DE69628936D1 - Test zur identifikation von inhibitoren der interaktion zwischen p53 und dm2 proteinen - Google Patents

Test zur identifikation von inhibitoren der interaktion zwischen p53 und dm2 proteinen

Info

Publication number
DE69628936D1
DE69628936D1 DE69628936T DE69628936T DE69628936D1 DE 69628936 D1 DE69628936 D1 DE 69628936D1 DE 69628936 T DE69628936 T DE 69628936T DE 69628936 T DE69628936 T DE 69628936T DE 69628936 D1 DE69628936 D1 DE 69628936D1
Authority
DE
Germany
Prior art keywords
formation
dna
interaction
identification
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69628936T
Other languages
English (en)
Other versions
DE69628936T2 (de
Inventor
Patrick Chene
Heinz-Kurt Hochkeppel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Publication of DE69628936D1 publication Critical patent/DE69628936D1/de
Application granted granted Critical
Publication of DE69628936T2 publication Critical patent/DE69628936T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
DE69628936T 1995-09-18 1996-09-10 Test zur identifikation von inhibitoren der interaktion zwischen p53 und dm2 proteinen Expired - Fee Related DE69628936T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95810576 1995-09-18
EP95810576 1995-09-18
PCT/EP1996/003957 WO1997011367A1 (en) 1995-09-18 1996-09-10 ASSAY FOR IDENTIFYING INHIBITORS OF THE INTERACTION BETWEEN PROTEINS p53 AND dm2

Publications (2)

Publication Number Publication Date
DE69628936D1 true DE69628936D1 (de) 2003-08-07
DE69628936T2 DE69628936T2 (de) 2004-05-27

Family

ID=8221793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628936T Expired - Fee Related DE69628936T2 (de) 1995-09-18 1996-09-10 Test zur identifikation von inhibitoren der interaktion zwischen p53 und dm2 proteinen

Country Status (7)

Country Link
US (1) US6492116B1 (de)
EP (1) EP0859956B1 (de)
AT (1) ATE244403T1 (de)
AU (1) AU7127296A (de)
DE (1) DE69628936T2 (de)
WO (1) WO1997011367A1 (de)
ZA (1) ZA967826B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9608937D0 (en) * 1996-04-29 1996-07-03 Cancer Res Campaign Tech Screening methods for therapeutics and peptides used in the screen
AU8284198A (en) * 1997-07-02 1999-01-25 Board Of Regents, The University Of Texas System P53 as a regulator of cell differentiation
DE19735221C1 (de) 1997-08-14 1999-05-06 Wolfgang Willi Prof Dr Deppert Beeinflussung der Bindung von p53 an Zielgene
US6020135A (en) * 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
DE69922372T2 (de) * 1998-05-26 2005-12-15 Agency For Science, Technology And Research Polypeptide aus creb-binding-protein und verwandtem protein p300 für die verwendung bei der transkriptionsregulation
MXPA06012294A (es) * 2004-04-22 2007-03-15 Johnson & Johnson Complejos de proteina diminuta doble 2 humana-inhibidor y usos de los mismos.
US20100129933A1 (en) * 2007-04-26 2010-05-27 Forschungszentrum Karlsruhe Gmbh Method for detecting the binding between mdm2 and the proteasome
WO2009070650A1 (en) * 2007-11-26 2009-06-04 The Research Foundation Of State University Of New York Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362623A (en) * 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
US5770377A (en) * 1994-07-20 1998-06-23 University Of Dundee Interruption of binding of MDM2 and P53 protein and therapeutic application thereof

Also Published As

Publication number Publication date
AU7127296A (en) 1997-04-09
WO1997011367A1 (en) 1997-03-27
EP0859956A1 (de) 1998-08-26
EP0859956B1 (de) 2003-07-02
ATE244403T1 (de) 2003-07-15
DE69628936T2 (de) 2004-05-27
US6492116B1 (en) 2002-12-10
ZA967826B (en) 1997-03-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee