DE69309479T2 - Markiertes monocyte-chemoattractant-proteinmaterial und medizinische anwendung - Google Patents

Markiertes monocyte-chemoattractant-proteinmaterial und medizinische anwendung

Info

Publication number
DE69309479T2
DE69309479T2 DE69309479T DE69309479T DE69309479T2 DE 69309479 T2 DE69309479 T2 DE 69309479T2 DE 69309479 T DE69309479 T DE 69309479T DE 69309479 T DE69309479 T DE 69309479T DE 69309479 T2 DE69309479 T2 DE 69309479T2
Authority
DE
Germany
Prior art keywords
marked
protein material
medical application
chemoattractant protein
monocyte chemoattractant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69309479T
Other languages
English (en)
Other versions
DE69309479D1 (de
Inventor
Steven L Kunkel
Leon R Lyle
Robert M Strieter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
University of Michigan
Original Assignee
University of Michigan
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan, Mallinckrodt Medical Inc filed Critical University of Michigan
Publication of DE69309479D1 publication Critical patent/DE69309479D1/de
Application granted granted Critical
Publication of DE69309479T2 publication Critical patent/DE69309479T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
DE69309479T 1992-10-05 1993-10-04 Markiertes monocyte-chemoattractant-proteinmaterial und medizinische anwendung Expired - Fee Related DE69309479T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/956,862 US5413778A (en) 1992-10-05 1992-10-05 Labelled monocyte chemoattractant protein material and medical uses thereof
PCT/US1993/009417 WO1994007542A2 (en) 1992-10-05 1993-10-04 Labelled monocyte chemoattractant protein material and medical uses thereof

Publications (2)

Publication Number Publication Date
DE69309479D1 DE69309479D1 (de) 1997-05-07
DE69309479T2 true DE69309479T2 (de) 1997-10-23

Family

ID=25498783

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309479T Expired - Fee Related DE69309479T2 (de) 1992-10-05 1993-10-04 Markiertes monocyte-chemoattractant-proteinmaterial und medizinische anwendung

Country Status (8)

Country Link
US (1) US5413778A (de)
EP (1) EP0662843B1 (de)
JP (1) JPH08502075A (de)
AT (1) ATE150977T1 (de)
AU (1) AU674039B2 (de)
CA (1) CA2145983C (de)
DE (1) DE69309479T2 (de)
WO (1) WO1994007542A2 (de)

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US5663450A (en) * 1993-08-17 1997-09-02 Cv Therapeutics Macrophage lipid chemoattractant
WO1995019436A1 (en) * 1994-01-13 1995-07-20 The Regents Of The University Of California Mammalian monocyte chemoattractant protein receptors
US6664367B1 (en) 1994-07-21 2003-12-16 Biosynthema, Inc. Stable analogs of bioactive peptides containing disulfide linkages
US6458349B1 (en) * 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US5981230A (en) * 1994-08-23 1999-11-09 Human Genome Sciences, Inc. Polynucleotide encoding chemokine β-4
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6498015B1 (en) 1995-06-07 2002-12-24 Icos Corporation Methods of identifying agents that modulate the binding between MDC and an MDC receptor
US6320023B1 (en) 1995-06-07 2001-11-20 Icos Corporation Macrophage derived chemokine
US6737513B1 (en) 1996-06-07 2004-05-18 Icos Corporation Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US6790947B1 (en) 1995-06-07 2004-09-14 Icos Corporation Polynucleotides encoding macrophage derived chemokine
US5688927A (en) * 1995-06-07 1997-11-18 Icos Corporation Macrophage derived chemokine
CZ29397A3 (cs) * 1995-06-07 1998-01-14 Icos Corporation Chemokiny pocházející z makrofágů a jejich analogy, polynukleotidy, které je kódují, použití těchto chemokinů a farmaceutické prostředky na jejich bázi
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
US6673915B1 (en) 1996-09-30 2004-01-06 General Hospital Corporation Nucleic acid encoding monocyte chemotactic protein 4
WO1998014573A1 (en) * 1996-09-30 1998-04-09 The General Hospital Corporation Mcp-4 and mcp-5: novel chemokines
EP0894134A1 (de) * 1996-11-15 1999-02-03 Indiana University Foundation Exodus chemokine, materialien und methoden
US6204024B1 (en) 1997-09-12 2001-03-20 Akzo Nobel N.V. CCR5 RNA transcription based amplification assay
US6337072B1 (en) 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
US6294655B1 (en) 1998-04-03 2001-09-25 Hyseq, Inc. Anti-interleukin-1 receptor antagonist antibodies and uses thereof
US6541623B1 (en) 1998-04-03 2003-04-01 Hyseq, Inc. Interleukin—1 receptor antagonist and uses thereof
US6426191B1 (en) 1998-04-03 2002-07-30 Hyseq, Inc. Assays involving an IL-1 receptor antagonist
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
EP1346731B1 (de) * 1998-07-22 2006-12-06 Osprey Pharmaceuticals Limited Konjugate zur Behandlung von Entzündungskrankheiten und von assozierter Gewebeschädigung
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
AU6278399A (en) * 1998-10-02 2000-04-26 Ludwig Institute For Cancer Research Tsg-5: a tnf-inducible gene
JP4868698B2 (ja) 2001-05-02 2012-02-01 パーデュー・リサーチ・ファウンデーション マクロファージが仲介する疾患の治療および診断
WO2003083059A2 (en) * 2002-03-26 2003-10-09 Centocor, Inc. Mcp-1 mutant proteins, antibodies, compositions, methods and uses
CA2484121A1 (en) * 2002-05-01 2003-11-13 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
WO2007006041A2 (en) * 2005-07-05 2007-01-11 Purdue Research Foundation Imaging and therapeutic method using monocytes
CA2677792C (en) 2007-02-07 2015-04-14 Purdue Research Foundation Positron emission tomography imaging method
MX361929B (es) 2010-11-19 2018-12-19 Eisai R&D Man Co Ltd Star Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes.

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US4276280A (en) * 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4520112A (en) * 1983-03-09 1985-05-28 The Johns Hopkins University Assay method for organic calcium antagonist drugs and a kit for such an assay
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5037630A (en) * 1985-01-14 1991-08-06 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4926869A (en) * 1986-01-16 1990-05-22 The General Hospital Corporation Method for the diagnosis and treatment of inflammation
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
EP0284071B1 (de) * 1987-03-26 1994-06-08 Neorx Corporation Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
AU623698B2 (en) * 1988-09-02 1992-05-21 Chiron Corporation Macrophage-derived inflammatory mediator (mip-2)
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US5198424A (en) * 1989-03-08 1993-03-30 Board Of Regents Of The University Of Oklahoma Functionally active selectin-derived peptides
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
NZ233601A (en) * 1989-05-09 1997-06-24 Gen Hospital Corp N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue
US5179078A (en) * 1989-05-12 1993-01-12 Dana Farber Cancer Institute Method of suppressing tumor formation in vivo
US5241049A (en) * 1989-12-22 1993-08-31 Zymogenetics, Inc. Neutrophil chemoattractants
US5079228A (en) * 1990-02-05 1992-01-07 Board Of Regents, The University Of Texas System Peptide inhibitors of neutrophil activating factor induced chemotaxis
JPH05507276A (ja) * 1990-05-03 1993-10-21 ニュー・イングランド・ディーコネス・ホスピタル・コーポレイション 動脈造影用合成ペプチド類
IE913192A1 (en) * 1990-09-12 1992-02-25 Scripps Research Inst Active site of interleukin-8: polypeptide analogs and¹antibodies

Also Published As

Publication number Publication date
EP0662843A1 (de) 1995-07-19
EP0662843B1 (de) 1997-04-02
AU5403294A (en) 1994-04-26
WO1994007542A3 (en) 1994-06-23
WO1994007542A2 (en) 1994-04-14
CA2145983A1 (en) 1994-04-14
AU674039B2 (en) 1996-12-05
DE69309479D1 (de) 1997-05-07
ATE150977T1 (de) 1997-04-15
CA2145983C (en) 2000-04-18
US5413778A (en) 1995-05-09
JPH08502075A (ja) 1996-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee