DE69226773D1 - Mikroelektrosprühverfahren and - device - Google Patents

Mikroelektrosprühverfahren and - device

Info

Publication number
DE69226773D1
DE69226773D1 DE1992626773 DE69226773A DE69226773D1 DE 69226773 D1 DE69226773 D1 DE 69226773D1 DE 1992626773 DE1992626773 DE 1992626773 DE 69226773 A DE69226773 A DE 69226773A DE 69226773 D1 DE69226773 D1 DE 69226773D1
Authority
DE
Germany
Prior art keywords
mikroelektrosprühverfahren
device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1992626773
Other languages
German (de)
Other versions
DE69226773T2 (en
Inventor
James Jorgenson
Daniel M Dohmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/700,572 priority Critical patent/US5115131A/en
Application filed by University of North Carolina, University of North Carolina at Chapel Hill filed Critical University of North Carolina
Priority to PCT/US1992/004015 priority patent/WO1992020437A1/en
Application granted granted Critical
Publication of DE69226773D1 publication Critical patent/DE69226773D1/en
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165Electrospray ionisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
DE1992626773 1991-05-15 1992-05-14 Mikroelektrosprühverfahren and - device Expired - Fee Related DE69226773D1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US07/700,572 US5115131A (en) 1991-05-15 1991-05-15 Microelectrospray method and apparatus
PCT/US1992/004015 WO1992020437A1 (en) 1991-05-15 1992-05-14 Microelectrospray method and apparatus

Publications (1)

Publication Number Publication Date
DE69226773D1 true DE69226773D1 (en) 1998-10-01

Family

ID=24814024

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1992626773 Expired - Lifetime DE69226773T2 (en) 1991-05-15 1992-05-14 Mikroelektrosprühverfahren and - device
DE1992626773 Expired - Fee Related DE69226773D1 (en) 1991-05-15 1992-05-14 Mikroelektrosprühverfahren and - device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1992626773 Expired - Lifetime DE69226773T2 (en) 1991-05-15 1992-05-14 Mikroelektrosprühverfahren and - device

Country Status (7)

Country Link
US (1) US5115131A (en)
EP (1) EP0586543B1 (en)
JP (1) JP3350547B2 (en)
AT (1) AT170332T (en)
CA (1) CA2102431C (en)
DE (2) DE69226773T2 (en)
WO (1) WO1992020437A1 (en)

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US5170053A (en) * 1990-08-30 1992-12-08 Finnigan Corporation Electrospray ion source and interface apparatus and method
US5245185A (en) * 1991-11-05 1993-09-14 Georgia Tech Research Corporation Interface device and process to couple planar electrophoresis with spectroscopic methods of detection
US5423964A (en) * 1993-08-02 1995-06-13 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US5504327A (en) * 1993-11-04 1996-04-02 Hv Ops, Inc. (H-Nu) Electrospray ionization source and method for mass spectrometric analysis
US20060277017A1 (en) * 1993-11-04 2006-12-07 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US5608217A (en) * 1994-03-10 1997-03-04 Bruker-Franzen Analytik Gmbh Electrospraying method for mass spectrometric analysis
DE4408032A1 (en) * 1994-03-10 1995-09-14 Bruker Franzen Analytik Gmbh A process for the ionization of solute atoms or molecules from liquids by electric spraying
DE4444229C2 (en) * 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Methods and apparatus for electrospray ionization mass spectrometer for storing
DE4415480C2 (en) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Apparatus and method for mass spectrometric analysis of mixtures of substances by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI)
IT1270203B (en) * 1994-06-09 1997-04-29 Fisons Instr Spa Method and device for the introduction of liquids into mass spectrometers by electrostatic spraying
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5572023A (en) * 1995-05-30 1996-11-05 Board Of Regents, The University Of Texas System Electrospray methods and apparatus for trace analysis
US6278111B1 (en) 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
US7047171B1 (en) 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US6068749A (en) * 1996-01-19 2000-05-30 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5838002A (en) * 1996-08-21 1998-11-17 Chem-Space Associates, Inc Method and apparatus for improved electrospray analysis
US5788166A (en) * 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6070779A (en) * 1997-02-06 2000-06-06 U.S. Philips Corporation Liquid dosing device
US5828062A (en) * 1997-03-03 1998-10-27 Waters Investments Limited Ionization electrospray apparatus for mass spectrometry
WO1998042007A1 (en) * 1997-03-15 1998-09-24 Analytica Of Branford, Inc. Disposable microtip probe for low flow electrospray
GB2366448B (en) * 1997-03-15 2002-04-10 Analytica Of Branford Inc Method for opening an electrospray tip
US6207955B1 (en) * 1998-09-28 2001-03-27 Varian, Inc. Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry
CA2305071C (en) 1999-04-12 2009-03-24 Mds Inc. High intensity ion source
US6407382B1 (en) 1999-06-04 2002-06-18 Technispan Llc Discharge ionization source
DE69931787T2 (en) 1999-11-11 2007-05-24 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Device and method for administering drops
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
US6768119B2 (en) * 2000-04-06 2004-07-27 De La Mora Juan F. Method and apparatus to produce ions and nanodrops from Taylor cones at reduced pressure
SE0004233D0 (en) * 2000-06-08 2000-11-17 Jonas Bergquist Jonas Electrospray source
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
CA2442342A1 (en) 2001-03-19 2002-09-26 Per Andersson A microfluidic system (edi)
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US20020168297A1 (en) * 2001-05-11 2002-11-14 Igor Shvets Method and device for dispensing of droplets
JP4080893B2 (en) 2001-05-24 2008-04-23 ニューオブジェクティブ,インク. Method and apparatus for feedback control of the electrospray
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
CA2462854A1 (en) 2001-10-05 2003-04-17 Yale University Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures
US6992299B2 (en) * 2002-12-18 2006-01-31 Brigham Young University Method and apparatus for aerodynamic ion focusing
SE0300454D0 (en) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US6870154B1 (en) 2004-02-27 2005-03-22 The University Of Western Ontario Capillary mixer with adjustable reaction chamber volume for mass spectrometry
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US20090218481A1 (en) * 2004-10-07 2009-09-03 Dewalch Norman Binz High-Speed Molecular Analyzer System and Method
US20090084979A1 (en) * 2004-10-07 2009-04-02 Dewalch Norman Binz High-speed molecular analyzer system and method
MX2007009668A (en) * 2005-02-11 2007-09-26 Battelle Memorial Institute Ehd aerosol dispensing device and spraying method.
US20060208186A1 (en) * 2005-03-15 2006-09-21 Goodley Paul C Nanospray ion source with multiple spray emitters
GB0524979D0 (en) * 2005-12-07 2006-01-18 Queen Mary & Westfield College An electrospray device and a method of electrospraying
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
GB0709517D0 (en) * 2007-05-17 2007-06-27 Queen Mary & Westfield College An electrostatic spraying device and a method of electrostatic spraying
KR101492886B1 (en) * 2007-07-09 2015-02-12 미들섹스 제네랄 인더스트리즈, 이이앤씨 System and method of improving throughput and vehicle utilization of monorail factory transport systems
US8173960B2 (en) * 2007-08-31 2012-05-08 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
US7671344B2 (en) * 2007-08-31 2010-03-02 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
GB2471520B (en) 2009-07-03 2013-08-21 Microsaic Systems Plc An electrospray pneumatic nebuliser ionisation source
CN102221576B (en) 2010-04-15 2015-09-16 岛津分析技术研发(上海)有限公司 A method of generating, method and apparatus for analysis of ions
CN105723213A (en) * 2013-08-29 2016-06-29 圣母大学 High sensitivity electrospray interface
US9711341B2 (en) * 2014-06-10 2017-07-18 The University Of North Carolina At Chapel Hill Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods
US9406492B1 (en) 2015-05-12 2016-08-02 The University Of North Carolina At Chapel Hill Electrospray ionization interface to high pressure mass spectrometry and related methods
CN105575752B (en) * 2016-03-04 2017-09-22 北京工业大学 A dual function inner diameter of the needle sheath flow and mass production method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4531056A (en) * 1983-04-20 1985-07-23 Yale University Method and apparatus for the mass spectrometric analysis of solutions
US4542293A (en) * 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4861988A (en) * 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
US4977320A (en) * 1990-01-22 1990-12-11 The Rockefeller University Electrospray ionization mass spectrometer with new features
US5015845A (en) * 1990-06-01 1991-05-14 Vestec Corporation Electrospray method for mass spectrometry

Also Published As

Publication number Publication date
DE69226773T2 (en) 1999-04-29
CA2102431A1 (en) 1992-11-16
EP0586543A1 (en) 1994-03-16
WO1992020437A1 (en) 1992-11-26
JP3350547B2 (en) 2002-11-25
CA2102431C (en) 2000-04-25
JPH06507997A (en) 1994-09-08
US5115131A (en) 1992-05-19
EP0586543A4 (en) 1995-12-20
EP0586543B1 (en) 1998-08-26
AT170332T (en) 1998-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee