DE69621877D1 - 4-Indolylpiperazinyl-Derivate - Google Patents

4-Indolylpiperazinyl-Derivate

Info

Publication number
DE69621877D1
DE69621877D1 DE69621877T DE69621877T DE69621877D1 DE 69621877 D1 DE69621877 D1 DE 69621877D1 DE 69621877 T DE69621877 T DE 69621877T DE 69621877 T DE69621877 T DE 69621877T DE 69621877 D1 DE69621877 D1 DE 69621877D1
Authority
DE
Germany
Prior art keywords
indolylpiperazinyl
derivatives
alkyl
indolylpiperazine
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69621877T
Other languages
English (en)
Other versions
DE69621877T2 (de
Inventor
John Patrick Yardley
Horace Fletcher
Michael Gerard Kelly
Alan Chapman White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd, American Home Products Corp filed Critical John Wyeth and Brother Ltd
Publication of DE69621877D1 publication Critical patent/DE69621877D1/de
Application granted granted Critical
Publication of DE69621877T2 publication Critical patent/DE69621877T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69621877T 1995-04-10 1996-04-04 4-Indolylpiperazinyl-Derivate Expired - Fee Related DE69621877T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/419,342 US5486518A (en) 1995-04-10 1995-04-10 4-indolylpiperazinyl derivatives

Publications (2)

Publication Number Publication Date
DE69621877D1 true DE69621877D1 (de) 2002-07-25
DE69621877T2 DE69621877T2 (de) 2002-12-19

Family

ID=23661842

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621877T Expired - Fee Related DE69621877T2 (de) 1995-04-10 1996-04-04 4-Indolylpiperazinyl-Derivate

Country Status (13)

Country Link
US (1) US5486518A (de)
EP (1) EP0737678B1 (de)
JP (1) JPH08319274A (de)
AT (1) ATE219484T1 (de)
CA (1) CA2173690A1 (de)
DE (1) DE69621877T2 (de)
DK (1) DK0737678T3 (de)
ES (1) ES2177727T3 (de)
HK (1) HK1010102A1 (de)
HU (1) HUP9600914A2 (de)
PT (1) PT737678E (de)
SI (1) SI0737678T1 (de)
TW (1) TW454005B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519025A (en) * 1995-04-10 1996-05-21 American Home Products Corporation 4-indolylpiperazinyl derivatives
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (de) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
CN1312802A (zh) * 1998-06-15 2001-09-12 美国家用产品公司 作为5－羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶
US6376494B1 (en) * 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
WO2000052002A1 (en) * 1999-03-02 2000-09-08 American Home Products Corporation N-substituted imide derivatives with serotonergic activity
US6306859B1 (en) 1999-03-02 2001-10-23 American Home Products Corporation N-substituted imide derivatives with serotonergic activity
BR0015539A (pt) 1999-11-12 2002-07-16 Wyeth Corp Adamantil e noradamantil aril- e aralquilpiperazinas ramificadas com atividade 5-ht1a de serotonina
US6831084B1 (en) 1999-11-12 2004-12-14 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
WO2002085871A2 (en) 2001-04-04 2002-10-31 Wyeth Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) * 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
US7179813B2 (en) * 2003-06-11 2007-02-20 Wyeth Bicyclic indolyl derivatives and methods for their use as serotonergic agents
BR112012005119A2 (pt) 2009-09-07 2016-11-22 Vifor Int Ag novos antagonistas de hepcidina etanodiaminas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) * 1970-02-02 1972-02-29 American Cyanamid Co N-(tert-aminoalkyl)-2-indenecarboxamides
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod History of piperazinyl carboxamide, their preparation and the pharmaceutical preparations containing them
NZ231631A (en) * 1988-12-08 1992-07-28 Duphar Int Res Heterocyclically-substituted piperazine and diazepine derivatives and anxiolytic compositions
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
FI102175B1 (fi) * 1989-04-22 1998-10-30 Wyeth John & Brother Ltd Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
ES2177727T3 (es) 2002-12-16
ATE219484T1 (de) 2002-07-15
SI0737678T1 (en) 2002-10-31
TW454005B (en) 2001-09-11
EP0737678A1 (de) 1996-10-16
EP0737678B1 (de) 2002-06-19
US5486518A (en) 1996-01-23
DE69621877T2 (de) 2002-12-19
JPH08319274A (ja) 1996-12-03
PT737678E (pt) 2002-11-29
HUP9600914A2 (hu) 1998-09-28
HK1010102A1 (en) 1999-06-11
CA2173690A1 (en) 1996-10-11
HU9600914D0 (en) 1996-05-28
DK0737678T3 (da) 2002-10-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: JOHN WYETH & BROTHER LTD., MAIDENHEAD, BERKSHIRE,

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee