DE69429990T2 - Verwendung vonSisovaleramid als mildes anxiolytisches und sedatives Mittel - Google Patents

Verwendung vonSisovaleramid als mildes anxiolytisches und sedatives Mittel

Info

Publication number
DE69429990T2
DE69429990T2 DE69429990T DE69429990T DE69429990T2 DE 69429990 T2 DE69429990 T2 DE 69429990T2 DE 69429990 T DE69429990 T DE 69429990T DE 69429990 T DE69429990 T DE 69429990T DE 69429990 T2 DE69429990 T2 DE 69429990T2
Authority
DE
Germany
Prior art keywords
isovaleramide
sedative
mild
anxiolytic
dosage levels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429990T
Other languages
English (en)
Other versions
DE69429990D1 (de
Inventor
F Balandrin
Wagenen C Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Pharmaceuticals Inc filed Critical NPS Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69429990D1 publication Critical patent/DE69429990D1/de
Publication of DE69429990T2 publication Critical patent/DE69429990T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69429990T 1993-06-11 1994-06-10 Verwendung vonSisovaleramid als mildes anxiolytisches und sedatives Mittel Expired - Fee Related DE69429990T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/075,126 US5506268A (en) 1993-06-11 1993-06-11 Use of isovaleramide as a mild anxiolytic and sedative agent
PCT/US1994/006356 WO1994028888A1 (en) 1993-06-11 1994-06-10 Use of isovaleramide as a mild anxiolytic and mild sedative agent

Publications (2)

Publication Number Publication Date
DE69429990D1 DE69429990D1 (de) 2002-04-04
DE69429990T2 true DE69429990T2 (de) 2002-09-05

Family

ID=22123718

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429990T Expired - Fee Related DE69429990T2 (de) 1993-06-11 1994-06-10 Verwendung vonSisovaleramid als mildes anxiolytisches und sedatives Mittel

Country Status (15)

Country Link
US (2) US5506268A (de)
EP (1) EP0706385B1 (de)
JP (2) JP3790267B2 (de)
KR (1) KR100341993B1 (de)
CN (1) CN1108793C (de)
AT (1) ATE213630T1 (de)
CA (1) CA2164842C (de)
DE (1) DE69429990T2 (de)
DK (1) DK0706385T3 (de)
ES (1) ES2170770T3 (de)
IL (1) IL109982A (de)
PT (1) PT706385E (de)
RU (1) RU2136271C1 (de)
TW (1) TW420606B (de)
WO (1) WO1994028888A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
US5786382A (en) * 1995-11-03 1998-07-28 Childers-Zadah; Vsande Use of valerian plant and/or root as a scent-attractant for stimulating canines and felines
US6589994B1 (en) * 1996-08-30 2003-07-08 Nps Pharmaceuticals, Inc. Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
EP0938304B1 (de) * 1996-08-30 2004-12-15 Nps Pharmaceuticals, Inc. Isovaleramid zur behandlung von schüttelkrämpfen, epilepsie, kopfschmerzen und spastischer lähmung
IL120006A (en) * 1997-01-14 2000-12-06 Yissum Res Dev Co Valnoctamide stereoisomers and a method for their synthesis and separation
DE69832302D1 (de) 1997-12-10 2005-12-15 Nps Pharma Inc Antikonvulsive und zns-aktive bis-fluoralkylamide
ES2242385T3 (es) * 1998-03-04 2005-11-01 Nps Pharmaceuticals, Inc. Composiciones que incluyen amina isovalerica e ibuprofeno.
EP1576962A1 (de) * 1998-03-04 2005-09-21 Nps Pharmaceuticals, Inc. Zusammensetzungen enthaltend Isovalerianamide zusammen mit ibuprofen
US6383527B1 (en) * 1999-03-04 2002-05-07 Nps Pharmaceuticals, Inc. Compositions comprising valerian extracts, isovaleric acid or derivatives thereof with a NSAID
US6346283B1 (en) 1999-03-26 2002-02-12 Ancile Pharmaceuticals Use of valeriana for the treatment of restless leg syndrome and related disorders
US7235258B1 (en) 1999-10-19 2007-06-26 Nps Pharmaceuticals, Inc. Sustained-release formulations for treating CNS-mediated disorders
RU2209062C1 (ru) * 2002-03-19 2003-07-27 Институт физиологии им. И.П.Павлова РАН Вещество, обладающее седативным действием
US6932971B2 (en) 2002-07-18 2005-08-23 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
WO2006012603A2 (en) * 2004-07-22 2006-02-02 Nps Pharmaceuticals, Inc. Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases
US9212155B2 (en) 2008-03-19 2015-12-15 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
KR102222910B1 (ko) 2019-04-30 2021-03-04 차은정 평상형 원목침대
KR102227555B1 (ko) 2019-12-24 2021-03-15 주식회사 리빙테크 황토볼이 구비된 편백나무 침대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4205083A (en) * 1968-03-30 1980-05-27 Kali-Chemie Aktiengesellschaft Cyclopentapyrans
US4246282A (en) * 1979-06-07 1981-01-20 Labaz ω-Dialkylalkanoic acid derivatives used to induce antianoxic activity
DE3026579A1 (de) * 1980-07-14 1982-02-11 Kali-Chemie Pharma Gmbh, 3000 Hannover 2,9-dioxatricyclo (4,3,1,o(pfeil hoch)3,7(pfeil hoch)) decane
US4814183A (en) * 1987-08-31 1989-03-21 Merck & Co., Inc. Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
DE4008403A1 (de) * 1990-03-16 1991-09-19 Merck Patent Gmbh Glykolsaeurederivate
FR2674524B1 (fr) * 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
IL109982A (en) 1998-09-24
US5763494A (en) 1998-06-09
IL109982A0 (en) 1994-10-07
CN1108793C (zh) 2003-05-21
AU701360B2 (en) 1999-01-28
TW420606B (en) 2001-02-01
ATE213630T1 (de) 2002-03-15
RU2136271C1 (ru) 1999-09-10
KR100341993B1 (ko) 2002-11-29
JPH09501908A (ja) 1997-02-25
ES2170770T3 (es) 2002-08-16
CA2164842A1 (en) 1994-12-22
EP0706385B1 (de) 2002-02-27
AU7100694A (en) 1995-01-03
DK0706385T3 (da) 2002-04-29
JP3790267B2 (ja) 2006-06-28
PT706385E (pt) 2002-07-31
EP0706385A1 (de) 1996-04-17
US5506268A (en) 1996-04-09
CN1127472A (zh) 1996-07-24
CA2164842C (en) 2006-08-29
DE69429990D1 (de) 2002-04-04
JP2006169259A (ja) 2006-06-29
WO1994028888A1 (en) 1994-12-22

Similar Documents

Publication Publication Date Title
DE69429990T2 (de) Verwendung vonSisovaleramid als mildes anxiolytisches und sedatives Mittel
AU4718496A (en) Use of aerogels in agriculture
DE69735581D1 (de) Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung
DE69421778D1 (de) Verwendung von wirksamen Mengen von aktiven Stoffen zur Behandlung von Mischhaut
DE69521799D1 (de) Polymer umhüllte tablette enthaltend amoxicillin und clavulanat
ATE135231T1 (de) Verwendung von ''cartilage-inducing factor'' (cif) zur behandlung von hemato- oder lymphopoietischen krankheiten
ES2160640T3 (es) Nuevos (r)-5-carbamoil-8-fluoro-3-amino disustituido en n,n-3,4-dihidro-2h-1-benzopiranos.
DE69726007D1 (de) Prodrogs und analoga von camptothecin und deren verwendung als arzneimittel
DE69624243T2 (de) Verwendung von unverdaulichen oligosacchariden zur vorbeugung und behandlung von mittelohrentzündung bei menschen
ES2062145T3 (es) 1,8-naftiridinas substituidas.
DE69803054D1 (de) Zusammensetzung auf der basis von pflanzenextrakten und ätherischen ölen, verwendbar in therapeutika, kosmetika und diätnahrung
DE68918120T2 (de) Polyaluminiumdialkylphosphat, dieses enthaltende Ölgeliermittel und dieses enthaltende Mittel zur äusserlichen Anwendung.
BG101849A (en) Bicyclic tachyquinine antagonists, their preparation and use in pharmaceutical compositions
DE69936779D1 (de) Verwendung von ngali nussöl zur behandlung/linderung der arthritisschmerzen und anderer ähnlichen störungen
EP0745597A3 (de) Melatonergische Indanylpiperazine oder Homopiperazine
Kieffer Cosmetic surgery of the aging face: social, psychological, and ethical implications
MX9803681A (es) Inhibicion de la expresion de membrana.
BG101696A (en) Solid dosed out overmectine-aontaining medicamentous forms
NO991047L (no) Transdermal terapeutisk tilnµrming involverende en kombinasjon av aktive substanser inneholdende °striol
IT241365Y1 (it) Anello antisvitamento in gomma speciale per monconi eattacchi avvitati su impianto dentale
MX9603809A (es) Preparado combinado farmaceutico con ketoprofeno.
UA7956C2 (uk) Пристрій для фіксації лікарського засобу на зубі
GEP20002177B (en) Ointment “Levaskani” for Treatment of Wounds and Burns

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee