CN107373662B - Instant honeysuckle extract and preparation method thereof - Google Patents

Instant honeysuckle extract and preparation method thereof Download PDF

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CN107373662B
CN107373662B CN201710554248.6A CN201710554248A CN107373662B CN 107373662 B CN107373662 B CN 107373662B CN 201710554248 A CN201710554248 A CN 201710554248A CN 107373662 B CN107373662 B CN 107373662B
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honeysuckle extract
instant
trehalose
mixture
drying apparatus
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CN107373662A (en
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许辉良
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JIANGXI QINGYUAN HANBEN BIOTECHNOLOGY CO., LTD.
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Jiangxi Genesis Herb Biotech Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a quick-soluble honeysuckle extract and a preparation method thereof. It is obtained by treating honeysuckle extract and trehalose at high temperature of 112-210 ℃. The product produced by the preparation technology has the characteristics of good dispersibility, quick dissolution, no fish eyes and the like.

Description

Instant honeysuckle extract and preparation method thereof
The technical field is as follows:
the invention relates to an instant honeysuckle extract and a preparation method thereof.
Background art:
honeysuckle is well known for its wide medicinal value since ancient times. The efficacy of the traditional Chinese medicine is mainly to clear away heat and toxic materials and mainly treat epidemic febrile disease fever, heat toxin and bloody dysentery, carbuncle, cellulitis, furuncle and the like. Modern researches prove that the honeysuckle contains pharmacological active ingredients such as chlorogenic acid and luteolin glycoside, has stronger inhibitory power on various pathogenic bacteria such as hemolytic streptococcus, staphylococcus aureus and the like and upper respiratory infection pathogenic viruses and the like, can enhance immunity, resist early pregnancy, protect liver, resist tumor, diminish inflammation, relieve fever, stop bleeding (blood coagulation), inhibit intestinal absorption of cholesterol and the like, has very wide clinical application, and can be used for treating more than 40 diseases such as respiratory infection, bacillary dysentery, acute urinary infection, hypertension and the like by being compatible with other medicines. It is widely used in medicine, food, health and other industries. The honeysuckle extract complete dissolution process needs two steps, firstly, water molecules penetrate into the honeysuckle extract to swell the honeysuckle extract, then the honeysuckle extract polymer molecules are uniformly distributed in water, and finally, complete hydration dissolution is achieved. However, in the actual preparation process of the honeysuckle extract solution, when the powder or extract of the honeysuckle extract is directly mixed with water, the non-starch polysaccharide and other carbohydrates in the honeysuckle extract which are firstly contacted with the water can quickly absorb water to swell and then dissolve, and the formed colloid layer delays the permeation of water molecules to the interior of the honeysuckle extract, so that the further hydration and dissolution of the honeysuckle extract are influenced, fish eyes are easily formed in the process, particles are cemented to form blocks, the use efficiency of the honeysuckle extract is reduced, and the further market application and expansion of the honeysuckle extract are also limited.
The invention content is as follows:
the inventor develops an instant honeysuckle extract and a preparation method thereof through intensive research and a large number of experiments.
In an embodiment of the present invention, an instant honeysuckle extract is provided, wherein the instant product comprises, based on the total weight of the instant honeysuckle extract: 190% (w/w), preferably 1-80% (w/w), 1-70% (w/w), 1-60% (w/w), 1-50% (w/w), 1-40% (w/w), 1-30% (w/w), 1-20% (w/w) or 1-10% (w/w) of the extract of honeysuckle flower, and 1099% (w/w), preferably 10-89% (w/w), 10-79% (w/w), 10-69% (w/w), 10-59% (w/w), 10-49% (w/w), 10-39% (w/w), 10-29% (w/w), 10-19% (w/w) of trehalose.
In the embodiment of the invention, preferably, the instant honeysuckle extract is prepared by heat-treating trehalose and honeysuckle extract at a high temperature of 112-210 ℃, preferably 112-205 ℃, 112-200 ℃, 112-195 ℃, 112-190 ℃, 112-185 ℃, 112-180 ℃, 112-175 ℃, 112-170 ℃, 112-165 ℃, 112-160 ℃, 112-155 ℃, 112-150 ℃, 112-145 ℃, 112-140 ℃, 112-135 ℃, 112-130 ℃, 112-125 ℃, 112-120 ℃ or 112-115 ℃.
In an embodiment of the present invention, the instant honeysuckle extract further comprises 0-89% (w/w), more preferably 0-79% (w/w), 0-69% (w/w), 0-59% (w/w), 0-49% (w/w), 0-39% (w/w), 0-29% (w/w) or 0-19% (w/w) of an auxiliary material, based on the total weight of the instant honeysuckle extract.
In an embodiment of the present invention, there is provided a method for preparing an instant honeysuckle extract, comprising:
a) mixing the honeysuckle extract with trehalose, wherein the content of the honeysuckle extract is 1-90% (w/w), preferably 1-80% (w/w), 1-70% (w/w), 1-60% (w/w), 1-50% (w/w), 1-40% (w/w), 1-30% (w/w), 1-20% (w/w) or 1-10% (w/w), based on the total weight of the instant honeysuckle extract; the trehalose content is 10-99% (w/w), preferably 10-89% (w/w), 10-79% (w/w), 10-69% (w/w), 10-59% (w/w), 10-49% (w/w), 10-39% (w/w), 10-29% (w/w), 10-19% (w/w);
b) the mixed material is subjected to high-temperature heat treatment at 112-210 ℃, preferably 112-200 ℃, 112-195 ℃, 112-190 ℃, 112-185 ℃, 112-180 ℃, 112-175 ℃, 112-170 ℃, 112-165 ℃, 112-160 ℃, 112-155 ℃, 112-150 ℃, 112-145 ℃, 112-140 ℃, 112-135 ℃, 112-130 ℃, 112-125 ℃, 112-120 ℃ or 112-115 ℃.
In an embodiment of the present invention, further, the honeysuckle extract and trehalose are mixed with an adjuvant in step a), preferably in an amount of 0-89% (w/w), more preferably 0-79% (w/w), 0-69% (w/w), 0-59% (w/w), 0-49% (w/w), 0-39% (w/w), 0-29% (w/w) or 0-19% (w/w), based on the total weight of the instant honeysuckle extract.
In an embodiment of the invention, the honeysuckle extract, trehalose and/or adjuvants are comminuted before, during or after the mixing in step a).
In an embodiment of the present invention, the honeysuckle extract, trehalose and/or adjuvants are dissolved before, during or after mixing in step a), said solvent being selected from water or organic solvents.
In an embodiment of the invention, before step b), the mixture is subjected to stirring, shearing, homogenizing and/or centrifuging, and then to oven-drying.
In an embodiment of the invention, the granulation is performed before the high temperature heat treatment.
In an embodiment of the invention, a size stabilization or a sieving is carried out in step c).
The applicant surprisingly found that trehalose can be mixed with honeysuckle extract uniformly to produce drastic shrinkage in a non-molten state within a specific temperature range, and the molecular morphology of the trehalose is changed, so that the trehalose can completely restrain and isolate viscous groups of the honeysuckle extract which is easy to glue, and the viscous groups can not agglomerate and disperse easily, and the instant honeysuckle extract produced by the method greatly improves the dispersibility and dissolution speed in water.
Drawings
FIG. 1: a graph comparing the dissolution of instant honeysuckle extract prepared according to the method of example with that of a control honeysuckle extract, wherein fig. 1a is a graph of the dissolution of instant honeysuckle extract prepared according to the method of example 5; FIG. 1b is a drawing showing the dissolution of the extract of honeysuckle flower produced by Jiangxi Qingyuan Chinese Biotech Co.
Detailed Description
The technical solution of the present invention is further specifically described below by way of specific examples, but the following examples should not be construed as limiting the present invention.
In the following examples, trehalose was purchased from japan forest resources co; other additives are available from Guangzhou Daizhihe food and chemical Co.
In each of the following examples, the percentages of each substance are percentages based on the total weight of the instant product produced.
Example 1
The preparation method comprises the steps of mixing 47.5% of trehalose, 2.5% of sodium citrate and 50% of honeysuckle extract (Jiangxi Qingyuan Han Biotech Co., Ltd.), crushing, placing in a drying device, carrying out heat treatment at 150 ℃ for 3 minutes, and then carrying out granulation and sieving to obtain the instant honeysuckle extract.
Adding 8g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 2%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, the concentration of which is 2%:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 2
55% of trehalose, 10% of maltodextrin and 35% of honeysuckle extract are mixed and crushed, then the mixture is placed in a drying device for heat treatment for 4 minutes at 140 ℃, and then the instant honeysuckle extract is obtained after granulation and sieving.
Adding 10g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.75%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.75%:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 3
66% of trehalose, 4% of erythritol and 30% of honeysuckle extract are mixed, crushed, placed in a drying device for heat treatment at 150 ℃ for 3 minutes, and then subjected to granulation and sieving to obtain the instant honeysuckle extract.
Adding 10g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 4
70 percent of trehalose, 5 percent of sodium carboxymethyl starch and 25 percent of honeysuckle extract are mixed and crushed, then the mixture is placed in a drying device for heat treatment for 3 minutes at 160 ℃, and then the instant honeysuckle extract is obtained after granulation and sieving.
Adding 12g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 5
Mixing 75% trehalose and 25% flos Lonicerae extract, pulverizing, heating at 210 deg.C for 2 min in a drying equipment, grading, and sieving to obtain instant flos Lonicerae extract.
Adding 16g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 2%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, the concentration of which is 2%:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 6
99% trehalose and 1% honeysuckle extract are mixed, crushed, then placed in a drying device for heat treatment for 40 minutes at 112 ℃, and then subjected to granulation and sieving to obtain the instant honeysuckle extract.
Adding 40g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 0.2%; the control test was a solution prepared from flos Lonicerae extract (0.2% concentration) of Jiangxi Qingyuan Han Biotech Co., Ltd.
Item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test More than 10 fish eyes Incompletely dissolved in 10 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 1 minute Are all dispersed
Example 7
Mixing 10% trehalose and 90% flos Lonicerae extract, pulverizing, heating at 170 deg.C for 3 min in a drying equipment, grading, and sieving to obtain instant flos Lonicerae extract.
Adding 5g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 2.25%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 2.25 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 8
The preparation method comprises the following steps of mixing 65% of trehalose, 10% of inulin and 25% of honeysuckle extract, crushing, then placing in a drying device for heat treatment at 130 ℃ for 10 minutes, and then carrying out granulation and sieving to obtain the instant honeysuckle extract.
Adding 12g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 9
60% trehalose, 10% potassium chloride and 30% honeysuckle extract are mixed, crushed and granulated, then the mixture is placed in a drying device for heat treatment for 3 minutes at 150 ℃, and then the mixture is granulated and sieved to obtain the instant honeysuckle extract.
Adding 10g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 10
80% trehalose and 20% honeysuckle extract are mixed, crushed, then placed in a drying device for heat treatment at 150 ℃ for 3 minutes, and then subjected to granulation and sieving to obtain the instant honeysuckle extract.
Adding 16g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.6%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.6 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 11
20% of trehalose, 76% of maltodextrin, 3% of potassium chloride and 1% of honeysuckle extract are mixed, crushed and granulated, then the mixture is placed in a drying device for heat treatment for 60 minutes at 135 ℃, and then the instant honeysuckle extract is obtained after granulation and sieving.
Adding 40g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 0.2%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 0.2%:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test More than 10 fish eyes Incompletely dissolved in 10 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 1 minute Are all dispersed
Example 12
Mixing 25% trehalose, 25% maltodextrin and 50% flos Lonicerae extract, pulverizing, heating at 145 deg.C for 40 min in a drying device, grading, and sieving to obtain instant flos Lonicerae extract.
Adding 6g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 13
50% trehalose and 50% honeysuckle extract are mixed, crushed and granulated, then the mixture is placed in a drying device for heat treatment for 3 minutes at 186 ℃, and then the mixture is granulated and sieved to obtain the honeysuckle extract.
Adding 6g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
Example 14
50 percent of trehalose and 50 percent of honeysuckle extract are mixed and crushed, then the mixture is placed in a drying device for heat treatment for 3 minutes at 150 ℃, and then the mixture is granulated and sieved to obtain the instant honeysuckle extract.
Adding 6g of the prepared instant honeysuckle extract into 200ml of water, and stirring, wherein the actual concentration of the honeysuckle extract is 1.5%; the control test is a solution prepared by using honeysuckle extract produced by Jiangxi Qingyuan Han Biotech limited, and the concentration of the solution is 1.5 percent:
item Fish eye count in 10 minutes Dissolution test Dispersibility
Control test Not counting fish eyes Not completely dissolved in 20 minutes Agglomerate of dough
The invention No fish eye Completely dissolved in 2 minutes Are all dispersed
The examples described above are only some preferred embodiments of the present invention and are not intended to limit the present invention in any way. On the basis of the invention, some modifications and optimizations of the formulation and process are possible. Accordingly, it is intended that the present invention cover the modifications and variations of this invention provided they do not depart from the spirit of the invention and its scope.

Claims (93)

1. An instant honeysuckle extract, characterized in that, according to the total weight of the instant honeysuckle extract, the instant honeysuckle extract comprises:
1-90% (w/w) of honeysuckle extract and 10-99% (w/w) of trehalose, wherein the instant honeysuckle extract is prepared by mixing trehalose and the honeysuckle extract and then carrying out heat treatment on the mixture at 112-210 ℃ in drying equipment.
2. The instant honeysuckle extract according to claim 1, comprising 1-80% (w/w) of the honeysuckle extract.
3. The instant honeysuckle extract according to claim 1, comprising 1-70% (w/w) of the honeysuckle extract.
4. The instant honeysuckle extract according to claim 1, comprising 1-60% (w/w) of the honeysuckle extract.
5. The instant honeysuckle extract according to claim 1, comprising 1-50% (w/w) of the honeysuckle extract.
6. The instant honeysuckle extract according to claim 1, comprising 1-40% (w/w) of the honeysuckle extract.
7. The instant honeysuckle extract according to claim 1, comprising 1-30% (w/w) of the honeysuckle extract.
8. The instant honeysuckle extract according to claim 1, comprising 1-20% (w/w) of the honeysuckle extract.
9. The instant honeysuckle extract according to claim 1, comprising 1-10% (w/w) of the honeysuckle extract.
10. The instant honeysuckle extract according to claim 1, comprising 10-89% (w/w) trehalose.
11. The instant honeysuckle extract according to claim 1, comprising 10-79% (w/w) trehalose.
12. The instant honeysuckle extract according to claim 1, comprising 10-69% (w/w) trehalose.
13. The instant honeysuckle extract according to claim 1, comprising 10-59% (w/w) trehalose.
14. The instant honeysuckle extract according to claim 1, comprising 10-49% (w/w) trehalose.
15. The instant honeysuckle extract according to claim 1, comprising 10-39% (w/w) trehalose.
16. The instant honeysuckle extract according to claim 1, comprising 10-29% (w/w) trehalose.
17. The instant honeysuckle extract according to claim 1, comprising 10-19% (w/w) trehalose.
18. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 205 ℃ in a drying device.
19. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 200 ℃ in a drying device.
20. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 195 ℃ in a drying apparatus.
21. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 190 ℃ in a drying device.
22. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 185 ℃ in a drying apparatus.
23. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 180 ℃ in a drying apparatus.
24. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at a temperature of 112 ℃ to 175 ℃ in a drying apparatus.
25. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 170 ℃ in a drying device.
26. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture in a drying apparatus at a temperature of 112 ℃ to 165 ℃.
27. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 160 ℃ in a drying apparatus.
28. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 155 ℃ in a drying device.
29. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 150 ℃ in a drying apparatus.
30. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 145 ℃ in a drying device.
31. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 140 ℃ in a drying device.
32. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 135 ℃ in a drying device.
33. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 130 ℃ in a drying apparatus.
34. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 125 ℃ in a drying apparatus.
35. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and the honeysuckle extract and heat-treating the mixture at 112 ℃ to 120 ℃ in a drying device.
36. The instant honeysuckle extract according to any one of claims 1 to 17, wherein the instant product is prepared by mixing trehalose and honeysuckle extract and heat-treating the mixture at 112 ℃ to 115 ℃ in a drying apparatus.
37. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 89% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
38. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 79% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
39. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 69% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
40. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 59% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
41. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 49% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
42. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 39% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
43. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 29% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
44. The instant honeysuckle extract according to any one of claims 1 to 17, further comprising 0 to 19% (w/w) of an adjuvant, based on the total weight of the instant honeysuckle extract.
45. A method of preparing an instant honeysuckle extract comprising:
a) mixing the honeysuckle extract with trehalose, wherein the content of the honeysuckle extract is 1-90% (w/w) according to the total weight of the instant honeysuckle extract; the content of trehalose is 10-99% (w/w);
b) heat treating the mixed material in a drying device at 112-210 ℃.
46. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-80% (w/w).
47. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-70% (w/w).
48. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-60% (w/w).
49. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-50% (w/w).
50. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-40% (w/w).
51. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-30% (w/w).
52. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-20% (w/w).
53. The method of claim 45, wherein the honeysuckle extract is present in an amount of 1-10% (w/w).
54. The method of claim 45, wherein the trehalose is present in an amount of 10-89% (w/w).
55. The method of claim 45, wherein the trehalose is present in an amount of 10-79% (w/w).
56. The method of claim 45, wherein the trehalose is present in an amount of 10-69% (w/w).
57. The method of claim 45, wherein the trehalose is present in an amount of 10-59% (w/w).
58. The method of claim 45, wherein the trehalose is present in an amount of 10-49% (w/w).
59. The method of claim 45, wherein the trehalose is present in an amount of 10-39% (w/w).
60. The method of claim 45, wherein the trehalose is present in an amount of 10-29% (w/w).
61. The method of claim 45, wherein the trehalose is present in an amount of 10-19% (w/w).
62. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 200 ℃.
63. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 195 ℃ in a drying apparatus.
64. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 190 ℃ in a drying apparatus.
65. The method of claim 45, wherein the mixture is subjected to a high temperature heat treatment at 112 ℃ to 185 ℃ in a drying apparatus.
66. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 180 ℃ in a drying apparatus.
67. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at a temperature of 112 ℃ to 175 ℃ in a drying apparatus.
68. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 170 ℃.
69. The method of claim 45, wherein the mixture is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 165 ℃.
70. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 160 ℃.
71. The method of claim 45, wherein the mixture is subjected to a high temperature heat treatment at 112 ℃ to 155 ℃ in a drying apparatus.
72. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 150 ℃.
73. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment in a drying apparatus at a temperature of 112 ℃ to 145 ℃.
74. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 140 ℃ in a drying apparatus.
75. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 135 ℃ in a drying apparatus.
76. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 130 ℃ in a drying apparatus.
77. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 125 ℃ in a drying apparatus.
78. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 120 ℃ in a drying apparatus.
79. The method of claim 45, wherein the mixed material is subjected to a high temperature heat treatment at 112 ℃ to 115 ℃ in a drying apparatus.
80. The method of any one of claims 45-79, wherein the honeysuckle extract and trehalose in step a) are mixed with excipients.
81. The method of claim 80, wherein the adjuvant is present in an amount of 0-89% (w/w) based on the total weight of the instant honeysuckle extract.
82. The method of claim 80, wherein the adjuvant is present in an amount of 0-79% (w/w) based on the total weight of the instant honeysuckle extract.
83. The method of claim 80, wherein the adjuvant is present in an amount of 0-69% (w/w) based on the total weight of the instant honeysuckle extract.
84. The method of claim 80, wherein the adjuvant is present in an amount of 0-59% (w/w) based on the total weight of the instant honeysuckle extract.
85. The method of claim 80, wherein the adjuvant is present in an amount of 0-49% (w/w) based on the total weight of the instant honeysuckle extract.
86. The method of claim 80, wherein the adjuvant is present in an amount of 0-39% (w/w) based on the total weight of the instant honeysuckle extract.
87. The method of claim 80, wherein the adjuvant is present in an amount of 0-29% (w/w) based on the total weight of the instant honeysuckle extract.
88. The method of claim 80, wherein the adjuvant is present in an amount of 0-19% (w/w) based on the total weight of the instant honeysuckle extract.
89. The method of claim 45, wherein the honeysuckle extract, trehalose and/or excipients are simultaneously or separately comminuted before, during or after mixing in step a).
90. The method of claim 45, wherein the honeysuckle extract, trehalose and/or excipients are dissolved separately or simultaneously before, during or after mixing in step a), said solvent being selected from water or an organic solvent.
91. The method of claim 45, wherein prior to step b), the mixture is subjected to homogenisation, shearing, homogenisation and/or centrifugation followed by oven drying.
92. The method of claim 45, wherein the granulation is performed prior to the high temperature heat treatment.
93. The process of claim 45, wherein the process includes step c) of size stabilization or sizing.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156967A (en) * 1994-06-02 1997-08-13 廓德伦特控股剑桥有限公司 Method of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby
CN1213299A (en) * 1996-02-09 1999-04-07 剑桥夸准脱控股有限公司 Solid formulations containing trehalose
CN1652699A (en) * 2002-05-08 2005-08-10 高砂香料工业株式会社 Powder composition
CN101257801A (en) * 2005-04-15 2008-09-03 柯米食品工程股份有限公司 Instant product
CN101926489A (en) * 2010-07-01 2010-12-29 石狮市华宝明祥食品有限公司 Algae drink and processing technology thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156967A (en) * 1994-06-02 1997-08-13 廓德伦特控股剑桥有限公司 Method of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby
CN1213299A (en) * 1996-02-09 1999-04-07 剑桥夸准脱控股有限公司 Solid formulations containing trehalose
CN1652699A (en) * 2002-05-08 2005-08-10 高砂香料工业株式会社 Powder composition
CN101257801A (en) * 2005-04-15 2008-09-03 柯米食品工程股份有限公司 Instant product
CN101926489A (en) * 2010-07-01 2010-12-29 石狮市华宝明祥食品有限公司 Algae drink and processing technology thereof

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