DE69732114D1 - Verfahren zum nachweis von autoimmunkrankheiten - Google Patents
Verfahren zum nachweis von autoimmunkrankheitenInfo
- Publication number
- DE69732114D1 DE69732114D1 DE69732114T DE69732114T DE69732114D1 DE 69732114 D1 DE69732114 D1 DE 69732114D1 DE 69732114 T DE69732114 T DE 69732114T DE 69732114 T DE69732114 T DE 69732114T DE 69732114 D1 DE69732114 D1 DE 69732114D1
- Authority
- DE
- Germany
- Prior art keywords
- autoimmune diseases
- detecting autoimmune
- detecting
- pgs
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/99—Isomerases (5.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US701928 | 1991-05-17 | ||
US08/701,928 US5939069A (en) | 1996-08-23 | 1996-08-23 | Materials and methods for detection and treatment of immune system dysfunctions |
PCT/US1997/014871 WO1998008101A1 (en) | 1996-08-23 | 1997-08-22 | Materials and methods for detection and treatment of immune system dysfunctions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69732114D1 true DE69732114D1 (de) | 2005-02-03 |
DE69732114T2 DE69732114T2 (de) | 2005-12-08 |
Family
ID=24819238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69732114T Expired - Lifetime DE69732114T2 (de) | 1996-08-23 | 1997-08-22 | Verfahren zum nachweis von autoimmunkrankheiten |
Country Status (11)
Country | Link |
---|---|
US (4) | US5939069A (de) |
EP (2) | EP1535614A3 (de) |
JP (1) | JP2001503251A (de) |
AT (1) | ATE286255T1 (de) |
AU (1) | AU4160097A (de) |
CA (1) | CA2259310A1 (de) |
DE (1) | DE69732114T2 (de) |
ES (1) | ES2234028T3 (de) |
NZ (3) | NZ525200A (de) |
PT (1) | PT920632E (de) |
WO (1) | WO1998008101A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5939069A (en) * | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
AU2001261409A1 (en) * | 2000-05-11 | 2001-11-20 | Oklahoma Medical Research Foundation | Prevention of insulin-dependent diabetes, complications thereof, or allograft rejection by inhibition of cyclooxygenase-2 activity with NS398 or PDTC |
US7790706B2 (en) * | 2002-06-14 | 2010-09-07 | The University Of Edinburgh | Treatment of inflammation with 5α reduced metabolites |
GB0213745D0 (en) * | 2002-06-14 | 2002-07-24 | Univ Edinburgh | Enzyme |
US20040121489A1 (en) * | 2002-08-29 | 2004-06-24 | Dharnidharka Vikas R. | COX-2 mediated altered prostaglandin balance in diabetes complications |
US20050260770A1 (en) * | 2004-04-01 | 2005-11-24 | Cohen Irun R | Antigen array and diagnostic uses thereof |
EP2506669B2 (de) | 2011-03-29 | 2023-10-11 | BSH Hausgeräte GmbH | Schaltungsvorrichtung |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US512447A (en) * | 1894-01-09 | Holder-plate for type | ||
US604260A (en) * | 1898-05-17 | Theron n | ||
US490385A (en) * | 1893-01-24 | Signors of one-half to bertha m | ||
US476659A (en) * | 1892-06-07 | Cultivator | ||
US449515A (en) * | 1891-03-31 | Lifting-jack | ||
US601815A (en) * | 1898-04-05 | Ore-separator | ||
US409243A (en) * | 1889-08-20 | Fence | ||
US538854A (en) * | 1895-05-07 | And james | ||
US643786A (en) * | 1897-06-26 | 1900-02-20 | Ernst Wilhelm Brackelsberg | Type-writing machine. |
US681842A (en) * | 1900-10-11 | 1901-09-03 | Edwin F Banfield | Lighting device for gas-burners. |
US4442118A (en) * | 1981-07-23 | 1984-04-10 | Ayerst, Mckenna & Harrison, Inc. | Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid |
US4490385A (en) * | 1981-11-09 | 1984-12-25 | Julian Lieb | Treatment of auto-immune and inflammatory diseases |
US4409243A (en) * | 1981-11-09 | 1983-10-11 | Julian Lieb | Treatment of auto-immune and inflammatory diseases |
US5476659A (en) * | 1982-11-09 | 1995-12-19 | The Scripps Research Institute | Cancerous B cell treatment using substituted nucleoside derivatives |
US4758583A (en) * | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
US4806523A (en) * | 1985-08-06 | 1989-02-21 | Collagen Corporation | Method of treating inflammation |
US4885367A (en) * | 1987-11-19 | 1989-12-05 | Taisho Pharmaceutical Co., Ltd. | Sulfonanilide compounds |
EP0502080A4 (en) * | 1989-11-21 | 1993-02-10 | The University Of Melbourne | Anti-inflammatory compositions and methods |
WO1991009598A1 (en) * | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
US5827513A (en) * | 1990-06-29 | 1998-10-27 | Schering Corporation | Methods of treating insulin-dependent diabetes mellitus by administration of IL-10 |
US5512447A (en) * | 1990-09-07 | 1996-04-30 | The Regents Of The University Of California | Methods for the diagnosis and treatment of diabetes |
IL101872A0 (en) | 1991-05-15 | 1992-12-30 | Univ Washington | Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
WO1993002690A1 (en) * | 1991-08-02 | 1993-02-18 | The General Hospital Corporation | Diagnosis and treatment of autoimmune diseases |
US5601815A (en) * | 1992-08-21 | 1997-02-11 | Schering Corp | IL-4 and IL-10 to downregulate delayed-type hypersensitivity and cytokine expresion by T-cells |
US6048850A (en) * | 1992-09-22 | 2000-04-11 | Young; Donald A. | Method of inhibiting prostaglandin synthesis in a human host |
DK0662837T3 (da) | 1992-10-01 | 1999-11-08 | Schering Corp | Anvendelse af IL-10 til forhindring af insulinafhængig diabetes mellitus |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
US5449688A (en) * | 1993-03-30 | 1995-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating chronic inflammatory diseases |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
AU1269495A (en) * | 1994-01-10 | 1995-08-01 | Merck Frosst Canada Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5985547A (en) * | 1994-03-04 | 1999-11-16 | Children's Hospital Of Philadelphia | Detection of a mutation in the HLA-DMβ gene in an immunocompromised patient |
CA2187345A1 (en) * | 1994-04-08 | 1995-10-19 | Howard L. Weiner | Treatment of autoimmune disease using oral tolerization and/or th2-enhancing cytokines |
AU4134996A (en) * | 1994-10-25 | 1996-05-15 | Washington University | Method of inhibiting nitric oxide formation |
PL321292A1 (en) * | 1995-01-12 | 1997-11-24 | Smithkline Beecham Corp | Novel xchemical compounds |
US5643786A (en) * | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
US5939069A (en) * | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
US5681842A (en) * | 1996-11-08 | 1997-10-28 | Abbott Laboratories | Prostaglandin synthase-2 inhibitors |
US6083919A (en) * | 1996-12-05 | 2000-07-04 | University Of Florida | Materials and methods for treating autoimmune disease |
-
1996
- 1996-08-23 US US08/701,928 patent/US5939069A/en not_active Expired - Lifetime
-
1997
- 1997-08-22 NZ NZ525200A patent/NZ525200A/en unknown
- 1997-08-22 EP EP04030800A patent/EP1535614A3/de not_active Withdrawn
- 1997-08-22 NZ NZ333831A patent/NZ333831A/xx unknown
- 1997-08-22 AT AT97939531T patent/ATE286255T1/de not_active IP Right Cessation
- 1997-08-22 AU AU41600/97A patent/AU4160097A/en not_active Abandoned
- 1997-08-22 EP EP97939531A patent/EP0920632B1/de not_active Expired - Lifetime
- 1997-08-22 WO PCT/US1997/014871 patent/WO1998008101A1/en active IP Right Grant
- 1997-08-22 JP JP51102998A patent/JP2001503251A/ja not_active Ceased
- 1997-08-22 CA CA002259310A patent/CA2259310A1/en not_active Abandoned
- 1997-08-22 PT PT97939531T patent/PT920632E/pt unknown
- 1997-08-22 US US08/916,586 patent/US6168792B1/en not_active Expired - Lifetime
- 1997-08-22 ES ES97939531T patent/ES2234028T3/es not_active Expired - Lifetime
- 1997-08-22 NZ NZ507110A patent/NZ507110A/en active Application Revival
- 1997-08-22 DE DE69732114T patent/DE69732114T2/de not_active Expired - Lifetime
-
1999
- 1999-05-28 US US09/322,628 patent/US6218133B1/en not_active Expired - Fee Related
-
2001
- 2001-03-29 US US09/821,435 patent/US6953578B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5939069A (en) | 1999-08-17 |
NZ525200A (en) | 2004-11-26 |
US6953578B2 (en) | 2005-10-11 |
US6168792B1 (en) | 2001-01-02 |
EP0920632A1 (de) | 1999-06-09 |
CA2259310A1 (en) | 1998-02-26 |
ATE286255T1 (de) | 2005-01-15 |
US20010021510A1 (en) | 2001-09-13 |
PT920632E (pt) | 2005-04-29 |
ES2234028T3 (es) | 2005-06-16 |
US6218133B1 (en) | 2001-04-17 |
EP1535614A3 (de) | 2007-03-28 |
EP1535614A2 (de) | 2005-06-01 |
WO1998008101A1 (en) | 1998-02-26 |
AU4160097A (en) | 1998-03-06 |
NZ333831A (en) | 2000-10-27 |
DE69732114T2 (de) | 2005-12-08 |
JP2001503251A (ja) | 2001-03-13 |
EP0920632B1 (de) | 2004-12-29 |
NZ507110A (en) | 2003-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., G |
|
8364 | No opposition during term of opposition |