DE69635020T2 - Use of FOS (fructooligosaccharides) to reduce LIPID PEROXID levels in blood - Google Patents

Description

technical Area

These The invention relates to a material which prevents an increase in lipid peroxides can. In particular, it relates to a material which increases lipid peroxide can prevent and contains fructo-oligosaccharides.

State of technology

The Majority of living organisms, including humans their life activity upright using oxygen. However, owns more active Oxygen (ozone) in the living body a high toxicity. Present studies show that oxygen disorders are closely related with age-related diseases, such as carcinogenesis, ischemic diseases, diabetes, different cellular dysfunction due to the formation of lipid peroxides, aging, etc. Especially become unsaturated fatty acids, which form the brain and the biomembranes of oxygen radicals attacked; As a result, the attacked unsaturated fatty acids Lipid peroxides over Lipid peroxidation chain reactions. It is believed that the formation of these lipid peroxides is not only with arterial sclerosis and liver disease, but as well associated with carcinogenesis, aging, etc.

Under these circumstances studies were carried out to find antioxidants in individual foods are included, and functional mechanisms, manufacturing process etc. with regard to the regulation of lipid peroxides in the living body enlighten. However, the Enlightenment is still today still insufficient. Regarding a diet To regulate the peroxidation of lipids the following points should be considered To be noted: (1) reduction of calorie intake; (2) reduction the absorption of unsaturated fatty acids; (3) addition of tocopherol or synthetic antioxidants, etc. However, it is not always easy to change the ingredients of the diet so that meets these requirements become.

Accordingly, it is urgently required to provide a food or beverage product which is inexpensive and has an excellent effect of inhibiting the increase of lipid peroxides without substantially changing the daily contents of the diet. The Japanese publication JP 22 95462 describes the antioxidant action of a composition containing a fructo-oligosaccharide (FOS) by synergetic action of another component; however, no indication can be found that FOS alone can have an antioxidant effect. Rather, it is claimed that FOS is used because of its proliferation effect on Lactobacillus bifidus.

epiphany the invention

The present inventors led intensive studies through to solve the above problems. in the Result turned out for the first time that fructooligosaccharides an excellent effect in inhibiting the increase of Have lipid peroxides. On the basis of these studies was the object of the present invention is achieved.

Accordingly, presents the present invention is a material for inhibiting lipid peroxide increase to disposal, which contains fructooligosaccharides.

fructooligosaccharides are a mixture of saccharides, with 1 to 3 fructo molecules attached to a fructose residue are bound by sucrose. Due to the excellent physiological Effects (promotion Growth of Bifidobacterium bifidus in the gut, maintenance a good intestinal flora, reduction of dental caries, etc.) won Fructooligosaccharides in the food industry as a new functional Dietary supplements increasingly important.

The present inventors investigated new physiological effects the fructooligosaccharides. The result turned out surprisingly out that fructo-oligosaccharides have an excellent effect inhibiting the increase of lipid peroxides. So far there is no report on the effect of fructo-oligosaccharides on the inhibition of a Increase in lipid peroxides. This is achieved by the present invention first disclosed.

The material according to the invention which inhibits the lipid-peroxide increase may be in the form of fructo-oligosaccharides, alone or in combination with a conventional additive, and may be administered to a mammal, including a human, in any form, e.g. B. as granules, capsules, tablets, powders, solutions, etc., are administered. Of course, it can be mixed with foods, spices, food additives, etc., and so absorbed. A number of foods and drinks are suitable therefor, without particular limitations, as long as the lipid peroxide-raising material of the present invention is incorporated therein, and the object of the present invention can be achieved therewith. Although the added amount of the material for inhibiting the lipid peroxide increase according to the present invention is not particularly limited, it may be used in a proportion of 50% by weight or less, preferably about 1 to 20% by weight, based on the fructo-oligosaccharides Considering the characteristics of the food or drink, the preference, the sweetness, the economy, etc., to be added. It may be added at a suitable stage during the manufacturing process. The daily uptake of the material for inhibiting the lipid peroxide increase according to the invention is preferably 25 g or less, more preferably 1 to 10 g, based on the fructo-oligosaccharides.

There Fructooligosaccharides are an indigestible sweetener that gets through as well as the calorie intake effectively reduced. Thus, fructooligosaccharides dissolve the above mentioned Object of the present invention also in this point. Accordingly, they are suitable as replacement or partial replacement for sugar. A particularly remarkable Effect can be achieved by their use as a spice in the household or for the daily Sweet from Coffee or tea.

Preferred embodiment the invention

The The following example serves to further illustrate the present Invention, limits but not one.

example 1

Mineralmischung:

AIN-76, Mischung

Vitaminmischung:

AIN-76, Vitaminmischung

Male 8 week old SD rats (Japan Clea Co.) were first fed for 3 days with a solid feed MF (Oriental Yeats Co., Ltd.). Based on the body weight on day 4, these rats were divided into 2 groups of 4 animals each. One group was a test feed which was free from fructooligosaccharides administered (control group), while the other test group (FO5 group) for 14 days to another test feed containing 5 wt .-% Meioligo P ^® (manufactured by Meiji Seika Kaisha, Ltd. , Fructooligosaccharide, purity ≥ 95 wt .-%) was administered. Table 1 shows the compositions of this test feed. Table 1

Mineral mixture:

AIN-76, mix

Vitamin mixture:

AIN-76, vitamin mixture

• (*: p < 0,01)

The animals were fed in a room at a temperature of 22 ± 2 ° C under exposure for 12 hours (8:00 to 20:00) daily. The animals were able to absorb food and drinking water (distilled water) ad libitum. At the completion of the test, an abdominal operation was performed under ether anesthesia, and the whole blood was collected from the lateral major vena cava. Using the blood thus collected, blood lipid peroxide levels were prepared using the lipid peroxide test "Wako" (U.S. from Wako Pure Chemical Industries, Ltd.). As shown by the results shown in Table 2, incorporation of the lipid-peroxide-raising inhibitor of the invention causes significantly less lipid peroxide levels in the blood in the FO5 group. Table 2

• (*: p <0.01)

Industrial applicability

The Inclusion of the material according to the invention to inhibit the lipid peroxide increase provides an excellent Means of preventing various diseases caused by the Formation of lipid peroxides are caused, such as cancer and arterial Sclerosis, to delay of aging, etc. The use of the material according to the invention In addition, inhibition of lipid peroxide increase allows convenient maintenance of food and drink with excellent effect of inhibiting the increase of lipid peroxides at low cost, which is very important to the present invention power.

Claims (2)

Use of fructo-oligosaccharides for the preparation of a preparation to lower the lipid peroxide level in the blood. Use of fructooligosaccharides according to claim 1, wherein the preparation in the form of granules, capsules, tablets, powders or solutions.