DE69530512D1 - Phosphatase-aktivierte quervernetzende konjugierende und reduzierende agenzien, verfahren unter verwendung solcher agenzien und reagenzien die phosphatase-aktivierte quervernetzende und konjugierende agenzien enthalten - Google Patents

Phosphatase-aktivierte quervernetzende konjugierende und reduzierende agenzien, verfahren unter verwendung solcher agenzien und reagenzien die phosphatase-aktivierte quervernetzende und konjugierende agenzien enthalten

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Publication number
DE69530512D1
DE69530512D1 DE69530512T DE69530512T DE69530512D1 DE 69530512 D1 DE69530512 D1 DE 69530512D1 DE 69530512 T DE69530512 T DE 69530512T DE 69530512 T DE69530512 T DE 69530512T DE 69530512 D1 DE69530512 D1 DE 69530512D1
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DE
Germany
Prior art keywords
agents
conjugating
networking
activated
phosphatase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530512T
Other languages
English (en)
Other versions
DE69530512T2 (de
Inventor
Christopher Bieniarz
Mazhar Husain
Douglas F Young
Zbigniew Skrzypczynski
Michael J Cornwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69530512D1 publication Critical patent/DE69530512D1/de
Application granted granted Critical
Publication of DE69530512T2 publication Critical patent/DE69530512T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1652—Polyol derivatives esterified at least twice by thiophosphoric acid groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69530512T 1994-12-02 1995-11-30 Phosphatase-aktivierte quervernetzende konjugierende und reduzierende agenzien, verfahren unter verwendung solcher agenzien und reagenzien die phosphatase-aktivierte quervernetzende und konjugierende agenzien enthalten Expired - Fee Related DE69530512T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/349,167 US5736624A (en) 1994-12-02 1994-12-02 Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
US349167 1994-12-02
PCT/US1995/015586 WO1996017580A2 (en) 1994-12-02 1995-11-30 Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents

Publications (2)

Publication Number Publication Date
DE69530512D1 true DE69530512D1 (de) 2003-05-28
DE69530512T2 DE69530512T2 (de) 2004-03-25

Family

ID=23371180

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530512T Expired - Fee Related DE69530512T2 (de) 1994-12-02 1995-11-30 Phosphatase-aktivierte quervernetzende konjugierende und reduzierende agenzien, verfahren unter verwendung solcher agenzien und reagenzien die phosphatase-aktivierte quervernetzende und konjugierende agenzien enthalten

Country Status (7)

Country Link
US (4) US5736624A (de)
EP (1) EP0795128B1 (de)
JP (1) JPH10509731A (de)
AT (1) ATE238549T1 (de)
DE (1) DE69530512T2 (de)
ES (1) ES2197214T3 (de)
WO (1) WO1996017580A2 (de)

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US6403359B1 (en) 1998-09-25 2002-06-11 V. I. TECHNOLOGIES, Inc. Solid phase quenching systems
US6617100B2 (en) 1998-09-25 2003-09-09 V.I. Technologies, Inc. Solid phase quenching systems
BR0007437A (pt) 1999-01-08 2001-11-20 Procter & Gamble Composições tópicas que compreendem tióisfuncionais protegidos
US6703007B2 (en) * 1999-01-08 2004-03-09 The Procter & Gamble Company Topical compositions comprising functional nucleophiles protected by phosphorus-containing moieties
GB0002626D0 (en) 2000-02-05 2000-03-29 Eastman Kodak Co Nonionic oligomeric surfactants and their use as dispersants and stabilisers
US6995248B2 (en) * 2001-07-16 2006-02-07 Dr. Chip Biotechnology, Inc. Immobilization of nucleic acids
US20030198966A1 (en) * 2002-04-19 2003-10-23 Stojanovic Milan N. Displacement assay for detection of small molecules
US7470516B2 (en) * 2003-04-14 2008-12-30 The Trustees Of Columbia University In The City Of New York Cross reactive arrays of three-way junction sensors for steroid determination
US20040203007A1 (en) * 2003-04-14 2004-10-14 Stojanovic Milan N. Cross reactive arrays of three-way junction sensors for steroid determination
US7351591B2 (en) * 2004-03-30 2008-04-01 Intel Corporation Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
CA2606018A1 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Nanoparticle conjugates
EP1877101B1 (de) 2005-04-28 2016-11-16 Ventana Medical Systems, Inc. Mit antikörpern über einen heterobifuntionellen peg-linker konjugierte enzyme
EP1951316B1 (de) 2005-11-23 2015-08-19 Ventana Medical Systems, Inc. Molekulares Konjugat
US7749957B2 (en) * 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
US7754680B2 (en) * 2007-07-26 2010-07-13 E. I. Du Pont De Nemours And Company Peptides for binding calcium carbonates and methods of use
CN114100588B (zh) * 2020-08-31 2024-03-22 泉州师范学院 一种含氮功能基团超高交联吸附剂及其制备方法和血液灌流器

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CA1023287A (en) * 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US4166105A (en) * 1973-07-30 1979-08-28 Block Engineering, Inc. Dye tagged reagent
US4169137A (en) * 1974-12-20 1979-09-25 Block Engineering, Inc. Antigen detecting reagents
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
US4652524A (en) * 1980-10-02 1987-03-24 Ivan E. Modrovich Soluble stabilized enzymes
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US4542104A (en) * 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
US4970074A (en) * 1987-06-29 1990-11-13 Abbott Laboratories Fluorophores for encapsulation into liposomes
US4994385A (en) * 1987-10-30 1991-02-19 Abbott Laboratories Heterobifunctional coupling agents
US4843126A (en) * 1987-12-30 1989-06-27 The Lubrizol Corporation Aminoplast catalyst and compositions
US5053520A (en) * 1988-09-22 1991-10-01 Abbott Laboratories Heterobifunctional maleimido containing coupling agents
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
US5376403A (en) * 1990-02-09 1994-12-27 Capote; Miguel A. Electrically conductive compositions and methods for the preparation and use thereof
WO1992008790A1 (en) * 1990-11-14 1992-05-29 Cargill, Incorporated Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
US5191066A (en) * 1990-12-07 1993-03-02 Abbott Laboratories Site-specific conjugation of immunoglobulins and detectable labels
JP3125428B2 (ja) * 1991-03-28 2001-01-15 和光純薬工業株式会社 修飾酵素
US5232484A (en) * 1991-08-13 1993-08-03 The Connecticut Agricultural Experiment Station Degradation of pesticides by ferric reagents and peroxide in the presence of light
CA2091544A1 (en) * 1992-03-26 1993-09-27 Shing F. Kwan Stabilization of functional proteins
US5674514A (en) * 1992-09-21 1997-10-07 Ciba-Geigy Corporation Storage stable pesticidal aqueous emulsions
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Also Published As

Publication number Publication date
WO1996017580A3 (en) 1996-10-10
ATE238549T1 (de) 2003-05-15
US6160153A (en) 2000-12-12
WO1996017580A2 (en) 1996-06-13
EP0795128A2 (de) 1997-09-17
US5789219A (en) 1998-08-04
US5736624A (en) 1998-04-07
DE69530512T2 (de) 2004-03-25
US6057429A (en) 2000-05-02
ES2197214T3 (es) 2004-01-01
EP0795128B1 (de) 2003-04-23
JPH10509731A (ja) 1998-09-22

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