DE69735897D1 - INDUCING FACTORS OF ENDODERM, HEART AND NEURONAL TISSUE - Google Patents

INDUCING FACTORS OF ENDODERM, HEART AND NEURONAL TISSUE

Info

Publication number
DE69735897D1
DE69735897D1 DE69735897T DE69735897T DE69735897D1 DE 69735897 D1 DE69735897 D1 DE 69735897D1 DE 69735897 T DE69735897 T DE 69735897T DE 69735897 T DE69735897 T DE 69735897T DE 69735897 D1 DE69735897 D1 DE 69735897D1
Authority
DE
Germany
Prior art keywords
frzb
cerberus
designated
growth factors
endoderm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69735897T
Other languages
German (de)
Inventor
Robertis M De
Tewis Bouwmeester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69735897D1 publication Critical patent/DE69735897D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Two novel proteins have been designated "cerberus" and "frzb-1," respectively. Cerberus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is designated "PAPC" which promotes the formation of dorsal mesoderm and somites in the embryo.
DE69735897T 1996-06-20 1997-06-19 INDUCING FACTORS OF ENDODERM, HEART AND NEURONAL TISSUE Expired - Fee Related DE69735897D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2015096P 1996-06-20 1996-06-20
US08/878,474 US6133232A (en) 1996-06-20 1997-06-18 Endoderm, cardiac and neural inducing factors
PCT/US1997/010942 WO1997048275A1 (en) 1996-06-20 1997-06-19 Endoderm, cardiac and neural inducing factors

Publications (1)

Publication Number Publication Date
DE69735897D1 true DE69735897D1 (en) 2006-06-22

Family

ID=26693096

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735897T Expired - Fee Related DE69735897D1 (en) 1996-06-20 1997-06-19 INDUCING FACTORS OF ENDODERM, HEART AND NEURONAL TISSUE

Country Status (8)

Country Link
US (1) US6133232A (en)
EP (1) EP0973391B1 (en)
JP (1) JP2002514043A (en)
AT (1) ATE326138T1 (en)
AU (1) AU723210B2 (en)
CA (1) CA2258789A1 (en)
DE (1) DE69735897D1 (en)
WO (1) WO1997048275A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049291B2 (en) * 1996-10-11 2006-05-23 The United States Of America As Represented By The Department Of Health And Human Services Isolation and method of using tissue growth-inducing Frzb protein
US6884871B2 (en) * 1996-10-11 2005-04-26 The United States Of America As Represented By The Department Of Health And Human Services Isolation and use of tissue growth-inducing Frzb protein
AU4981797A (en) * 1996-10-11 1998-05-11 Government Of The United States Of America, The Isolation and method of using tissue growth-inducing frzb protein
AU741708B2 (en) * 1997-02-11 2001-12-06 Amrad Operations Pty. Limited A new cytokine family and uses thereof
WO1998034951A1 (en) * 1997-02-11 1998-08-13 Amrad Operations Pty. Ltd. A new cytokine family and uses thereof
EP0975752A1 (en) * 1997-04-29 2000-02-02 Regeneron Pharmaceuticals, Inc. Human cerberus protein
US6165748A (en) * 1997-07-11 2000-12-26 Genetics Institute, Inc. Frazzled nucleotide sequences and expression products
DE19747418C1 (en) * 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor protein of the wnt signaling pathway
US20030096951A1 (en) * 1998-08-14 2003-05-22 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
US6344541B1 (en) * 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
DE10119729A1 (en) 2001-04-21 2002-10-31 Bayer Cropscience Gmbh Synergistic herbicidal compositions containing herbicides from the group benzoylcyclohexanediones for use in maize crops
DE10119727A1 (en) 2001-04-21 2002-10-31 Bayer Cropscience Gmbh Synergistic herbicidal compositions containing herbicides from the group of benzoylcyclohexanediones for use in rice crops
DE10119728A1 (en) 2001-04-21 2002-10-31 Bayer Cropscience Gmbh Synergistic herbicidal compositions containing herbicides from the group of benzoylcyclohexanediones for use in rice crops
US7713526B2 (en) * 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
WO2002088081A2 (en) * 2001-05-01 2002-11-07 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
US7193069B2 (en) * 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
US20100183695A1 (en) * 2004-05-27 2010-07-22 John Knopf Cerberus/coco derivatives and uses thereof
US9045553B2 (en) 2004-05-27 2015-06-02 Acceleron Pharma, Inc. Cerberus/Coco derivatives and uses thereof
AU2007332819A1 (en) * 2006-12-08 2008-06-19 Acceleron Pharma Inc. Uses of cerberus, coco and derivatives thereof
US10398765B2 (en) 2014-07-03 2019-09-03 Yale University Dickkopf2 (Dkk2) inhibition suppresses tumor formation
CA3003252C (en) 2015-10-28 2024-06-25 Yale University Humanized anti-dkk2 antibody and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU676847B2 (en) * 1992-09-03 1997-03-27 Regeneron Pharmaceuticals, Inc. Dorsal tissue affecting factor and compositions
ZA936478B (en) * 1992-09-03 1994-09-30 Regeneron Pharma Dorsal tissue affecting factor and compositions
US5457048A (en) * 1993-12-03 1995-10-10 La Jolla Cancer Research Foundation Eph-related tyrosine kinases, nucleotide sequences and methods of use

Also Published As

Publication number Publication date
US6133232A (en) 2000-10-17
EP0973391A4 (en) 2003-09-03
EP0973391B1 (en) 2006-05-17
EP0973391A1 (en) 2000-01-26
CA2258789A1 (en) 1997-12-24
AU3576597A (en) 1998-01-07
AU723210B2 (en) 2000-08-17
WO1997048275A1 (en) 1997-12-24
ATE326138T1 (en) 2006-06-15
JP2002514043A (en) 2002-05-14

Similar Documents

Publication Publication Date Title
DE69735897D1 (en) INDUCING FACTORS OF ENDODERM, HEART AND NEURONAL TISSUE
HUP0105027A2 (en) Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds and their use
Bosch et al. Axonal signals regulate expression of glia maturation factor-beta in Schwann cells: an immunohistochemical study of injured sciatic nerves and cultured Schwann cells
CA2596597A1 (en) Method for stimulation collagen synthesis and/or kgf expression
DE602004026898D1 (en) COMPOSITIONS FOR THE DIAGNOSIS AND THERAPY OF DISEASES RELATED TO ANOMALICAL EXPRESSION OF FUTRINES (R-SPONDINES)
DE69840909D1 (en) ANALOG OF COCAINE
DE69527049T2 (en) THERAPEUTIC USES OF BACTERICIDES / PERMEABILITY-INCREASING PROTEIN DIMER PRODUCTS
WO1996019580A3 (en) Telomerase protein component
AU2010200621A1 (en) Use of low-dose erythropoietin for stimulation of endothelial progenitor cells, for organ regeneration and for slowing the progression of end-organ damage
EA200001247A1 (en) N-BONDED SULPHONAMIDES OF N-HETEROCYCLIC CARBONIC ACIDS OR ISATERES OF CARBONIC ACIDS
WO2001066596A3 (en) Human fgf-23 gene and gene expression products
ATE337339T1 (en) THERAPEUTIC USE OF SMR1 PROTEIN AND ITS ACTIVE DERIVATIVES
DE69221486T2 (en) BOMBESIN ANALOG
CA2193993A1 (en) New hil-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
DE60138552D1 (en) PEPTIDES WITH INTEGRIN BINDING MOTIVATION AND TREATMENT METHODS FOR MUSCLE DISEASES
MX9307983A (en) AMINO ACID DERIVATIVES OF HETERO CYCLES AS PROTEIN QUINASE C. INHIBITORS
ATE294236T1 (en) PROMOTER OF THE TIE RECEPTOR PROTEIN KINASE
NZ332829A (en) Use of a polypeptide corresponding to a serine threonine kinase receptor, ALK-7 for neurological diseases
DE69501359T2 (en) Use of phosphate diesters for the treatment of diseases of the retina
EP0948536A4 (en) A g protein-coupled receptor with an enlarged extracellular domain
ES2135398T3 (en) COMPOUND AND COMPOSITIONS OF INHIBITION OF BONE RESORPTION.
KR100488038B1 (en) New bpc peptide salts with organo-protective activity the process for their preparation and their use in therapy
EP1059931B1 (en) Utilization of cd137 in order to promote the proliferation of peripheral monocytes
DE69102069D1 (en) 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE TREATMENT OF CHRONICALLY INFLAMMABLE BELLY DISEASES.
KR960000248A (en) Bone Metabolism Disorders

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee