DE69226773D1 - MICROELECTRO SPRAYING METHOD AND DEVICE - Google Patents

MICROELECTRO SPRAYING METHOD AND DEVICE

Info

Publication number
DE69226773D1
DE69226773D1 DE69226773T DE69226773T DE69226773D1 DE 69226773 D1 DE69226773 D1 DE 69226773D1 DE 69226773 T DE69226773 T DE 69226773T DE 69226773 T DE69226773 T DE 69226773T DE 69226773 D1 DE69226773 D1 DE 69226773D1
Authority
DE
Germany
Prior art keywords
solution
terminal portion
capillary tube
electrospraying
electrospray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226773T
Other languages
German (de)
Other versions
DE69226773T2 (en
Inventor
James Jorgenson
Daniel M Dohmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of DE69226773D1 publication Critical patent/DE69226773D1/en
Publication of DE69226773T2 publication Critical patent/DE69226773T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Optical Measuring Cells (AREA)

Abstract

A method of generating an electrospray from a solution is disclosed which is useful for electrospraying at low flow rates, for electrospraying directly into a vacuum, or both. The method comprises the steps of causing the solution to flow through a capillary tube to an outlet opening formed in the terminal portion thereof. The capillary tube terminal portion has an inner diameter of not more than 50 micrometers and an outer diameter of not more than 150 micrometers. An electrical potential difference is provided between the capillary tube terminal portion and a conductor spaced from said terminal portion, with the potential sufficient to cause the solution to electrospray from the capillary outlet. The method is particularly useful for detecting analytes in the solution being electrosprayed by mass spectral analysis.
DE69226773T 1991-05-15 1992-05-14 MICROELECTRO SPRAYING METHOD AND DEVICE Expired - Fee Related DE69226773T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/700,572 US5115131A (en) 1991-05-15 1991-05-15 Microelectrospray method and apparatus
PCT/US1992/004015 WO1992020437A1 (en) 1991-05-15 1992-05-14 Microelectrospray method and apparatus

Publications (2)

Publication Number Publication Date
DE69226773D1 true DE69226773D1 (en) 1998-10-01
DE69226773T2 DE69226773T2 (en) 1999-04-29

Family

ID=24814024

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226773T Expired - Fee Related DE69226773T2 (en) 1991-05-15 1992-05-14 MICROELECTRO SPRAYING METHOD AND DEVICE

Country Status (7)

Country Link
US (1) US5115131A (en)
EP (1) EP0586543B1 (en)
JP (1) JP3350547B2 (en)
AT (1) ATE170332T1 (en)
CA (1) CA2102431C (en)
DE (1) DE69226773T2 (en)
WO (1) WO1992020437A1 (en)

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US5504327A (en) * 1993-11-04 1996-04-02 Hv Ops, Inc. (H-Nu) Electrospray ionization source and method for mass spectrometric analysis
US7047171B1 (en) 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US20060277017A1 (en) * 1993-11-04 2006-12-07 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
DE4408032A1 (en) * 1994-03-10 1995-09-14 Bruker Franzen Analytik Gmbh Process for the ionization of dissolved atoms or molecules from liquids by electrical spraying
US5608217A (en) * 1994-03-10 1997-03-04 Bruker-Franzen Analytik Gmbh Electrospraying method for mass spectrometric analysis
DE4444229C2 (en) * 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Methods and devices for electrospray ionization for storage mass spectrometers
DE4415480C2 (en) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Device and method for the mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI)
IT1270203B (en) * 1994-06-09 1997-04-29 Fisons Instr Spa PROCEDURE AND DEVICE FOR THE INTRODUCTION OF LIQUIDS IN MASS SPECTROMETERS BY ELECTROSTATIC SPRAYING
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5572023A (en) * 1995-05-30 1996-11-05 Board Of Regents, The University Of Texas System Electrospray methods and apparatus for trace analysis
US5838002A (en) * 1996-08-21 1998-11-17 Chem-Space Associates, Inc Method and apparatus for improved electrospray analysis
US6278111B1 (en) 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
WO1997026072A1 (en) * 1996-01-19 1997-07-24 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5788166A (en) * 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6070779A (en) * 1997-02-06 2000-06-06 U.S. Philips Corporation Liquid dosing device
US5828062A (en) * 1997-03-03 1998-10-27 Waters Investments Limited Ionization electrospray apparatus for mass spectrometry
WO1998042007A1 (en) * 1997-03-15 1998-09-24 Analytica Of Branford, Inc. Disposable microtip probe for low flow electrospray
GB2366663B (en) * 1997-03-15 2002-04-24 Analytica Of Branford Inc Disposable microchip probe for low flow electrospray
US6207955B1 (en) * 1998-09-28 2001-03-27 Varian, Inc. Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry
US6586731B1 (en) 1999-04-12 2003-07-01 Mds Inc. High intensity ion source apparatus for mass spectrometry
US6407382B1 (en) 1999-06-04 2002-06-18 Technispan Llc Discharge ionization source
DE69931787T2 (en) 1999-11-11 2007-05-24 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Device and method for administration of drops
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
US6768119B2 (en) * 2000-04-06 2004-07-27 De La Mora Juan F. Method and apparatus to produce ions and nanodrops from Taylor cones at reduced pressure
SE0004233D0 (en) * 2000-06-08 2000-11-17 Jonas Bergquist Jonas Electrospray emitter
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6653625B2 (en) 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
JP4199544B2 (en) 2001-03-19 2008-12-17 ユィロス・パテント・アクチボラグ Microfluidic system (EDI)
US20020168297A1 (en) * 2001-05-11 2002-11-14 Igor Shvets Method and device for dispensing of droplets
DE02744176T1 (en) 2001-05-24 2005-01-13 New Objective, Inc., Woburn METHOD AND DEVICE FOR ELECTROSPRAY WITH FEEDBACK CONTROL
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
WO2003031931A2 (en) 2001-10-05 2003-04-17 Yale University Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures
WO2004057638A2 (en) * 2002-12-18 2004-07-08 Brigham Young University Method and apparatus for aerodynamic ion focusing
SE0300454D0 (en) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US6870154B1 (en) 2004-02-27 2005-03-22 The University Of Western Ontario Capillary mixer with adjustable reaction chamber volume for mass spectrometry
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US20090218481A1 (en) * 2004-10-07 2009-09-03 Dewalch Norman Binz High-Speed Molecular Analyzer System and Method
US20090084979A1 (en) * 2004-10-07 2009-04-02 Dewalch Norman Binz High-speed molecular analyzer system and method
US7798420B2 (en) * 2005-02-11 2010-09-21 Battelle Memorial Institute Aerosol dispensing device and method
US20060208186A1 (en) * 2005-03-15 2006-09-21 Goodley Paul C Nanospray ion source with multiple spray emitters
GB0524979D0 (en) * 2005-12-07 2006-01-18 Queen Mary & Westfield College An electrospray device and a method of electrospraying
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
GB0709517D0 (en) * 2007-05-17 2007-06-27 Queen Mary & Westfield College An electrostatic spraying device and a method of electrostatic spraying
DE112008001754T5 (en) * 2007-07-09 2010-05-20 Middlesex General Industries, Inc., Woburn System and method for improving throughput and vehicle utilization of monorail factory transport systems
US8173960B2 (en) * 2007-08-31 2012-05-08 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
US7671344B2 (en) * 2007-08-31 2010-03-02 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
GB2471520B (en) 2009-07-03 2013-08-21 Microsaic Systems Plc An electrospray pneumatic nebuliser ionisation source
CN102221576B (en) 2010-04-15 2015-09-16 岛津分析技术研发（上海）有限公司 The method and apparatus of a kind of generation, analysis ion
EP3042190B1 (en) * 2013-08-29 2024-04-03 University of Notre Dame du Lac High sensitivity electrospray interface
US9711341B2 (en) * 2014-06-10 2017-07-18 The University Of North Carolina At Chapel Hill Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods
CN115295394A (en) * 2015-05-12 2022-11-04 北卡罗来纳-查佩尔山大学 Electrospray ionization interface for high pressure mass spectrometry and related methods
US9406492B1 (en) * 2015-05-12 2016-08-02 The University Of North Carolina At Chapel Hill Electrospray ionization interface to high pressure mass spectrometry and related methods
US10818486B2 (en) * 2015-12-18 2020-10-27 Dh Technologies Development Pte. Ltd. System for minimizing electrical discharge during ESI operation
CN105575752B (en) * 2016-03-04 2017-09-22 北京工业大学 A kind of difunctional uniform internal diameter skin liquid spectrum nozzle needle and preparation method
US10763095B2 (en) * 2016-06-02 2020-09-01 Shimadzu Corporation Ionizer and mass spectrometer system

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US4542293A (en) * 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4531056A (en) * 1983-04-20 1985-07-23 Yale University Method and apparatus for the mass spectrometric analysis of solutions
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4861988A (en) * 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
US4977320A (en) * 1990-01-22 1990-12-11 The Rockefeller University Electrospray ionization mass spectrometer with new features
US5015845A (en) * 1990-06-01 1991-05-14 Vestec Corporation Electrospray method for mass spectrometry

Also Published As

Publication number Publication date
DE69226773T2 (en) 1999-04-29
EP0586543A1 (en) 1994-03-16
US5115131A (en) 1992-05-19
EP0586543A4 (en) 1995-12-20
EP0586543B1 (en) 1998-08-26
ATE170332T1 (en) 1998-09-15
CA2102431A1 (en) 1992-11-16
WO1992020437A1 (en) 1992-11-26
JP3350547B2 (en) 2002-11-25
CA2102431C (en) 2000-04-25
JPH06507997A (en) 1994-09-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee