DE69710879T2 - Arzneimittel auf basis von progesteron und östradiol - Google Patents
Arzneimittel auf basis von progesteron und östradiolInfo
- Publication number
- DE69710879T2 DE69710879T2 DE69710879T DE69710879T DE69710879T2 DE 69710879 T2 DE69710879 T2 DE 69710879T2 DE 69710879 T DE69710879 T DE 69710879T DE 69710879 T DE69710879 T DE 69710879T DE 69710879 T2 DE69710879 T2 DE 69710879T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- oil
- progesterone
- östradiol
- dissolve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 4
- 229960003387 progesterone Drugs 0.000 title abstract 2
- 239000000186 progesterone Substances 0.000 title abstract 2
- 239000002775 capsule Substances 0.000 abstract 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9604349A FR2747042B1 (fr) | 1996-04-05 | 1996-04-05 | Medicament a base de progesterone et d'oestradiol |
PCT/FR1997/000612 WO1997037642A1 (fr) | 1996-04-05 | 1997-04-04 | Medicament a base de progesterone et d'oestradiol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69710879D1 DE69710879D1 (de) | 2002-04-11 |
DE69710879T2 true DE69710879T2 (de) | 2002-11-14 |
Family
ID=9490985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69710879T Expired - Lifetime DE69710879T2 (de) | 1996-04-05 | 1997-04-04 | Arzneimittel auf basis von progesteron und östradiol |
Country Status (9)
Country | Link |
---|---|
US (1) | US6077531A (de) |
EP (1) | EP0896529B1 (de) |
JP (1) | JP2000508309A (de) |
AT (1) | ATE213934T1 (de) |
CA (1) | CA2251002C (de) |
DE (1) | DE69710879T2 (de) |
ES (1) | ES2172782T3 (de) |
FR (1) | FR2747042B1 (de) |
WO (1) | WO1997037642A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
FR2777784B1 (fr) * | 1998-04-27 | 2004-03-19 | Arepa | Composition pharmaceutique a base d'estrogene et de progesterone |
US6544553B1 (en) * | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
FR2832065B1 (fr) * | 2001-11-13 | 2004-11-05 | Besins Int Belgique | Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations |
AU2003208679A1 (en) | 2002-02-08 | 2003-09-02 | Advanced Animal Technology Limited | Control of a biological function |
ES2537551T3 (es) * | 2003-06-13 | 2015-06-09 | Skendi Finance, Ltd. | Formulación de estradiol-progesterona de liberación lenta |
CA2540838C (en) | 2003-10-03 | 2014-12-16 | Thorn Bioscience, Llc | Process for the synchronization of ovulation for timed breeding without heat detection |
US8075910B2 (en) * | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
BRPI1014362A2 (pt) | 2009-04-23 | 2016-04-05 | Pennatek Llc | método e composição para sincronizar o tempo de inseminação |
WO2011073995A2 (en) | 2009-12-14 | 2011-06-23 | Lincoln Pharmaceuticals Limited | Liquid vaginal spray of progesterone |
UY33103A (es) * | 2009-12-15 | 2011-07-29 | Techsphere S A De C V | Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico |
BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
JP2016508030A (ja) | 2012-11-28 | 2016-03-17 | ジェイビーエス ユナイテッド アニマル ヘルス セカンド エルエルシー | 未経産ブタにおける授精の時期を同期化するための方法および組成物 |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
MX2016013693A (es) | 2014-07-29 | 2017-10-31 | Therapeuticsmd Inc | Crema transdermica. |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
EP3435977A4 (de) | 2016-04-01 | 2019-10-16 | Therapeuticsmd, Inc. | Pharmazeutische steroidhormonzusammensetzung |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
US4624665A (en) * | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
US4900734A (en) * | 1987-08-27 | 1990-02-13 | Maxson Wayne S | Novel pharmaceutical composition containing estradiol and progesterone for oral administration |
US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
WO1995000125A1 (en) * | 1993-06-18 | 1995-01-05 | Smithkline Beecham Corporation | Soft-shelled gelatin encapsulated particles |
-
1996
- 1996-04-05 FR FR9604349A patent/FR2747042B1/fr not_active Expired - Fee Related
-
1997
- 1997-04-04 DE DE69710879T patent/DE69710879T2/de not_active Expired - Lifetime
- 1997-04-04 WO PCT/FR1997/000612 patent/WO1997037642A1/fr active IP Right Grant
- 1997-04-04 ES ES97919485T patent/ES2172782T3/es not_active Expired - Lifetime
- 1997-04-04 US US09/155,331 patent/US6077531A/en not_active Expired - Lifetime
- 1997-04-04 AT AT97919485T patent/ATE213934T1/de not_active IP Right Cessation
- 1997-04-04 EP EP97919485A patent/EP0896529B1/de not_active Expired - Lifetime
- 1997-04-04 CA CA002251002A patent/CA2251002C/fr not_active Expired - Lifetime
- 1997-04-04 JP JP9535916A patent/JP2000508309A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US6077531A (en) | 2000-06-20 |
ES2172782T3 (es) | 2002-10-01 |
EP0896529B1 (de) | 2002-03-06 |
CA2251002A1 (fr) | 1997-10-16 |
EP0896529A1 (de) | 1999-02-17 |
JP2000508309A (ja) | 2000-07-04 |
FR2747042B1 (fr) | 1998-06-05 |
ATE213934T1 (de) | 2002-03-15 |
DE69710879D1 (de) | 2002-04-11 |
FR2747042A1 (fr) | 1997-10-10 |
WO1997037642A1 (fr) | 1997-10-16 |
CA2251002C (fr) | 2007-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8328 | Change in the person/name/address of the agent |
Representative=s name: PATENTANWAELTE VON KREISLER, SELTING, WERNER ET CO |