DE69310540D1 - Verhindern von spaltung von n-terminalen aminosäuren durch endogene aminopeptidasen während die expression von fremden genen in bakterien - Google Patents
Verhindern von spaltung von n-terminalen aminosäuren durch endogene aminopeptidasen während die expression von fremden genen in bakterienInfo
- Publication number
- DE69310540D1 DE69310540D1 DE69310540T DE69310540T DE69310540D1 DE 69310540 D1 DE69310540 D1 DE 69310540D1 DE 69310540 T DE69310540 T DE 69310540T DE 69310540 T DE69310540 T DE 69310540T DE 69310540 D1 DE69310540 D1 DE 69310540D1
- Authority
- DE
- Germany
- Prior art keywords
- amino acid
- aminopeptidases
- pro
- pct
- terminal amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004400 Aminopeptidases Human genes 0.000 title abstract 5
- 108090000915 Aminopeptidases Proteins 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 150000001413 amino acids Chemical group 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929225021A GB9225021D0 (en) | 1992-11-30 | 1992-11-30 | Organic compounds |
| PCT/EP1993/003349 WO1994012659A1 (en) | 1992-11-30 | 1993-11-29 | Preventing endogenous aminopeptidase mediated n-terminal amino acid cleavage during expression of foreign genes in bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69310540D1 true DE69310540D1 (de) | 1997-06-12 |
| DE69310540T2 DE69310540T2 (de) | 1998-01-02 |
Family
ID=10725879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69310540T Expired - Fee Related DE69310540T2 (de) | 1992-11-30 | 1993-11-29 | Verhindern von spaltung von n-terminalen aminosäuren durch endogene aminopeptidasen während die expression von fremden genen in bakterien |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6165746A (de) |
| EP (1) | EP0670907B1 (de) |
| JP (1) | JPH08503376A (de) |
| AT (1) | ATE152772T1 (de) |
| CA (1) | CA2145384A1 (de) |
| DE (1) | DE69310540T2 (de) |
| DK (1) | DK0670907T3 (de) |
| ES (1) | ES2101489T3 (de) |
| GB (1) | GB9225021D0 (de) |
| GR (1) | GR3023348T3 (de) |
| WO (1) | WO1994012659A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743600B1 (en) | 1999-04-30 | 2004-06-01 | Monsanto Technologies Llc | Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase |
| US6794159B1 (en) * | 1999-04-30 | 2004-09-21 | Pharmacia Corporation | Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase |
| DK1572127T4 (da) * | 2002-02-14 | 2014-11-24 | Univ Leland Stanford Junior | Enzymbehandling af fødevarer til cøliaki |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| WO2004045392A2 (en) | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| WO2005061529A1 (ja) * | 2003-12-01 | 2005-07-07 | Meiji Dairies Corporation | アンジオテンシン変換酵素阻害ペプチド |
| US8148105B2 (en) * | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
| NZ580425A (en) * | 2007-03-16 | 2011-12-22 | Univ Leland Stanford Junior | Combination enzyme therapy for digestion of dietary gluten |
| EP3914706A4 (de) * | 2019-01-21 | 2022-12-28 | Encodia, Inc. | Verfahren und zusammensetzungen von beschleunigungsreaktionen für die polypeptidanalyse und zugehörige verwendungen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50112428A (de) * | 1974-02-18 | 1975-09-03 | ||
| IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
| WO1986001229A1 (en) * | 1984-08-16 | 1986-02-27 | Bio-Technology General Corp. | Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby |
| WO1986007380A1 (en) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Process for preparing polypeptide |
| US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
| JPS63258969A (ja) * | 1986-12-06 | 1988-10-26 | Lion Corp | 金属材の表面被覆組成物 |
| JPH02151669A (ja) * | 1988-12-02 | 1990-06-11 | Daicel Chem Ind Ltd | 塗料組成物 |
-
1992
- 1992-11-30 GB GB929225021A patent/GB9225021D0/en active Pending
-
1993
- 1993-11-29 WO PCT/EP1993/003349 patent/WO1994012659A1/en active IP Right Grant
- 1993-11-29 AT AT94901914T patent/ATE152772T1/de not_active IP Right Cessation
- 1993-11-29 ES ES94901914T patent/ES2101489T3/es not_active Expired - Lifetime
- 1993-11-29 US US08/446,667 patent/US6165746A/en not_active Expired - Fee Related
- 1993-11-29 CA CA002145384A patent/CA2145384A1/en not_active Abandoned
- 1993-11-29 EP EP94901914A patent/EP0670907B1/de not_active Expired - Lifetime
- 1993-11-29 DE DE69310540T patent/DE69310540T2/de not_active Expired - Fee Related
- 1993-11-29 JP JP6512780A patent/JPH08503376A/ja not_active Withdrawn
- 1993-11-29 DK DK94901914.5T patent/DK0670907T3/da active
-
1997
- 1997-05-08 GR GR970400969T patent/GR3023348T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0670907T3 (da) | 1997-08-25 |
| CA2145384A1 (en) | 1994-06-09 |
| GR3023348T3 (en) | 1997-08-29 |
| DE69310540T2 (de) | 1998-01-02 |
| US6165746A (en) | 2000-12-26 |
| EP0670907B1 (de) | 1997-05-07 |
| GB9225021D0 (en) | 1993-01-20 |
| WO1994012659A1 (en) | 1994-06-09 |
| ES2101489T3 (es) | 1997-07-01 |
| JPH08503376A (ja) | 1996-04-16 |
| EP0670907A1 (de) | 1995-09-13 |
| ATE152772T1 (de) | 1997-05-15 |
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| DE69310540D1 (de) | Verhindern von spaltung von n-terminalen aminosäuren durch endogene aminopeptidasen während die expression von fremden genen in bakterien | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN |
|
| 8339 | Ceased/non-payment of the annual fee |