DE69329641T2 - Verfahren zur mehrfachen ligase-kettenreaktion - Google Patents
Verfahren zur mehrfachen ligase-kettenreaktionInfo
- Publication number
- DE69329641T2 DE69329641T2 DE69329641T DE69329641T DE69329641T2 DE 69329641 T2 DE69329641 T2 DE 69329641T2 DE 69329641 T DE69329641 T DE 69329641T DE 69329641 T DE69329641 T DE 69329641T DE 69329641 T2 DE69329641 T2 DE 69329641T2
- Authority
- DE
- Germany
- Prior art keywords
- chain reaction
- ligase chain
- multiple ligase
- reaction
- ligase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86070292A | 1992-03-31 | 1992-03-31 | |
PCT/US1993/003034 WO1993020227A1 (en) | 1992-03-31 | 1993-03-31 | Method of multiplex ligase chain reaction |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69329641D1 DE69329641D1 (de) | 2000-12-14 |
DE69329641T2 true DE69329641T2 (de) | 2001-06-21 |
Family
ID=25333823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329641T Expired - Fee Related DE69329641T2 (de) | 1992-03-31 | 1993-03-31 | Verfahren zur mehrfachen ligase-kettenreaktion |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP0633944B1 (de) |
JP (1) | JPH07505293A (de) |
AU (1) | AU3942993A (de) |
CA (1) | CA2133220A1 (de) |
DE (1) | DE69329641T2 (de) |
ES (1) | ES2153379T3 (de) |
TW (1) | TW260672B (de) |
WO (1) | WO1993020227A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10330982A1 (de) * | 2003-07-09 | 2005-02-17 | Prisma Diagnostika Gmbh | Vorrichtung und Verfahren zur simultanen Bestimmung von Blutgruppenantigenen |
DE10330981B4 (de) * | 2003-07-09 | 2010-04-01 | Medion Diagnostics Ag | Vorrichtung und Verfahren zur simultanen Durchführung von Blutgruppenbestimmung, Serumgegenprobe und Antikörpersuch-Test |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7960494A (en) * | 1993-10-21 | 1995-05-08 | Abbott Laboratories | Apparatus and method for detecting a target ligand |
US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
DE69427876T2 (de) * | 1994-05-23 | 2002-04-11 | Biotronics Corp | Methode zur detektion einer gezielten nukleinsäure |
US5667974A (en) * | 1995-06-07 | 1997-09-16 | Abbott Laboratories | Method for detecting nucleic acid sequences using competitive amplification |
SE504798C2 (sv) * | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
US6764835B2 (en) | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
AU735440B2 (en) * | 1996-02-09 | 2001-07-05 | Cornell Research Foundation Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
EP1736554B1 (de) | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Bestimmung von Unterschieden in der Nukleinsäuresequenz mittels einer Kombination von Ligasebestimmung und Polymerasekettenreaktion |
US6312892B1 (en) * | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
AU6871798A (en) * | 1997-03-28 | 1998-10-22 | Zymogenetics Inc. | Human chemokine zsig-35 |
US6395472B1 (en) | 1999-02-05 | 2002-05-28 | Abbott Laboratories | Methods of utilizing the TT virus |
EP1218536A2 (de) | 1999-02-12 | 2002-07-03 | Genset | Biallele marker abgeleitet von genomischen regionen, die gene enthalten, die am arachidonsäure stoffwechsel beteiligt sind |
AU2001293366A1 (en) | 2000-04-14 | 2001-10-30 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
WO2002053768A2 (en) * | 2001-01-05 | 2002-07-11 | Diagnosticart Llc | Dna rapid immune detection methods and apparatus |
CA2456571A1 (en) | 2001-08-10 | 2003-02-20 | Genset Sa | Human secreted proteins, their encoding polynucleotides, and uses thereof |
EP1436621B1 (de) * | 2001-09-17 | 2010-12-22 | Phadia AB | Mehrfachanalytassay-vorrichtung mit multi-spot-nachweiszone |
CA2507125C (en) * | 2002-11-25 | 2014-04-22 | Masafumi Matsuo | Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
JP4933258B2 (ja) | 2003-09-22 | 2012-05-16 | クイデル コーポレーション | 試料中の複数分析物の検出装置 |
WO2005069969A2 (en) | 2004-01-21 | 2005-08-04 | University Of Utah Research Foundation | Mutant sodium channel nav1.7 and methods related thereto |
USRE48960E1 (en) | 2004-06-28 | 2022-03-08 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
EP4272748A3 (de) | 2004-06-28 | 2024-03-27 | The University Of Western Australia | Antisense-oligonukleotide zur induzierung von exon-skipping und verfahren zur verwendung davon |
JP5669397B2 (ja) | 2007-03-01 | 2015-02-12 | シムフォゲン・アクティーゼルスカブSymphogen A/S | 同族抗体をクローニングするための方法 |
JP5864257B2 (ja) | 2008-10-24 | 2016-02-17 | サレプタ セラピューティクス, インコーポレイテッド | Dmdのための複数のエキソンスキッピング組成物 |
CN105838714B (zh) | 2009-11-12 | 2020-07-17 | 西澳大利亚大学 | 反义分子和治疗疾病的方法 |
EA035882B1 (ru) | 2013-03-14 | 2020-08-27 | Сарепта Терапьютикс, Инк. | Антисмысловые олигонуклеотиды, обеспечивающие пропуск экзонов, для лечения мышечной дистрофии |
BR112015022998A2 (pt) | 2013-03-15 | 2017-11-14 | Sarepta Therapeutics Inc | composições melhoradas para o tratamento de distrofia muscular |
CN104764877A (zh) * | 2014-05-14 | 2015-07-08 | 陈岩松 | 一种免疫层析检测方法及试纸 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4435504A (en) * | 1982-07-15 | 1984-03-06 | Syva Company | Immunochromatographic assay with support having bound "MIP" and second enzyme |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
US4855225A (en) * | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
DE3887491T2 (de) * | 1987-12-21 | 1994-07-07 | Abbott Lab | Chromatographische Bindungstesteinrichtungen und Verfahren. |
CA1341584C (en) * | 1988-04-06 | 2008-11-18 | Bruce Wallace | Method of amplifying and detecting nucleic acid sequences |
AU629845B2 (en) * | 1988-08-30 | 1992-10-15 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
CA1339731C (en) * | 1988-10-12 | 1998-03-17 | Charles T. Caskey | Multiplex genomic dna amplification for deletion detection |
KR950013953B1 (ko) * | 1990-01-26 | 1995-11-18 | 애보트 래보라토리즈 | 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법 |
-
1993
- 1993-03-31 CA CA002133220A patent/CA2133220A1/en not_active Abandoned
- 1993-03-31 WO PCT/US1993/003034 patent/WO1993020227A1/en active IP Right Grant
- 1993-03-31 DE DE69329641T patent/DE69329641T2/de not_active Expired - Fee Related
- 1993-03-31 EP EP93908700A patent/EP0633944B1/de not_active Expired - Lifetime
- 1993-03-31 JP JP5517672A patent/JPH07505293A/ja active Pending
- 1993-03-31 AU AU39429/93A patent/AU3942993A/en not_active Abandoned
- 1993-03-31 ES ES93908700T patent/ES2153379T3/es not_active Expired - Lifetime
- 1993-03-31 EP EP00102158A patent/EP1018649A3/de not_active Withdrawn
- 1993-04-16 TW TW082102966A patent/TW260672B/zh active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10330982A1 (de) * | 2003-07-09 | 2005-02-17 | Prisma Diagnostika Gmbh | Vorrichtung und Verfahren zur simultanen Bestimmung von Blutgruppenantigenen |
DE10330981B4 (de) * | 2003-07-09 | 2010-04-01 | Medion Diagnostics Ag | Vorrichtung und Verfahren zur simultanen Durchführung von Blutgruppenbestimmung, Serumgegenprobe und Antikörpersuch-Test |
Also Published As
Publication number | Publication date |
---|---|
TW260672B (de) | 1995-10-21 |
EP1018649A2 (de) | 2000-07-12 |
JPH07505293A (ja) | 1995-06-15 |
ES2153379T3 (es) | 2001-03-01 |
EP1018649A3 (de) | 2000-11-29 |
EP0633944A4 (de) | 1998-02-04 |
EP0633944A1 (de) | 1995-01-18 |
WO1993020227A1 (en) | 1993-10-14 |
DE69329641D1 (de) | 2000-12-14 |
CA2133220A1 (en) | 1993-10-14 |
EP0633944B1 (de) | 2000-11-08 |
AU3942993A (en) | 1993-11-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |