DE753891C - Process for the production of therapeutically applicable, oligodynamically acting products, such as ointments and the like. like - Google Patents

Description

Process for the production of therapeutically applicable, oligodynamic effective products such as ointments and the like.

It has long been known therapeutically applicable products, such as ointments, pastes, plasters, ovules, suppositories and the like, with the incorporation of disinfectants or other therapeutically 'applicable compounds or substances.

There are now products of the type mentioned above, such as ointments od..dgl. Which contain oligodynamically acting agents as an active ingredient getting produced. Agents with an oligodynamic effect, such as Sillbèr, Silberoxyd 11. Like., were not considered for this purpose from the start, since their effectiveness under the influence of sulfur compounds such as hydrogen sulfide and the like, which Almost always present in body fluids such as blood, wound serum, pus and the like are, quickly wears off.

Attempts have now been made to obtain silver manganite, whose use as a sulfur-resistant one oligodynamically acting agent has recently become known, in feiazerteilltemX State in ointments and ointment bases, such as fats, oils and the like, to incorporate. The products thus obtained were, however, more uneven Effect and showed the disadvantage that they had more of their germicidal power when stored or lost less.

Thorough experiments have shown that this problem can be remedied and can achieve products with excellent oligodynamic long-term effects, if you have the silver manganite in or on carriers, such as. B.

Silica gel, bolus, active charcoal, cellulose (pulp), to the emergence brings and the products thus obtained in fine powder or powder form in the Imports oils, fats, ointment bases, etc.

To produce the powdery products you can, for. B. proceed in such a way, that the carrier material, for. B. silica gel, with a solution containing silver salt, e.g. silver nitrate and permanganate, in suitable proportions, impregnated and the silver permanganate formed primarily by reduction to the desired silver manganite convicted.

Dextrose, aldephydeiuinide-like substances can be used as reducing agents In certain cases, the reduction can also take effect through the carrier substances themselves The carrier material can be subjected to the loading in finely powdered form or the carrier material in coarser, z. B. coarse powder or granular form apply and the loaded material by dry or wet grinding, optionally with the addition of protective substances, e.g. B. Colloids, in products of desired degree of fineness, e.g. B. powdered products, transfer.

According to one embodiment, the silver manganite is resorbable Documents such as B. glucose, milk sugar, fibrins, catgut waste od. generated.

The powdery products loaded with silver manganite, which if necessary by measures such as mixing or grinding with other inert or self-effective Powders or powders that can be mixed are now more customary according to the invention Incorporated into oils, fats, ointment bases and the like. This is how you are in able to produce desired products such as ointments, emulsions, pastes, plasters, ovules, Suppositories and the like, and to obtain products which are excellent have oligodynamic effects and retain them even after prolonged storage. In some cases special effects can still be achieved. So you can z. B. by Use of large-surface carrier material, such as silica gel or bolus, suction effects exercise, by using absorbable carrier material, the products for special effects make suitable etc.

The production of a 10% silver manganite ointment can e.g. B. like this take place that 1 part of a 10% silver manganite powder with g parts of a suitable ointment base intimately mixed.

To obtain ointments of particular fineness, you can z. B. like this process that one loaded with silver manganite within the meaning of the invention carrier substances with liquid portions of the ointment base intimately, z. B. by grinding, mixed and then mix in the more solid components of the ointment, plaster, etc.

The incorporation of the powder loaded with silver manganite into ointment bases, Ointments and the like can e.g. B. can also be made in such a way that the powder is under Addition of protective colloids, e.g. B. Tannin, with aqueous or oily liquids intimately ground and the mixture then with the other components of the ointment, the plaster, etc. intimately mixed.

To increase the therapeutic effect of the preparations one can use such method that one uses ointment bases, their pe values of the pH concentration corresponds to or adapted to body tissue. The setting to desired pn can be done by adding suitable buffers.

Claims (3)

PATENT CLAIMS: I. Process for the production of therapeutically applicable oligo, dynamically acting products such as ointments, pastes, plasters, ovules, suppositories and the like., characterized in that carriers loaded with silver manganite, such as Silica gel, bolus and the like, on which the silver manganite is deposited by chemical reaction has been produced and which, if necessary, by wet or dry grinding, optionally with the addition of protective substances (colloids) in the desired degree of fineness have been transferred into the products to be manufactured, e.g. B. ointments, or into suitable raw materials, such as B. Oils, fats, ointment bases and the like, can be incorporated. 2. The method according to claim I, characterized in that absorbable, Carriers loaded with silver manganite are used. 3. The method according to claim I and 2, characterized in that the powdery carriers loaded with silver manganite liquids, e.g. B. water or oily or aqueous-oily liquids, optionally with the addition of Colloids are incorporated and that Mixture with other ingredients of the products to be manufactured is mixed. ~~~~~~~ To delimit the subject matter of the invention From the state of the art, the following publications are considered in the granting procedure drawn: German patent specifications No. 329,189, 441067, 563,643; German Dental weekly publication I933, pp. 42I to 426, 877, 1202 and I228.