DE69431714T2 - Verfahren und zusammensetzung zur verdauung von gewebe - Google Patents

Verfahren und zusammensetzung zur verdauung von gewebe

Info

Publication number
DE69431714T2
DE69431714T2 DE69431714T DE69431714T DE69431714T2 DE 69431714 T2 DE69431714 T2 DE 69431714T2 DE 69431714 T DE69431714 T DE 69431714T DE 69431714 T DE69431714 T DE 69431714T DE 69431714 T2 DE69431714 T2 DE 69431714T2
Authority
DE
Germany
Prior art keywords
composition
digesting tissue
digesting
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431714T
Other languages
English (en)
Other versions
DE69431714D1 (de
Inventor
Catherine Lee
Cynthia Hornacek
Thanh Dinh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Application granted granted Critical
Publication of DE69431714D1 publication Critical patent/DE69431714D1/de
Publication of DE69431714T2 publication Critical patent/DE69431714T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69431714T 1993-04-16 1994-04-13 Verfahren und zusammensetzung zur verdauung von gewebe Expired - Fee Related DE69431714T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/049,015 US5422261A (en) 1993-04-16 1993-04-16 Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells
PCT/US1994/004070 WO1994023743A1 (en) 1993-04-16 1994-04-13 Method and compositions for digesting tissue

Publications (2)

Publication Number Publication Date
DE69431714D1 DE69431714D1 (de) 2002-12-19
DE69431714T2 true DE69431714T2 (de) 2003-09-18

Family

ID=21957634

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431714T Expired - Fee Related DE69431714T2 (de) 1993-04-16 1994-04-13 Verfahren und zusammensetzung zur verdauung von gewebe

Country Status (6)

Country Link
US (2) US5422261A (de)
EP (1) EP0693935B1 (de)
JP (1) JPH08509219A (de)
CA (1) CA2160532A1 (de)
DE (1) DE69431714T2 (de)
WO (1) WO1994023743A1 (de)

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US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
WO1996000283A1 (en) * 1994-06-24 1996-01-04 Boehringer Mannheim Corporation A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum
US6958150B2 (en) * 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
WO1996034093A1 (en) * 1995-04-25 1996-10-31 Baxter International Inc. Composition containing collagenase and chymopapain for isolating hepatocytes and pancreatic islet cells
US5670358A (en) * 1995-10-19 1997-09-23 Baxter International Inc. Method for inhibiting chymopapain and papain enzyme activity with polysaccharides of animal origin
US5989888A (en) * 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
US5830741A (en) * 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
WO1998036704A1 (en) * 1997-02-20 1998-08-27 Keller Gregory S Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US7767452B2 (en) 1997-02-20 2010-08-03 Kleinsek Don A Tissue treatments with adipocyte cells
US5891083A (en) * 1997-04-22 1999-04-06 Capella; Rafael F. Suction lipolysis
WO1999016865A1 (en) * 1997-09-26 1999-04-08 Novo Nordisk A/S Use of proteases in passaging of adherent animal or human cell cultures
US5955257A (en) * 1997-10-21 1999-09-21 Regents Of The University Of Minnesota Infusible grade short-term cell storage medium for mononuclear cells
US6899889B1 (en) * 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US6830756B2 (en) 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
CA2385488C (en) * 1999-09-24 2015-07-07 Nicholas F. Franano Systems and methods for opening obstructed biological conduits
US6428785B1 (en) 1999-10-28 2002-08-06 Immunolytics Inc. Method and composition for treating prostate cancer
US7799325B2 (en) * 1999-11-05 2010-09-21 Kleinsek Donald A Removal of hypertrophic scars
US20080267923A2 (en) * 1999-11-05 2008-10-30 Donald Kleinsek Hair undifferentiated cells
US20080286242A2 (en) * 1999-11-05 2008-11-20 Donald Kleinsek Augmentation and repair of spincter defects with cells including mesenchymal cells
EP1263931A4 (de) * 1999-11-05 2009-07-15 Gerigene Medical Corp Verstärkung und reparatur von altersbedingten schwächen des weichteilgewebes
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
US7112576B1 (en) 1999-12-10 2006-09-26 Regents Of The University Of Minnesota Compositions and methods for cryopreservation of peripheral blood lymphocytes
US20090130066A1 (en) * 2000-11-06 2009-05-21 Gerigene Medical Corporation Augmentation and repair of sphincter defects with cells including muscle cells
WO2002092794A2 (en) * 2001-05-17 2002-11-21 Isotis N.V. Isolation method of mesenchymal cells
US6623959B2 (en) 2001-06-13 2003-09-23 Ethicon, Inc. Devices and methods for cell harvesting
ES2396964T3 (es) * 2001-10-01 2013-03-01 Matrizyme Pharma Corporation Uso de colagenasa para facilitar el cruce con alambre de guia de oclusiones arteriales crónicas
ES2428941T3 (es) * 2003-03-10 2013-11-12 Expression Pathology, Inc. Preparación líquida de tejidos a partir de muestras biológicas, tejidos y células procesadas histopatológicamente
JP2007508018A (ja) 2003-10-08 2007-04-05 べト−ステム インコーポレイテッド 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US8579852B2 (en) * 2006-09-14 2013-11-12 Omeed Memar Apparatus and methods for repairing tissue defects
US7771754B2 (en) * 2006-09-14 2010-08-10 Omeed Memar Apparatus and methods for repairing tissue defects
EP2034010A1 (de) * 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Zusammensetzungen zur Reparatur und/oder Behandlung von verletztem Rückenmarksgewebe
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
WO2010108237A1 (en) 2009-03-27 2010-09-30 Orthocell Pty Ltd Method of tissue repair
MX2012006661A (es) 2009-12-08 2012-11-12 Healthpoint Ltd Composiciones enzimaticas de desbridamiento de heridas con actividad enzimatica mejorada.
SG10201912961QA (en) 2011-05-18 2020-03-30 Univ California Compositions and Methods for Treating Retinal Diseases
WO2013070734A1 (en) 2011-11-07 2013-05-16 Chaudhry Hina W Methods of cardiac repair
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
CA3044250A1 (en) 2016-11-17 2018-05-24 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
TW201920654A (zh) 2017-06-05 2019-06-01 加州大學董事會 用來治療視網膜疾病的組合物及其製造與使用方法

Family Cites Families (18)

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US3558433A (en) * 1967-11-07 1971-01-26 Baxter Laboratories Inc Process for purification of chymopapain
US4167447A (en) * 1976-07-19 1979-09-11 The United States Of America As Represented By The Secretary Of Agriculture Method for insolubilizing enzymes on chitosan
DE2633601A1 (de) * 1976-07-27 1978-02-02 Henkel Kgaa Fluessiges, als wasch- und reinigungsmittel verwendbares, enzymhaltiges konzentrat
JPS5411293A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease
JPS5411294A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease
GB2064543A (en) * 1979-12-07 1981-06-17 Slovenska Akademia Vied An Agent for the Release of Cells From Tissues or From the Surface of a Cultivation Vessel
FR2474052B1 (fr) * 1980-01-21 1984-04-20 Agronomique Inst Nat Rech Nouvelle collagenase, procede d'obtention et applications
US4374926A (en) * 1981-05-13 1983-02-22 Smith Laboratories, Inc. Method for the production of improved chymopapain
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
US4812314A (en) * 1986-02-24 1989-03-14 Yissum Research & Dev. Co. Of The Hebrew Univ. Of Jerusalem And Hadassah Medical Organization Lipid replacement therapy
US5227157A (en) * 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
DE3713197A1 (de) * 1987-04-18 1988-11-03 Knoll Ag Verfahren zur langzeitkultur von bandscheiben und daraus isolierbare zellkulturen
US4978332A (en) * 1987-09-28 1990-12-18 Matrix Pharmaceutical, Inc. Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas
SE8801701D0 (sv) * 1988-05-05 1988-05-05 Pharmacia Ab Production technology based on enzymic method
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
EP0444270A1 (de) * 1990-02-26 1991-09-04 Thomas Jefferson University Vorrichtung zur Abscheidung von Endothelzellen
US5177017A (en) * 1990-03-22 1993-01-05 Trigen, Inc. Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum

Also Published As

Publication number Publication date
US5424208A (en) 1995-06-13
JPH08509219A (ja) 1996-10-01
CA2160532A1 (en) 1994-10-27
WO1994023743A1 (en) 1994-10-27
US5422261A (en) 1995-06-06
EP0693935B1 (de) 2002-11-13
DE69431714D1 (de) 2002-12-19
EP0693935A1 (de) 1996-01-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee