DE69407961D1 - Hydrophobe aminocoumarin-derivate, ihre verwendung als substrate für proteolytische enzyme, oder zur herstellung dieser substrate - Google Patents

Hydrophobe aminocoumarin-derivate, ihre verwendung als substrate für proteolytische enzyme, oder zur herstellung dieser substrate

Info

Publication number
DE69407961D1
DE69407961D1 DE69407961T DE69407961T DE69407961D1 DE 69407961 D1 DE69407961 D1 DE 69407961D1 DE 69407961 T DE69407961 T DE 69407961T DE 69407961 T DE69407961 T DE 69407961T DE 69407961 D1 DE69407961 D1 DE 69407961D1
Authority
DE
Germany
Prior art keywords
substrates
hydrophobic
production
proteolytic enzymes
aminocoumarin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69407961T
Other languages
English (en)
Other versions
DE69407961T2 (de
Inventor
Joseph Chalom
Pascal Batiment C Lesueur
Valerie Charlot
Antoine Reveilleau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SERATEC SARL
Original Assignee
SERATEC SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SERATEC SARL filed Critical SERATEC SARL
Publication of DE69407961D1 publication Critical patent/DE69407961D1/de
Application granted granted Critical
Publication of DE69407961T2 publication Critical patent/DE69407961T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives
    • C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69407961T 1993-04-08 1994-04-08 Hydrophobe aminocoumarin-derivate, ihre verwendung als substrate für proteolytische enzyme, oder zur herstellung dieser substrate Expired - Fee Related DE69407961T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9304190A FR2703683B1 (fr) 1993-04-08 1993-04-08 Dérivés d'aminocoumarines hydrophobes, et leur utilisation comme substrats d'enzymes protéolytiques ou pour la préparation de tels substrats.
PCT/FR1994/000394 WO1994024118A1 (fr) 1993-04-08 1994-04-08 Derives d'aminocoumarines hydrophobes, et leur utilisation comme substrats d'enzymes proteolytiques ou pour la preparation de tels substrats

Publications (2)

Publication Number Publication Date
DE69407961D1 true DE69407961D1 (de) 1998-02-19
DE69407961T2 DE69407961T2 (de) 1998-08-27

Family

ID=9445897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69407961T Expired - Fee Related DE69407961T2 (de) 1993-04-08 1994-04-08 Hydrophobe aminocoumarin-derivate, ihre verwendung als substrate für proteolytische enzyme, oder zur herstellung dieser substrate

Country Status (4)

Country Link
EP (1) EP0693064B1 (de)
DE (1) DE69407961T2 (de)
FR (1) FR2703683B1 (de)
WO (1) WO1994024118A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5280357B2 (ja) 2006-07-07 2013-09-04 スティーブン・ピー・ガベック Ｐｄｅ４の二環式ヘテロアリール阻害剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53108974A (en) * 1977-03-03 1978-09-22 Ajinomoto Co Inc 7-arginylamino-4-methylcoumarin
JPS5524147A (en) * 1978-08-10 1980-02-21 Ajinomoto Co Inc Peptide derivative
US4294923A (en) * 1979-04-23 1981-10-13 Smith Robert E Substrates and method for determining enzymes
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
DE3614647A1 (de) * 1986-04-30 1987-11-05 Euratom 7-phenylessigsaeure-4-alkyl-coumarinylamide, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase
DE69024717T2 (de) * 1989-08-17 1997-02-06 Abbott Lab 7-Hydroxy-Cumarine mit Substituenten in 4-Stellung
FR2677023B1 (fr) * 1991-05-30 1994-02-25 Eurobio Laboratoires Derives de coumarine hydrosolubles, leur preparation et leur utilisation comme substrat d'enzyme.

Also Published As

Publication number Publication date
EP0693064A1 (de) 1996-01-24
WO1994024118A1 (fr) 1994-10-27
DE69407961T2 (de) 1998-08-27
FR2703683A1 (fr) 1994-10-14
FR2703683B1 (fr) 1995-07-07
EP0693064B1 (de) 1998-01-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee