DE7411543U - INHALER FOR POWDERED SUBSTANCES - Google Patents
INHALER FOR POWDERED SUBSTANCESInfo
- Publication number
- DE7411543U DE7411543U DE7411543U DE7411543U DE7411543U DE 7411543 U DE7411543 U DE 7411543U DE 7411543 U DE7411543 U DE 7411543U DE 7411543 U DE7411543 U DE 7411543U DE 7411543 U DE7411543 U DE 7411543U
- Authority
- DE
- Germany
- Prior art keywords
- inhaler
- pump
- capsule
- perforating needle
- locking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
Dft. STE-H&» S. BESZEiJESDft. STE-H & »S. BESZEiJES
3 DAOHAU bsi MÜHCHEN3 DAOHAU to MÜHCHEN
Afci HcIDEVIEQ ?.
TELEPHON: DACHAU 43 71Afci HcIDEVIEQ?.
TELEPHONE: DACHAU 43 71
P 6?IP 6? I
B e ω c b rB e ω c b r
zur Patentomieldungfor patent application
I.S.P. S.p.A. Trossano s/T.? (Hilano), ItalienI.S.P. Spa. Trossano s / T.? (Hilano), Italy
"betreffend"concerning
Inhalntor1 fib? pf:lvori*örnip;e Sv;batanaoaInhaler 1 fib? pf: lvori * örnip; e Sv; batanaoa
Die Erfindung betrifft einen Inhalator sur Yera'breis von pulverfönaigon Araneinittelno The invention relates to an inhaler sur Yera'breis from pulverfönaigon Araneinmittel o
IjS sind bereits Inhalatorea lator Vcrvxenclujig einer elastischen i'u'ape und einer !Tadel zun Durcb-Gtoßen einer eino Arzneimittolsubstrma enthaltenden Kapsel.bekannt. !21 all';cT;ioinon iat aber deren Arbaiten nicht völlig zufriedenstellend, ihre· Ausführung ziemlich, koapliüiex't und der Platzbedarf durch ihre Ab-nenr.vinsen ^roß.Inhaler reactors with an elastic tape and a reprimand for pushing a capsule containing a drug substrate are already known. ! 21 all '; c T ; ioinon iat but their work is not completely satisfactory, their execution fairly, koapliüiex't and the space required by their ab-nenr.vinsen ^ roß.
—-
7411543 05.OZ767411543 05.OZ76
OH. CTEPHAN Q. BESZEDEb PATENTANWALT OH. CTEPHAN Q. BESZEDEb PATENT ADVOCATE
806 DACHAU bei MÖNCHEN806 DACHAU near MÖNCHEN
POSTFACH 1.68PO Box 1.68
AM HEIDEWEG 2AM HEIDEWEG 2
Konto-Nr. 136S 7tAccount no. 136S 7t
Bankkonto Nr. GO 637 bei der Kreis- und Stadtsparkasse Dacheil'iAdersdorf (BLZ 700 515 40)Bank account no.GO 637 at the Kreis- und Stadtsparkasse Dacheil'iAdersdorf (bank code 700 515 40)
22. Oktober 1975 G 74 115 43.8 P 672October 22, 1975 G 74 115 43.8 P 672
Die Bauteile 1 und 2 beziehungsweise 10 und 21 können als gegenüber den anderen Bestandteilen des Inhalators beweglich angesehen werden, wie es aus einem Vergleich der Figuren 1 und 4 hervorgeht.The components 1 and 2 or 10 and 2 1 can be viewed as movable with respect to the other components of the inhaler, as can be seen from a comparison of FIGS. 1 and 4.
Der Inhalator umfaßt ferner Anschlagmuffen 7i 7'» welche mit je einem inneren Anschlag 20, 20', von welchen jeder mit einem Anschlag 19 beziehungsweise 19' des jeweiligen Perforiernadelhalterelementes 2 beziehungsweise 2' zusammenwirkt, versehen sind, wie es insbesondere in Figur 1 dargestellt ist. Die Anschlagmuffen 7, 71 sind durch Verkleben oder durch Rändelungen, wie es in Figur 3 dargestellt ist, an die bei 17 aneinandergeschraubten Kapselhalterteile 3j 4, welche einen Hohlraum 8 zur Aufnahme der Kapsel 16 bilden, starr befestigt. Beide Kapselhalterteile 3» 4 haben je einen Durchtritt 18, 18', welche den Durchgang der Perforiernadeln 5, 51 und von Luft gestatten. Um die Perforiernadel 5, 5' von der Kapsel 16 getrennt zu halten, sind zwei Rückholfedern 21, 21' an den manteiförmigen Enden jedes Perforiernadelhalterelementes 2, 21 in je einem ringförmigen Hohlraum zur Aufnahme von zylindrischen Rückholfedern 21 beziehungsweise 21' zusammengedrückt angeordnet, so daß die Rückholfedern 21 beziehungsweise 21' zwischen dem Boden des Rückholfederhaltehohlraumes und den Enden der Verlängerung des Perforiernadelhalterelementes 2 beziehungsweise 21 arbeiten. 14 ist eine Aus-The inhaler further comprises stop sleeves 7i 7 '' which are each provided with an inner stop 20, 20 ', each of which interacts with a stop 19 or 19' of the respective perforating needle holder element 2 or 2 ', as shown in particular in FIG . The stop sleeves 7, 7 1 are rigidly attached by gluing or knurling, as shown in FIG. Both capsule holder parts 3 »4 each have a passage 18, 18 ', which allow the passage of the perforating needles 5, 5 1 and air. In order to keep the perforating needle 5, 5 'separated from the capsule 16, two return springs 21, 21' are arranged pressed together at the jacket-shaped ends of each perforating needle holder element 2, 2 1 in an annular cavity for receiving cylindrical return springs 21 and 21 ', respectively that the return springs 21 and 21 'work between the bottom of the return spring holding cavity and the ends of the extension of the perforating needle holder element 2 and 2 1 , respectively. 14 is an
7411543 05.01767411543 05.0176
Der Erfindung· liegt die Aufgabe zugrunde, einen über den angegebenen Stand der Technik vorbesserten Inhalator von einfacher Ausführung, rascher und sicherer Wirkung und verringerten Abmessungen zu schaffen.The invention · is based on the object of a Inhaler improved over the stated state of the art of simple execution, quick and safe operation and reduced dimensions.
Die Erfindung geht von einem Inhalator für in einer mittels einer Perforiernadel zu durchstoßenden Kapsel enthaltene pi/lvürföraige Substanzen, welche mit Hilfe einer Pumpe zu verteilen sind, mit eineia oberen Teil, an dessen EndQ die pulverförmige Substanz austritt, einem mittleren Teil und einem unteren Teil aum Anschließen an die Pumpe aus. Die oben angeführte Problemstellung wird hierbei dadurch gelöst, daß der Inhalator durch ein ortsfestes mittleres Element als mittleren Teil, das von zwei, vorzugsx<reise durch Verschrauben beziehungsweise eine Bajonettkupplung, miteinander zu verbindenden Kapselhalterteilen gebildet ist und einen Hohlraum zur Aufnahme der Kapsel aufweist, und zwei gegeneinander bewegliche Perforiernadelhalterelemente im oberen Teil beziehungsweise unteren Teil, welche in die beiden. Kapselhalterteile gegen die Wirkung von Rückholfedern teleskopartig hineinbewegbar sind, gekennzeichnet ist.The invention relates to an inhaler for contained in a capsule to be pierced by means of a perforating needle pi / lvüröraige substances, which with the help of a Pump are to be distributed, with an upper part on its EndQ the powdery substance emerges, a middle one Part and a lower part for connecting to the pump. The above-mentioned problem is thereby solved solved that the inhaler through a stationary middle element as the middle part, which of two, preferred x <travels is formed by screwing or a bayonet coupling to be connected to each other capsule holder parts and has a cavity for receiving the capsule, and two perforating needle holder elements which are movable relative to one another in the upper part and lower part, which in the two. Capsule holder parts against the action of return springs are telescopically movable in, is characterized.
Gemäß einer Ausgestaltung des Erfindungsgedankens ist es zweckmäßig, daß die beiden Kapselhalterteile des mittleren Elementes mit Anschlagmuffen nebst je einem inneren Anschlag, von welchen jeder in der Ruhestellung mit einem Anschlag des jeweiligen Perforiernadelhalterelementes in Anlage zu bringen ist, verbunden sind, vorzugsweise durch Verkleben beziehungsweise Reibungsverriegelung, und in der Arbeitsstellung beziehungsweise beim Durchstoßen der Kapsel der Anschlag des jeweiligen Perforiernidelhalterelementes mit dem jeweiligen Kapselhalterteil in Anlage zu bringen ist.According to one embodiment of the inventive concept, it is expedient that the two capsule holder parts of the middle Element with stop sleeves plus one inner stop each, each of which in the rest position with a stop of the respective perforating needle holder element in Is to bring plant, are connected, preferably by gluing or friction locking, and in the Working position or the stop of the respective perforating pin holder element when the capsule is pierced is to be brought into contact with the respective capsule holder part.
7411543 Q5.02J67411543 Q5.02J6
Eej ist auch gemäß einer weiteren Ausgestaltung vorteilhaft, daß die Roibun^sVerriogelung der Perforiorcad 1-halterelcsento mit dera oberen Clement beziehungsweise dem iliiaehluiostück des unteren üloLientoo für die Pu.ipc üox-jio die Kupplun^sverriegelung der Anschlagmuffon. mit den Kapse1 haltorteilen durch Hilcporippen mit Öägezühnen gebildetEej is also advantageous according to a further embodiment, that the Roibun ^ sVerriogelung the Perforiorcad 1-halterelcsento with dera upper Clement respectively the iliiaehluio piece of the lower üloLientoo for the Pu.ipc üox-jio the coupling lock of the stop muffon. with the caps 1 holder parts formed by Hilcporippen with Öägezhnen
Vorzucstireise ist das untere Element des Inhalators von solcher Porin, daß bei ITichtp.etorauch der Inhalatorkorper innerhalb der Pumpe lamgekehrt» zweckmäßigerw iao bei aurrechter Stellung der Purape nach unton, eingesetzt v/erdcn kann, wodurch eine beträchtliche Verrincei-uns des PlatKbodarfcs nebst Steigerung der Gebrauchsfähi^keit und ein gefällico^ kompaktes Aussehen des Gerätes erreicht werden.Pre-travel is the lower element of the inhaler from such a porin that at ITichtp.etorauch the inhalator body is within the pump turned upside down »more expediently w iao with aurgere Position of the Purape towards Unton, can be inserted, thereby making a considerable verrincei-us des PlatKbodarfcs in addition to an increase in usability and a pleasing quality compact appearance of the device can be achieved.
Nach einer besonders vorteilhaften Ausführungsforn der Er findung ist daher das Profil der zylindrischen Oberfläche dos unteren Teiles des Inhalators glatt beziehungsweise poliert und gleichförmig und von einem Vorsprung, an welchen das Mund stück der Pumpe durch Reibungsverriogolung in Anlage su bringen ist, unterbrochen. Dabei sind vorzugsweice die Berührung stellen der zylindrischen Oberfläche des unteren Teiles des Inhalator^ mit der geraden Oberfläche des Vorsprunges Verriegelungsstellen zur Reibungsverriegelung mit der Pumpe im gebrauchsbereiten Zustand des Inhalators. Auch sind vorzugsweise die Berührunjsstellen der zylindrischen Oberfläche des unteren Teiles des Inhalators mit der gekrümmten Oberfläche des V.orsprung^s Verriegelungsstellcn zur Reibungsverriegeluug mit der Punpe im Ruhezustand des Inhalators.According to a particularly advantageous embodiment of the Er finding is therefore the profile of the cylindrical surface dos lower part of the inhaler smooth or polished and uniform and of a protrusion on which the mouth part of the pump is brought into the system by frictional locking, interrupted. Touch is preferred make the cylindrical surface of the lower part of the inhaler ^ locking points with the straight surface of the projection for frictional locking with the pump when the inhaler is ready for use. Also are preferred the contact points of the cylindrical surface of the lower part of the inhaler with the curved surface of the protrusion of the locking position for friction locking with the pump while the inhaler is at rest.
Der erfindungsgemäße Inhalator wird an Hand des folgenden Ausführungsbeispieles in Verbindung mit den beiliegenden Zeichnungen näher erläutert.The inhaler of the present invention is illustrated by the following Embodiment explained in more detail in connection with the accompanying drawings.
7411543 05.02.767411543 02/05/76
_ 4- —
Hierbei sind:_ 4- -
Here are:
Figur 1 ein Lü;i;;cschnitt durch einen erfindun;;s~ graiißon Inhalator in GruMctellui'^ beziehungsweise vor Ingebrauchnahme,Figure 1 a Lü; i ;; c section through an invention ;; s ~ gray inhaler in GruMctellui '^ respectively before use,
Figur 2 oin Schnitt längs der Linie II II vonFigure 2 o in section along the line II II of
Figur 1,Figure 1,
Figur 3 ein in Figur 1 enthaltener Kupplungsteil des erfindungGgemäßen Inhalators in demgegenüber vergrößerter Darrteilung undFIG. 3 shows a coupling part of the inhaler according to the invention contained in FIG. 1 in contrast enlarged presentation and
Figur 4 der Inhalator vor Figur 1 nach Ingebrauchnahme beziehungsweise nach den Durchstoßen einer darin enthaltenen Kapsel»FIG. 4 shows the inhaler in front of FIG. 1 after it has been used or after piercing a capsule contained therein »
Gemäß den Figuren 1 und 4- umfaßt der Inhalator ein oberes Element 1, aus welchem ein von einer Kapsel 16 nach dem Durchstoßen verteiltes Pulver zum Ausströmen gebracht wird, und ein Anschlußstück beziehungsweise Mundstück 10 zum Anschließen des Inhalators an eine herkömmliche Pumpe 15« Da die Pumpe 15 eine große Zahl von Ausführungen haben kann, wird sie nicht näher beschrieben und ist nur schematisch dargestellt. In oberen Element 1 beziehungsweise im Anschlußstück 10 sind Perforiernadelh^lterelemente beziehungsweise -anschlußstüclie 2, 2' befestigt, wobei die Verbindung durch Verkleben oder durch Kündelungen 13t deren Profile gemäß Figur 3 eine iieibungsverriegelung bewirken, herbeigeführt wird, wie uus Figur 2 hervorgeht, ist die Perforiernadel 5 beziehungsweise 51 in dos Porforiornadelhultcrolcment 2 beziehungsweise 2' hineingeschoben und wird durch vier radiale Rippen 9 beziehungsweise 91» welche neben dem Halten der Perforiernadel 5 beziehungsweise 5* den Durchgang von Luft gestatten, gehalten.According to FIGS. 1 and 4, the inhaler comprises an upper element 1, from which a powder distributed by a capsule 16 after being pierced is made to flow out, and a connector or mouthpiece 10 for connecting the inhaler to a conventional pump 15 Pump 15 can have a large number of designs, it is not described in detail and is only shown schematically. Perforiernadelh ^ lterelemente or -anschlussstüclie 2, 2 'are attached in the upper element 1 or in the connection piece 10, the connection being brought about by gluing or by means of bundles 13t whose profiles according to FIG Perforating needle 5 or 5 1 is pushed into dos Porforiornadelhultcrolcment 2 or 2 'and is held by four radial ribs 9 or 9 1 ' which, in addition to holding the perforating needle 5 or 5 *, allow air to pass through.
7411543 05.02.767411543 02/05/76
trittsöffnung für die Arzneimittel sub stanz und 22 der Einlaß für die durch die Pumpe 15 gepumpte Luft·opening for the drug substance and 22 the inlet for the air pumped by the pump 15
AOAO
Die Rippen 9» 91 legen sowohl Luftdurchgänge fest als auch verbinden sie die Perforiernadelhalterung mit dem Körper des betreffenden Perforiernadelhalterelementes 2 beziehungsweise 2'.The ribs 9 »9 1 both define air passages and connect the perforating needle holder to the body of the relevant perforating needle holder element 2 or 2 '.
In Figur 1 sind die inneren Anschläge 20, 20' der Anschlagmuffen 7» 71 in Anlage mit den Anschlägen 19» 19' der Perforiernadelhalterelemente 2, 21 gezeigt, während sich in Figur 2 die Anschläge 19* 19' der Perforiernadelhalterelemente 2, 21 mit den rohrförmigen Verlängerungen 6, 61 der Kapselhalterelemente J, 4 in Anlage befinden.In Figure 1, the internal stops 20, 20 'of the stop sleeves 7 »7 1 into abutment with the stops 19' 19 'of the Perforiernadelhalterelemente 2 shown 2 1, while in Figure 2, the stops 19 * 19' of the Perforiernadelhalterelemente 2, 2 1 are in contact with the tubular extensions 6, 6 1 of the capsule holder elements J, 4.
In den Figuren 1 und 4 ist das Profil der zylindrischen Oberfläcne des unteren Teiles 10 des Inhalatorkörpers, welcher durch Reibungsverriegelung mit der Pumpe 15 von geeigneten Abmessungen verbunden ist, glatt beziehungsweise poliert und gleichförmig und von einem Vorsprung 11, dessen Berührungsstellen 12, 12' mit der zylindrischen Oberfläche des unteren Teiles 10 des Inhalatorkörpers die Anschlagstellen zur Reibungsverriegelung mit der Pumpe 15 darstellen, wenn der Inhalator gebrauchsbereit ist beziehungsweise nicht gebraucht wird, unterbrochen.In Figures 1 and 4, the profile is the cylindrical Surface of the lower part 10 of the inhaler body, which by frictional locking with the pump 15 of suitable Dimensions is connected, smooth or polished and uniform and by a projection 11, the points of contact 12, 12 'with the cylindrical surface of the lower Part 10 of the inhaler body represent the stop points for frictional locking with the pump 15 when the inhaler is ready for use or is not used, interrupted.
Die Arbeitsweise des Inhalators ist wie folgt:The way the inhaler works is as follows:
Zunächst wird der innerhalb der Pumpe 1.5 umgekehrt, zweckmäßigerweise bei aufrechter Stellung der Pumpe 15 nach unten, angeordnete Inhalatorkörper von der letzteren entfernt und innerhalb derselben durch Reibungsverriegelung in seiner mit der Pompe 15 gleichsinnigen Anordnung, zweckmäßigerweise in aufrechter Stellung bei aufrechter Stellung der Pumpe 15, mit der Pumpe 15 verbundene Dann wird der Kapselhalterteil 4First, the inside of the pump 1.5 is reversed, expediently with the pump 15 in an upright position below, located inhaler body removed from the latter and within the same by friction locking in its with the Pompe 15 arrangement in the same direction, expediently in the upright position with the upright position of the pump 15, connected to the pump 15 Then the capsule holder part 4
— 1 —- 1 -
7411543 05.01767411543 05.0176
vom Kapselhalterteil 3 abgeschraubt und die Kapsel 16 eingesetzt, worauf das obere Element 1 und das Anschlußstück 10 des unteren Teiles gegeneinanderbewegt werden, das heißt eine Verkürzung beziehungsweise Stauchung des Inhalators längs der Pfeile A und B hervorgerufen wird, was zu zwei diametral entgegengesetzten Einstichen in die Kapsel 16 führt. Daher genügt es, die Pumpe 15 zu drücken, um den pulverförmigen Inhalt der Kapsel 16 in einsn Hohlraum von Mensch oder Tier, wie Nasenhöhlen beziehungsweise andere Hohlräume des menschlichen oder tierischen Körpers, einzuführen.unscrewed from the capsule holder part 3 and inserted the capsule 16, whereupon the upper element 1 and the connecting piece 10 of the lower part are moved towards one another, that is to say one Shortening or compression of the inhaler along the arrows A and B is brought about, resulting in two diametricals opposite punctures in the capsule 16 leads. It is therefore sufficient to press the pump 15 to dispense the powdery content the capsule 16 in a cavity of humans or animals, such as nasal cavities or other cavities of the human or animal body.
Aus dem Obigen geht die große Vereinfachung, welche durch den erfindungsgemäßen Inhalator mit sehr wenigen Teilen erreicht wurde, weswegen der Zusammenbau nur mit sehr geringen Kosten verbunden ist, hervor.From the above goes the great simplification, which was achieved by the inhaler according to the invention with very few parts, which is why the assembly only with very low cost.
/11/ 11
SchutzansprücheProtection claims
7411543 05.01767411543 05.0176
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2257673A IT986056B (en) | 1973-04-04 | 1973-04-04 | INSUFFLATOR FOR POWDER-SHAPED MEDICATIONS |
IT2569873A IT1045851B (en) | 1973-06-22 | 1973-06-22 | Inhaler for administering powdered medicaments - offers long term trouble free efficiency from particularly simple, inexpensive construction |
Publications (1)
Publication Number | Publication Date |
---|---|
DE7411543U true DE7411543U (en) | 1976-02-05 |
Family
ID=26328226
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE7411543U Expired DE7411543U (en) | 1973-04-04 | 1974-04-02 | INHALER FOR POWDERED SUBSTANCES |
DE2415961A Pending DE2415961A1 (en) | 1973-04-04 | 1974-04-02 | INHALER FOR POWDERED SUBSTANCES |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2415961A Pending DE2415961A1 (en) | 1973-04-04 | 1974-04-02 | INHALER FOR POWDERED SUBSTANCES |
Country Status (7)
Country | Link |
---|---|
US (1) | US3906950A (en) |
JP (1) | JPS5048782A (en) |
BE (1) | BE813143A (en) |
CH (1) | CH569486A5 (en) |
DE (2) | DE7411543U (en) |
FR (1) | FR2224175B1 (en) |
GB (1) | GB1436813A (en) |
Families Citing this family (212)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
IT1017153B (en) * | 1974-07-15 | 1977-07-20 | Isf Spa | APPARATUS FOR INHALATIONS |
YU41046B (en) * | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
GB1521000A (en) * | 1975-06-13 | 1978-08-09 | Syntex Puerto Rico Inc | Inhalation device |
GB1562732A (en) * | 1976-02-10 | 1980-03-12 | Allen & Hanburys Ltd | Device for dispensing medicaments |
US4095596A (en) * | 1976-11-26 | 1978-06-20 | Smithkline Corporation | Nasal inhaler |
IT1116047B (en) * | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA |
JPS57500862A (en) * | 1979-10-30 | 1982-05-20 | ||
DE3345722A1 (en) * | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | INHALATOR |
US4620847A (en) * | 1984-06-01 | 1986-11-04 | Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov | Device for administering powdered substances |
US4645487A (en) * | 1984-06-05 | 1987-02-24 | Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov | Device for administering powdered substances |
IT1222509B (en) * | 1987-08-17 | 1990-09-05 | Miat Spa | INSUFFLATOR FOR THE ADMINISTRATION OF DRUGS IN THE FORM OF PRE-DOSED POWDER IN OPERATIONS |
IT1228460B (en) * | 1989-02-23 | 1991-06-19 | Phidea S R L | DISPOSABLE INHALER WITH PRE-PERFORATED CAPSULE |
US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
IT1237118B (en) * | 1989-10-27 | 1993-05-18 | Miat Spa | MULTI-DOSE INHALER FOR POWDER DRUGS. |
DE4027391A1 (en) * | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | GAS-FREE INHALATION DEVICE |
US6540154B1 (en) | 1991-04-24 | 2003-04-01 | Aerogen, Inc. | Systems and methods for controlling fluid feed to an aerosol generator |
US7628339B2 (en) | 1991-04-24 | 2009-12-08 | Novartis Pharma Ag | Systems and methods for controlling fluid feed to an aerosol generator |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
DE4128295A1 (en) * | 1991-08-27 | 1993-03-04 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
DK198591D0 (en) * | 1991-12-10 | 1991-12-10 | Novo Nordisk As | APPARATUS |
HU216405B (en) * | 1993-03-03 | 1999-06-28 | Tenax Corp. | Dry powder inhalator medicament carrier |
US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
US5488946A (en) * | 1994-03-01 | 1996-02-06 | Calhoun; Clifford A. | Emergency breathing device for opening cartridges |
JP3372105B2 (en) * | 1994-05-26 | 2003-01-27 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
CA2199417C (en) * | 1994-10-24 | 2008-07-08 | Brian John Bellhouse | Particle delivery |
US5901703A (en) * | 1995-02-06 | 1999-05-11 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
JP3308425B2 (en) * | 1995-03-10 | 2002-07-29 | 株式会社ユニシアジェックス | Nasal administration device |
US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US5758637A (en) * | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
US6209538B1 (en) | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5988163A (en) * | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
DE19533979A1 (en) * | 1995-09-14 | 1997-03-20 | Alfred Von Schuckmann | Device for the dosed, airborne delivery of substances |
JP3317827B2 (en) * | 1995-10-09 | 2002-08-26 | 株式会社ユニシアジェックス | Dosing device |
US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
JP3328132B2 (en) * | 1996-03-21 | 2002-09-24 | 株式会社ユニシアジェックス | Inhaler type dispenser |
AUPN976496A0 (en) * | 1996-05-10 | 1996-05-30 | Glaxo Wellcome Australia Ltd | Unit dose dispensing device |
EP0991443A1 (en) * | 1997-06-23 | 2000-04-12 | Marco Cecchini | Inhaling device |
JP3488620B2 (en) * | 1998-02-05 | 2004-01-19 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
JP3530004B2 (en) * | 1998-02-06 | 2004-05-24 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
US7112341B1 (en) | 1999-04-13 | 2006-09-26 | Nektar Therapeutics | Pulmonary administration of dry powder formulations for treating infertility |
US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
WO2001000654A2 (en) * | 1999-06-29 | 2001-01-04 | Pharmaceutical Discovery Corporation | Purification and stabilization of peptide and proteins in pharmaceutical agents |
US7464706B2 (en) * | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
HU229310B1 (en) * | 1999-10-29 | 2013-10-28 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
DE19960459A1 (en) * | 1999-12-15 | 2001-06-21 | Pfeiffer Erich Gmbh & Co Kg | Media Donor |
US20010029947A1 (en) * | 1999-12-17 | 2001-10-18 | Steve Paboojian | Receptacles to facilitate the extraction of powders |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US6968840B2 (en) | 2000-05-05 | 2005-11-29 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US7600511B2 (en) | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
MXPA02010884A (en) | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Apparatus and methods for the delivery of medicaments to the respiratory system. |
US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
US7100600B2 (en) | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US6948494B1 (en) | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
AU2001283546A1 (en) | 2000-08-14 | 2002-02-25 | Advanced Inhalation Research, Inc. | Inhalation device and method |
US6766799B2 (en) * | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
GB2380410B (en) * | 2001-10-05 | 2003-11-19 | Alchemy Healthcare Ltd | Apparatus for the nasal or oral delivery of a medicament |
MXPA04004631A (en) * | 2001-11-14 | 2004-08-12 | Nektar Therapeutics Al Corp | Aerosolization apparatus comprising connectable body and endpiece. |
US7368102B2 (en) * | 2001-12-19 | 2008-05-06 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
AU2003202925B2 (en) | 2002-01-07 | 2008-12-18 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
ITMI20020078A1 (en) * | 2002-01-16 | 2003-07-16 | Fabrizio Niccolai | DEVICE USABLE IN THE TREATMENT OF RESPIRATORY TRACT AFFECTIONS |
DE60318938T2 (en) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | INHALER |
JP3950738B2 (en) * | 2002-05-14 | 2007-08-01 | 株式会社 バイオアクティス | Nasal powder medicine administration device |
WO2003097126A2 (en) | 2002-05-20 | 2003-11-27 | Aerogen, Inc. | Aerosol for medical treatment and methods |
US20040206350A1 (en) * | 2002-12-19 | 2004-10-21 | Nektar Therapeutics | Aerosolization apparatus with non-circular aerosolization chamber |
US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
CN1758930B (en) | 2003-03-27 | 2010-06-09 | 株式会社新日本科学 | Powder medicine applicator for nasal cavity |
MXPA05010842A (en) | 2003-04-09 | 2006-03-30 | Nektar Therapeutics | Aerosolization apparatus with air inlet shield. |
US8869794B1 (en) * | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
CN101027082A (en) * | 2004-01-12 | 2007-08-29 | 曼恩坎德公司 | Method of reducing serum proinsulin levels in type 2 diabetics |
JP2007522246A (en) * | 2004-02-12 | 2007-08-09 | ネクター セラピューティクス | Interleukin-13 antagonist powder, spray-dried particles, and method |
US20080248999A1 (en) * | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US7290541B2 (en) | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
US7267121B2 (en) | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
CN1946453A (en) * | 2004-04-23 | 2007-04-11 | 米斯提克医药有限公司 | Multiple unit dose drug delivery system |
US7611709B2 (en) * | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
US7723306B2 (en) * | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
US7727962B2 (en) * | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
JP2008503500A (en) | 2004-06-18 | 2008-02-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | Treatment of bronchial infections |
EP1785145A4 (en) | 2004-08-10 | 2008-08-13 | Translational Res Ltd | Transnasal composition having immediate action and high absorbability |
EP1786784B1 (en) | 2004-08-20 | 2010-10-27 | MannKind Corporation | Catalysis of diketopiperazine synthesis |
CA2578175C (en) | 2004-08-23 | 2014-10-14 | Mannkind Corporation | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
GB0420513D0 (en) * | 2004-09-15 | 2004-10-20 | Optinose As | Powder delivery devices |
BRPI0516701B1 (en) | 2004-11-10 | 2017-11-28 | Cipla Ltd. | INHALER DEVICE FOR INHALATION OF A MEDICATION OF A PERFORABLE CAPSULE |
PT1901749T (en) | 2005-05-18 | 2016-11-04 | Raptor Pharmaceuticals Inc | Aerosolized fluoroquinolones and uses thereof |
US8524735B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US7614429B2 (en) * | 2005-05-18 | 2009-11-10 | Symyx Solutions, Inc. | Apparatus and methods for storing and dispensing solid material |
MX2007014867A (en) | 2005-05-25 | 2008-02-21 | Aerogen Inc | Vibration systems and methods. |
US7803404B2 (en) | 2005-09-14 | 2010-09-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
WO2007041481A1 (en) * | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
BRPI0707991B8 (en) | 2006-02-22 | 2021-05-25 | Mannkind Corp | methods of preparing a dry powder medicine with an improved pharmaceutical property, said dry powder and using an effective amount of the dry powder |
DE102006010089A1 (en) | 2006-02-24 | 2007-10-18 | Aha-Kunststofftechnik Gmbh | The dry powder inhaler |
CA2649109A1 (en) * | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
EP1844805A1 (en) * | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH & Co.KG | Inhaler |
US7806117B2 (en) * | 2006-06-07 | 2010-10-05 | Shin Nippon Biomedical Laboratories, Ltd. | Peroral powder delivery device |
UY30418A1 (en) * | 2006-06-16 | 2008-01-31 | Cipla Ltd | IMPROVED DRY POWDER INHALER |
EP2116264B1 (en) | 2006-12-26 | 2017-09-27 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
CA2886385A1 (en) * | 2007-01-09 | 2008-07-17 | Mystic Pharmaceuticals, Inc. | Intranasal cartridge devices |
GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
US8683995B2 (en) | 2007-05-16 | 2014-04-01 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
CN105776119B (en) | 2007-05-16 | 2019-04-23 | 神秘制药公司 | Combination unit dose dispensing containers |
US9248076B2 (en) | 2007-05-16 | 2016-02-02 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
US8496002B2 (en) * | 2007-06-12 | 2013-07-30 | Civitas Therapeutics, Inc. | Powder inhaler devices |
EP2020249A1 (en) * | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
CA2886525A1 (en) * | 2007-09-14 | 2009-03-19 | Mystic Pharmaceuticals, Inc. | Deep draw container forming method |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
JP5350388B2 (en) * | 2007-10-25 | 2013-11-27 | ノバルティス アーゲー | Powder preparation of unit dose drug package |
AU2009204309B2 (en) * | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
SI2082769T1 (en) | 2008-01-24 | 2015-10-30 | Vectura Delivery Devices Limited | Inhaler |
CN101980738A (en) | 2008-02-07 | 2011-02-23 | 华盛顿大学 | Circumferential aerosol device |
CN101980743B (en) * | 2008-03-27 | 2014-04-02 | 曼金德公司 | A dry powder inhalation system |
EP2570147B1 (en) | 2008-06-13 | 2017-10-18 | MannKind Corporation | A dry powder inhaler and system for drug delivery |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
TWI614024B (en) | 2008-08-11 | 2018-02-11 | 曼凱公司 | Use of ultrarapid acting insulin |
WO2010033207A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
US20110171312A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Modified therapeutic peptides, methods of their preparation and use |
PL2344129T3 (en) | 2008-10-07 | 2018-07-31 | Horizon Orphan Llc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
JP2012505222A (en) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | Inhalation of levofloxacin to reduce lung inflammation |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
PL2405963T3 (en) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Apparatus, system and method for measuring resistance of an inhaler |
WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
KR20180079458A (en) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | Diketopiperazine microparticles with defined specific surface areas |
WO2011013003A2 (en) * | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
ES2739979T3 (en) | 2009-09-04 | 2020-02-05 | Horizon Orphan Llc | Use of levofloxacin spray for the treatment of cystic fibrosis |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
CA2779488A1 (en) | 2009-11-12 | 2011-05-19 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
RU2531455C2 (en) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Systems and methods for dry powder drugs delivery |
EP3012258B1 (en) | 2010-06-24 | 2018-09-19 | Gilead Sciences, Inc. | Pharmaceutical composition comprising a pyrazolo[1,5-a]pyrimidine derivative as an antiviral agent |
PL2595980T3 (en) | 2010-07-22 | 2015-03-31 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
TW201305185A (en) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
ES2646748T3 (en) | 2010-12-07 | 2017-12-15 | Respira Therapeutics, Inc. | Dry powder inhaler |
DK2670242T3 (en) | 2011-01-31 | 2022-05-02 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
CN103917265B (en) | 2011-03-03 | 2017-02-15 | 英倍尔药业股份有限公司 | Nasal drug delivery device |
CN105667994B (en) | 2011-04-01 | 2018-04-06 | 曼金德公司 | Blister package for pharmaceutical kit |
JP6645735B2 (en) | 2011-05-09 | 2020-02-14 | インペル ニューロファーマ インコーポレイテッド | Nose delivery nozzle |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
WO2013016784A1 (en) | 2011-08-04 | 2013-02-07 | Victor Esteve | Dry powder inhaler |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
US10463815B2 (en) | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
EP2834258B1 (en) * | 2012-03-13 | 2017-01-04 | Gilead Sciences, Inc. | 2'- substituted carba-nucleoside analogs for antiviral treatment |
JP2015516976A (en) | 2012-04-17 | 2015-06-18 | ギリアード サイエンシーズ, インコーポレイテッド | Compounds and methods for antiviral treatment |
WO2013184951A2 (en) * | 2012-06-06 | 2013-12-12 | Aerodesigns, Inc. | Aerosol dispenser with replaceable cartridge |
CN108057154B (en) | 2012-07-12 | 2021-04-16 | 曼金德公司 | Dry powder drug delivery system and method |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
CA2906817C (en) | 2013-03-15 | 2022-01-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
EP2991713B1 (en) | 2013-04-28 | 2019-06-19 | Impel Neuropharma Inc. | Medical unit dose container |
EP3607941A1 (en) | 2013-04-30 | 2020-02-12 | Otitopic Inc. | Dry powder formulations and methods of use |
WO2015006639A1 (en) | 2013-07-12 | 2015-01-15 | SILVA, John, H. | Mouthpiece for inhalers |
BR112015031590B1 (en) | 2013-07-16 | 2021-05-18 | Victor Esteve | powder inhaler |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
CA3172586A1 (en) | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Aerosol imatininb compounds and uses thereof |
JP2016530930A (en) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | Ventilation device and method |
UA119050C2 (en) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections |
EP3091976A4 (en) | 2014-01-10 | 2017-10-11 | Genoa Pharmaceuticals Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
PL3107548T3 (en) | 2014-02-20 | 2022-10-31 | Otitopic Inc. | Dry powder formulations for inhalation |
USD752734S1 (en) | 2014-03-10 | 2016-03-29 | Civitas Therapeutics, Inc. | Inhaler grip |
USD752204S1 (en) | 2014-03-10 | 2016-03-22 | Civitas Therapeutics, Inc. | Indicator for an inhaler |
USD755367S1 (en) | 2014-03-10 | 2016-05-03 | Civitas Therapeutics, Inc. | Indicator for an inhaler |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
USD748242S1 (en) | 2014-07-11 | 2016-01-26 | H. Stuart Campbell | Inhaler mouthpiece |
TWI678369B (en) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidines useful for treating respiratory syncitial virus infections |
TWI673283B (en) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
JP2018501903A (en) | 2015-01-14 | 2018-01-25 | レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. | Powder dispersion method and apparatus |
US10874139B2 (en) * | 2015-07-07 | 2020-12-29 | Altria Client Services Llc | E-vapor device including capsule containing pre-vapor formulation |
WO2017044897A1 (en) | 2015-09-10 | 2017-03-16 | Impel Neuropharma Inc. | In-line nasal delivery device |
US10940274B2 (en) | 2015-12-01 | 2021-03-09 | Cipla Limited | Nasal spray assembly |
JP6976970B2 (en) * | 2016-07-07 | 2021-12-08 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Nicotine inhaler system |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
FR3072313B1 (en) * | 2017-10-12 | 2019-10-11 | Aptar France Sas | DEVICE FOR DISPENSING FLUID PRODUCT |
CA3081680A1 (en) | 2017-11-21 | 2019-05-31 | Impel Neuropharma, Inc. | Intranasal device with inlet interface |
US11571532B2 (en) | 2017-11-21 | 2023-02-07 | Impel Pharmaceuticals Inc. | Intranasal device with dip tube |
KR20200118032A (en) | 2018-01-05 | 2020-10-14 | 임펠 뉴로파마 인코포레이티드 | Intranasal delivery of dihydroergotamine by precise olfactory organ device |
CA3087698A1 (en) | 2018-01-05 | 2019-07-11 | Impel Neuropharma, Inc. | Intranasal delivery of olanzapine by precision olfactory device |
WO2020018959A1 (en) | 2018-07-19 | 2020-01-23 | Impel Neuropharma, Inc. | Respiratory tract delivery of levodopa and dopa decarboxylase inhibitor for treatment of parkinson's disease |
CN109078245A (en) * | 2018-10-11 | 2018-12-25 | 上海博极给药医药科技有限公司 | A kind of double-capsule type powder inhaler |
CN113473967B (en) | 2019-01-03 | 2022-09-09 | 英倍尔制药公司 | Transnasal drug delivery device |
EP3969085A4 (en) | 2019-05-17 | 2023-06-21 | Impel Pharmaceuticals Inc. | Single-use nasal delivery device |
WO2021130638A1 (en) | 2019-12-24 | 2021-07-01 | Carna Biosciences, Inc. | Diacylglycerol kinase modulating compounds |
TWI775313B (en) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | Antiviral compounds |
TW202322824A (en) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | Antiviral compounds |
TWI791193B (en) | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | Antiviral compounds |
JP7429799B2 (en) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | antiviral compounds |
KR20230006891A (en) | 2020-05-01 | 2023-01-11 | 길리애드 사이언시즈, 인코포레이티드 | 2,4-dioxopyrimidine compounds that inhibit CD73 |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
EP4359389A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
CA3222439A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
KR20240005901A (en) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | Diacylglycerol Kinase Modulating Compounds |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
WO2023077030A1 (en) | 2021-10-29 | 2023-05-04 | Gilead Sciences, Inc. | Cd73 compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2307986A (en) * | 1940-02-15 | 1943-01-12 | Bolte | Insufflator |
US2519555A (en) * | 1945-08-31 | 1950-08-22 | Abbott Lab | Sterile medicament insufflator cartridge and insufflator |
US2517482A (en) * | 1949-04-09 | 1950-08-01 | Sharp & Dohme Inc | Inhaler |
US2581182A (en) * | 1950-03-14 | 1952-01-01 | Abbott Lab | Inhaler |
US2946332A (en) * | 1957-12-23 | 1960-07-26 | Nysco Lab Inc | Insufflator |
US3669113A (en) * | 1966-03-07 | 1972-06-13 | Fisons Ltd | Inhalation device |
US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
-
1974
- 1974-03-29 FR FR7411171A patent/FR2224175B1/fr not_active Expired
- 1974-04-01 BE BE142716A patent/BE813143A/en unknown
- 1974-04-01 GB GB1440174A patent/GB1436813A/en not_active Expired
- 1974-04-02 DE DE7411543U patent/DE7411543U/en not_active Expired
- 1974-04-02 US US457270A patent/US3906950A/en not_active Expired - Lifetime
- 1974-04-02 DE DE2415961A patent/DE2415961A1/en active Pending
- 1974-04-03 CH CH465574A patent/CH569486A5/xx not_active IP Right Cessation
- 1974-04-03 JP JP49037060A patent/JPS5048782A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GB1436813A (en) | 1976-05-26 |
CH569486A5 (en) | 1975-11-28 |
US3906950A (en) | 1975-09-23 |
FR2224175B1 (en) | 1978-04-14 |
JPS5048782A (en) | 1975-05-01 |
BE813143A (en) | 1974-07-31 |
DE2415961A1 (en) | 1974-10-17 |
FR2224175A1 (en) | 1974-10-31 |
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