DE865453C - Process for the preparation of non-hygroscopic choline salts - Google Patents

Process for the preparation of non-hygroscopic choline salts

Info

Publication number
DE865453C
DE865453C DEB13563A DEB0013563A DE865453C DE 865453 C DE865453 C DE 865453C DE B13563 A DEB13563 A DE B13563A DE B0013563 A DEB0013563 A DE B0013563A DE 865453 C DE865453 C DE 865453C
Authority
DE
Germany
Prior art keywords
salts
choline
preparation
calcium
choline salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB13563A
Other languages
German (de)
Inventor
Heinrich Dr Hopff
Hermann Dr Spaenig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to DEB13563A priority Critical patent/DE865453C/en
Application granted granted Critical
Publication of DE865453C publication Critical patent/DE865453C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung nichthygroskopischer Cholinsalze Bei der therapeutischen Anwendung des Cholins treten infolge der Hygroskopizität der verwendeten Cholinsalze erhebliche Schwierigkeiten auf, da die daraus hergestellten Tabletten an der Luft zum Zerfließen und zur Verfärbung neigen.Process for the preparation of non-hygroscopic choline salts therapeutic application of choline occur as a result of the hygroscopicity of the used Choline salts present considerable difficulties, as the tablets made from them tend to flow and discolour when exposed to air.

Es wurde nun gefunden, daß man diesen Nachteil beheben kann, indem man saure Salze aus Cholin und mehrbasischen Säuren mit Calcium- oder Magnesiumverbindungen behandelt und in die entsprechenden Calcium- oder Magnesiumdoppelsalze überführt. Geeignete Cholinsalze sind z. B. Monocholincitrat, Monocholinphosphat und andere Salze des Cholins mit mehrbasischen Säuren, die noch durch :Metalle ersetzbare Wasserstoffatome enthalten.It has now been found that this disadvantage can be remedied by acidic salts from choline and polybasic acids with calcium or magnesium compounds treated and converted into the corresponding calcium or magnesium double salts. Suitable choline salts are e.g. B. monocholine citrate, monocholine phosphate and others Salts of choline with polybasic acids, which are still hydrogen atoms that can be replaced by metals contain.

Die Herstellung der Calcium- bzw. Magnesiumcholindoppelsalze kann in der Weise erfolgen, daß man wäßrige oder alkoholische Lösungen der sauren Cholinsalze mit etwa der äquimolekularen Menge Calciumhydroxyd oder Calciumcarbonat bzw. den entsprechenden Magnesiumverbindungen neutralisiert. Dabei scheiden sich die gebildeten Doppelsalze entweder sofort oder nach demEindampfen der Lösung als helle Pulver ab. Zur Ausfällung der Doppelsalze kann man auch die Reaktionslösung mit organischen Lösungsmitteln versetzen. Beispiel 295 Teile saures Cholincitrat werden in q.oo Teilen Wasser gelöst und unter Rühren mit 74 Teilen Calciumhydroxyd versetzt. Das Reaktionsgemisch erwärmt sich auf etwa 5o°, wobei das Calciumhydroxyd vollkommen in Lösung geht. Nach dem Eindampfen der Lösung unter vermindertem Druck erhält man das Calciumsalz des Cholincitrates als weißes Pulver (33o Teile).The calcium or magnesium choline double salts can be prepared in such a way that aqueous or alcoholic solutions of the acidic choline salts are neutralized with approximately an equimolecular amount of calcium hydroxide or calcium carbonate or the corresponding magnesium compounds. The double salts formed separate out as a light powder either immediately or after the solution has evaporated. Organic solvents can also be added to the reaction solution to precipitate the double salts. Example 295 parts of acid choline citrate are dissolved in 100 parts of water, and 74 parts of calcium hydroxide are added with stirring. The reaction mixture heats up to about 50 °, the calcium hydroxide completely dissolving. After evaporating the solution under reduced pressure, the calcium salt of choline citrate is obtained as a white powder (330 parts).

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung nichthygroskopischer Cholinsalze, dadurch gekennzeichnet, daß man Salze aus Cholin und mehrbasischen Säuren, die noch durch Metalle ersetzbare Wasserstoffatome enthalten, mit Calcium- oder Magnesiumverbindungen behandelt und in die entsprechenden Calcium- oder Magnesiumcholindoppelsalze überführt.PATENT CLAIM: Process for the production of non-hygroscopic choline salts, characterized in that one salts of choline and polybasic acids, which still contain metal-replaceable hydrogen atoms, with calcium or magnesium compounds treated and converted into the corresponding calcium or magnesium choline double salts.
DEB13563A 1951-02-02 1951-02-02 Process for the preparation of non-hygroscopic choline salts Expired DE865453C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB13563A DE865453C (en) 1951-02-02 1951-02-02 Process for the preparation of non-hygroscopic choline salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB13563A DE865453C (en) 1951-02-02 1951-02-02 Process for the preparation of non-hygroscopic choline salts

Publications (1)

Publication Number Publication Date
DE865453C true DE865453C (en) 1953-02-02

Family

ID=6957608

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB13563A Expired DE865453C (en) 1951-02-02 1951-02-02 Process for the preparation of non-hygroscopic choline salts

Country Status (1)

Country Link
DE (1) DE865453C (en)

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