DE69332023D1 - Neue pyridyl-und pyrimidylpiperazin-derivate - Google Patents

Neue pyridyl-und pyrimidylpiperazin-derivate

Info

Publication number
DE69332023D1
DE69332023D1 DE69332023T DE69332023T DE69332023D1 DE 69332023 D1 DE69332023 D1 DE 69332023D1 DE 69332023 T DE69332023 T DE 69332023T DE 69332023 T DE69332023 T DE 69332023T DE 69332023 D1 DE69332023 D1 DE 69332023D1
Authority
DE
Germany
Prior art keywords
pct
piperazine derivatives
sec
different
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332023T
Other languages
English (en)
Other versions
DE69332023T2 (de
Inventor
Curt Nordvi
Lisbeth Abramo
Torbjoern Lundstedt
Gunnar Olsson
Martin Brodszki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum AB filed Critical Biovitrum AB
Application granted granted Critical
Publication of DE69332023D1 publication Critical patent/DE69332023D1/de
Publication of DE69332023T2 publication Critical patent/DE69332023T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69332023T 1992-07-31 1993-07-16 Neue pyridyl-und pyrimidylpiperazin-derivate Expired - Fee Related DE69332023T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9202265A SE9202265D0 (sv) 1992-07-31 1992-07-31 Novel- pyridyl and pyrimidylpiperazine derivatives
PCT/SE1993/000632 WO1994003430A1 (en) 1992-07-31 1993-07-16 Novel pyridyl- and pyrimidylpiperazine derivatives

Publications (2)

Publication Number Publication Date
DE69332023D1 true DE69332023D1 (de) 2002-07-18
DE69332023T2 DE69332023T2 (de) 2002-11-07

Family

ID=20386859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332023T Expired - Fee Related DE69332023T2 (de) 1992-07-31 1993-07-16 Neue pyridyl-und pyrimidylpiperazin-derivate

Country Status (16)

Country Link
US (2) US5652240A (de)
EP (1) EP0652867B1 (de)
JP (1) JP3426601B2 (de)
CN (2) CN1087901A (de)
AT (1) ATE219059T1 (de)
AU (1) AU679923B2 (de)
CA (1) CA2141209C (de)
DE (1) DE69332023T2 (de)
DK (1) DK0652867T3 (de)
ES (1) ES2178642T3 (de)
IL (1) IL106469A (de)
NZ (1) NZ254308A (de)
PT (1) PT652867E (de)
SE (1) SE9202265D0 (de)
WO (1) WO1994003430A1 (de)
ZA (1) ZA935533B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9201956D0 (sv) * 1992-06-25 1992-06-25 Kabi Pharmacia Ab Novel nicotinicacid esters
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
SE0201544D0 (sv) * 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
AU2003300147A1 (en) * 2003-01-06 2004-08-10 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
US8013156B2 (en) 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
US7381822B2 (en) * 2004-03-31 2008-06-03 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292321A (en) * 1979-05-24 1981-09-29 Warner-Lambert Company 1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US4994459A (en) * 1989-12-11 1991-02-19 American Home Products Corporation Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity
GB9021453D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5432179A (en) * 1991-07-19 1995-07-11 Zeria Pharmaceutical Co., Ltd. Piperazine derivatives and pharmaceuticals containing the same
US5418236A (en) * 1993-12-23 1995-05-23 Ortho Pharmaceutical Corporation Anxiolytic aroyl piperidinyl and piperazinylacyl pyrroles

Also Published As

Publication number Publication date
NZ254308A (en) 1997-09-22
US5652240A (en) 1997-07-29
SE9202265D0 (sv) 1992-07-31
AU679923B2 (en) 1997-07-17
CN1087901A (zh) 1994-06-15
IL106469A0 (en) 1993-11-15
ES2178642T3 (es) 2003-01-01
CA2141209C (en) 2005-04-05
JPH07509711A (ja) 1995-10-26
PT652867E (pt) 2002-10-31
JP3426601B2 (ja) 2003-07-14
EP0652867A1 (de) 1995-05-17
US6326371B1 (en) 2001-12-04
DK0652867T3 (da) 2002-10-07
DE69332023T2 (de) 2002-11-07
IL106469A (en) 1997-02-18
CN1629156A (zh) 2005-06-22
ATE219059T1 (de) 2002-06-15
AU4594993A (en) 1994-03-03
EP0652867B1 (de) 2002-06-12
CA2141209A1 (en) 1994-02-17
WO1994003430A1 (en) 1994-02-17
ZA935533B (en) 1994-02-24

Similar Documents

Publication Publication Date Title
EP0628311A4 (de) Antidepressivum.
PH23068A (en) Novel nitromethylene derivatives
DE69328165D1 (de) Neue piperazincarboxamide
ATE204272T1 (de) Neue pyridon carbonsäure-derivate
DE69332023T2 (de) Neue pyridyl-und pyrimidylpiperazin-derivate
ATE168105T1 (de) Melamine derivate zur verwendung in der behandlung von krebs
BG101601A (en) Pharmaceutical piperazine compounds
DK0706517T3 (da) Pyridazinonderivater med farmaceutisk virkning
DE69300162D1 (de) 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidin-4-carbonsäureamidderivate, ihre Herstellung und ihre Anwendung in der Therapeutica.
MX9603868A (es) Composicion farmaceutica de derivados de indeno para la regulacion de la apoptosis.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee