DE69418321D1 - TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION - Google Patents

TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION

Info

Publication number
DE69418321D1
DE69418321D1 DE69418321T DE69418321T DE69418321D1 DE 69418321 D1 DE69418321 D1 DE 69418321D1 DE 69418321 T DE69418321 T DE 69418321T DE 69418321 T DE69418321 T DE 69418321T DE 69418321 D1 DE69418321 D1 DE 69418321D1
Authority
DE
Germany
Prior art keywords
dihydrofuran
cyclopentene
furan
cyano
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69418321T
Other languages
German (de)
Other versions
DE69418321T2 (en
Inventor
Rolf Hohlweg
Erik Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Addex Pharmaceuticals SA
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE69418321D1 publication Critical patent/DE69418321D1/en
Publication of DE69418321T2 publication Critical patent/DE69418321T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Tricyclic benzazepines having the general formula nd beta -marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran, thiophene, oxazole, pyrrole, pyrroline, tetrahydropyridine or dioxole ring, R1 is H or alkyl, R2 and R3 independently are H, alkoxy, halogen, nitro, cyano or hydroxy, or R2 and R3 together may form a furan, dihydrofuran, cyclopentene or dioxole ring and R4 is H, alkoxy, nitro, cyano, hydroxy or halogen, or a pharmaceutically acceptable salt thereof, are useful in treatment of certain disorders in the central nervous system, e.g., psychosis, pain, depression, sleep disturbances, dyskinesia, Parkinson's disease, stroke.
DE69418321T 1993-03-10 1994-02-18 TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION Expired - Lifetime DE69418321T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93267A DK26793D0 (en) 1993-03-10 1993-03-10 BENZOFURANYL- OR DIHYDROBENZOFURANYL-SUBSTITUTED TRICYCLIC BENZAZEPINES USING AND PREPARING
PCT/DK1994/000069 WO1994020472A1 (en) 1993-03-10 1994-02-18 Heterocyclic compounds, their use and preparation

Publications (2)

Publication Number Publication Date
DE69418321D1 true DE69418321D1 (en) 1999-06-10
DE69418321T2 DE69418321T2 (en) 1999-12-30

Family

ID=8091615

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418321T Expired - Lifetime DE69418321T2 (en) 1993-03-10 1994-02-18 TRICYCLIC BENZODIAZEPINE, THEIR USE AND PRODUCTION

Country Status (19)

Country Link
US (1) US5512562A (en)
EP (1) EP0688320B1 (en)
JP (1) JP3779319B2 (en)
KR (1) KR960701022A (en)
CN (1) CN1045957C (en)
AT (1) ATE179700T1 (en)
AU (1) AU682494B2 (en)
CA (1) CA2157668C (en)
DE (1) DE69418321T2 (en)
DK (2) DK26793D0 (en)
ES (1) ES2133542T3 (en)
FI (1) FI111944B (en)
GR (1) GR3030864T3 (en)
IL (1) IL108730A (en)
NO (1) NO953543L (en)
NZ (1) NZ262098A (en)
TW (1) TW279861B (en)
WO (1) WO1994020472A1 (en)
ZA (1) ZA941377B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0888324A1 (en) * 1996-03-08 1999-01-07 Synthelabo 2-aminoethyl-benzofuran derivatives, preparation thereof and therapeutical use thereof
FR2745815B1 (en) * 1996-03-08 1998-06-26 Synthelabo BENZOFURANE DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2752840A1 (en) * 1996-08-29 1998-03-06 Synthelabo 7-Amino ethyl benzothiophene derivatives
AU742873B2 (en) * 1997-03-12 2002-01-17 Addex Pharma Sa Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
CA2335310A1 (en) * 1998-06-30 2000-01-06 Kenneth Lee Hauser Azepine derivatives having effects on serotonin related systems
ATE307133T1 (en) 2001-07-13 2005-11-15 Pharmacia & Upjohn Co Llc HEXAHYDROAZEPINO(4.5-G)INDOLES AND INDOLINES AS 5-HT RECEPTOR LIGANDS
GB0412314D0 (en) * 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
GB0414795D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Compounds
PL2528922T3 (en) * 2010-01-27 2018-01-31 Ab Pharma Ltd Polyheterocyclic compounds as hcv inhibitors
MX2015008034A (en) * 2012-12-21 2016-03-07 Abt Holding Co Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof.
CN105566262B (en) * 2016-01-11 2017-10-27 华东理工大学 Alkyl amine compound of benzofuran 7 and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255445A (en) * 1980-03-07 1981-03-10 Smithkline Corporation 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
CA1234110A (en) * 1983-08-12 1988-03-15 Joel G. Berger Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
DK157925C (en) * 1985-04-22 1990-08-27 Novo Industri As 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
DK180485D0 (en) * 1985-04-22 1985-04-23 Novo Industri As NITROGEN CONTAINING COMPOUNDS

Also Published As

Publication number Publication date
KR960701022A (en) 1996-02-24
NZ262098A (en) 1996-11-26
JPH08507498A (en) 1996-08-13
GR3030864T3 (en) 1999-11-30
ES2133542T3 (en) 1999-09-16
EP0688320A1 (en) 1995-12-27
NO953543D0 (en) 1995-09-08
ATE179700T1 (en) 1999-05-15
CN1121710A (en) 1996-05-01
DK26793D0 (en) 1993-03-10
CA2157668C (en) 2006-05-30
CN1045957C (en) 1999-10-27
ZA941377B (en) 1995-08-28
JP3779319B2 (en) 2006-05-24
FI954229A0 (en) 1995-09-08
IL108730A (en) 1999-08-17
FI954229A (en) 1995-09-08
EP0688320B1 (en) 1999-05-06
DK0688320T3 (en) 1999-11-01
CA2157668A1 (en) 1994-09-15
FI111944B (en) 2003-10-15
US5512562A (en) 1996-04-30
WO1994020472A1 (en) 1994-09-15
TW279861B (en) 1996-07-01
DE69418321T2 (en) 1999-12-30
NO953543L (en) 1995-09-08
AU6138694A (en) 1994-09-26
IL108730A0 (en) 1994-05-30
AU682494B2 (en) 1997-10-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CENES LTD., CAMBRIDGE, GB

8327 Change in the person/name/address of the patent owner

Owner name: ADDEX PHARMACEUTICALS SA, GENF/GENEVE, CH