrazolone, quinoline, Phenetidine and sulfanilamide compounds, alkaloids, tar preparations; b) medication, in which an accumulation in the gastrointestinal tract or an absorption inhibition is desired is, so preferably disinfectants and chemotherapeutic agents, e.g. B.

Acridine and quinoline derivatives, emetine, sulfanilamides, anthelmintics; c) Antibiotics that are destroyed by gastric hydrochloric acid during oral administration be e.g. B.

Penicillin; d) drugs acting on the gastrointestinal tract, such as Adsonbeuüa, Antacida, Astringentia, Antidiarrhoica, Mucilages, anti-secretions and antispasmodic agents, bitter substances, essential oils, laxatives; e) Orally administered analgesics, antipyretics, aesthetics, hypnotics, sedatives, Excitants, Analeptics, Diuretics, Heart Remedies, Roboratia, Nutritional Preparations and Expektorantia.

Furthermore, the products of the invention can be used alone or if desired combined with other substances in powder form, in the form of granules, pills, Tablets, dragees, pensions, emulsions, lozenges, wafers, capsules, sweets etc. use.

Claims (7)

PATENT CLAIMS: I. Process for the production of alkali metal pectin aluminates for therapeutic use, characterized in that a pectin, e.g. B. citrus pectin, Apple pectin, beet pectin or the like, with an alkali and an aluminum compound is implemented. 2. The method according to claim I, characterized in that the aluminum compound a water soluble compound is used. 3. Process according to Claims I and 2, characterized in that the reaction takes place in a weakly acidic to weakly alkaline medium. 4. Process according to Claims I to 3, characterized in that the reaction takes place in an aqueous medium. 5. Process according to Claims I to 4, characterized in that the reaction in an organic solvent, e.g. B. ethyl alcohol, acetone, isopropyl alcohol etc., takes place. 6. Process according to Claims I to 3, characterized in that the pectin is first saponified with the aqueous alkali and then the reaction product is made to react with an aluminum salt. 7. Process according to Claims I to 3, characterized in that an alkali hydroxide solution reacted with aluminum hydroxide and the resulting alkali aluminate is brought to implementation with pectin.