DE69711393D1 - Homogener diagnose assay welcher auf der simultanen vervielfältigung der zielprobe und des signals beruht - Google Patents

Homogener diagnose assay welcher auf der simultanen vervielfältigung der zielprobe und des signals beruht

Info

Publication number
DE69711393D1
DE69711393D1 DE69711393T DE69711393T DE69711393D1 DE 69711393 D1 DE69711393 D1 DE 69711393D1 DE 69711393 T DE69711393 T DE 69711393T DE 69711393 T DE69711393 T DE 69711393T DE 69711393 D1 DE69711393 D1 DE 69711393D1
Authority
DE
Germany
Prior art keywords
signal
target sample
diagnostic assay
simultaneous duplication
homogeneous diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69711393T
Other languages
English (en)
Inventor
Jozsef Hepp
Zsolt Lengyel
Rajiv Pande
Janos Botyanszki
Miklos Sahin-Toth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navix Inc
Original Assignee
Navix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Navix Inc filed Critical Navix Inc
Application granted granted Critical
Publication of DE69711393D1 publication Critical patent/DE69711393D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/119—Triple helix formation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69711393T 1996-07-25 1997-07-16 Homogener diagnose assay welcher auf der simultanen vervielfältigung der zielprobe und des signals beruht Expired - Lifetime DE69711393D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/692,825 US5858665A (en) 1996-07-25 1996-07-25 Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
PCT/US1997/012415 WO1998004739A2 (en) 1996-07-25 1997-07-16 Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification

Publications (1)

Publication Number Publication Date
DE69711393D1 true DE69711393D1 (de) 2002-05-02

Family

ID=24782181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69711393T Expired - Lifetime DE69711393D1 (de) 1996-07-25 1997-07-16 Homogener diagnose assay welcher auf der simultanen vervielfältigung der zielprobe und des signals beruht

Country Status (7)

Country Link
US (2) US5858665A (de)
EP (1) EP0918883B1 (de)
JP (1) JP2002515749A (de)
AU (1) AU728416B2 (de)
CA (1) CA2261607A1 (de)
DE (1) DE69711393D1 (de)
WO (1) WO1998004739A2 (de)

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US6492120B1 (en) * 2000-11-02 2002-12-10 University Of Maryland Nucleic acid hybridization assay utilizing tricyclic target and signal amplification
WO2002048402A2 (en) * 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
CA2439074A1 (en) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
EP1366197B1 (de) 2001-03-09 2007-05-09 Nugen Technologies, Inc. Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
US20070059692A1 (en) * 2002-10-28 2007-03-15 Xiaolian Gao Array oligomer synthesis and use
JP2006523465A (ja) 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
EP1668158B1 (de) * 2003-08-11 2010-10-20 Georgia State University Research Foundation, Inc. Rna-nachweis und quantifizierung
US20050095595A1 (en) * 2003-10-29 2005-05-05 Pittaro Richard J. Methods and systems for improving of polymer analysis
KR101041106B1 (ko) * 2003-11-25 2011-06-13 한면기 핵산과 단백질의 신규한 실시간 탐지방법
US7582430B2 (en) * 2004-01-20 2009-09-01 United States Of America As Represented By The Secretary Of The Army Immunoliposome-nucleic acid amplification (ILNAA) assay
US20050250134A1 (en) * 2004-03-02 2005-11-10 Dawei Sheng Fluorescent energy transfer labeled nucleic acid substrates and methods of use thereof
EP1929046B1 (de) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Verbessertes nukleinsäureamplifikationsverfahren
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
CA2965207C (en) * 2008-08-15 2020-12-15 Cascade Biosystems, Inc. Methods using enzymatic amplification cascades for detecting target nucleic acid in a sample
EP2536843B1 (de) 2010-02-15 2016-10-05 Cascade Biosystems, Inc. Verfahren und material zur detektion von kontamination in lebensmitteln.
WO2011100750A1 (en) 2010-02-15 2011-08-18 Cascade Biosystems, Inc. Methods and materials for detecting genetic or epigenetic elements
US8470533B2 (en) * 2010-02-15 2013-06-25 Cascade Biosystems, Inc. Methods and materials for assessing RNA expression
US8597886B2 (en) * 2010-02-15 2013-12-03 Cascade Biosystems, Inc. Methods and materials for detecting viral or microbial infections
AU2011242404B2 (en) * 2010-04-23 2015-09-10 Australian Centre For Plant Functional Genomics Pty Ltd Tethered enzyme mediated nucleic acid detection
AU2012380717B2 (en) 2012-05-24 2018-08-16 Fundacio Institucio Catalana De Recerca I Estudis Avancats Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
WO2016086004A1 (en) * 2014-11-26 2016-06-02 Cascade Biosystems, Inc. Detecting nucleic acid
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
CN105039519B (zh) * 2015-06-12 2018-01-02 青岛科技大学 一种基于足点域杂交的dna测定新方法
WO2017210341A1 (en) 2016-05-31 2017-12-07 The Regents Of The University Of California Methods for evaluating, monitoring, and modulating aging process
WO2018009705A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Liver cancer methylation markers and uses thereof
CN107847515B (zh) 2016-07-06 2021-01-29 优美佳生物技术有限公司 实体瘤甲基化标志物及其用途
EP3481941A4 (de) 2016-07-06 2020-04-15 Youhealth Biotech, Limited Methylierungsmarker für brust- und ovarialkrebs und deren verwendung
EP3481951A4 (de) 2016-07-06 2020-08-05 Youhealth Biotech, Limited Methylierungsmarker für kolonkarzinom und verwendungen davon
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
CN110603329B (zh) 2017-03-02 2023-12-05 优美佳肿瘤技术有限公司 用于诊断肝细胞癌和肺癌的甲基化标志物
WO2020077409A1 (en) 2018-10-17 2020-04-23 The University Of Queensland Epigenetic biomarker and uses therefor

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Also Published As

Publication number Publication date
AU3666897A (en) 1998-02-20
EP0918883A2 (de) 1999-06-02
WO1998004739A2 (en) 1998-02-05
US6114117A (en) 2000-09-05
US5858665A (en) 1999-01-12
JP2002515749A (ja) 2002-05-28
AU728416B2 (en) 2001-01-11
CA2261607A1 (en) 1998-02-05
EP0918883B1 (de) 2002-03-27

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