GB2295395A - Models of Alzheimer's Disease - Google Patents

Models of Alzheimer's Disease

Info

Publication number
GB2295395A
GB2295395A GB9602484A GB9602484A GB2295395A GB 2295395 A GB2295395 A GB 2295395A GB 9602484 A GB9602484 A GB 9602484A GB 9602484 A GB9602484 A GB 9602484A GB 2295395 A GB2295395 A GB 2295395A
Authority
GB
United Kingdom
Prior art keywords
alzheimer
disease
models
animals
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9602484A
Other versions
GB2295395B (en
GB9602484D0 (en
Inventor
Brian Anderton
Christopher Charles Joh Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST OF PSYCHIATRY
Original Assignee
INST OF PSYCHIATRY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939316727A external-priority patent/GB9316727D0/en
Application filed by INST OF PSYCHIATRY filed Critical INST OF PSYCHIATRY
Priority to GB9602484A priority Critical patent/GB2295395B/en
Publication of GB9602484D0 publication Critical patent/GB9602484D0/en
Publication of GB2295395A publication Critical patent/GB2295395A/en
Application granted granted Critical
Publication of GB2295395B publication Critical patent/GB2295395B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Abstract

Transgenic cell and animal models for Alzheimer's disease are described. Cells of the animals and the cell models themselves comprise a recombinant DNA construct comprising a control sequence and, under the control of the control sequence, a DNA sequence encoding a kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-forming tau. The transgenic cells and animals may be used for testing potential therapeutic agents for Alzheimer's disease.
GB9602484A 1993-08-12 1994-08-01 Models of Alzheimer's disease Expired - Fee Related GB2295395B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9602484A GB2295395B (en) 1993-08-12 1994-08-01 Models of Alzheimer's disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939316727A GB9316727D0 (en) 1993-08-12 1993-08-12 Models of alzheimers's disease
PCT/GB1994/001669 WO1995005466A1 (en) 1993-08-12 1994-08-01 Models of alzheimer's disease
GB9602484A GB2295395B (en) 1993-08-12 1994-08-01 Models of Alzheimer's disease

Publications (3)

Publication Number Publication Date
GB9602484D0 GB9602484D0 (en) 1996-04-03
GB2295395A true GB2295395A (en) 1996-05-29
GB2295395B GB2295395B (en) 1998-04-01

Family

ID=26303359

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9602484A Expired - Fee Related GB2295395B (en) 1993-08-12 1994-08-01 Models of Alzheimer's disease

Country Status (1)

Country Link
GB (1) GB2295395B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019810A1 (en) * 1990-06-15 1991-12-26 California Biotechnology Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
WO1993002189A1 (en) * 1991-07-18 1993-02-04 The Regents Of The University Of California Transgenic animal models for alzheimer's disease
WO1993007280A1 (en) * 1991-10-04 1993-04-15 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Astrocyte-specific transcription of human genes
WO1993011231A1 (en) * 1991-12-06 1993-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tools for the diagnosis and treatment of alzheimer's disease

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019810A1 (en) * 1990-06-15 1991-12-26 California Biotechnology Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
WO1993002189A1 (en) * 1991-07-18 1993-02-04 The Regents Of The University Of California Transgenic animal models for alzheimer's disease
WO1993007280A1 (en) * 1991-10-04 1993-04-15 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Astrocyte-specific transcription of human genes
WO1993011231A1 (en) * 1991-12-06 1993-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tools for the diagnosis and treatment of alzheimer's disease

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
EMBO JOURNAL, Vol. 11, No. 11, 1992, pages 3953-3961 *
EMBO JOURNAL, Vol. 11, No. 4, 1992, pages 1593-1597 *
EMBO JOURNAL, Vol. 11, No. 6, 1992, pages 2131-2138 *
EMBO JOURNAL, Vol. 12, No. 2, 1993, pages 803-808 *
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol. 51, No. 5, 1992, pages 499-505 *
NEUROSCIENCE LETTERS, Vol. 147, 1992, pages 58-62 *
PROC.NATL.ACAC.SCI.,USA, Vol. 87, 1990, pages 9703-9707 *

Also Published As

Publication number Publication date
GB2295395B (en) 1998-04-01
GB9602484D0 (en) 1996-04-03

Similar Documents

Publication Publication Date Title
DK549189D0 (en) GALANTHAMINE ANALOGUE AND USE OF THESE FOR THE PREPARATION OF MEDICINALS FOR TREATMENT OF ALZHEIMER'S DISEASE
DE69312317T2 (en) VERIFICATION OF DAIRY LIVING
IT1208521B (en) ELECTRODE, APPARATUS AND DEFIBRILLATION FOR IMPLANTATION IN HUMAN OR ANIMAL BODIES.
DE69130289T2 (en) THERAPEUTIC USE OF ACTIN BINDING COMPOUNDS
NO972451L (en) Heterocyclyloxy and thiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and preparations and process for use thereof
DE69841994D1 (en) 32 Human secreted proteins
DE69412195D1 (en) Device for imaging corneal cells
DK10782A (en) N-BENZOYL-N! -PHENYLURINE INGREDIENTS AND PROCEDURES
ATE163050T1 (en) NUCLEOTIDE SEQUENCES
DK0394035T3 (en) Genes encoding a protein with human MACIF activity, expression vectors containing these genes, transformant cells, and proteins with human MACIF activity
GB2295395A (en) Models of Alzheimer's Disease
DE3852625T2 (en) Vectors and compounds for the expression of zymogen forms of human protein C.
ES2063521T3 (en) MIXTURE OF SUBSTANCES WITH THERAPEUTIC ACTION CONSISTING OF GLUTATION AND ANTOCIAN COMPOUNDS.
DK325289A (en) STRONTIUM SALT, METHOD OF PREPARING IT, AND PHARMACEUTICAL AGENTS CONTAINING SALT
DE3886517D1 (en) Human prourokinase-like polypeptide.
WO2001002552A3 (en) Double transgenic animals as models for neurodegenerative disease
NO890174L (en) RECOMBINANT INTERLEUKIN-1ALFA POLYPEPTIDES.
ATE393229T1 (en) TAU-OPATHY MODEL
DK131188D0 (en) 3- (2-HALOGENALKYL) -1,4-OXATHIINES AND 2 (2-HALOGENALKYL) -1,4-DITHIINES, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE FOR THE TREATMENT OF LEUKAEMI AND TUMORS
DK221488A (en) DETERGENTS AND PROCEDURES FOR TANNING
DK555281A (en) TRIFLUORMETHOXYPHENYL-THIOPHOSPHORIC ACID ESTERS AND DIHTIOHOSPHORIC ACID ESTERS, AND PROCEDURES FOR PREPARING IT
DK625587D0 (en) ARTIFICIAL Bait, AND PROCEDURE FOR PREPARING THEREOF
Jacobson STUDIES ON THE NEURAL CONTROL OF LOCOMOTION IN THE CHICK.
ES2076238T3 (en) ADNC THAT CODES PLACENTA PROTEIN 9 (PP9), ITS ISOLATION AND USE.
NO900080L (en) BIOLOGICAL ACTIVE MIXTURE PROTEIN MIXTURE, A PROCEDURE FOR PREPARING IT AND USING THE MIXTURE.

Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20010801