DE835146C - Process for the preparation of theobromine calcium salicylate - Google Patents
Process for the preparation of theobromine calcium salicylateInfo
- Publication number
- DE835146C DE835146C DEK6279A DEK0006279A DE835146C DE 835146 C DE835146 C DE 835146C DE K6279 A DEK6279 A DE K6279A DE K0006279 A DEK0006279 A DE K0006279A DE 835146 C DE835146 C DE 835146C
- Authority
- DE
- Germany
- Prior art keywords
- theobromine
- calcium salicylate
- preparation
- theobromine calcium
- salicylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UFGVUHDWEQMLGF-UHFFFAOYSA-L calcium;2-carboxyphenolate;3,7-dimethyl-2-oxopurin-6-olate Chemical compound [Ca+2].OC1=CC=CC=C1C([O-])=O.CN1C(=O)[N-]C(=O)C2=C1N=CN2C UFGVUHDWEQMLGF-UHFFFAOYSA-L 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 2
- 239000011575 calcium Substances 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- ZRMDPUXBTGYVAR-UHFFFAOYSA-N calcium;3,7-dimethylpurine-2,6-dione Chemical compound [Ca].CN1C(=O)NC(=O)C2=C1N=CN2C ZRMDPUXBTGYVAR-UHFFFAOYSA-N 0.000 claims description 2
- 239000007900 aqueous suspension Substances 0.000 claims 1
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 8
- 229960004559 theobromine Drugs 0.000 description 4
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von Theobromin-Calciumsalicylat Bei der Reinigung des Theobromins über das Kalksalz fällt regelmäßig in erheblicher Menge das basische Kalksalz des Theobromins von der Formel C; H,, 02N4 . Ca (O H)2 -#- H20 an, das infolge seiner Schwerlöslichkeit in Wasser den Reinigungsprozeß des Theobromins außerordentlich erschwert und in umständlicher und verlustbringender Weise wieder in Theobromin zurückverwandelt werden muß.Process for the preparation of theobromine calcium salicylate In the Purification of theobromine via the lime salt regularly falls in considerable quantities the basic lime salt of theobromine of formula C; H ,, 02N4. Ca (O H) 2 - # - H20, which due to its poor solubility in water, the purification process of the Theobromine is extremely difficult and cumbersome and loss-making Way must be converted back to theobromine.
Es wurde nun gefunden, daß dieses basische "rheobromincalcium leicht mit Salicylsäure unter Bildung von Theobromin-Calciumsalicylat der Formel C; H; 02N, - Ca - OOC - C,;H,OH + H20 reagiert. Es gelingt auf diesem einfachen Wege, Theobromin-Caiciumsalicylat in reinster Form und mit hoher Ausbeute herzustellen.It has now been found that this basic "rheobromine calcium" easily with salicylic acid to form theobromine calcium salicylate of the formula C; H; 02N, - Ca - OOC - C,; H, OH + H20 reacts. In this simple way it is possible Produce theobromine calcium salicylate in its purest form and with high yield.
Das Verfahrensprodukt findet als Heilmittel Verwendung. Beispiel 272,3 g basisches Theobromincalcium von der Formel C-Hb 02N4 - Ca(OH)2 +H20 werden unter kräftigem Rühren in iooo ccm heißem Wasser suspendiert und bei ioo° mit i38,1 g Salicylsäure versetzt. Das erhaltene Theobromin-Calciumsalicylat C; H7 02N4 Ca - OOC - C,; H40H + H20 fällt in gut filtrierbarer, reiner Form aus und wird nach dem Erkalten abfiltriert. Die Ausbeute ist nahezu quantitativ.The process product is used as a medicinal product. Example 272.3 g of basic theobromine calcium of the formula C-Hb 02N4 - Ca (OH) 2 + H20 are suspended in 100 cc of hot water with vigorous stirring and 38.1 g of salicylic acid are added at 100 °. Theobromine calcium salicylate obtained C; H7 02N4 Ca - OOC - C ,; H40H + H20 precipitates in an easily filterable, pure form and is filtered off after cooling. The yield is almost quantitative.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK6279A DE835146C (en) | 1950-09-10 | 1950-09-10 | Process for the preparation of theobromine calcium salicylate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK6279A DE835146C (en) | 1950-09-10 | 1950-09-10 | Process for the preparation of theobromine calcium salicylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE835146C true DE835146C (en) | 1952-03-27 |
Family
ID=7211234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEK6279A Expired DE835146C (en) | 1950-09-10 | 1950-09-10 | Process for the preparation of theobromine calcium salicylate |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE835146C (en) |
-
1950
- 1950-09-10 DE DEK6279A patent/DE835146C/en not_active Expired
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