DE69402311D1 - Oxidationsprodukte von cephalomanine - Google Patents

Oxidationsprodukte von cephalomanine

Info

Publication number
DE69402311D1
DE69402311D1 DE69402311T DE69402311T DE69402311D1 DE 69402311 D1 DE69402311 D1 DE 69402311D1 DE 69402311 T DE69402311 T DE 69402311T DE 69402311 T DE69402311 T DE 69402311T DE 69402311 D1 DE69402311 D1 DE 69402311D1
Authority
DE
Germany
Prior art keywords
cephalomanine
oxidation products
oxidation
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69402311T
Other languages
English (en)
Other versions
DE69402311T2 (de
Inventor
Christopher K C O Hause Murray
Jeffrey T C O Hause Beckvermit
Timothy D C O Hauser Ziebarth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hauser Chemical Research Inc
Original Assignee
Hauser Chemical Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hauser Chemical Research Inc filed Critical Hauser Chemical Research Inc
Application granted granted Critical
Publication of DE69402311D1 publication Critical patent/DE69402311D1/de
Publication of DE69402311T2 publication Critical patent/DE69402311T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DE69402311T 1993-04-26 1994-04-25 Oxidationsprodukte von cephalomanine Expired - Fee Related DE69402311T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/053,902 US5336684A (en) 1993-04-26 1993-04-26 Oxidation products of cephalomannine
PCT/US1994/004519 WO1994025449A1 (en) 1993-04-26 1994-04-25 Oxidation products of cephalomannine

Publications (2)

Publication Number Publication Date
DE69402311D1 true DE69402311D1 (de) 1997-04-30
DE69402311T2 DE69402311T2 (de) 1997-09-18

Family

ID=21987320

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69402311T Expired - Fee Related DE69402311T2 (de) 1993-04-26 1994-04-25 Oxidationsprodukte von cephalomanine

Country Status (7)

Country Link
US (1) US5336684A (de)
EP (1) EP0696279B1 (de)
JP (1) JP3759602B2 (de)
AU (1) AU685119B2 (de)
CA (1) CA2161138C (de)
DE (1) DE69402311T2 (de)
WO (1) WO1994025449A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
DE69703294T2 (de) * 1996-05-22 2001-05-17 Protarga Inc Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6469186B1 (en) 2000-11-08 2002-10-22 Actipharm, Inc. Process for mass production of GMP paclitaxel and related taxanes
WO2002076402A2 (en) 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
AU2002305099A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty alcohol drug conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol

Also Published As

Publication number Publication date
DE69402311T2 (de) 1997-09-18
EP0696279A1 (de) 1996-02-14
AU685119B2 (en) 1998-01-15
AU6773594A (en) 1994-11-21
WO1994025449A1 (en) 1994-11-10
CA2161138A1 (en) 1994-11-10
JPH08509733A (ja) 1996-10-15
US5336684A (en) 1994-08-09
CA2161138C (en) 2006-07-25
EP0696279B1 (de) 1997-03-26
JP3759602B2 (ja) 2006-03-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee