DE69824191D1 - Denatonium capsaicinat und verfahren zu ihrer herstellung - Google Patents
Denatonium capsaicinat und verfahren zu ihrer herstellungInfo
- Publication number
- DE69824191D1 DE69824191D1 DE69824191T DE69824191T DE69824191D1 DE 69824191 D1 DE69824191 D1 DE 69824191D1 DE 69824191 T DE69824191 T DE 69824191T DE 69824191 T DE69824191 T DE 69824191T DE 69824191 D1 DE69824191 D1 DE 69824191D1
- Authority
- DE
- Germany
- Prior art keywords
- denatonium
- production
- capsaicinate
- denatonium capsaicinate
- lidocaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/16—Antifouling paints; Underwater paints
- C09D5/1606—Antifouling paints; Underwater paints characterised by the anti-fouling agent
- C09D5/1612—Non-macromolecular compounds
- C09D5/1625—Non-macromolecular compounds organic
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/929,621 US5891919A (en) | 1997-09-19 | 1997-09-19 | Denatonium capsaicinate and methods of producing the same |
US929621 | 1997-09-19 | ||
PCT/US1998/015836 WO1999015495A1 (en) | 1997-09-19 | 1998-07-31 | Denatonium capsaicinate and methods of producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69824191D1 true DE69824191D1 (de) | 2004-07-01 |
DE69824191T2 DE69824191T2 (de) | 2005-05-04 |
Family
ID=25458174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69824191T Expired - Fee Related DE69824191T2 (de) | 1997-09-19 | 1998-07-31 | Denatonium capsaicinat und verfahren zu ihrer herstellung |
Country Status (6)
Country | Link |
---|---|
US (1) | US5891919A (de) |
EP (1) | EP1015418B1 (de) |
AT (1) | ATE267802T1 (de) |
AU (1) | AU8603598A (de) |
DE (1) | DE69824191T2 (de) |
WO (1) | WO1999015495A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7011843B2 (en) * | 1997-10-01 | 2006-03-14 | Lts Lohmann-Therapie Systeme Ag | Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system |
US20010041694A1 (en) * | 1999-12-27 | 2001-11-15 | Larry Clark | Identification of snake repellents |
GB0026137D0 (en) * | 2000-10-25 | 2000-12-13 | Euro Celtique Sa | Transdermal dosage form |
US7157103B2 (en) | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
US7144587B2 (en) * | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US7141250B2 (en) * | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
US7632321B2 (en) * | 2001-11-01 | 2009-12-15 | Idatech, Llc | Fuel processing systems, fuel cell systems, and improved feedstocks therefor |
US20040076671A1 (en) * | 2002-10-21 | 2004-04-22 | Aletha Tippett | Methods and compositions for topical wound treatment |
AU2004230915B2 (en) * | 2003-04-08 | 2008-08-07 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
WO2005027642A1 (en) * | 2003-09-25 | 2005-03-31 | Darren Wayne Eade | Repellent preparations |
DK1765292T3 (en) | 2004-06-12 | 2018-01-02 | Collegium Pharmaceutical Inc | ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS |
MX2007006253A (es) * | 2004-11-24 | 2007-10-18 | Anesiva Inc | Formulacion de gel de capsaicinoide y usos para esta. |
US20090306429A1 (en) * | 2004-12-06 | 2009-12-10 | Henk Pluim | Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of a quaternary ammonium salt |
CN101111473A (zh) * | 2004-12-06 | 2008-01-23 | 迪士曼药品和化学品有限公司 | 氢氧化季铵的制备及其用于制备季铵盐的用途 |
ES2273588B1 (es) * | 2005-07-29 | 2008-04-01 | Relats, S.A. | Metodo para la fabricacion de fundas protectoras de cables, tubos y similares. |
US7707961B2 (en) * | 2005-08-12 | 2010-05-04 | Tmc-Ip, Llc | Apparatus for applying chemical coatings |
US20070036902A1 (en) * | 2005-08-12 | 2007-02-15 | O'neal Hubert R | Method for applying chemical coatings |
WO2007041272A2 (en) * | 2005-09-30 | 2007-04-12 | Maxam Industries, Inc. | Long lasting natural anti-pest additive |
MX348214B (es) * | 2006-03-10 | 2017-06-05 | Archer Daniels Midland Co | Metodos y composiciones para productividad aumentada en animales. |
US7582783B2 (en) * | 2006-03-23 | 2009-09-01 | White Flower Associates Llp | Analgesics, anaesthetics, antifoulants, aversants, irritants, incapacitants and compositions containing the same |
MX2009003996A (es) * | 2006-10-17 | 2009-07-22 | Labtec Gmbh | Etiqueta adhesiva con agente amargante y agentes fluidificantes para secreciones de las vias respiratorias naturales. |
WO2008080980A1 (de) * | 2006-12-29 | 2008-07-10 | Patrick Franke | Medicinal composition |
US7754096B2 (en) * | 2007-02-01 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Liquefied-gas aerosol dusting composition containing denatonium benzoate |
GB0712142D0 (en) * | 2007-06-24 | 2007-08-01 | Drew Anthony N | Beach Wax |
DE202008014092U1 (de) * | 2008-10-23 | 2010-03-11 | Rehau Ag + Co | Rohr |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
CA2991216C (en) | 2010-12-22 | 2020-04-28 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
ES2581323T3 (es) | 2010-12-23 | 2016-09-05 | Purdue Pharma Lp | Formas de dosificación oral sólida resistentes a alteraciones |
BR112013017411B1 (pt) | 2011-01-07 | 2022-03-22 | Anji Pharma (Us) Llc | Uso de uma composição compreendendo metformina ou um sal da mesma |
US9795792B2 (en) | 2011-02-25 | 2017-10-24 | Medtronic, Inc. | Emergency mode switching for non-pacing modes |
US9925264B2 (en) | 2011-05-10 | 2018-03-27 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
EP3569227A1 (de) | 2011-05-10 | 2019-11-20 | Itochu Chemical Frontier Corporation | Nichtwässriges pflaster |
US11786455B2 (en) | 2011-05-10 | 2023-10-17 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
DK2823815T3 (en) | 2011-09-27 | 2018-08-06 | Itochu Chemical Frontier Corp | NON-DIFFICULT PLASTER |
EA033067B1 (ru) | 2012-01-06 | 2019-08-30 | Элселикс Терапьютикс, Инк. | Способ лечения метаболических расстройств у пациента, имеющего противопоказание к назначению бигуанидного соединения |
AU2012363873B2 (en) | 2012-01-06 | 2017-11-23 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
WO2013139706A1 (en) * | 2012-03-23 | 2013-09-26 | Roblon Aktieselskab | Pest-repellent dielectric cable |
CN104780915A (zh) | 2012-07-11 | 2015-07-15 | 埃尔舍利克斯治疗公司 | 包含他汀、双胍和用于减小心脏代谢风险的其它药剂的组合物 |
JP6333855B2 (ja) | 2013-01-05 | 2018-05-30 | エルセリクス セラピューティクス インコーポレイテッド | ビグアナイドを含む遅延放出組成物 |
BR112015017451B1 (pt) | 2013-02-05 | 2023-01-10 | Purdue Pharma L.P. | Formulações farmacêuticas resistentes à violação |
US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
WO2015134829A1 (en) | 2014-03-07 | 2015-09-11 | The Procter & Gamble Company | Compositions comprising a pungent agent |
US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
DE102016009766A1 (de) | 2016-08-11 | 2018-02-15 | Julius-Maximilians-Universität Würzburg | Herstellung von Bitterstoffderivaten |
PT3755685T (pt) | 2018-02-21 | 2023-05-11 | Univ Wuerzburg J Maximilians | Derivados de denatónio de aminometilo funcionalizado e respetivas preparação e utilização |
BR112021000106B1 (pt) * | 2018-07-05 | 2024-01-02 | Upl Ltd | Composições inovadoras para agentes de amargor |
AR118158A1 (es) * | 2019-02-20 | 2021-09-22 | Upl Ltd | Un método y composición para repeler insectos usando un agente repelente |
CA3130564A1 (en) * | 2019-02-20 | 2020-08-27 | Upl Ltd | Spray composition of aversive agent |
MA55320A (fr) | 2019-03-11 | 2022-01-19 | Nocion Therapeutics Inc | Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation |
JP2022527690A (ja) | 2019-03-11 | 2022-06-03 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
EP3937945A4 (de) | 2019-03-11 | 2023-01-04 | Nocion Therapeutics, Inc. | Geladene ionenkanalblocker und verfahren zur verwendung |
US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CN114828845A (zh) | 2019-11-06 | 2022-07-29 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
JP2023517604A (ja) | 2020-03-11 | 2023-04-26 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
CA3210834A1 (en) * | 2021-03-05 | 2022-09-09 | Monika Backhaus-Ricoult | Porous ceramic polymer composites for preventing rodent damage |
US20230172187A1 (en) * | 2021-12-02 | 2023-06-08 | Max A Different Breed L.L.C. | Predator reactive multi-layer repellant device |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3080327A (en) * | 1959-11-20 | 1963-03-05 | T & H Smith Ltd | Quaternary salts as denaturants for organic substances |
US3268577A (en) * | 1960-11-15 | 1966-08-23 | Edinburgh Pharmaceutical Ind L | Quaternary organic salts of omega-dialkylamino-2, 6-dimethylacetanilides |
US4005038A (en) * | 1974-04-15 | 1977-01-25 | Peerless Paint And Varnish Corporation | Paint composition containing denatonium benzoate or lignocaine benzyl octanoate with a latex resin binder for application over old paint films to prevent ingestion of poisons therefrom |
CA1196928A (en) * | 1981-04-30 | 1985-11-19 | Edward L. Grew | Lignocaine benzyl benzoate |
US4652577A (en) * | 1984-11-02 | 1987-03-24 | Atomergic Chemetals Corporation | Denatonium saccharide, compositions and method of use |
US4661504A (en) * | 1984-11-02 | 1987-04-28 | Atomergic Chemetals Corporation | Denatonium saccharide compositions and method of use |
US5008289A (en) * | 1988-12-02 | 1991-04-16 | Galenpharma, Inc. | Composition for treating nasal disorders and headaches |
US4997853A (en) * | 1988-12-02 | 1991-03-05 | Galenpharma, Inc. | Method and compositions utilizing capsaicin as an external analgesic |
US5403868A (en) * | 1988-12-23 | 1995-04-04 | Sandoz Ltd. | Capsaicin derivatives |
ATE155317T1 (de) * | 1990-05-22 | 1997-08-15 | Nippon Kayaku Kk | Harzformmasse zum schutz gegen beschädigung durch tierverbiss |
US5322862A (en) * | 1990-05-22 | 1994-06-21 | Nippon Kayaku Kabushiki Kaisha | Resin molding composition for preventing gnawing damage by animals |
US5094782A (en) * | 1990-12-24 | 1992-03-10 | National Science Council Of Republic Of China | Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug |
FI91535C (fi) * | 1992-07-28 | 1994-07-11 | Hurme Consulting Oy | Menetelmä tiesuolan denaturoimiseksi ja denaturoitu tiesuola |
US5397385A (en) * | 1994-03-28 | 1995-03-14 | Watts; James L. | Anti-fouling coating composition containing capsaicin |
-
1997
- 1997-09-19 US US08/929,621 patent/US5891919A/en not_active Expired - Fee Related
-
1998
- 1998-07-31 EP EP98937289A patent/EP1015418B1/de not_active Expired - Lifetime
- 1998-07-31 AT AT98937289T patent/ATE267802T1/de not_active IP Right Cessation
- 1998-07-31 DE DE69824191T patent/DE69824191T2/de not_active Expired - Fee Related
- 1998-07-31 WO PCT/US1998/015836 patent/WO1999015495A1/en active IP Right Grant
- 1998-07-31 AU AU86035/98A patent/AU8603598A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU8603598A (en) | 1999-04-12 |
DE69824191T2 (de) | 2005-05-04 |
EP1015418B1 (de) | 2004-05-26 |
ATE267802T1 (de) | 2004-06-15 |
WO1999015495A1 (en) | 1999-04-01 |
US5891919A (en) | 1999-04-06 |
EP1015418A1 (de) | 2000-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |