DE69714654T2 - Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen - Google Patents

Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen Download PDF

Info

Publication number
DE69714654T2
DE69714654T2 DE69714654T DE69714654T DE69714654T2 DE 69714654 T2 DE69714654 T2 DE 69714654T2 DE 69714654 T DE69714654 T DE 69714654T DE 69714654 T DE69714654 T DE 69714654T DE 69714654 T2 DE69714654 T2 DE 69714654T2
Authority
DE
Germany
Prior art keywords
porphyrin
group
avidin
metal
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714654T
Other languages
German (de)
English (en)
Other versions
DE69714654D1 (de
Inventor
Dr. Gregor Sagner
Richard Robert De Haas
Rob Van Gijlswijk
Prof. Dr. Hans Tanke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of DE69714654D1 publication Critical patent/DE69714654D1/de
Publication of DE69714654T2 publication Critical patent/DE69714654T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
DE69714654T 1996-06-04 1997-06-04 Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen Expired - Lifetime DE69714654T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96108951 1996-06-04
EP96108951 1996-06-04

Publications (2)

Publication Number Publication Date
DE69714654D1 DE69714654D1 (de) 2002-09-19
DE69714654T2 true DE69714654T2 (de) 2004-02-19

Family

ID=8222846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714654T Expired - Lifetime DE69714654T2 (de) 1996-06-04 1997-06-04 Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen

Country Status (4)

Country Link
US (1) US6004530A (https=)
JP (1) JP3934205B2 (https=)
AT (1) ATE222254T1 (https=)
DE (1) DE69714654T2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
US20040058401A1 (en) * 1999-04-13 2004-03-25 Blaise Bossy Method for detecting rare event
WO2001002370A1 (en) * 1999-07-01 2001-01-11 University Of Maryland, College Park Nickel-based reagents for detecting dna and dna-protein contacts
US7371579B1 (en) 1999-07-01 2008-05-13 The University Of Maryland Nickel-based reagents for detecting DNA and DNA-protein contacts
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US6949347B2 (en) * 2002-03-05 2005-09-27 Aclara Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
DE10214019A1 (de) * 2002-03-30 2003-10-16 Detlef Mueller-Schulte Lumineszierende, sphärische, nicht autofluoreszierende Silicagel-Partikel mit veränderbaren Emissionsintensitäten und -frequenzen
US7375216B2 (en) * 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
AU2003237349B2 (en) 2002-06-04 2010-06-03 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin halide compounds
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7486815B2 (en) * 2004-02-20 2009-02-03 Microsoft Corporation Method and apparatus for scene learning and three-dimensional tracking using stereo video cameras
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7247375B2 (en) * 2004-04-30 2007-07-24 Kimberly-Clark Worldwide, Inc. Polymeric matrices for the encapsulation of phosphorescent molecules for analytical applications
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US7238301B2 (en) * 2004-06-29 2007-07-03 Kimberly-Clark Worldwide, Inc. Cross-linked encapsulated phosphorescent molecules
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7906276B2 (en) * 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7939342B2 (en) * 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7803319B2 (en) 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
US7858384B2 (en) 2005-04-29 2010-12-28 Kimberly-Clark Worldwide, Inc. Flow control technique for assay devices
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7829347B2 (en) 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
FR2892723B1 (fr) * 2005-11-03 2009-04-24 Biomerieux Sa Nouveaux monomeres electropolymerisables, solubles en solution aqueuse, comportant une metalloporphyrine.
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7745158B2 (en) * 2005-12-14 2010-06-29 Kimberly-Clark Worldwide, Inc. Detection of secreted aspartyl proteases from Candida species
US7618810B2 (en) 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US7645583B2 (en) * 2005-12-14 2010-01-12 Kimberly-Clark Worldwide, Inc. Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin
US8758989B2 (en) * 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7960371B2 (en) 2006-10-04 2011-06-14 Infacare Pharmaceutical Corporation High-purity large-scale preparation of stannsoporfin
US20080113955A1 (en) * 2006-10-04 2008-05-15 Benjamin Levinson Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
EP1936345B1 (en) * 2006-12-22 2012-06-20 Sony Deutschland Gmbh Temperature and temperature distribution sensing with high resolution in microscopic electronic devices and biological objects
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
JP2011122956A (ja) * 2009-12-11 2011-06-23 Tosoh Corp 高感度な核酸検出方法
US9447107B2 (en) 2010-09-10 2016-09-20 University Of Southern California Broadly absorbing metalloporphyrin-based multichromophoric arrays for triplet harvesting
PL2691398T3 (pl) 2011-03-30 2017-07-31 Infacare Pharmaceutical Corporation Sposoby syntezy mezoporfiryn metali
WO2017139679A1 (en) 2016-02-12 2017-08-17 The Regents Of The University Of California Systems and compositions for diagnosing pathogenic fungal infection and methods of using the same
CA3018365A1 (en) 2016-03-23 2017-09-28 The General Hospital Corporation Assays and methods for detecting udp-glucose
EP3607320A4 (en) 2017-04-03 2021-04-21 The Regents of the University of California COMPOSITIONS AND METHODS OF DIAGNOSING Pancreatic Cancer
US20210002692A1 (en) * 2018-03-28 2021-01-07 Sony Corporation Target substance detection method, target substance detection kit, and target substance detection device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375972A (en) * 1979-10-17 1983-03-08 Allied Corporation Heterogeneous chemiluminescent immunoassays utilizing metallo porphyrin tag
EP0127797B1 (de) * 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4877872A (en) * 1986-06-24 1989-10-31 The University Of Toledo Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes
WO1995029921A1 (en) * 1994-04-29 1995-11-09 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules

Also Published As

Publication number Publication date
JP3934205B2 (ja) 2007-06-20
ATE222254T1 (de) 2002-08-15
US6004530A (en) 1999-12-21
DE69714654D1 (de) 2002-09-19
JPH1067791A (ja) 1998-03-10

Similar Documents

Publication Publication Date Title
DE69714654T2 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
DE69923859T2 (de) Porphyrin-Verbindungen, ihre Konjugate und Testmethoden basierend auf der Verwendung besagter Konjugate
DE69801682T2 (de) Versteifte trimethin-cyaninfarbstoffe
DE3912046B4 (de) Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
EP1732935A2 (de) Lanthanoidchelate und ihre anwendung in der bioanalytik
EP2164924B1 (de) Verfahren zur verbesserung der photostabilität und/oder kontrolle der fluoreszenzintensität von fluoreszenzfarbstoffen
DE3881735T2 (de) Diagnostischer Fluoreszenztest, Testbestandteile und Konjugate.
EP0209875A1 (de) Resorufin-Derivate sowie Verfahren zu deren Herstellung
EP0747447B1 (de) Neue Oxazinfarbstoffe und ihre Verwendung als Fluoreszenzmarker
DE102019120455B4 (de) Verfahren zur simultanen Bestimmung verschiedener Analyte in einer Umweltprobe, gestützt auf Kern/Schale-Mikropartikel
EP0330050B1 (de) Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
DE69430523T2 (de) Herstellung von photoprotein konjugaten und verfahren zu ihrer verwendung
EP3461814A1 (de) Neue poly-sulfonierte fluoreszenz-farbstoffe
DE29610062U1 (de) Versteifte Monomethincyanin-Farbstoffe
DE3751673T2 (de) Test, Indikatoren, Immunogene und Antikörper für Benzodiazepine
DE3629194A1 (de) Biotinylierungsreagentien
DE4439347A1 (de) Metallkomplexe mit geladenem Linker
DE60214709T2 (de) Verfahren zur Erhöhung der Hydrophilie von Fluoreszenzmarker-Verbindungen
DE19923168A1 (de) Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
EP1273584B1 (de) Verbindungen auf der Basis von 2-bzw. 4-Chromenyliden-Merocyaninen und ihre Verwendung
EP0811626B1 (en) Use of metallo-porphyrin conjugates for the detection of biological substances
DE19925402A1 (de) Screening von Target-Ligand-Wechselwirkungen
EP0628819A2 (de) Beschichtete Träger, Verfahren zu ihrer Herstellung und ihre Verwendung zur Immobilisierung von Biomolekülen an Oberflächen von Festkörpern
WO2000064987A1 (de) Neue amidopyrylium-fluoreszenz-farbstoffe
DE69931467T2 (de) Neue komplexe, die vernetztes avidin enthalten, verfahren zur herstellung und analyseverfahren, das diese verwendet

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition