DE69418321D1 - TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION - Google Patents
TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTIONInfo
- Publication number
- DE69418321D1 DE69418321D1 DE69418321T DE69418321T DE69418321D1 DE 69418321 D1 DE69418321 D1 DE 69418321D1 DE 69418321 T DE69418321 T DE 69418321T DE 69418321 T DE69418321 T DE 69418321T DE 69418321 D1 DE69418321 D1 DE 69418321D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydrofuran
- cyclopentene
- furan
- cyano
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Tricyclic benzazepines having the general formula nd beta -marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran, thiophene, oxazole, pyrrole, pyrroline, tetrahydropyridine or dioxole ring, R1 is H or alkyl, R2 and R3 independently are H, alkoxy, halogen, nitro, cyano or hydroxy, or R2 and R3 together may form a furan, dihydrofuran, cyclopentene or dioxole ring and R4 is H, alkoxy, nitro, cyano, hydroxy or halogen, or a pharmaceutically acceptable salt thereof, are useful in treatment of certain disorders in the central nervous system, e.g., psychosis, pain, depression, sleep disturbances, dyskinesia, Parkinson's disease, stroke.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK93267A DK26793D0 (en) | 1993-03-10 | 1993-03-10 | BENZOFURANYL- OR DIHYDROBENZOFURANYL-SUBSTITUTED TRICYCLIC BENZAZEPINES USING AND PREPARING |
PCT/DK1994/000069 WO1994020472A1 (en) | 1993-03-10 | 1994-02-18 | Heterocyclic compounds, their use and preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69418321D1 true DE69418321D1 (en) | 1999-06-10 |
DE69418321T2 DE69418321T2 (en) | 1999-12-30 |
Family
ID=8091615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69418321T Expired - Lifetime DE69418321T2 (en) | 1993-03-10 | 1994-02-18 | TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION |
Country Status (19)
Country | Link |
---|---|
US (1) | US5512562A (en) |
EP (1) | EP0688320B1 (en) |
JP (1) | JP3779319B2 (en) |
KR (1) | KR960701022A (en) |
CN (1) | CN1045957C (en) |
AT (1) | ATE179700T1 (en) |
AU (1) | AU682494B2 (en) |
CA (1) | CA2157668C (en) |
DE (1) | DE69418321T2 (en) |
DK (2) | DK26793D0 (en) |
ES (1) | ES2133542T3 (en) |
FI (1) | FI111944B (en) |
GR (1) | GR3030864T3 (en) |
IL (1) | IL108730A (en) |
NO (1) | NO953543L (en) |
NZ (1) | NZ262098A (en) |
TW (1) | TW279861B (en) |
WO (1) | WO1994020472A1 (en) |
ZA (1) | ZA941377B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2745815B1 (en) * | 1996-03-08 | 1998-06-26 | Synthelabo | BENZOFURANE DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
JP2000506157A (en) * | 1996-03-08 | 2000-05-23 | サンテラボ | (2-Aminoethyl) benzofuran derivatives, their production and their therapeutic use |
FR2752840A1 (en) * | 1996-08-29 | 1998-03-06 | Synthelabo | 7-Amino ethyl benzothiophene derivatives |
AU742873B2 (en) | 1997-03-12 | 2002-01-17 | Addex Pharma Sa | Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |
US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
AU4727799A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Azepine derivatives having effects on serotonin related systems |
WO2003006466A1 (en) | 2001-07-13 | 2003-01-23 | Pharmacia & Upjohn Company | Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands |
GB0412314D0 (en) * | 2004-06-02 | 2004-07-07 | Glaxo Group Ltd | Compounds |
GB0414795D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Compounds |
CN102140100B (en) * | 2010-01-27 | 2014-06-11 | 爱博新药研发(上海)有限公司 | Polycyclic compound for inhibiting hepatitis C virus efficiently, preparation method thereof and application thereof |
CN105101967B (en) | 2012-12-21 | 2019-06-28 | 雅培控股公司 | As thrombocytin 5-HT2CThe benzazepines of receptors ligand and its application |
CN105566262B (en) * | 2016-01-11 | 2017-10-27 | 华东理工大学 | Alkyl amine compound of benzofuran 7 and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255445A (en) * | 1980-03-07 | 1981-03-10 | Smithkline Corporation | 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
CA1234110A (en) * | 1983-08-12 | 1988-03-15 | Joel G. Berger | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions |
DK180485D0 (en) * | 1985-04-22 | 1985-04-23 | Novo Industri As | NITROGEN CONTAINING COMPOUNDS |
DK157925C (en) * | 1985-04-22 | 1990-08-27 | Novo Industri As | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE |
-
1993
- 1993-03-10 DK DK93267A patent/DK26793D0/en not_active Application Discontinuation
-
1994
- 1994-02-18 JP JP51947094A patent/JP3779319B2/en not_active Expired - Fee Related
- 1994-02-18 AU AU61386/94A patent/AU682494B2/en not_active Ceased
- 1994-02-18 DK DK94908289T patent/DK0688320T3/en active
- 1994-02-18 CA CA002157668A patent/CA2157668C/en not_active Expired - Fee Related
- 1994-02-18 NZ NZ262098A patent/NZ262098A/en not_active IP Right Cessation
- 1994-02-18 CN CN94191882A patent/CN1045957C/en not_active Expired - Fee Related
- 1994-02-18 DE DE69418321T patent/DE69418321T2/en not_active Expired - Lifetime
- 1994-02-18 WO PCT/DK1994/000069 patent/WO1994020472A1/en active IP Right Grant
- 1994-02-18 AT AT94908289T patent/ATE179700T1/en not_active IP Right Cessation
- 1994-02-18 EP EP94908289A patent/EP0688320B1/en not_active Expired - Lifetime
- 1994-02-18 ES ES94908289T patent/ES2133542T3/en not_active Expired - Lifetime
- 1994-02-18 KR KR1019950703762A patent/KR960701022A/en not_active Application Discontinuation
- 1994-02-22 TW TW083101509A patent/TW279861B/zh active
- 1994-02-22 IL IL10873094A patent/IL108730A/en not_active IP Right Cessation
- 1994-02-24 US US08/202,401 patent/US5512562A/en not_active Expired - Lifetime
- 1994-02-28 ZA ZA941377A patent/ZA941377B/en unknown
-
1995
- 1995-09-08 FI FI954229A patent/FI111944B/en not_active IP Right Cessation
- 1995-09-08 NO NO953543A patent/NO953543L/en not_active Application Discontinuation
-
1999
- 1999-07-27 GR GR990401950T patent/GR3030864T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK0688320T3 (en) | 1999-11-01 |
KR960701022A (en) | 1996-02-24 |
US5512562A (en) | 1996-04-30 |
TW279861B (en) | 1996-07-01 |
AU682494B2 (en) | 1997-10-09 |
EP0688320A1 (en) | 1995-12-27 |
ES2133542T3 (en) | 1999-09-16 |
IL108730A (en) | 1999-08-17 |
IL108730A0 (en) | 1994-05-30 |
NO953543D0 (en) | 1995-09-08 |
CA2157668A1 (en) | 1994-09-15 |
ZA941377B (en) | 1995-08-28 |
FI111944B (en) | 2003-10-15 |
ATE179700T1 (en) | 1999-05-15 |
FI954229A (en) | 1995-09-08 |
JPH08507498A (en) | 1996-08-13 |
EP0688320B1 (en) | 1999-05-06 |
NO953543L (en) | 1995-09-08 |
JP3779319B2 (en) | 2006-05-24 |
CA2157668C (en) | 2006-05-30 |
CN1045957C (en) | 1999-10-27 |
FI954229A0 (en) | 1995-09-08 |
CN1121710A (en) | 1996-05-01 |
NZ262098A (en) | 1996-11-26 |
DE69418321T2 (en) | 1999-12-30 |
GR3030864T3 (en) | 1999-11-30 |
DK26793D0 (en) | 1993-03-10 |
AU6138694A (en) | 1994-09-26 |
WO1994020472A1 (en) | 1994-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CENES LTD., CAMBRIDGE, GB |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: ADDEX PHARMACEUTICALS SA, GENF/GENEVE, CH |