DE69323070T2 - Methandiphosphonsäure-derivat, verfahren zu ihrer herstellung und pharmazeutische verwendung davon - Google Patents

Methandiphosphonsäure-derivat, verfahren zu ihrer herstellung und pharmazeutische verwendung davon

Info

Publication number
DE69323070T2
DE69323070T2 DE69323070T DE69323070T DE69323070T2 DE 69323070 T2 DE69323070 T2 DE 69323070T2 DE 69323070 T DE69323070 T DE 69323070T DE 69323070 T DE69323070 T DE 69323070T DE 69323070 T2 DE69323070 T2 DE 69323070T2
Authority
DE
Germany
Prior art keywords
production
acid derivative
pharmaceutical use
methandiphosphonic
methandiphosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323070T
Other languages
English (en)
Other versions
DE69323070D1 (de
Inventor
Keijiro Takanishi
Norio Kawabe
Teruo Nakadate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of DE69323070D1 publication Critical patent/DE69323070D1/de
Application granted granted Critical
Publication of DE69323070T2 publication Critical patent/DE69323070T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
    • C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE69323070T 1992-10-30 1993-10-29 Methandiphosphonsäure-derivat, verfahren zu ihrer herstellung und pharmazeutische verwendung davon Expired - Fee Related DE69323070T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4292685A JPH06135976A (ja) 1992-10-30 1992-10-30 メタンジホスホン酸誘導体、その製造方法およびその医薬用途
PCT/JP1993/001579 WO1994010181A1 (fr) 1992-10-30 1993-10-29 Derive de methanediphosphonate, son procede de production et son utilisation pharmaceutique

Publications (2)

Publication Number Publication Date
DE69323070D1 DE69323070D1 (de) 1999-02-25
DE69323070T2 true DE69323070T2 (de) 1999-05-20

Family

ID=17784980

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323070T Expired - Fee Related DE69323070T2 (de) 1992-10-30 1993-10-29 Methandiphosphonsäure-derivat, verfahren zu ihrer herstellung und pharmazeutische verwendung davon

Country Status (6)

Country Link
US (1) US5565440A (de)
EP (1) EP0627438B1 (de)
JP (1) JPH06135976A (de)
CA (1) CA2127115C (de)
DE (1) DE69323070T2 (de)
WO (1) WO1994010181A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203309A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
JPS6366190A (ja) * 1986-09-05 1988-03-24 Yamanouchi Pharmaceut Co Ltd ジフエニルアゾ−ルジホスホン酸誘導体
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
WO1992003451A1 (en) * 1990-08-21 1992-03-05 The Upjohn Company Bisphosphonic acid derivatives as anti-arthritic agents
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
US5204334A (en) * 1990-10-18 1993-04-20 Ciba-Geigy Corporation Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders
ATE165603T1 (de) * 1991-09-05 1998-05-15 Toray Industries Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel

Also Published As

Publication number Publication date
EP0627438A1 (de) 1994-12-07
DE69323070D1 (de) 1999-02-25
CA2127115A1 (en) 1994-05-01
JPH06135976A (ja) 1994-05-17
EP0627438A4 (de) 1995-02-01
EP0627438B1 (de) 1999-01-13
WO1994010181A1 (fr) 1994-05-11
US5565440A (en) 1996-10-15
CA2127115C (en) 1997-12-09

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DE69323070D1 (de) Methandiphosphonsäure-derivat, verfahren zu ihrer herstellung und pharmazeutische verwendung davon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee