DE69232682D1 - Verfahren zur selektiven vermehrung von cd34 positiven zellen - Google Patents

Verfahren zur selektiven vermehrung von cd34 positiven zellen

Info

Publication number
DE69232682D1
DE69232682D1 DE69232682T DE69232682T DE69232682D1 DE 69232682 D1 DE69232682 D1 DE 69232682D1 DE 69232682 T DE69232682 T DE 69232682T DE 69232682 T DE69232682 T DE 69232682T DE 69232682 D1 DE69232682 D1 DE 69232682D1
Authority
DE
Germany
Prior art keywords
selectively
propaging
positive cells
stem cells
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232682T
Other languages
English (en)
Other versions
DE69232682T2 (de
Inventor
Shelly Heimfeld
J Berenson
Ruigao Fei
A Goffe
R Peterson
H Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexell Therapeutics Inc
Original Assignee
Nexell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexell Therapeutics Inc filed Critical Nexell Therapeutics Inc
Publication of DE69232682D1 publication Critical patent/DE69232682D1/de
Application granted granted Critical
Publication of DE69232682T2 publication Critical patent/DE69232682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Secondary Cells (AREA)
DE69232682T 1991-10-23 1992-10-22 Verfahren zur selektiven vermehrung von cd34 positiven zellen Expired - Lifetime DE69232682T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78048891A 1991-10-23 1991-10-23
PCT/US1992/009019 WO1993008268A1 (en) 1991-10-23 1992-10-22 Methods for selectively expanding stem cells

Publications (2)

Publication Number Publication Date
DE69232682D1 true DE69232682D1 (de) 2002-08-22
DE69232682T2 DE69232682T2 (de) 2003-03-13

Family

ID=25119727

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232682T Expired - Lifetime DE69232682T2 (de) 1991-10-23 1992-10-22 Verfahren zur selektiven vermehrung von cd34 positiven zellen

Country Status (8)

Country Link
EP (1) EP0614485B1 (de)
JP (1) JPH07503127A (de)
AT (1) ATE220715T1 (de)
CA (1) CA2122141C (de)
DE (1) DE69232682T2 (de)
DK (1) DK0614485T3 (de)
ES (1) ES2180539T3 (de)
WO (1) WO1993008268A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554512A (en) * 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
NZ314644A (en) 1993-05-24 2000-11-24 Immunex Corp Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue
US5409813A (en) * 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US6190655B1 (en) 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
US7294331B2 (en) 1994-03-07 2007-11-13 Immunex Corporation Methods of using flt3-ligand in hematopoietic cell transplantation
US5580724A (en) * 1994-03-25 1996-12-03 Board Of Regents, The University Of Texas System Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis
US5972627A (en) * 1994-06-15 1999-10-26 Systemix, Inc. Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby
US5985660A (en) * 1994-06-15 1999-11-16 Systemix, Inc. Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5663051A (en) * 1994-08-31 1997-09-02 Activated Cell Therapy, Inc. Separation apparatus and method
US5646004A (en) * 1994-08-31 1997-07-08 Activated Cell Therapy, Inc. Methods for enriching fetal cells from maternal body fluids
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5648223A (en) * 1994-08-31 1997-07-15 Activated Cell Therapy, Inc. Methods for enriching breast tumor cells
US5674750A (en) * 1995-05-19 1997-10-07 T. Breeders Continuous selective clonogenic expansion of relatively undifferentiated cells
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US6015554A (en) * 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
US7361330B2 (en) 1995-10-04 2008-04-22 Immunex Corporation Methods of using flt3-ligand in the treatment of fibrosarcoma
ATE432085T1 (de) 1995-10-04 2009-06-15 Immunex Corp Stimulationsfaktor für dendriten
US7150992B1 (en) 1995-10-04 2006-12-19 Innunex Corporation Methods of preparing dendritic cells with flt3-ligand and antigen
EP0877795A4 (de) * 1996-01-16 2003-03-05 Depuy Orthopaedics Inc Isolierung von vorläuferzellen aus hematopoietischen und nicht hematopoietischen gewebe und deren verwendung
US6429012B1 (en) 1997-10-06 2002-08-06 Viacell, Inc. Cell population containing non-fetal hemangioblasts and method for producing same
EP1070757B1 (de) 1998-04-08 2005-02-02 Shionogi & Co., Ltd. Verfahren um Vorläuferzellen von Osteoklasten zu isolieren und ihre Differenzierung in Osteoklasten zu induzieren.
EP1105463A1 (de) * 1998-08-24 2001-06-13 t. Breeders, Inc. Hemangioblasten enthaltender zellverband und dessen herstellungsverfahren
EP1697399B1 (de) 2003-12-12 2016-11-23 GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS Epitop humaner zytotoxischer t-lymphozyten und dessen agonistenepitop aus der nichtvariablen zahl der tandem-wiederholungssequenz von muc-1
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
WO2010055900A1 (ja) 2008-11-14 2010-05-20 ディナベック株式会社 樹状細胞の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087570A (en) * 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5622853A (en) * 1990-05-01 1997-04-22 Becton Dickinson And Company T lymphocyte precursor
US5154921A (en) * 1990-07-13 1992-10-13 Dana-Farber Cancer Institute, Inc. Promotion of maturation of hematopoietic progenitor cells

Also Published As

Publication number Publication date
ES2180539T3 (es) 2003-02-16
CA2122141A1 (en) 1993-04-29
EP0614485A1 (de) 1994-09-14
CA2122141C (en) 2007-07-17
EP0614485B1 (de) 2002-07-17
DE69232682T2 (de) 2003-03-13
WO1993008268A1 (en) 1993-04-29
JPH07503127A (ja) 1995-04-06
DK0614485T3 (da) 2002-10-28
ATE220715T1 (de) 2002-08-15

Similar Documents

Publication Publication Date Title
DE69232682T2 (de) Verfahren zur selektiven vermehrung von cd34 positiven zellen
MX9201113A (es) Metodo para identificar o tamizar agonistas o antagonistas de la amilina.
ATE397752T1 (de) Verfahren und verwendung von anordungen von proteinfixierungsmitteln
AU6380001A (en) Porous ferro- or ferrimagnetic glass particles for isolating molecules
DE69013702T2 (de) Verfahren zur Extraktion und Abscheidung und Vorrichtung zur Verwendung von überkritischem Druck.
DE59510976D1 (de) Verfahren zur isolierung von zellinhaltsstoffen, wie nucleinsäuren, aus natürlichen quellen
DE3382193D1 (de) Verfahren zur herstellung von wasserstoffreichem gas aus kohlenwasserstoffen.
TR28236A (tr) Santrifüjlü ayirici ve ayirma yöntemi.
DE68911508D1 (de) Verfahren zur herstellung von linear ausgedehnten polyalkylenpolyaminen.
DE69524369T2 (de) Verfahren zur Extraktion von Karotenoiden aus Bakterienzellen
ES2169025T3 (es) Compuestos, vectores y procedimiento para expresar fosfolipasa a2 citosolica humana.
DE69910253D1 (de) Verfahren zur herstellung von inaktivierten, w/ö emulsion adjuvierten, impfstoffen
ATE126531T1 (de) Verfahren zur gewinnung von natürlich hergestelltem chymosin.
DE69006489T2 (de) Verfahren zur kontinuierlichen wiedergewinnung von fluorwasserstoffgas.
DE912476T1 (de) Verfahren zur abtrennung von difluormethan
ATE199446T1 (de) Verfahren zur herstellung von dichtungsringen aus blähgraphit
DE69319715D1 (de) Verfahren zur Analyse, Abtrennung und Mikroverkapselung von zellulären Elementen
DE3874507D1 (de) Verfahren zur trennung von dichlorcumolisomeren.
DE69001391D1 (de) Verfahren zur rueckfuehrung von bei der entklebung von lack, entstandenen abfaellen und endprodukt.
DE69624730T2 (de) Verfahren zur selektiven spaltung von naphthalin-ringen
DE59801387D1 (de) Verfahren zur abtrennung von 6-aminocapronitril aus mischungen, die 6-aminocapronitril und ein imin enthalten
DE3769357D1 (de) Verfahren zur gewinnung von polymerisaten aus ihren dispersionen.
DE3781722D1 (de) Verfahren zur adsorptiven trennung von dichlortoluen.
DE59105196D1 (de) Verfahren zur prüfung von anordnungen.
ATE146594T1 (de) Verfahren zur gewinnung von zellen, die informationen tragen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition