DE69224327D1 - Nucleotide sequences - Google Patents

Nucleotide sequences

Info

Publication number
DE69224327D1
DE69224327D1 DE69224327T DE69224327T DE69224327D1 DE 69224327 D1 DE69224327 D1 DE 69224327D1 DE 69224327 T DE69224327 T DE 69224327T DE 69224327 T DE69224327 T DE 69224327T DE 69224327 D1 DE69224327 D1 DE 69224327D1
Authority
DE
Germany
Prior art keywords
nucleotide sequences
methods
yacs
alzheimer
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224327T
Other languages
German (de)
Other versions
DE69224327T2 (en
Inventor
Rakesh Anand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919112801A external-priority patent/GB9112801D0/en
Priority claimed from GB919112795A external-priority patent/GB9112795D0/en
Priority claimed from GB919112799A external-priority patent/GB9112799D0/en
Priority claimed from GB919112797A external-priority patent/GB9112797D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69224327D1 publication Critical patent/DE69224327D1/en
Publication of DE69224327T2 publication Critical patent/DE69224327T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Yeast artificial chromosomes (YACs), nucleotide sequences and polypeptides derived therefrom. Their use in methods for the detection, diagnosis and therapy of Alzheimer's disease. Their use in the preparation of transfected cells and transgenic animals. Diagnostic kits for use in the methods of the invention.
DE69224327T 1991-06-13 1992-06-08 Nucleotide sequences Expired - Fee Related DE69224327T2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919112801A GB9112801D0 (en) 1991-06-13 1991-06-13 Polynucleotides
GB919112795A GB9112795D0 (en) 1991-06-13 1991-06-13 Nucleotide sequence
GB919112799A GB9112799D0 (en) 1991-06-13 1991-06-13 Nucleic acid sequences
GB919112797A GB9112797D0 (en) 1991-06-13 1991-06-13 Nucleotide sequences

Publications (2)

Publication Number Publication Date
DE69224327D1 true DE69224327D1 (en) 1998-03-12
DE69224327T2 DE69224327T2 (en) 1998-06-10

Family

ID=27450699

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224327T Expired - Fee Related DE69224327T2 (en) 1991-06-13 1992-06-08 Nucleotide sequences

Country Status (10)

Country Link
US (1) US5525467A (en)
EP (1) EP0518583B1 (en)
JP (1) JPH05211897A (en)
AT (1) ATE163050T1 (en)
AU (1) AU662150B2 (en)
CA (1) CA2071105A1 (en)
DE (1) DE69224327T2 (en)
GB (1) GB2256642B (en)
IE (1) IE71923B1 (en)
NZ (1) NZ242955A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023049A2 (en) * 1993-04-02 1994-10-13 The Johns Hopkins University The introduction and expression of large genomic sequences in transgenic animals
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
FR2742758A1 (en) * 1994-10-28 1997-06-27 Ass Fr Contre Les Myopathies Probes for diagnosing Alzheimer's disease
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6210919B1 (en) 1995-04-28 2001-04-03 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6531586B1 (en) 1995-04-28 2003-03-11 The Hospital For Sick Children Genetic sequences related to Alzheimer's Disease
WO1997027296A1 (en) * 1996-01-26 1997-07-31 Hsc Research And Development Limited Partnership Nucleic acids and proteins related to alzheimer's disease, and uses therefor
US20030131364A1 (en) * 1999-04-27 2003-07-10 Karen Duff Method for producing transgenic animal models with modulated phenotype and animals produced therefrom
WO2006032021A2 (en) 2004-09-14 2006-03-23 Yale University Identification of gene associated with reading disability and uses therefor
WO2014074755A1 (en) 2012-11-07 2014-05-15 Yale University Assessing risk of reading and language impairment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724412D0 (en) * 1987-10-19 1987-11-25 Medical Res Council Protein
AU3204689A (en) * 1988-02-10 1989-09-06 Children's Medical Center Corporation Amyloid protein precursors, genetic probes, antibodies, and methods of use
US5015570A (en) * 1988-05-13 1991-05-14 Molecular Therapeutics, Inc. Molecular diagnosis of Alzheimer Disease
GB8920211D0 (en) * 1989-09-07 1989-10-18 Ici Plc Diagnostic method
EP0421099A3 (en) * 1989-09-25 1991-11-21 American Cyanamid Company Methods for modulating promoter responsible for beta amyloid precursor protein expression
GB8921791D0 (en) * 1989-09-27 1989-11-08 Imp Cancer Res Tech Disease gene
WO1991017269A1 (en) * 1990-05-03 1991-11-14 Ig Laboratories, Inc. A method for mapping a eukaryotic chromosome
IT1243515B (en) * 1990-09-17 1994-06-16 Fidia Spa METHOD FOR DETERMINING THE DIFFERENTIAL EXPRESSION OF MESSANGERS RNA FOR AMYLOID PRECURSOR PROTEIN (AMYLOID PRECURSOR PROTEIN, APP)
FI904766A (en) * 1990-09-27 1992-03-28 Locus Genex Oy FOERFARANDE FOER DETEKTERING AV PROTEIN.

Also Published As

Publication number Publication date
GB9212431D0 (en) 1992-07-22
NZ242955A (en) 1995-01-27
EP0518583B1 (en) 1998-02-04
AU662150B2 (en) 1995-08-24
ATE163050T1 (en) 1998-02-15
DE69224327T2 (en) 1998-06-10
CA2071105A1 (en) 1992-12-14
JPH05211897A (en) 1993-08-24
US5525467A (en) 1996-06-11
GB2256642A (en) 1992-12-16
GB2256642B (en) 1995-12-06
IE71923B1 (en) 1997-03-12
AU1821592A (en) 1992-12-17
EP0518583A1 (en) 1992-12-16
IE921722A1 (en) 1992-12-16

Similar Documents

Publication Publication Date Title
EP0252685A3 (en) Diagnostic methods for detecting lymphomas in humans
DE69333008D1 (en) PROBE FOR DIAGNOSIS OF AN CONTAGIOUS DISEASE
DE69534468D1 (en) GROWTH DIFFERENTIATION FACTOR 11
DE68916693D1 (en) Molecular diagnosis of Alzheimer's disease.
Kondrashev et al. Coloration of corneas in fish: A list of species.
EP0259160A3 (en) Synthetic genes for human interleukin 1-alpha
AU4691589A (en) Feline infectious peritonitis virus diagnostic tools
DE69224327T2 (en) Nucleotide sequences
DE69334211D1 (en) MULTIDRUG RESISTANCE GEN
GB2235769B (en) Detection of inherited disease alleles in DNA samples using yeast artificial chromosomes
DE69604228T2 (en) Pupil measurement arrangement and Alzheimer's disease diagnosis system
DE3881783T2 (en) Toothbrush for regulating the brushing rhythm.
NO985280D0 (en) Use of a mutation in the gene for human G protein 3 subunit for the diagnosis of diseases
DK0870036T3 (en) Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences therefore encoding
DE69013139T2 (en) Means for the prevention, diagnosis and therapy of rheumatic, autoimmune, skin and connective tissue diseases of unknown etiology and methods for their preparation and use.
AU6919691A (en) In vivo animal model for studying alzheimer's disease
GB2295395A (en) Models of Alzheimer's Disease
IT8784934A0 (en) PROCEDURE FOR OBTAINING ARTIFICIAL STONES FROM FLOORS AND CLADDINGS AND STONES SO OBTAINED.
DE68914886D1 (en) Agent for the treatment of Raynaud's disease.
FI903637A0 (en) DIAGNOSTIC ANALYSIS FOR THE CONDITION OF ANALYSIS OF CLINICAL TREATMENT.
ATE45271T1 (en) MEANS AND METHODS FOR OPTIMIZING THE TISSUE MASS OF ORGANS WITHIN THE GENETIC VARIETY IN HUMANS AND ANIMALS.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee