DE8808872U1 - Reactor for carrying out chemical reactions on insoluble carriers - Google Patents

Reactor for carrying out chemical reactions on insoluble carriers

Info

Publication number
DE8808872U1
DE8808872U1 DE8808872U DE8808872U DE8808872U1 DE 8808872 U1 DE8808872 U1 DE 8808872U1 DE 8808872 U DE8808872 U DE 8808872U DE 8808872 U DE8808872 U DE 8808872U DE 8808872 U1 DE8808872 U1 DE 8808872U1
Authority
DE
Germany
Prior art keywords
reactor
glass
carrying
chemical reactions
out chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8808872U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gausepohl Heinrich Dipl-Ing 6900 Heidelberg De
Original Assignee
Gausepohl Heinrich Dipl-Ing 6900 Heidelberg De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gausepohl Heinrich Dipl-Ing 6900 Heidelberg De filed Critical Gausepohl Heinrich Dipl-Ing 6900 Heidelberg De
Priority to DE8808872U priority Critical patent/DE8808872U1/en
Publication of DE8808872U1 publication Critical patent/DE8808872U1/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B01J2219/00288—Reactor vessels with top and bottom openings in the shape of syringes
    • B01J2219/0029—Reactor vessels with top and bottom openings in the shape of syringes with pistons or plungers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Anmelder:
Dipl. Ing. H. GausepohlApplicant:
Dipl. Ing. H. Gausepohl

St. Peter str. 11
6900 HeidelbergSt. Peter str. 11
6900 Heidelberg

Reaktor zur Durchführung chemischer Reaktionen an unlöslichen TrägernReactor for carrying out chemical reactions on insoluble carriers

Beschreibung:Description:

Bei der Handhabung von festen Trägern für chemische Reaktionen kommt es durch verschiedene Manipulationen zu Verlusten von Träger. Um das zu vermeiden, wurde ein Reaktor konstruiert, der während der Durchführung der Reaktionen nicht geöffnet werden muß. Er besteht aus einer Spritze aus Glas in die mit Hilfe einer Teflondichtung eine Filterscheibe aus Glas oder Polyolefin fest eingesetzt wurde. Das Volumen des Reaktors kann während der Durchführung chemischer Reaktionen durch Verschieben des Stempels verändert werden, was bei herkömmlichen Systemen (Reaktorkartuschen) nicht der Fall ist. Der feste Träger befindet sich während der Reaktion in der Spritze zwischen Stempel und Filterscheibe. Durch die Verwendung eines gasdichten Stempels ist es möglich, Chemikalien über eine aufgesetzte Kanüle aufzuziehen und wieder auszudrücken. Durch die Verwendung inerter Materialien wie Glas, Teflon und Polyolefin lassen sich Reaktionen mit beliebigen Chemikalien durchführen. Der beschriebene Reaktor wird hergestellt aus einer gasdichten Präzisionsspritze aus Glas. Die beschriebene Vorrichtung ist insbesondere geeignet zur manuellen Durchführung der Synthese von Peptiden und Oligonucleotiden an festen Trägern, sowie den damit in Zusammenhang stehenden Reaktionen.When handling solid carriers for chemical reactions, various manipulations lead to losses of carrier. To avoid this, a reactor was constructed that does not have to be opened during the reaction. It consists of a glass syringe into which a filter disk made of glass or polyolefin is firmly inserted using a Teflon seal. The volume of the reactor can be changed during the chemical reaction by moving the plunger, which is not the case with conventional systems (reactor cartridges). The solid carrier is located in the syringe between the plunger and the filter disk during the reaction. By using a gas-tight plunger, it is possible to draw chemicals in and out of an attached cannula. By using inert materials such as glass, Teflon and polyolefin, reactions can be carried out with any chemical. The reactor described is made from a gas-tight precision syringe made of glass. The device described is particularly suitable for manually carrying out the synthesis of peptides and oligonucleotides on solid supports, as well as the associated reactions.

• at• at

Q 88 08 872.3
Bezugzeiöhenllste zur ZeichnungQ88 08 872.3
Reference height to drawing

Der Reaktor, bestehend aus einem Glaskörper (1), der mit Hilfe einer Teflondichtung (?.) fixierten Filterscheibe (3), Lueransatz (4) und gasdichtem Stempel (5) mit Teflonkappe (6), ist in der hoiliononHon 7oirhnunn im OmarcnhniH Harnactollt j, g — ___.__....... «._. &bgr;»«_...The reactor, consisting of a glass body (1), the filter disk (3) fixed with the aid of a Teflon seal (?.) , Luer connector (4) and gas-tight plunger (5) with Teflon cap (6), is in the hoiliononHon 7oirhnunn in the OmarcnhniH Harnactollt j, g — ___.__....... «._. &bgr; »«_...

Claims (5)

Reaktor zur Durchfuhrung chemischer Reaktionen an unlöslichen Trägern der den Einschluß des Trägers während der Dauer der einzelnen Reaktionsschritte erlaubt, dadurch gekennzeichnetReactor for carrying out chemical reactions on insoluble carriers which allows the inclusion of the carrier during the duration of the individual reaction steps, characterized 1. - daß die chemikalienberührten Teile aus inerten Materialien1. - that the parts in contact with chemicals are made of inert materials wie Glas (1), Teflon (2, 4, 6) und Polyolefin oder Glas (3) bestehen.such as glass (1), Teflon (2, 4, 6) and polyolefin or glass (3). 2. - daß der Reaktionsraum auf derAusgangsseite durch eine2. - that the reaction space on the output side is Filterscheibe (3) aus Glas oder Polyolefin abgeschlossen ist,Filter disc (3) made of glass or polyolefin, 3. - daß insbesondere im Falle der Glasfritte diese durch eine3. - that, particularly in the case of glass frit, this is Teflondichtung (2) fixiert ist.Teflon seal (2) is fixed. 4. - daß der Reaktionsraum auf der anderen Seite durch einen4. - that the reaction space on the other side is verschiebbaren Stempel (5) mit einer gasdicht an der Wand anliegenden Teflonkappe (6) begrenzt wird.movable stamp (5) with a gastight Teflon cap (6) that is attached to the wall. 5. - daß die Vorrichtung auf der Ausgangsseite einen Lueran-5. - that the device has a Lueran on the output side satz für eine Kanüle zum Aufziehen der Chemikalien hat.set for a cannula to draw up the chemicals.
DE8808872U 1988-07-11 1988-07-11 Reactor for carrying out chemical reactions on insoluble carriers Expired DE8808872U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8808872U DE8808872U1 (en) 1988-07-11 1988-07-11 Reactor for carrying out chemical reactions on insoluble carriers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE8808872U DE8808872U1 (en) 1988-07-11 1988-07-11 Reactor for carrying out chemical reactions on insoluble carriers

Publications (1)

Publication Number Publication Date
DE8808872U1 true DE8808872U1 (en) 1988-12-29

Family

ID=6825858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8808872U Expired DE8808872U1 (en) 1988-07-11 1988-07-11 Reactor for carrying out chemical reactions on insoluble carriers

Country Status (1)

Country Link
DE (1) DE8808872U1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386238A4 (en) * 1988-07-25 1990-12-27 Spetsialnoe Konstruktorskoe Bjuro Biologicheskogo Priborostroenia Akademii Nauk Sssr Reactor for solid-phase synthesis of biopolymers
EP0529573A1 (en) * 1991-08-24 1993-03-03 Shimadzu Corporation Solid-phase synthesizer
EP0555706A1 (en) * 1992-01-29 1993-08-18 Shimadzu Corporation Agitation stabilizer in solidphase peptide synthesizer
EP0558050A1 (en) * 1992-02-28 1993-09-01 Shimadzu Corporation Apparatus and method for isolation of synthetic peptide without loss of reagents
WO1994001213A1 (en) * 1992-07-06 1994-01-20 Beckman Instruments, Inc. Synthesis reaction column
EP0529504A3 (en) * 1991-08-26 1994-04-06 Shimadzu Corp
DE19723469A1 (en) * 1997-06-04 1998-12-10 Dirk Dr Vetter Assay reactor e.g. for synthesis of peptide(s), oligo-nucleotide(s)
WO1998040159A3 (en) * 1997-03-10 1999-01-07 Trega Biosciences Inc Apparatus and method for combinatorial chemistry synthesis

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386238A4 (en) * 1988-07-25 1990-12-27 Spetsialnoe Konstruktorskoe Bjuro Biologicheskogo Priborostroenia Akademii Nauk Sssr Reactor for solid-phase synthesis of biopolymers
EP0529573A1 (en) * 1991-08-24 1993-03-03 Shimadzu Corporation Solid-phase synthesizer
US5288464A (en) * 1991-08-24 1994-02-22 Shimadzu Corporation Solid-phase synthesizer
EP0529504A3 (en) * 1991-08-26 1994-04-06 Shimadzu Corp
US5395594A (en) * 1991-08-26 1995-03-07 Shimadzu Corporation Simultaneous multiple chemical synthesizer
EP0555706A1 (en) * 1992-01-29 1993-08-18 Shimadzu Corporation Agitation stabilizer in solidphase peptide synthesizer
US5344613A (en) * 1992-01-29 1994-09-06 Shimadzu Corporation Agitation stabilizer in solid-phase peptide synthesizer
EP0558050A1 (en) * 1992-02-28 1993-09-01 Shimadzu Corporation Apparatus and method for isolation of synthetic peptide without loss of reagents
WO1994001213A1 (en) * 1992-07-06 1994-01-20 Beckman Instruments, Inc. Synthesis reaction column
WO1998040159A3 (en) * 1997-03-10 1999-01-07 Trega Biosciences Inc Apparatus and method for combinatorial chemistry synthesis
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
DE19723469A1 (en) * 1997-06-04 1998-12-10 Dirk Dr Vetter Assay reactor e.g. for synthesis of peptide(s), oligo-nucleotide(s)

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