DE79124C - Process, liquids, which in addition to essential bezw. contain oily at the same time watery components, to be filled into gelatine or other capsules - Google Patents
Process, liquids, which in addition to essential bezw. contain oily at the same time watery components, to be filled into gelatine or other capsulesInfo
- Publication number
- DE79124C DE79124C DENDAT79124D DE79124DA DE79124C DE 79124 C DE79124 C DE 79124C DE NDAT79124 D DENDAT79124 D DE NDAT79124D DE 79124D A DE79124D A DE 79124DA DE 79124 C DE79124 C DE 79124C
- Authority
- DE
- Germany
- Prior art keywords
- gelatine
- capsules
- essential
- same time
- addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002775 capsule Substances 0.000 title claims description 11
- 229920000159 gelatin Polymers 0.000 title claims description 9
- 235000019322 gelatine Nutrition 0.000 title claims description 9
- 239000001828 Gelatine Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 3
- 239000007788 liquid Substances 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229940098465 Tincture Drugs 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 240000000306 Carapichea ipecacuanha Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960005208 ipecacuanha Drugs 0.000 description 2
- 229940050957 opium tincture Drugs 0.000 description 2
- 239000011257 shell material Substances 0.000 description 2
- 210000002784 Stomach Anatomy 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 240000006745 Valeriana officinalis Species 0.000 description 1
- 241000750042 Vini Species 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
PATENTSCHRIFTPATENT LETTERING
KLASSE 3O: Gesundheitspflege.CLASS 3O: Healthcare.
JOH. LEHMANN in BERLIN. . *JOH. LEHMANN in BERLIN. . *
Patentirt im Deutschen Reiche vom ι. Februar 1894 ab.Patented in the German Empire from ι. February 1894 onwards.
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Gelatine- und anderen Arzneikapseln, welches sich im wesentlichen dadurch kennzeichnet, dafs mit dem Kapsel- oder Hüllenmaterial ein geeigneter Theil des Medicamentes vermischt und hierdurch die Hülle selbst zu einem Theil des Medicamentes gemacht wird, der zugleich auch Träger der anderen Bestandtheile ist.The present invention relates to a method of making gelatin and others Medicinal capsules, which is essentially characterized by the fact that with the Capsule or shell material a suitable part of the medicament mixed and thereby the cover itself is made a part of the medicament, which at the same time is also Is the carrier of the other components.
Bis jetzt war es beispielsweise nicht möglich, die bekannte Tinctura anticholerica, bestehend aus: Tincturae Opii crocätae 7,5, Vini Ipeca-cuänhae 5,0, Tincturae Valerianae aethereae 15,0, Olei Menthae piperitäe guttae XXX dauernd haltbar in Gelatinekapseln zu füllen, da schon nach wenigen Stunden die in der Tinktur enthaltenen wässerigen Bestandtheile der Opiumtinktur und des Ipecacuanha-Weines die Gelatinehülle lösten und durchbrachen.For example, until now it was not possible to consist of the well-known tinctura anticholerica from: Tincturae Opii crocätae 7.5, Vini Ipeca-cuänhae 5.0, Tincturae Valerianae aethereae 15.0, Olei Menthae piperitäe guttae XXX permanent Can be filled in gelatine capsules for a long time, as the tincture contained in the tincture after just a few hours the aqueous components of the opium tincture and the ipecacuanha wine form the gelatine coating loosened and broke through.
Nun ist jedoch für die Darreichung der obenbezeichneten Tinktur gerade die Gelatine-, kapsel die angemessenste Arzneiform, weil erstens dem Patienten die lastige und vielen sogar schwierige Arbeit des Abtröpfelrfs der genauen Dosis erspart bleibt; zweitens, weil die Hülle der Kapsel eine Verflüchtigung des ätherischen Inhaltes der Tinktur (was beim Abtröpfeln auf Zucker oder in Wasser gar nicht zu vermeiden ist) absolut verhindert, und drittens endlich, weil dadurch, dafs sich die Kapsel erst im Magen auflöst, die beabsichtigte belebende Wirkung des Aethers auch thatsächlich herbeigeführt wird.Now, however, it is precisely the gelatine, capsule the most appropriate dosage form, because firstly, the patient is troublesome and many even the difficult work of dripping off the exact dose is spared; second, because the shell of the capsule a volatilization of the essential content of the tincture (which is the case with Dripping on sugar or in water cannot be avoided at all) absolutely prevented, and thirdly, because, because the capsule first dissolves in the stomach, is what it was intended to do the invigorating effect of the ether is actually brought about.
Mit der gegenwärtigen Erfindung ist es nun ermöglicht, die eingangs erwähnten Schwierigkeiten und Nachtheile durch das nachfolgend beschriebene Verfahren vollkommen zu beseitigen. With the present invention it is now possible to overcome the difficulties mentioned at the beginning and to completely eliminate disadvantages by the procedure described below.
Die beiden ersten Bestandtheile der als Beispiel gewählten Tinktur, die Opiumtinktur und der Ipecacuanha-Wein, werden zunächst vermengt, darauf zur Syrupconsistenz auf dem Wasserbade eingedampft und schliefslich in einem bestimmten Verhältnisse mit Gelatinemasse zusammengemischt. Diese Mischung wird nun ebenso wie gewöhnliche Gelatinemasse zu Kapseln verarbeitet, deren Inhalt aus den anderen beiden Bestandteilen der Tinktur, der ätherischen Baldriantinktur und dem Pfeffermünzöl, sich zusammensetzt. Da nun letztere beiden Flüssigkeiten die Gelatine nicht angreifen, so erhält man auf die beschriebene Weise als Product eine auf die Dauer haltbare Kapsel.The first two components of the tincture chosen as an example, the opium tincture and the Ipecacuanha wine, are first mixed, then to the syrup consistency on the Water bath evaporated and finally in a certain proportions with gelatin mass mixed together. This mixture is now just like ordinary gelatin too Capsules processed, the contents of which are made up of the other two ingredients of the tincture, the essential tincture of valerian and peppermint oil. Since now the latter Both liquids do not attack the gelatin, so one obtains the one described As a product, a long-lasting capsule.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE79124C true DE79124C (en) |
Family
ID=351782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT79124D Expired - Lifetime DE79124C (en) | Process, liquids, which in addition to essential bezw. contain oily at the same time watery components, to be filled into gelatine or other capsules |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE79124C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4201178A1 (en) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | METHOD FOR THE PRODUCTION OF WEICHGELATINE CAPSULES AFTER A DRIPPING PROCESS |
-
0
- DE DENDAT79124D patent/DE79124C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4201178A1 (en) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | METHOD FOR THE PRODUCTION OF WEICHGELATINE CAPSULES AFTER A DRIPPING PROCESS |
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