DE69839536D1 - G-Protein Chimären - Google Patents

G-Protein Chimären

Info

Publication number
DE69839536D1
DE69839536D1 DE69839536T DE69839536T DE69839536D1 DE 69839536 D1 DE69839536 D1 DE 69839536D1 DE 69839536 T DE69839536 T DE 69839536T DE 69839536 T DE69839536 T DE 69839536T DE 69839536 D1 DE69839536 D1 DE 69839536D1
Authority
DE
Germany
Prior art keywords
amino acids
chimeric
compound
observing
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839536T
Other languages
English (en)
Inventor
Andrew J Brown
Simon J Dowell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE69839536D1 publication Critical patent/DE69839536D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69839536T 1997-09-13 1998-09-11 G-Protein Chimären Expired - Lifetime DE69839536D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9719496.3A GB9719496D0 (en) 1997-09-13 1997-09-13 G protien chimeras

Publications (1)

Publication Number Publication Date
DE69839536D1 true DE69839536D1 (de) 2008-07-03

Family

ID=10819017

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69829485T Expired - Lifetime DE69829485T2 (de) 1997-09-13 1998-09-11 Chimäre des g-proteins
DE69839536T Expired - Lifetime DE69839536D1 (de) 1997-09-13 1998-09-11 G-Protein Chimären

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69829485T Expired - Lifetime DE69829485T2 (de) 1997-09-13 1998-09-11 Chimäre des g-proteins

Country Status (9)

Country Link
US (1) US6509447B1 (de)
EP (2) EP1533379B1 (de)
JP (2) JP4587563B2 (de)
AT (2) ATE291627T1 (de)
AU (1) AU9086398A (de)
DE (2) DE69829485T2 (de)
ES (1) ES2308104T3 (de)
GB (1) GB9719496D0 (de)
WO (1) WO1999014344A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067277B1 (en) 1999-12-23 2006-06-27 H. Lundbeck A/S Chimeric G proteins and uses thereof
CA2482915A1 (en) * 2002-04-16 2003-10-23 Kyowa Hakko Kogyo Co., Ltd. Endocrine cell lines and method of using the same
DE10233516A1 (de) * 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
CN101166527A (zh) 2005-04-27 2008-04-23 艾尼纳制药公司 用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法
EP2308840A1 (de) 2005-06-30 2011-04-13 Prosidion Limited GPCR-Agonisten
ATE487940T1 (de) 2006-04-11 2010-11-15 Arena Pharm Inc Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
WO2008081204A1 (en) 2007-01-04 2008-07-10 Prosidion Limited Piperidine gpcr agonists
AR064736A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr
EP2200609A1 (de) 2007-09-10 2010-06-30 Prosidion Limited Verbindungen zur behandlung von stoffwechselstörungen
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
EP2108960A1 (de) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof
JP2022545558A (ja) * 2019-08-26 2022-10-27 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 操作された治療用微生物および関連受容体についての組成物および使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
WO1998016557A1 (en) * 1996-10-11 1998-04-23 The General Hospital Corporation Assays for g-protein-linked receptors

Also Published As

Publication number Publication date
JP2010279369A (ja) 2010-12-16
EP1012311A1 (de) 2000-06-28
US6509447B1 (en) 2003-01-21
EP1533379B1 (de) 2008-05-21
ATE396273T1 (de) 2008-06-15
AU9086398A (en) 1999-04-05
JP5108062B2 (ja) 2012-12-26
EP1012311B1 (de) 2005-03-23
ES2308104T3 (es) 2008-12-01
DE69829485D1 (de) 2005-04-28
DE69829485T2 (de) 2006-05-04
ATE291627T1 (de) 2005-04-15
GB9719496D0 (en) 1997-11-19
WO1999014344A1 (en) 1999-03-25
JP4587563B2 (ja) 2010-11-24
JP2001516587A (ja) 2001-10-02
EP1533379A1 (de) 2005-05-25

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