DE69718638D1 - Tropanderivate insbesondere verwendbar zur detektion von dopamin transporters - Google Patents

Tropanderivate insbesondere verwendbar zur detektion von dopamin transporters

Info

Publication number
DE69718638D1
DE69718638D1 DE69718638T DE69718638T DE69718638D1 DE 69718638 D1 DE69718638 D1 DE 69718638D1 DE 69718638 T DE69718638 T DE 69718638T DE 69718638 T DE69718638 T DE 69718638T DE 69718638 D1 DE69718638 D1 DE 69718638D1
Authority
DE
Germany
Prior art keywords
tropanderivates
particularly applicable
dopamine transporters
derivatives
transporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69718638T
Other languages
English (en)
Other versions
DE69718638T2 (de
Inventor
Laurent Mauclaire
Patrick Edmond
Denis Guilloteau
Jean-Claude Besnard
Yves Frangin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of DE69718638D1 publication Critical patent/DE69718638D1/de
Application granted granted Critical
Publication of DE69718638T2 publication Critical patent/DE69718638T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69718638T 1996-05-10 1997-05-07 Tropanderivate insbesondere verwendbar zur detektion von dopamin transporters Expired - Fee Related DE69718638T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9605839A FR2748475B1 (fr) 1996-05-10 1996-05-10 Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
PCT/FR1997/000825 WO1997043285A1 (fr) 1996-05-10 1997-05-07 Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine

Publications (2)

Publication Number Publication Date
DE69718638D1 true DE69718638D1 (de) 2003-02-27
DE69718638T2 DE69718638T2 (de) 2003-11-27

Family

ID=9492014

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718638T Expired - Fee Related DE69718638T2 (de) 1996-05-10 1997-05-07 Tropanderivate insbesondere verwendbar zur detektion von dopamin transporters

Country Status (11)

Country Link
US (1) US6180083B1 (de)
EP (1) EP0901491B1 (de)
JP (1) JP2000510141A (de)
AT (1) ATE231506T1 (de)
CA (1) CA2254089A1 (de)
DE (1) DE69718638T2 (de)
DK (1) DK0901491T3 (de)
ES (1) ES2190533T3 (de)
FR (1) FR2748475B1 (de)
PT (1) PT901491E (de)
WO (1) WO1997043285A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044747A1 (en) * 1999-02-01 2000-08-03 Wake Forest University Tropane derivatives as serotonin transporter antagonists
EP1212103B1 (de) 1999-04-26 2004-11-03 Emory University 4-fluoroalkyl-3-halophenyl nortropane
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
WO2003093412A2 (en) 2002-04-30 2003-11-13 Emory University Tumor imaging compounds
US7602851B2 (en) * 2003-07-18 2009-10-13 Microsoft Corporation Intelligent differential quantization of video coding
CA2612186A1 (en) 2005-06-23 2007-01-04 Emory University Imaging agents
JP2008081433A (ja) * 2006-09-27 2008-04-10 Pola Chem Ind Inc ドーパミントランスポーターイメージング剤
US20100221181A1 (en) * 2007-09-26 2010-09-02 Koninklijke Philips Electronics N.V. Method of differentially diagnosing different types of dementia
WO2009055922A1 (en) 2007-10-31 2009-05-07 Alseres Pharmaceuticals, Inc. Labeled iodinated tropane formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
JP3731005B2 (ja) * 1995-06-06 2006-01-05 ジーイー ヘルスケア リミテッド モノアミン再取込み部位をマッピングするためのヨウ素標識ニューロプローブ

Also Published As

Publication number Publication date
FR2748475A1 (fr) 1997-11-14
CA2254089A1 (fr) 1997-11-20
ATE231506T1 (de) 2003-02-15
US6180083B1 (en) 2001-01-30
FR2748475B1 (fr) 1999-04-16
WO1997043285A1 (fr) 1997-11-20
EP0901491A1 (de) 1999-03-17
DK0901491T3 (da) 2003-05-12
DE69718638T2 (de) 2003-11-27
PT901491E (pt) 2003-06-30
ES2190533T3 (es) 2003-08-01
JP2000510141A (ja) 2000-08-08
EP0901491B1 (de) 2003-01-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8339 Ceased/non-payment of the annual fee