DE69333468D1 - Schützende antikörper induzierende antigene aus plasmodium falciparum - Google Patents
Schützende antikörper induzierende antigene aus plasmodium falciparumInfo
- Publication number
- DE69333468D1 DE69333468D1 DE69333468T DE69333468T DE69333468D1 DE 69333468 D1 DE69333468 D1 DE 69333468D1 DE 69333468 T DE69333468 T DE 69333468T DE 69333468 T DE69333468 T DE 69333468T DE 69333468 D1 DE69333468 D1 DE 69333468D1
- Authority
- DE
- Germany
- Prior art keywords
- plasmodium falciparum
- protective antibodies
- inducing antigens
- antigens made
- antibodies inducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000223960 Plasmodium falciparum Species 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 230000001681 protective effect Effects 0.000 title 1
- 230000003229 cytophilic effect Effects 0.000 abstract 2
- IIFDPDVJAHQFSR-WHFBIAKZSA-N Asn-Glu Chemical compound NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O IIFDPDVJAHQFSR-WHFBIAKZSA-N 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 102400000368 Surface protein Human genes 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 210000003936 merozoite Anatomy 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9212488A FR2697022B1 (fr) | 1992-10-19 | 1992-10-19 | Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination. |
FR9212488 | 1992-10-19 | ||
PCT/FR1993/001024 WO1994009140A1 (fr) | 1992-10-19 | 1993-10-18 | Antigenes de plasmodium falciparum inducteurs d'anticorps protecteurs |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69333468D1 true DE69333468D1 (de) | 2004-05-06 |
DE69333468T2 DE69333468T2 (de) | 2005-01-05 |
Family
ID=9434668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333468T Expired - Lifetime DE69333468T2 (de) | 1992-10-19 | 1993-10-18 | Schützende antikörper induzierende antigene aus plasmodium falciparum |
Country Status (9)
Country | Link |
---|---|
US (4) | US6017538A (de) |
EP (2) | EP1471150A3 (de) |
AT (1) | ATE263243T1 (de) |
DE (1) | DE69333468T2 (de) |
DK (1) | DK0666916T3 (de) |
ES (1) | ES2218520T3 (de) |
FR (1) | FR2697022B1 (de) |
PT (1) | PT666916E (de) |
WO (1) | WO1994009140A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2672290B1 (fr) * | 1991-02-05 | 1995-04-21 | Pasteur Institut | Sequences peptidiques specifiques des stades hepatiques de p. falciparum porteuses d'epitopes capables de stimuler les lymphocytes t. |
US20030161840A1 (en) | 1992-10-19 | 2003-08-28 | Institut Pasteur | Plasmodium falciparum antigens inducing protective antibodies |
FR2697022B1 (fr) * | 1992-10-19 | 1994-12-16 | Pasteur Institut | Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination. |
FR2735478B1 (fr) * | 1995-06-13 | 1997-08-22 | Pasteur Institut | Molecules polypeptidiques de stade pre-erythrocytaire du paludisme |
WO2001056594A1 (en) | 2000-02-04 | 2001-08-09 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
EP1201250A1 (de) * | 2000-10-25 | 2002-05-02 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Immunogenische Zusammensetzung die hepatische Phaseantigene aus Plasmodium enthält |
US20030104003A1 (en) * | 2001-05-25 | 2003-06-05 | James Anthony A. | Novel surface protein of the malaria parasite plasmodium falciparum |
GB2378949B (en) * | 2001-08-16 | 2005-09-07 | Morten Steen Hanefeld Dziegiel | Recombinant anti-plasmodium falciparum antibodies |
NZ539509A (en) * | 2002-10-23 | 2008-05-30 | Glaxosmithkline Biolog Sa | Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine |
DK200201741A (da) * | 2002-11-12 | 2003-09-16 | Statens Seruminstitut | Vaccine comprising chimeric malaria proteins derived from Plasmodium falciparum |
WO2004054508A2 (en) * | 2002-12-12 | 2004-07-01 | Walter Reed Army Institute Of Research Department Of The Army | Immunogenic compositions including rough phenotype brucella host strains and complementation dna fragments |
US20050112133A1 (en) * | 2003-10-24 | 2005-05-26 | Pierre Druilhe | GLURP-MSP3 fusion protein, immunogenic compositions and malarial vaccines containing it |
US8168166B2 (en) * | 2003-12-19 | 2012-05-01 | Seattle Biomedical Research Institute | Live genetically attenuated malaria vaccine |
GB0329958D0 (en) * | 2003-12-24 | 2004-01-28 | Univ Manchester | Treatment of viral infections |
GB0404374D0 (en) * | 2004-02-27 | 2004-03-31 | Univ Manchester | Treatment of bacterial infections |
EP1742619A2 (de) * | 2004-05-07 | 2007-01-17 | The President and Fellows of Harvard College | Impstoff gegen pulmonale malaria |
US7488489B2 (en) * | 2004-08-03 | 2009-02-10 | Institut Pasteur | Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies |
EP1803731A4 (de) * | 2004-09-28 | 2011-01-26 | Univ Gunma Nat Univ Corp | Verfahren zur herstellung eines teilpeptids des enolaseproteins aus plasmodiumfalciparum |
GB0513096D0 (en) * | 2005-06-28 | 2005-08-03 | Strathclyde | Treatment of microbial infections |
JP4480728B2 (ja) * | 2006-06-09 | 2010-06-16 | パナソニック株式会社 | Memsマイクの製造方法 |
KR20140070659A (ko) * | 2009-05-05 | 2014-06-10 | 카딜라 핼쓰캐어 리미티드 | 홍역-말라리아 조합 백신 |
CA2809463C (en) * | 2010-09-27 | 2021-05-25 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
FR2990697B1 (fr) * | 2012-05-21 | 2015-12-18 | Assist Publ Hopitaux Marseille | Procede d'attenuation d'une bacterie du complexe mycobacterium tuberculosis pour la fabrication d'un vaccin contre la tuberculose |
US20160320404A1 (en) | 2015-03-04 | 2016-11-03 | Sanaria Inc. | Serum antibody assay for determining protection from malaria, and pre-erythrocytic subunit vaccines |
WO2017024084A1 (en) * | 2015-08-03 | 2017-02-09 | University Of Washington | Immunogenic compositions, antigen screening methods, and methods of generating immune responses |
US10183067B1 (en) * | 2017-05-05 | 2019-01-22 | Microvax, Llc | TAA/CD4OL composition/vaccine for malaria |
WO2018207134A1 (en) * | 2017-05-11 | 2018-11-15 | King Abdullah University Of Science And Technology | Immunogens obtained from plasmodium yoelii using quantitative sequence-linkage group selection method |
US11013791B2 (en) * | 2017-06-22 | 2021-05-25 | The Government Of The United States, As Represented By The Secretary Of The Army | NYVAC-based plasmodium malaria vaccine |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002472A1 (fr) * | 1982-12-27 | 1984-07-05 | Pasteur Institut | Fractions polypeptidiques inductrices d'anticorps protecteurs contre des parasites du paludisme et compositions immunogenes les contenant |
US4632909A (en) * | 1983-10-31 | 1986-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies which block infectivity of malarial parasites to mosquitoes |
US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
US4835259A (en) * | 1984-09-14 | 1989-05-30 | Scripps Clinic And Research Foundation | Merozoite surface glycoproteins |
US4978621A (en) * | 1985-09-03 | 1990-12-18 | Scripps Clinic And Research Foundation | Merozoite surface antigens |
WO1988000595A1 (en) * | 1986-07-17 | 1988-01-28 | Saramane Pty. Ltd. | Merozoite surface antigen of plasmodium falciparum |
US4897354A (en) * | 1986-07-28 | 1990-01-30 | University Of Hawaii | Monoclonal antibody-specific merozoite antigens |
US4957738A (en) * | 1987-01-14 | 1990-09-18 | Patarroyo Manuel E | Protein copolymer malaria vaccine |
FR2610631B1 (fr) * | 1987-02-09 | 1989-11-24 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum dans les hepatocytes, et leurs utilisations, notamment pour le diagnostic du paludisme ou dans des compositions de vaccins contre le paludisme |
US5225534A (en) * | 1987-09-08 | 1993-07-06 | Hoffmann-La Roche Inc. | Recombinant malarial polypeptides |
US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
US5585268A (en) * | 1987-12-30 | 1996-12-17 | Behringwerke Aktiengesellschaft | Malaria-specific DNA sequences, expression products thereof, and the use thereof |
ATE129504T1 (de) * | 1988-09-12 | 1995-11-15 | Saramane Pty Ltd | Allelische varianten von -i(plasmodium falciparum) merozoit-oberflächen-antigen. |
FR2645877B1 (fr) * | 1989-04-12 | 1991-07-05 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes |
FR2665365B1 (fr) * | 1990-08-06 | 1995-04-28 | Pasteur Institut | Antigene de plasmodium falciparum susceptible d'induire des anticorps protecteurs - application a la vaccination. |
US5993823A (en) * | 1990-12-18 | 1999-11-30 | Institut Pasteur De Lille | Cytotoxic T lymphocyte-inducing lipopeptides and methods of use |
GB9203821D0 (en) * | 1992-02-22 | 1992-04-08 | Medical Res Council | Improvements in or relating to malaria vaccine |
FR2697022B1 (fr) * | 1992-10-19 | 1994-12-16 | Pasteur Institut | Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination. |
US20030161840A1 (en) * | 1992-10-19 | 2003-08-28 | Institut Pasteur | Plasmodium falciparum antigens inducing protective antibodies |
FR2735478B1 (fr) * | 1995-06-13 | 1997-08-22 | Pasteur Institut | Molecules polypeptidiques de stade pre-erythrocytaire du paludisme |
US7078043B2 (en) * | 1999-04-20 | 2006-07-18 | Medical Research Council | Malaria vaccine |
WO2001034188A1 (en) * | 1999-11-12 | 2001-05-17 | University Of Hawaii | Malaria vaccine |
CA2390747A1 (en) * | 1999-12-09 | 2001-06-14 | Institut Pasteur | Systemic immune response induced by mucosal administration of lipid-tailed polypeptides without adjuvant |
EP1201250A1 (de) * | 2000-10-25 | 2002-05-02 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Immunogenische Zusammensetzung die hepatische Phaseantigene aus Plasmodium enthält |
US7306806B2 (en) * | 2001-01-26 | 2007-12-11 | United States Of America As Represented By The Secretary Of The Army | Recombinant P. falciparum merozoite protein-142 vaccine |
US20030059436A1 (en) * | 2001-03-02 | 2003-03-27 | St. Elizabeth's Medical Center, Inc. | Band 3 antigenic peptides, malaria polypeptides and uses thereof |
US20030104003A1 (en) * | 2001-05-25 | 2003-06-05 | James Anthony A. | Novel surface protein of the malaria parasite plasmodium falciparum |
GB2378949B (en) * | 2001-08-16 | 2005-09-07 | Morten Steen Hanefeld Dziegiel | Recombinant anti-plasmodium falciparum antibodies |
WO2003062374A2 (en) * | 2001-11-09 | 2003-07-31 | Entremed, Inc. | Synthetic genes for malarial proteins and methods of use |
NZ539509A (en) * | 2002-10-23 | 2008-05-30 | Glaxosmithkline Biolog Sa | Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine |
DK200201741A (da) * | 2002-11-12 | 2003-09-16 | Statens Seruminstitut | Vaccine comprising chimeric malaria proteins derived from Plasmodium falciparum |
ATE448307T1 (de) * | 2003-10-24 | 2009-11-15 | Pasteur Institut | Msp-3-ähnliche genfamilie |
US20050112133A1 (en) * | 2003-10-24 | 2005-05-26 | Pierre Druilhe | GLURP-MSP3 fusion protein, immunogenic compositions and malarial vaccines containing it |
US7488489B2 (en) * | 2004-08-03 | 2009-02-10 | Institut Pasteur | Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies |
-
1992
- 1992-10-19 FR FR9212488A patent/FR2697022B1/fr not_active Expired - Lifetime
-
1993
- 1993-10-18 EP EP04003945A patent/EP1471150A3/de not_active Withdrawn
- 1993-10-18 ES ES93923584T patent/ES2218520T3/es not_active Expired - Lifetime
- 1993-10-18 DK DK93923584T patent/DK0666916T3/da active
- 1993-10-18 EP EP93923584A patent/EP0666916B1/de not_active Expired - Lifetime
- 1993-10-18 PT PT93923584T patent/PT666916E/pt unknown
- 1993-10-18 AT AT93923584T patent/ATE263243T1/de active
- 1993-10-18 WO PCT/FR1993/001024 patent/WO1994009140A1/fr active IP Right Grant
- 1993-10-18 US US08/416,711 patent/US6017538A/en not_active Expired - Lifetime
- 1993-10-18 DE DE69333468T patent/DE69333468T2/de not_active Expired - Lifetime
-
1999
- 1999-07-19 US US09/356,497 patent/US6472519B1/en not_active Expired - Fee Related
-
2002
- 2002-09-11 US US10/238,741 patent/US6949627B2/en not_active Expired - Fee Related
-
2005
- 2005-06-02 US US11/142,392 patent/US7211256B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0666916A1 (de) | 1995-08-16 |
PT666916E (pt) | 2004-08-31 |
DK0666916T3 (da) | 2004-08-02 |
ES2218520T3 (es) | 2004-11-16 |
EP0666916B1 (de) | 2004-03-31 |
WO1994009140A1 (fr) | 1994-04-28 |
FR2697022B1 (fr) | 1994-12-16 |
FR2697022A1 (fr) | 1994-04-22 |
US6949627B2 (en) | 2005-09-27 |
EP1471150A2 (de) | 2004-10-27 |
US20050266017A1 (en) | 2005-12-01 |
US20040096466A1 (en) | 2004-05-20 |
US6472519B1 (en) | 2002-10-29 |
ATE263243T1 (de) | 2004-04-15 |
US6017538A (en) | 2000-01-25 |
EP1471150A3 (de) | 2009-10-21 |
DE69333468T2 (de) | 2005-01-05 |
US7211256B2 (en) | 2007-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |