DE69839921D1 - Verwendung von an polyamid gebundenen nukleinsäure-oligomeren zur erzeugung einer biologischen reaktion - Google Patents

Verwendung von an polyamid gebundenen nukleinsäure-oligomeren zur erzeugung einer biologischen reaktion

Info

Publication number
DE69839921D1
DE69839921D1 DE69839921T DE69839921T DE69839921D1 DE 69839921 D1 DE69839921 D1 DE 69839921D1 DE 69839921 T DE69839921 T DE 69839921T DE 69839921 T DE69839921 T DE 69839921T DE 69839921 D1 DE69839921 D1 DE 69839921D1
Authority
DE
Germany
Prior art keywords
pna oligomers
materials
biological response
oligomers
provides methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69839921T
Other languages
English (en)
Inventor
Elliott Richelson
Beth Marie Tyler
Daniel J Mccormick
Bernadette Marie Cusack
Clark V Hoshall
Christopher Lee Douglas
Karen Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Mayo Foundation for Medical Education and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/953,269 external-priority patent/US6472209B1/en
Priority claimed from US09/168,791 external-priority patent/US6723560B2/en
Application filed by Mayo Foundation for Medical Education and Research filed Critical Mayo Foundation for Medical Education and Research
Application granted granted Critical
Publication of DE69839921D1 publication Critical patent/DE69839921D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
DE69839921T 1997-10-17 1998-10-16 Verwendung von an polyamid gebundenen nukleinsäure-oligomeren zur erzeugung einer biologischen reaktion Expired - Fee Related DE69839921D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/953,269 US6472209B1 (en) 1997-10-17 1997-10-17 Using polyamide nucleic acid oligomers to engender a biological response
US09/016,685 US6743627B1 (en) 1997-10-17 1998-01-30 Using polyamide nucleic acid oligomers to engender a biological response
US16851998A 1998-10-08 1998-10-08
US09/168,714 US6989270B1 (en) 1997-10-17 1998-10-08 Using polyamide nucleic acid oligomers to engender a biological response
US09/168,791 US6723560B2 (en) 1998-10-08 1998-10-08 Using polyamide nucleic acid oligomers to engender a biological response
PCT/US1998/021888 WO1999020643A1 (en) 1997-10-17 1998-10-16 Using polyamide nucleic acid oligomers to engender a biological response

Publications (1)

Publication Number Publication Date
DE69839921D1 true DE69839921D1 (de) 2008-10-02

Family

ID=27533701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839921T Expired - Fee Related DE69839921D1 (de) 1997-10-17 1998-10-16 Verwendung von an polyamid gebundenen nukleinsäure-oligomeren zur erzeugung einer biologischen reaktion

Country Status (12)

Country Link
US (1) US6989270B1 (de)
EP (1) EP1042349B1 (de)
JP (1) JP2003523307A (de)
AT (1) ATE405575T1 (de)
AU (1) AU741246B2 (de)
BR (1) BR9814866A (de)
CA (1) CA2306731A1 (de)
DE (1) DE69839921D1 (de)
DK (1) DK1042349T3 (de)
ES (1) ES2312192T3 (de)
IL (1) IL135705A0 (de)
WO (1) WO1999020643A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6472209B1 (en) 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
CA1268404A (en) 1985-03-15 1990-05-01 Antivirals Inc. Polynucleotide assay reagent and method
US5470974A (en) 1985-03-15 1995-11-28 Neu-Gene Development Group Uncharged polynucleotide-binding polymers
US5783682A (en) 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
WO1995004749A1 (en) 1993-08-05 1995-02-16 Isis Pharmaceuticals, Inc. Oligomers for modulating metabolic function
WO1995004748A1 (en) 1993-08-09 1995-02-16 Isis Pharmaceuticals, Inc. Oligomers for modulating viral processes
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US5703067A (en) * 1995-05-08 1997-12-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU5856596A (en) 1995-05-10 1996-11-29 Isis Pharmaceuticals, Inc. Inhibition of transcription factor-mediated transcriptional activation by oligomer strand invasion
US6015710A (en) 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
GB9608803D0 (en) 1996-04-27 1996-07-03 Univ Newcastle Mitochondrial dna defects
CA2291839A1 (en) 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
EP0998577B1 (de) 1997-07-24 2004-10-27 Perseptive Biosystems, Inc. Konjugate von transportpeptiden und nukleinsäureanaloga und deren verwendung
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
AU9570898A (en) 1997-09-18 1999-04-05 Gene Therapy Systems, Inc. Chemical modification of dna using peptide nucleic acid conjugates
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6472209B1 (en) * 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

Also Published As

Publication number Publication date
EP1042349B1 (de) 2008-08-20
ES2312192T3 (es) 2009-02-16
US6989270B1 (en) 2006-01-24
WO1999020643A1 (en) 1999-04-29
AU741246B2 (en) 2001-11-29
CA2306731A1 (en) 1999-04-29
JP2003523307A (ja) 2003-08-05
ATE405575T1 (de) 2008-09-15
IL135705A0 (en) 2001-05-20
DK1042349T3 (da) 2008-11-10
BR9814866A (pt) 2001-11-20
WO1999020643A9 (en) 1999-08-05
AU1094099A (en) 1999-05-10
EP1042349A4 (de) 2004-07-28
EP1042349A1 (de) 2000-10-11

Similar Documents

Publication Publication Date Title
ATE246361T1 (de) Verfahren zur bestimmung von ige
DE69735445D1 (de) Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
SE0003286D0 (sv) Method and kit for human identification
ATE335845T1 (de) Elektrophoretische analyse von molekülen mit immobilisierten sonden
DE69813158T2 (de) Assays zur Bestimmung von Proteinfragmenten in biologischen Medien
ATE529509T1 (de) Selektion von proteinen unter verwendung von rna- protein-fusionen
DE60029092D1 (de) Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
DK1044374T3 (da) Glucosebiosensor
DE60035691D1 (de) Verfahren zur Erkennung von Einzel-Nukleotid-Polymorphismen
ATE21173T1 (de) Methode zur fluoreszenz-spektroskopischen bestimmung von biologisch aktiven substanzen.
ATE188292T1 (de) Verfahren zur nachweis von marijuana in einer haar probe
DE3779706T2 (de) Enzymsensor zur bestimmung von glutaminat-konzentration.
ATE309333T1 (de) Synthetische polynukleotide
ATE318930T1 (de) Nukleinsäuresonden zur detektion von candida- spezies
ATE321886T1 (de) Oligonukleotide und diese enthaltende komplexe zur detektion der anwesenheit oder abwesenheit einer zielnukleinsäure in einer probe
DE59408917D1 (de) Verfahren zur identifizierung von menschlichen und tierischen zellen mit der fähigkeit zu unbegrenzter proliferation oder zur tumorbildung
DE60137322D1 (de) Verbesserungen in bezug auf die analyse von dns-proben
DE69839921D1 (de) Verwendung von an polyamid gebundenen nukleinsäure-oligomeren zur erzeugung einer biologischen reaktion
DE59814359D1 (de) Mikrostrukturierter biosensor, verwendung des biosensors und verfahren zur immobilisierung von biokatalysatoren
EP0990901A3 (de) Computergestützte Identifizierung von Paraproteinen
EP0809103A3 (de) Stabile Denaturierungsmittel für elektroforetische Techniken und dafür geeignete Verfahren
DE69429428D1 (de) Methode zur analyse des dna-gehalts von tumorzellen mittels tumorzellenanreicherung
DE69531505D1 (de) Verfahren zur zellerkennung
ATE230033T1 (de) Verwendung von primern für universelle fingerprint-analysen
ATE269417T1 (de) Verfahren zur erkennung und messung von gespleisten nukleinsäuren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee