DE69927369D1 - Hemmung xenoreaktiver antikörper - Google Patents
Hemmung xenoreaktiver antikörperInfo
- Publication number
- DE69927369D1 DE69927369D1 DE69927369T DE69927369T DE69927369D1 DE 69927369 D1 DE69927369 D1 DE 69927369D1 DE 69927369 T DE69927369 T DE 69927369T DE 69927369 T DE69927369 T DE 69927369T DE 69927369 D1 DE69927369 D1 DE 69927369D1
- Authority
- DE
- Germany
- Prior art keywords
- xenoantigen
- xenopolymer
- antibodies
- host
- xenograft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- PFAXACNYGZVKMX-UHFFFAOYSA-N fenethazine Chemical compound C1=CC=C2N(CCN(C)C)C3=CC=CC=C3SC2=C1 PFAXACNYGZVKMX-UHFFFAOYSA-N 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6052598A | 1998-04-15 | 1998-04-15 | |
PCT/US1999/008326 WO1999052561A1 (en) | 1998-04-15 | 1999-04-15 | Inhibition of xenoreactive antibodies |
US60525 | 2002-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69927369D1 true DE69927369D1 (de) | 2006-02-02 |
DE69927369T2 DE69927369T2 (de) | 2006-06-22 |
Family
ID=22030043
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69927369T Expired - Fee Related DE69927369T2 (de) | 1998-04-15 | 1999-04-15 | Hemmung xenoreaktiver antikörper |
DE1087791T Pending DE1087791T1 (de) | 1998-04-15 | 1999-04-15 | Hemmung xenoreaktiver antikörper |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1087791T Pending DE1087791T1 (de) | 1998-04-15 | 1999-04-15 | Hemmung xenoreaktiver antikörper |
Country Status (10)
Country | Link |
---|---|
US (3) | US6572867B1 (de) |
EP (1) | EP1087791B1 (de) |
JP (1) | JP2002511431A (de) |
AT (1) | ATE304865T1 (de) |
AU (1) | AU761831B2 (de) |
CA (1) | CA2326618A1 (de) |
DE (2) | DE69927369T2 (de) |
ES (1) | ES2249890T3 (de) |
HK (1) | HK1036223A1 (de) |
WO (1) | WO1999052561A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2173500A (en) * | 1998-12-09 | 2000-06-26 | La Jolla Pharmaceutical Company | Methods and formulations for reducing circulating antibodies |
US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
WO2001051499A1 (en) * | 2000-01-13 | 2001-07-19 | Alchemia Pty Ltd | METHODS FOR SYNTHESIS OF α-D-GAL (1→3) GAL-CONTAINING OLIGOSACCHARIDES |
US7270961B2 (en) * | 2002-04-16 | 2007-09-18 | Hui Sunny Chang | In vitro assay for quantitating secreted antibodies in lymphocyte supernatant for evaluation of vaccine or antigen induced specific antibody secretion from ex vivo circulating antibody-secreting lymphocytes |
US20060099169A1 (en) * | 2004-10-13 | 2006-05-11 | Ilypsa, Inc. | Toxin binding compositions |
US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
FR2886298A1 (fr) * | 2005-05-24 | 2006-12-01 | Ifremer | Anticorps ou fragment d'anticorps couple a un agent immunogene |
US8450068B2 (en) | 2007-02-16 | 2013-05-28 | University Of Virginia Patent Foundation | IgE antibodies to chimeric or humanized IgG therapeutic monoclonal antibodies as a screening test for anaphylaxis |
EP2095829A1 (de) * | 2008-02-27 | 2009-09-02 | LEK Pharmaceuticals D.D. | Selenhaltige Modifizierungsmittel und Konjugate |
US9891219B2 (en) * | 2008-10-10 | 2018-02-13 | Mayo Foundation For Medical Education And Research | Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
WO2011139488A2 (en) | 2010-05-06 | 2011-11-10 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing cardiac xenograft rejection |
US20130149331A1 (en) * | 2011-05-03 | 2013-06-13 | Peng George Wang | Rhamnose and forssman conjugated immunogenic agents |
US9533214B2 (en) | 2012-09-25 | 2017-01-03 | Igt | Gaming system and method for providing plays of multiple games |
EP3116887B1 (de) | 2014-03-13 | 2021-02-17 | Universität Basel | Carbohydrat-liganden, die an gegen myelin-assoziertes -glukoprotein igm-antikörper binden |
EP2987503A1 (de) * | 2014-08-22 | 2016-02-24 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Verfahren und Reagenzien zur Prävention und/oder Behandlung von Infektionen |
CN107106607A (zh) | 2014-10-22 | 2017-08-29 | 印第安纳大学研究与技术公司 | 适用于异种移植的三重转基因猪 |
EP3350193B1 (de) | 2015-09-16 | 2020-12-23 | Universität Basel | An antikörper gegen glycoepitope von glycosphingolipiden bindende kohlenhydratliganden |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8001748L (sv) * | 1980-03-05 | 1981-09-06 | Kaellenius Gunilla | Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik |
US5126131A (en) * | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
US5191066A (en) * | 1990-12-07 | 1993-03-02 | Abbott Laboratories | Site-specific conjugation of immunoglobulins and detectable labels |
US5651968A (en) * | 1991-08-23 | 1997-07-29 | Alberta Research Council | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
US5879675A (en) * | 1994-03-15 | 1999-03-09 | Medical College Of Pennsylvania And Hahnemann University | Compositions and methods for vaccines comprising α-galactosyl epitopes |
US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
USRE39245E1 (en) * | 1995-12-21 | 2006-08-22 | Procur Ab | Galactopyranosides and their use |
AU6319198A (en) * | 1997-02-05 | 1998-08-25 | Biotransplant Incorporated | Induction of b cell tolerance |
US6676946B2 (en) * | 1997-03-27 | 2004-01-13 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof |
DE69835201T2 (de) * | 1997-04-18 | 2007-06-14 | Novartis Ag | Neoglycoproteine |
US6096725A (en) * | 1997-07-02 | 2000-08-01 | Neose Technologies, Inc. | Methods of using αGal oligosaccharides as immune system targeting agents |
-
1999
- 1999-04-15 CA CA002326618A patent/CA2326618A1/en not_active Abandoned
- 1999-04-15 EP EP99917553A patent/EP1087791B1/de not_active Expired - Lifetime
- 1999-04-15 ES ES99917553T patent/ES2249890T3/es not_active Expired - Lifetime
- 1999-04-15 DE DE69927369T patent/DE69927369T2/de not_active Expired - Fee Related
- 1999-04-15 US US09/292,153 patent/US6572867B1/en not_active Expired - Fee Related
- 1999-04-15 WO PCT/US1999/008326 patent/WO1999052561A1/en active IP Right Grant
- 1999-04-15 AT AT99917553T patent/ATE304865T1/de not_active IP Right Cessation
- 1999-04-15 AU AU35645/99A patent/AU761831B2/en not_active Ceased
- 1999-04-15 JP JP2000543171A patent/JP2002511431A/ja active Pending
- 1999-04-15 DE DE1087791T patent/DE1087791T1/de active Pending
-
2001
- 2001-09-28 HK HK01106879A patent/HK1036223A1/xx not_active IP Right Cessation
-
2003
- 2003-03-28 US US10/402,845 patent/US20040141944A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/932,737 patent/US20080124396A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2326618A1 (en) | 1999-10-21 |
US20040141944A1 (en) | 2004-07-22 |
AU3564599A (en) | 1999-11-01 |
WO1999052561A1 (en) | 1999-10-21 |
EP1087791A1 (de) | 2001-04-04 |
ES2249890T3 (es) | 2006-04-01 |
EP1087791B1 (de) | 2005-09-21 |
US6572867B1 (en) | 2003-06-03 |
DE1087791T1 (de) | 2002-02-21 |
AU761831B2 (en) | 2003-06-12 |
DE69927369T2 (de) | 2006-06-22 |
ATE304865T1 (de) | 2005-10-15 |
JP2002511431A (ja) | 2002-04-16 |
HK1036223A1 (en) | 2001-12-28 |
US20080124396A1 (en) | 2008-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |