DE69405483T2 - Apparatus for mixing and determining homogeneity "on-line" - Google Patents

Apparatus for mixing and determining homogeneity "on-line"

Info

Publication number
DE69405483T2
DE69405483T2 DE69405483T DE69405483T DE69405483T2 DE 69405483 T2 DE69405483 T2 DE 69405483T2 DE 69405483 T DE69405483 T DE 69405483T DE 69405483 T DE69405483 T DE 69405483T DE 69405483 T2 DE69405483 T2 DE 69405483T2
Authority
DE
Germany
Prior art keywords
line
mixing
homogeneity
determining homogeneity
potency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69405483T
Other languages
German (de)
Other versions
DE69405483D1 (en
Inventor
Paul K Aldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22190294&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69405483(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69405483D1 publication Critical patent/DE69405483D1/en
Application granted granted Critical
Publication of DE69405483T2 publication Critical patent/DE69405483T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/20—Mixers with rotating receptacles with receptacles rotating about an axis at an angle to their longitudinal axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
    • B01F29/401—Receptacles, e.g. provided with liners
    • B01F29/4011—Receptacles, e.g. provided with liners characterised by the shape or cross-section of the receptacle, e.g. of Y-, Z -, S -, or X shape
    • B01F29/40118—V or W shapes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
    • B01F29/403—Disposition of the rotor axis
    • B01F29/4036—Disposition of the rotor axis with a plurality of rotating receptacles
    • B01F29/40363—Disposition of the rotor axis with a plurality of rotating receptacles having perpendicular axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/60—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/60—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
    • B01F29/62—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers without bars, i.e. without mixing elements; characterised by the shape or cross section of the receptacle, e.g. of Y-, Z-, S- or X- shape; with cylindrical receptacles rotating about an axis at an angle to their longitudinal axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71705—Feed mechanisms characterised by the means for feeding the components to the mixer using belts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms

Abstract

This invention relates to an apparatus for mixing compositions of matter into a homogeneous mixture and detecting on-line the homogeneity and potency of the mixture, and a method for using the same. More particularly, this invention relates to an apparatus for mixing the components of a pharmaceutical composition into a homogeneous mixture and detecting on-line the homogeneity and potency of said pharmaceutical composition. <IMAGE>
DE69405483T 1993-06-29 1994-06-03 Apparatus for mixing and determining homogeneity "on-line" Expired - Fee Related DE69405483T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8523093A 1993-06-29 1993-06-29

Publications (2)

Publication Number Publication Date
DE69405483D1 DE69405483D1 (en) 1997-10-16
DE69405483T2 true DE69405483T2 (en) 1998-01-15

Family

ID=22190294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69405483T Expired - Fee Related DE69405483T2 (en) 1993-06-29 1994-06-03 Apparatus for mixing and determining homogeneity "on-line"

Country Status (12)

Country Link
EP (1) EP0631810B1 (en)
JP (1) JP2650619B2 (en)
KR (1) KR0162110B1 (en)
CN (1) CN1062490C (en)
AT (1) ATE157905T1 (en)
AU (1) AU660875B2 (en)
BR (1) BR9402570A (en)
CA (1) CA2126826C (en)
DE (1) DE69405483T2 (en)
DK (1) DK0631810T3 (en)
ES (1) ES2106449T3 (en)
GR (1) GR3025143T3 (en)

Families Citing this family (36)

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ITBO940193A1 (en) * 1994-05-06 1995-11-06 Corob Srl DEVICE FOR MIXING PAINTS, VARNISHES AND FLUID PRODUCTS IN GENERAL AND PROCEDURE FOR ITS CONTROL.
US5504332A (en) * 1994-08-26 1996-04-02 Merck & Co., Inc. Method and system for determining the homogeneity of tablets
EP0706050A1 (en) * 1994-10-07 1996-04-10 Bp Chemicals S.N.C. Lubricant property determination
EP0706041A1 (en) * 1994-10-07 1996-04-10 Bp Chemicals S.N.C. Chemicals property determination
EP0801298B1 (en) * 1996-04-09 2006-06-21 Innovene Europe Limited Control of process
EP0706049A1 (en) * 1994-10-07 1996-04-10 Bp Chemicals S.N.C. Cracking property determination
EP0706040A1 (en) * 1994-10-07 1996-04-10 Bp Chemicals S.N.C. Property determination
IT232075Y1 (en) * 1994-10-11 1999-08-16 Corob Srl MIXER OF PRODUCTS GENERALLY LOCATED IN CONTAINERS AND SUPPORT AND CLAMPING GROUP FOR AT LEAST ONE OF SUCH CONTAINERS,
EP0801299B1 (en) * 1996-04-09 2004-03-17 Eutech Engineering Solutions Limited Process control
SE9802690D0 (en) * 1998-08-07 1998-08-07 Astra Ab Mixing apparatus
GB0003641D0 (en) * 2000-02-17 2000-04-05 Astrazeneca Uk Ltd Mixing apparatus and method
NZ519822A (en) * 2000-02-17 2004-02-27 Astrazeneca Uk Ltd Mixing apparatus and method
SE0000522D0 (en) * 2000-02-17 2000-02-17 Astrazeneca Ab Mixing apparatus
AU2003228683A1 (en) 2002-04-25 2003-11-10 Glaxo Group Limited Magnetoacoustic sensor system and associated method for sensing environmental conditions
DE102007014844B3 (en) * 2007-03-28 2008-06-05 Glatt Systemtechnik Gmbh Observation window's optical transmissibility monitoring method, involves outputting analysis signal by analysis unit when spectroscopic data does not decrease below product-specific threshold value within preset time
JP2009247999A (en) * 2008-04-07 2009-10-29 Nisshin Engineering Co Ltd Mixer
WO2011086380A2 (en) * 2010-01-15 2011-07-21 Malvern Instruments Limited Spectrometric characterization of heterogeneity
DE102011113880A1 (en) 2011-09-22 2013-03-28 Haver Engineering Gmbh Pelletizer and method
CN103657488A (en) * 2013-12-18 2014-03-26 常熟振氟新材料有限公司 Novel V-shaped mixing machine
CN103940785A (en) * 2014-04-10 2014-07-23 江苏大学 On-line mixed pesticide concentration measuring device based on transmission and scattering
CN104596934A (en) * 2014-12-30 2015-05-06 浙江海洋学院 Spectrophotometer with mixer
CN106064034A (en) * 2016-07-04 2016-11-02 苏州北开生化设备有限公司 A kind of self controllable vacuum V-Mixer and using method thereof
CN106268456A (en) * 2016-08-26 2017-01-04 天津市金桥焊材集团有限公司 A kind of device for mixing chemical powder
CN107824098B (en) * 2017-11-23 2024-01-19 广东嘉俊陶瓷有限公司 Base material stirring mechanism
CN108267565B (en) * 2018-01-03 2022-03-11 西南石油大学 Device and method for detecting mixing uniformity of thick oil and thin oil and performing secondary separation after mixing
CN108854656A (en) * 2018-05-03 2018-11-23 柳伟军 A kind of Petroleum refining catalyst zeolite molecular sieve production raw material mixing machine
CN109012376B (en) * 2018-08-10 2021-06-29 昆明理工大学 High-flux high-efficiency powder mixer
CN109569358A (en) * 2018-12-19 2019-04-05 长沙凯天工研院环保服务有限公司 On-line NIR monitors the stirring equipment of soil stabilization process
CN110411978B (en) * 2019-07-26 2020-05-22 中国农业大学 Material uniformity detection equipment and detection method
CN113203827B (en) * 2020-03-03 2023-09-29 大唐环境产业集团股份有限公司 NO is measured in multichannel sampling mixing stirring x Method and apparatus of (a)
CN112206711B (en) * 2020-09-10 2022-06-17 佛山科学技术学院 Method, device and system for detecting reagent mixing state
CN112206702A (en) * 2020-09-27 2021-01-12 重庆航天工业有限公司 Automatic mixing device and system
CN112588157B (en) * 2020-11-20 2023-12-12 湖南开磷雁峰塔涂料有限公司 Anticorrosive coating is with mixing agitated vessel
CN112717838B (en) * 2020-12-30 2022-07-26 山东鑫生工贸有限公司 Rotary reaction catalytic device
CN112871002A (en) * 2021-01-12 2021-06-01 长飞光纤光缆股份有限公司 Uniform mixing method of multi-component powder raw materials
CN114471275A (en) * 2021-12-30 2022-05-13 西安近代化学研究所 Mixing roller, medicine mixing detection equipment, medicine mixing detection method and application

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GB590441A (en) * 1945-04-18 1947-07-17 Sidney Tyler Improvements relating to blending apparatus of the rotary drum mixer type
US2514126A (en) * 1949-12-08 1950-07-04 Patterson Kelley Co Blending or mixing apparatus
DE1905290A1 (en) * 1969-02-04 1970-10-01 Dynamit Nobel Ag Rotary transmission for treatment of abra - sive materials
GB1386312A (en) * 1972-10-30 1975-03-05 Inoue Japax Res Manufacture of settable dental compositions
GB1545538A (en) * 1975-11-17 1979-05-10 Gradient Pty Ltd Method and apparatus for simultaneously recording reaction times
JPS54127065A (en) * 1978-03-22 1979-10-02 Kubota Ltd Position control device of mixer
US4361404A (en) * 1981-04-06 1982-11-30 Pettibone Corporation Mixing equipment and agitator therefor for use with granular material and method of producing prepared granular material
DE3337403A1 (en) * 1983-10-14 1985-05-02 Seyd Fertigbeton Berlin, Zweigniederlassung der Readymix Transportbeton GmbH, 4030 Ratingen Process and apparatus for preparing mixtures
DE3412620A1 (en) * 1984-04-04 1985-10-17 Basf Ag, 6700 Ludwigshafen LASER OPTICAL ARRANGEMENT FOR MEASURING THE DEGREE OF DISPERSION IN FLOWING SYSTEMS
JPS61230727A (en) * 1985-04-03 1986-10-15 Nippon Paint Co Ltd Dispersing apparatus
SU1402856A1 (en) * 1985-12-13 1988-06-15 Ивановский государственный университет Apparatus for preparing thermochromatic compounds and for measuring chromatotemperature characteristics thereof
JPH02273535A (en) * 1989-04-13 1990-11-08 Fujitsu Ltd Gas flow control device
GB2252259A (en) * 1990-12-19 1992-08-05 Unilever Plc Controlling process for producing dispersions
JPH0516134A (en) * 1991-06-06 1993-01-26 Yokohama Rubber Co Ltd:The Control method for closed type mixer and its device

Also Published As

Publication number Publication date
KR0162110B1 (en) 1998-11-16
DE69405483D1 (en) 1997-10-16
JP2650619B2 (en) 1997-09-03
BR9402570A (en) 1995-04-11
EP0631810B1 (en) 1997-09-10
EP0631810A1 (en) 1995-01-04
DK0631810T3 (en) 1997-10-20
CN1100002A (en) 1995-03-15
CA2126826C (en) 1999-02-23
JPH0768146A (en) 1995-03-14
KR950001299A (en) 1995-01-03
CA2126826A1 (en) 1994-12-30
ES2106449T3 (en) 1997-11-01
GR3025143T3 (en) 1998-02-27
ATE157905T1 (en) 1997-09-15
AU660875B2 (en) 1995-07-06
CN1062490C (en) 2001-02-28
AU6599794A (en) 1995-01-27

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8339 Ceased/non-payment of the annual fee