DE69530196D1 - METHOD FOR PREVENTING THE AGGREGATION OF PROTEINS / PEPTIDES IN REHYDRATION OR THAWING - Google Patents
METHOD FOR PREVENTING THE AGGREGATION OF PROTEINS / PEPTIDES IN REHYDRATION OR THAWINGInfo
- Publication number
- DE69530196D1 DE69530196D1 DE69530196T DE69530196T DE69530196D1 DE 69530196 D1 DE69530196 D1 DE 69530196D1 DE 69530196 T DE69530196 T DE 69530196T DE 69530196 T DE69530196 T DE 69530196T DE 69530196 D1 DE69530196 D1 DE 69530196D1
- Authority
- DE
- Germany
- Prior art keywords
- thawing
- aggregation
- rehydration
- peptides
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 238000004220 aggregation Methods 0.000 title abstract 2
- 230000002776 aggregation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000010257 thawing Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 3
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Abstract
The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25296794A | 1994-06-02 | 1994-06-02 | |
PCT/GB1995/001277 WO1995033488A1 (en) | 1994-06-02 | 1995-06-02 | Method of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530196D1 true DE69530196D1 (en) | 2003-05-08 |
DE69530196T2 DE69530196T2 (en) | 2003-11-20 |
Family
ID=22958303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530196T Revoked DE69530196T2 (en) | 1994-06-02 | 1995-06-02 | METHOD FOR PREVENTING THE AGGREGATION OF PROTEINS / PEPTIDES IN REHYDRATION OR THAWING |
Country Status (10)
Country | Link |
---|---|
US (2) | US6890512B2 (en) |
EP (1) | EP0762897B1 (en) |
JP (2) | JP4142095B2 (en) |
CN (1) | CN1188171C (en) |
AT (1) | ATE235919T1 (en) |
DE (1) | DE69530196T2 (en) |
DK (1) | DK0762897T3 (en) |
ES (1) | ES2194911T3 (en) |
PT (1) | PT762897E (en) |
WO (1) | WO1995033488A1 (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5621094A (en) * | 1990-05-14 | 1997-04-15 | Quadrant Holdings Cambridge Limited | Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol |
US5955448A (en) * | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
WO1995033488A1 (en) | 1994-06-02 | 1995-12-14 | Quadrant Holdings Cambridge Limited | Method of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
JPH10508744A (en) | 1994-09-22 | 1998-09-02 | クオドラント ホールディングス ケンブリッジ リミテッド | Compositions for hydration and nutritional use during athletics and methods of making the same |
US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
AU716785B2 (en) | 1995-07-27 | 2000-03-09 | Genentech Inc. | Stabile isotonic lyophilized protein formulation |
US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
IL124275A (en) | 1997-05-02 | 2002-03-10 | Bio Merieux Vitek Inc | Method for generating nucleic acid sequences |
US6558901B1 (en) | 1997-05-02 | 2003-05-06 | Biomerieux Vitek | Nucleic acid assays |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
RU2244556C2 (en) | 1999-02-22 | 2005-01-20 | Юниверсити Оф Коннектикут | New albumin-free compositions of factor viii |
FR2791895B1 (en) * | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | USE OF TREHALOSE TO STABILIZE A LIQUID VACCINE |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
EP1458360B1 (en) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonary delivery of aminoglycosides |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
WO2003079993A2 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | hGH (HUMAN GROWTH HORMONE) FORMULATIONS FOR PULMONARY ADMINISTRATION |
WO2005007282A2 (en) * | 2003-05-13 | 2005-01-27 | Minerva Biotechnologies Corporation | Storage and use of colloids |
JP4836797B2 (en) | 2003-10-23 | 2011-12-14 | 大塚製薬株式会社 | Controlled release sterile injection aripiprazole formulations and methods |
EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
RU2008117396A (en) | 2005-10-04 | 2009-11-10 | Альк-Абелло А/С (Dk) | SOLID VACCINE COMPOSITION |
WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
DK2131857T3 (en) * | 2007-03-22 | 2015-09-14 | Univ Colorado Regents | A method of producing an immunologically active adjuvansbundet dried vaccine composition |
WO2008125940A2 (en) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticles comprising non-crystalline drug |
US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
WO2008135852A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Pharmaceutical compositions comprising nanoparticles and casein |
EP2162120B1 (en) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
BRPI0813698A2 (en) * | 2007-07-09 | 2014-12-30 | Novartis Ag | CONSERVATION OF SECONDARY PEPTIDE STRUCTURE |
US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
AR067747A1 (en) | 2007-07-31 | 2009-10-21 | Otsuka Pharma Co Ltd | METHODS TO PRODUCE SUSPENSION OF ARIPIPRAZOL AND LIOFILIZED FORMULATION |
US20090081785A1 (en) * | 2007-09-24 | 2009-03-26 | Hememics Biotechnologies, Inc. | Desiccated Biologics And Methods Of Preparing The Same |
US20090090022A1 (en) * | 2007-10-09 | 2009-04-09 | Hememics Biotechnologies, Inc. | Desiccation Chamber and Methods for Drying Biological Materials |
US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
EP2240162A4 (en) * | 2007-12-06 | 2013-10-09 | Bend Res Inc | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
JP4563476B2 (en) | 2008-07-09 | 2010-10-13 | パナソニック株式会社 | Encoder, decoder and encoding method |
WO2010036226A1 (en) * | 2008-09-26 | 2010-04-01 | George Nelson | Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis |
JP5779780B2 (en) | 2008-11-07 | 2015-09-16 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Factor VIII formulation |
US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
US20120241356A1 (en) * | 2009-07-06 | 2012-09-27 | Sanofi-Aventis Deutschland Gmbh | Heat- and vibration-stable insulin preparations |
US9943075B2 (en) | 2010-02-17 | 2018-04-17 | Hememics Biotechnologies, Inc. | Preservation solutions for biologics and methods related thereto |
JP5341059B2 (en) * | 2010-11-09 | 2013-11-13 | 株式会社大塚製薬工場 | Stem cell suspension |
ES2870529T3 (en) | 2010-12-09 | 2021-10-27 | Abbott Point Of Care Inc | Apparatus that uses an anti-adsorption agent to facilitate mixing and analysis of samples |
KR102374576B1 (en) * | 2011-05-17 | 2022-03-15 | 솔리제닉스, 인크. | Thermostable vaccine compositions and methods of preparing same |
CN104023743B (en) | 2011-10-25 | 2017-05-03 | 普罗西纳治疗有限公司 | Antibody formulations and methods |
US20150044251A1 (en) * | 2011-12-23 | 2015-02-12 | Novartis Ag | Stable compositions for immunising against staphylococcus aureus |
JP5432322B2 (en) * | 2012-05-08 | 2014-03-05 | 株式会社大塚製薬工場 | Mammalian cell suspension for prevention of pulmonary embolism containing trehalose |
KR20150034170A (en) * | 2012-06-25 | 2015-04-02 | 이머전트 프로덕트 디벨롭먼트 게이더스버그 인코포레이티드 | Temperature stable vaccine formulations |
WO2015100344A1 (en) | 2013-12-27 | 2015-07-02 | Emergent Product Development Gaithersburg Inc. | Temperature stable vaccine formulations |
WO2016069173A2 (en) * | 2014-09-29 | 2016-05-06 | Cook General Biotechnology Llc | Uses of trehalose in cell suspensions |
WO2017172679A1 (en) * | 2016-03-28 | 2017-10-05 | Cook General Biotechnology Llc | Viable cell compositions, and methods related to same |
CN107307422B (en) * | 2017-07-07 | 2018-09-18 | 许辉良 | Instant Herba Dendrobii extract and preparation method thereof |
CN107373663B (en) * | 2017-07-07 | 2020-12-25 | 江西清源汉本生物科技有限公司 | Instant chrysanthemum extract and preparation method thereof |
CN107373662B (en) * | 2017-07-07 | 2020-12-22 | 江西清源汉本生物科技有限公司 | Instant honeysuckle extract and preparation method thereof |
CA3078625C (en) | 2017-10-09 | 2023-01-17 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
US20200325020A1 (en) * | 2017-10-25 | 2020-10-15 | Merck Sharp & Dohme Corp. | Adjuvanted vaccines |
WO2020185916A1 (en) | 2019-03-14 | 2020-09-17 | Terumo Bct Biotechnologies, Llc | Lyophilization container fill fixture, system and method of use |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3557717A (en) | 1968-05-17 | 1971-01-26 | Gen Mills Inc | Process for making candy floss |
US3619294A (en) | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Method of combining crystalline sugar with impregnating agents and products produced thereby |
US3632357A (en) | 1969-07-29 | 1972-01-04 | Standard Brands Inc | Method of producing hard candy |
US3655442A (en) | 1969-08-27 | 1972-04-11 | California & Hawaiian Sugar | Method of making sugar and sugar products |
US4127502A (en) | 1977-06-10 | 1978-11-28 | Eastman Kodak Company | Stabilizers for reconstituted, lyophilized samples |
DE2748132A1 (en) | 1977-10-27 | 1979-05-03 | Behringwerke Ag | STABILIZER FOR POLYSACCHARIDE |
US4158544A (en) | 1978-07-17 | 1979-06-19 | Beckman Instruments, Inc. | Process for preparing a biological composition for use as a reference control in diagnostic analysis |
US4588744A (en) | 1978-09-19 | 1986-05-13 | Mchugh John E | Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide |
US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US4327077A (en) | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US4457916A (en) | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
US4883762A (en) | 1983-06-06 | 1989-11-28 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
US4865871A (en) | 1983-08-23 | 1989-09-12 | Board Of Regents The University Of Texas System | Method for cryopreparing biological tissue |
DE3445010A1 (en) | 1984-12-10 | 1986-06-19 | Boehringer Mannheim Gmbh | CONTROL OR OAK SERUM FOR LIPID DIAGNOSTICS |
DE229810T1 (en) | 1985-07-09 | 1987-11-05 | Quadrant Bioresources Ltd., Soulbury, Leighton Buzzard, Bedfordshire | PROTECTION OF PROTEINS AND SIMILAR. |
US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
US4762857A (en) | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
US5037644A (en) * | 1986-10-27 | 1991-08-06 | Cetus Corporation | Pharmaceutical compositions of recombinant interleukin-2 and formulation processes |
GB8715238D0 (en) * | 1987-06-29 | 1987-08-05 | Quadrant Bioresources Ltd | Food process |
GB8801338D0 (en) | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
CA1331133C (en) | 1988-03-01 | 1994-08-02 | Michael Jon Pikal | Pharmaceutical growth hormone formulations |
US5262296A (en) * | 1988-03-30 | 1993-11-16 | Toray Industries, Inc. | Freeze-dried composition containing enzyme-labeled anti-human interferon-β antibody and enzyme immunoassay kit containing the composition |
US5059518A (en) * | 1988-10-20 | 1991-10-22 | Coulter Corporation | Stabilized lyophilized mammalian cells and method of making same |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
GB8917470D0 (en) | 1989-07-31 | 1989-09-13 | Quadrant Bioresources Ltd | Composition and method |
AU650678B2 (en) | 1990-08-10 | 1994-06-30 | Analytical Control Systems, Inc. | Stabilization (using gelatin from a cold water fish) of enzymes in diagnostic controls |
US5200399A (en) | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
US5242792A (en) * | 1991-02-25 | 1993-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides |
US5422384A (en) | 1992-11-25 | 1995-06-06 | Battelle Memorial Institute | Glass/polymer composites and methods of making |
EP0717988B1 (en) | 1993-08-20 | 2001-10-17 | Nippon Shinyaku Company, Limited | Gastric remaining preparation, swollen molding, and production process |
US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
WO1995033488A1 (en) * | 1994-06-02 | 1995-12-14 | Quadrant Holdings Cambridge Limited | Method of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby |
US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
AU713599B2 (en) | 1995-06-07 | 1999-12-09 | Quadrant Drug Delivery Limited | Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby |
-
1995
- 1995-06-02 WO PCT/GB1995/001277 patent/WO1995033488A1/en active IP Right Grant
- 1995-06-02 DE DE69530196T patent/DE69530196T2/en not_active Revoked
- 1995-06-02 ES ES95921031T patent/ES2194911T3/en not_active Expired - Lifetime
- 1995-06-02 AT AT95921031T patent/ATE235919T1/en not_active IP Right Cessation
- 1995-06-02 JP JP50054296A patent/JP4142095B2/en not_active Expired - Fee Related
- 1995-06-02 CN CNB951944339A patent/CN1188171C/en not_active Expired - Fee Related
- 1995-06-02 DK DK95921031T patent/DK0762897T3/en active
- 1995-06-02 PT PT95921031T patent/PT762897E/en unknown
- 1995-06-02 EP EP95921031A patent/EP0762897B1/en not_active Revoked
-
2001
- 2001-04-16 US US09/836,625 patent/US6890512B2/en not_active Expired - Fee Related
-
2005
- 2005-03-18 US US11/084,223 patent/US20050163750A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008010077A patent/JP2008179636A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP4142095B2 (en) | 2008-08-27 |
CN1156967A (en) | 1997-08-13 |
JPH10500990A (en) | 1998-01-27 |
DK0762897T3 (en) | 2003-07-21 |
WO1995033488A1 (en) | 1995-12-14 |
US20010055583A1 (en) | 2001-12-27 |
DE69530196T2 (en) | 2003-11-20 |
ES2194911T3 (en) | 2003-12-01 |
US20050163750A1 (en) | 2005-07-28 |
PT762897E (en) | 2003-07-31 |
EP0762897B1 (en) | 2003-04-02 |
US6890512B2 (en) | 2005-05-10 |
JP2008179636A (en) | 2008-08-07 |
EP0762897A1 (en) | 1997-03-19 |
CN1188171C (en) | 2005-02-09 |
ATE235919T1 (en) | 2003-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69530196D1 (en) | METHOD FOR PREVENTING THE AGGREGATION OF PROTEINS / PEPTIDES IN REHYDRATION OR THAWING | |
ATE159429T1 (en) | METHOD FOR DELIVERING AGENTS TO TARGET CELLS | |
DK332684D0 (en) | MODIFIED PROTEASE INHIBITORS AND THEIR PREPARATION AND USE | |
ATE132164T1 (en) | METHOD FOR INCREASE AND INHIBITING THE EFFECT OF AN INSULIN-LIKE GROWTH FACTOR | |
DE69231469D1 (en) | USE OF GENTISIC ACID OR GENTISYL ALCOHOL TO STABILIZE RADIO-LABELED PEPTIDES AND PROTEINS | |
WO1998020133A3 (en) | Proteins with enhanced levels of essential amino acids | |
DE69535948D1 (en) | WDP-40 ABREGING PEPTIDES AND THEIR USE | |
NO891940D0 (en) | PROCEDURE FOR SELECTIVE AA REDUCE PERMEABILITY OF OIL-FREE ZONES IN UNDERGRADUATE FORMS. | |
DK0572688T3 (en) | Peptides, with organ-protective activity, method for their preparation and their use in therapy | |
MX9203519A (en) | RECOMBINATION METHOD FOR THE PRODUCTION OF SERINE PROTEASE INHIBITORS AND DNA SEQUENCES USEFUL FOR THEM. | |
DE68927379D1 (en) | SLIDE BLOCKING PEPTIDES | |
DK568287A (en) | RELATIVELY LOW MOLECULAR PEPTIDES AND THEIR USE AS RENIN INHIBITORS | |
HUP9900506A2 (en) | Prothrombin derivatives | |
ATE270305T1 (en) | PEPTIDES OF THE ANTISECRETORIC FACTOR, WHICH REGULATES ILLEGAL CHANGES IN PERMEABILITY | |
DK0901526T3 (en) | Cortistatin: neuropeptides, compositions and methods | |
DE68917837D1 (en) | Peptide compounds. | |
ATE226591T1 (en) | OLIGOPEPTIDES DERIVED FROM FRAGMENTS OF C-REACTIVE PROTEIN | |
NO892266L (en) | AMBLYOMMIN, A NEW EFFECT FOR ANTICOAGULATION THERAPY. | |
FI891020A (en) | Method for preparing eglin mutants with protease inhibitor activity | |
NO941377D0 (en) | Cell cycle controlling preparations and methods for using them | |
HUT37557A (en) | Presrving of spice paprika grist | |
ATE33718T1 (en) | APPARATUS FOR THE SEQUENTIAL DEGRADATION OF PEPTIDES AND PROTEINS. | |
WO1998029436A3 (en) | Lebetin peptides as platelet aggregation inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: QUADRANT DRUG DELIVERY LTD., RUDDINGTON, NOTTINGHA |
|
8331 | Complete revocation |