DE86146C - - Google Patents

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Publication number
DE86146C
DE86146C DENDAT86146D DE86146DA DE86146C DE 86146 C DE86146 C DE 86146C DE NDAT86146 D DENDAT86146 D DE NDAT86146D DE 86146D A DE86146D A DE 86146DA DE 86146 C DE86146 C DE 86146C
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DE
Germany
Prior art keywords
copper
salt
solution
blood
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DENDAT86146D
Other languages
German (de)
Publication of DE86146C publication Critical patent/DE86146C/de
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

KAISERLICHESIMPERIAL

PATENTAMT.PATENT OFFICE.

Zur Darstellung des Kupferhämols bereitet man eine Lösung von möglichst neutralem weinsauren Kupferoxydnatron in destillirtem Wasser von der Concentration, dafs in 1 ecm nicht mehr als 3 mg Kupfer enthalten sind. Nun löst man frisches Rinderblut in ioTheilen möglichst kalten, mit Kohlensäure geschwängerten , destillirten Wassers, filtrirt die ungelöst bleibenden Stromata ab und setzt der Lösung vorsichtig unter Umrühren so lange von der Kupferlösung zu, bis eine Lösung des Kupferblutgemisches nach dem Filtriren nicht mehr roth, sondern farblos aussieht und mit gelbem Blutlaugensalz und einem Tropfen Säure versetzt braunes Ferrocyankupfer erkennen läfst.A solution that is as neutral as possible is prepared for the representation of the copper hemol tartrate of copper oxide in distilled water of the concentration, so that in 1 ecm it does not contain more than 3 mg of copper. Fresh bovine blood is now dissolved in io parts Distilled water, as cold as possible, impregnated with carbonic acid, filters the undissolved water Remaining stroma and the solution carefully while stirring for so long Copper solution until there is no longer a solution of the copper blood mixture after filtering looks red but colorless and has yellow blood liquor salt and a drop of acid added to it allows you to recognize brown ferrocyan copper.

Der Niederschlag wird durch Centrifugiren oder in der Filterpresse von der Lauge getrennt und mit destillirtem Wasser bis zum Verschwinden der Kupferreaction ausgewaschen, sodann vorsichtig bei niederer Temperatur getrocknet. The precipitate is separated from the liquor by centrifugation or in a filter press and washed out with distilled water until the copper reaction disappears, then carefully dried at low temperature.

Während alle bekannten Kupfersalze, selbst das als mildestes derartiges Präparat bekannte weinsaure Kupferoxydnatron bei Einspritzungen den Blutfarbstoff an sich ziehen und dadurch Zerstörung der rothen Blutkörperchen, Methämoglobinbildung, Freiwerden von Fibrinferment und Gerinnung in den kleinsten Gefäfsen veranlassen, ist es eine speeifische Eigenschaft des Kupferhämols, im Organismus kreisen zu können, ohne derartige Veränderungen hervorzurufen. While all known copper salts, even that known as the mildest such preparation Tartaric acid copper oxide, when injected, attracts the blood pigment and thereby destroys it red blood cells, methaemoglobin formation, release of fibrin ferment and cause coagulation in the smallest vessels, it is a specific property of the Copper hemols to be able to circle in the organism without causing such changes.

Das Präparat soll daher als mildes Kuperpräparat medicinische Anwendung finden.The preparation should therefore be used medicinally as a mild copper preparation.

Claims (1)

Patent-Anspruch:Patent claim: Verfahren zur Darstellung einer als Kupferhämol bezeichneten Verbindung des Blutfarbstoffes mit Kupfer gemäfs dem durch das Patent Nr. 83532 geschützten Verfahren unter Ersatz der Eisensalz- durch Kupfersalzlösung, bestehend in dem Fällen einer Blutlösung mit einer neutralen verdünnten Lösung eines Kupfersalzes oder eines Kupferalkalidoppelsalzes bei einer 00C. nicht erheblich übersteigenden niederen Temperatur.A process for the preparation of a compound referred to as Kupferhämol the blood pigment with copper gemäfs the by the patent no. 83532 protected, with the replacement of the iron salt by the copper salt solution consisting in the cases of blood solution with a neutral dilute solution of a copper salt or a copper alkali metal double salt at a 0 0 C. not significantly exceeding low temperature.
DENDAT86146D Active DE86146C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE86146T

Publications (1)

Publication Number Publication Date
DE86146C true DE86146C (en)

Family

ID=5641175

Family Applications (2)

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DENDAT86146D Active DE86146C (en)

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Application Number Title Priority Date Filing Date
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DE (2) DE86146C (en)

Also Published As

Publication number Publication date
DE83532C (en)

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